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1. A Conversation with Karl Deisseroth
by Deisseroth, Karl and Witkowski, Jan
Cold Spring Harbor symposia on quantitative biology, 2014, Volume 79, pp. 266 - 268
Mice | Optogenetics | Animals | Interpersonal Relations | Humans | Neurons - physiology
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2. Full Text Optogenetics: 10 years of microbial opsins in neuroscience
by Deisseroth, Karl
Nature Neuroscience, ISSN 1097-6256, 08/2015, Volume 18, Issue 9, pp. 1213 - 1225
Over the past 10 years, the development and convergence of microbial opsin engineering, modular genetic methods for cell-type targeting and optical strategies... 
OPTICAL CONTROL | LIGHT-INDUCED ACTIVATION | IN-VIVO CONTROL | REMOTE-CONTROL | GREEN-ALGAE | RESTORES VISUAL RESPONSES | DEEP BRAIN-STIMULATION | NEURAL CIRCUITRY | NEUROSCIENCES | PREFRONTAL CORTEX | VENTRAL TEGMENTAL AREA | Rhodopsins, Microbial - genetics | Neurosciences | Optogenetics - methods | Opsins - genetics | Protein Structure, Secondary | Humans | Opsins - biosynthesis | Optogenetics - trends | Animals | Opsins - chemistry | Photic Stimulation - methods | Light | Rhodopsins, Microbial - biosynthesis | Bacteriorhodopsins - chemistry | Rhodopsins, Microbial - chemistry | Bacteriorhodopsins - biosynthesis | Bacteriorhodopsins - genetics | Physiological aspects | Opsins | Research
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3. Full Text Optogenetics
by Deisseroth, Karl
Nature Methods, ISSN 1548-7091, 01/2011, Volume 8, Issue 1, pp. 26 - 29
Optogenetics is a technology that allows targeted, fast control of precisely defined events in biological systems as complex as freely moving mammals. By... 
PROTEIN | HALOBACTERIUM-HALOBIUM | CHANNEL | IN-VIVO CONTROL | LIGHT | BIOCHEMICAL RESEARCH METHODS | NEURONS | NEURAL CIRCUITRY | BRAIN | Animals | Humans | Light | Gene Expression Regulation - radiation effects | Neurons - metabolism | Genetic Techniques | Neurons - radiation effects | Photic Stimulation | Gene expression | Neurosciences | Research | Optics | Genetics | Research methodology | Technological change | Innovations
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4. Full Text Circuit dynamics of adaptive and maladaptive behaviour
by Deisseroth, Karl
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7483, pp. 309 - 317
The recent development of technologies for investigating specific components of intact biological systems has allowed elucidation of the neural circuitry... 
OPTOGENETIC CONTROL | CONNECTIVITY | MULTIDISCIPLINARY SCIENCES | LATERAL HABENULA | ANIMAL-MODELS | NETWORKS | DOPAMINERGIC-NEURONS | GAMMA RHYTHM | DEEP BRAIN-STIMULATION | REWARD | AMYGDALA | Mental Disorders - pathology | Animals | Depressive Disorder - pathology | Health | Depressive Disorder - physiopathology | Humans | Deep Brain Stimulation | Behavior - physiology | Neural Pathways | Mental Disorders - physiopathology | Psychological research | Adjustment (Psychology) | Research | Electrodes | Neurosciences | Social research | Brain research | Disease | Anatomy & physiology | Behavior
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5. Full Text CLARITY for mapping the nervous system
by Chung, Kwanghun and Deisseroth, Karl
Nature Methods, ISSN 1548-7091, 04/2013, Volume 10, Issue 6, pp. 508 - 513
With potential relevance for brain-mapping work, hydrogel-based structures can now be built from within biological tissue to allow subsequent removal of lipids... 
MOUSE-BRAIN | TOMOGRAPHY | ZEBRAFISH | CORTEX | ILLUMINATION | SYNAPTIC PARTNERS | RECONSTRUCTION | LIGHT-SHEET MICROSCOPY | HIGH-RESOLUTION | BIOCHEMICAL RESEARCH METHODS | NEURONS | Diagnostic Imaging - methods | Animals | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Microscopy | Synapses - physiology | Humans | Brain Mapping - methods | Methods | Brain mapping | Research | Neurology | Tissue | Biotechnology | Nervous system | Brain research
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6. Full Text Optogenetic investigation of neural circuits underlying brain disease in animal models
by Tye, Kay M and Deisseroth, Karl
Nature Reviews Neuroscience, ISSN 1471-003X, 04/2012, Volume 13, Issue 4, pp. 251 - 266
Optogenetic tools have provided a new way to establish causal relationships between brain activity and behaviour in health and disease. Although no animal... 
POSTTRAUMATIC-STRESS-DISORDER | TREATMENT-RESISTANT DEPRESSION | NUCLEUS-ACCUMBENS DOPAMINE | IN-VIVO CONTROL | REWARD-SEEKING BEHAVIOR | CONTEXTUAL FEAR | MAJOR DEPRESSION | CONDITIONED FEAR | NEUROSCIENCES | NATIONAL COMORBIDITY SURVEY | PARKINSONS-DISEASE | Neuroimaging - methods | Animals | Nerve Net - physiopathology | Brain Diseases - physiopathology | Neurons - physiology | Disease Models, Animal | Brain | Nervous system diseases | Genetic engineering | Investigations
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7. Full Text Optogenetics and Psychiatry: Applications, Challenges, and Opportunities
by Deisseroth, Karl
Biological Psychiatry, ISSN 0006-3223, 2012, Volume 71, Issue 12, pp. 1030 - 1032
Psychiatry | CIRCUITS | CREB PHOSPHORYLATION | CORTEX | PSYCHIATRY | NEURONS | CONDITIONED FEAR | DEEP BRAIN-STIMULATION | NEUROSCIENCES | Gene Targeting | Gene Expression | Animals | Humans | Neurons - physiology | Psychiatry - methods | Photic Stimulation | Mental Disorders - physiopathology
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8. Full Text Optical and chemical discoveries recognized for impact on biology and psychiatry
by Deisseroth, Karl
EMBO reports, ISSN 1469-221X, 06/2017, Volume 18, Issue 6, pp. 859 - 860
Karl Deisseroth was awarded the 2017 quadrennial 4 million euro Else Kröner Fresenius Prize today for the “discoveries of optogenetics and of hydrogel‐tissue... 
CIRCUIT DYNAMICS | OPTOGENETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCE | SYSTEMS | BRAIN | CELL BIOLOGY | Neurosciences - methods | Psychiatry - methods | Optogenetics - methods | Humans | Neurochemistry | Brain | Hydrogels | Information processing | Genetics | Optics | Mental depression | Psychiatry | Neurological disorders | Structure-function relationships | Neuroscience | S&S: Health & Disease | S&S: Technology | Opinion
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9. Full Text Advanced CLARITY for rapid and high-resolution imaging of intact tissues
by Tomer, Raju and Tomer, Raju and Ye, Li and Ye, Li and Hsueh, Brian and Hsueh, Brian and Deisseroth, Karl and Deisseroth, Karl
Nature protocols, ISSN 1754-2189, 2014, Volume 9, Issue 7, pp. 1682 - 1697
CLARITY is a method for chemical transformation of intact biological tissues into a hydrogel-tissue hybrid, which becomes amenable to interrogation with light... 
MOUSE-BRAIN | VISUALIZATION | 2-PHOTON EXCITATION | ULTRAMICROSCOPY | PLANE ILLUMINATION MICROSCOPY | RECONSTRUCTION | LIGHT-SHEET MICROSCOPY | BIOCHEMICAL RESEARCH METHODS | MORPHOLOGY | PHOTODAMAGE | CIRCUIT | Brain - metabolism | Microscopy - methods | Animals | Hydrogel, Polyethylene Glycol Dimethacrylate | Brain - pathology | Mice | Optics and Photonics | Tissue Embedding - methods | High resolution spectroscopy | Usage | Research | Tissues | Neurophysiology
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10. Full Text Integration of optogenetics with complementary methodologies in systems neuroscience
by Kim, Christina K and Adhikari, Avishek and Deisseroth, Karl
Nature Reviews Neuroscience, ISSN 1471-003X, 04/2017, Volume 18, Issue 4, pp. 222 - 235
Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring local or global activity in timing, magnitude or individual-cell... 
LATERAL HYPOTHALAMUS | TOP-DOWN CONTROL | IN-VIVO CONTROL | HIPPOCAMPAL-PREFRONTAL INPUT | NEURAL ACTIVITY | CIRCUIT ARCHITECTURE | CLOSED-LOOP | INTACT-TISSUE | HIGH-SPEED | NEUROSCIENCES | CELLULAR-RESOLUTION | Neuroimaging - methods | Optogenetics - trends | Animals | Electrophysiology - methods | Optogenetics - methods | Neuroanatomy - methods | Neurosciences - methods | Neurosciences - trends | Human-machine systems | Neurosciences | Innovations
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11. Full Text Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
by Sohal, Vikaas S and Zhang, Feng and Yizhar, Ofer and Deisseroth, Karl
Nature, ISSN 0028-0836, 06/2009, Volume 459, Issue 7247, pp. 698 - 702
Synchronized oscillations and inhibitory interneurons have important and interconnected roles within cortical microcircuits. In particular, interneurons... 
SYNCHRONIZATION | NEOCORTEX | PYRAMIDAL CELLS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | POSITIVE INTERNEURONS | CONNECTIONS | OSCILLATIONS | NEURAL CIRCUITRY | MODULATION | TRANSGENIC MICE | Cell Line | Interneurons - physiology | Neocortex - physiology | Signal Transduction | Evoked Potentials | Periodicity | Electrophysiology | Cortical Synchronization | Animals | Cerebral Cortex - physiology | Interneurons - cytology | Mice | Photic Stimulation | Parvalbumins - physiology | Prefrontal Cortex - physiology | Albumin | Physiological aspects | Chemical properties | Neurons | Gamma rays | Standard deviation | Reverse engineering | Information processing
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