Cold Spring Harbor symposia on quantitative biology, 2014, Volume 79, pp. 266 - 268
Journal Article
Nature Neuroscience, ISSN 1097-6256, 08/2015, Volume 18, Issue 9, pp. 1213 - 1225
Over the past 10 years, the development and convergence of microbial opsin engineering, modular genetic methods for cell-type targeting and optical strategies...
OPTICAL CONTROL | LIGHT-INDUCED ACTIVATION | IN-VIVO CONTROL | REMOTE-CONTROL | GREEN-ALGAE | RESTORES VISUAL RESPONSES | DEEP BRAIN-STIMULATION | NEURAL CIRCUITRY | NEUROSCIENCES | PREFRONTAL CORTEX | VENTRAL TEGMENTAL AREA | Rhodopsins, Microbial - genetics | Neurosciences | Optogenetics - methods | Opsins - genetics | Protein Structure, Secondary | Humans | Opsins - biosynthesis | Optogenetics - trends | Animals | Opsins - chemistry | Photic Stimulation - methods | Light | Rhodopsins, Microbial - biosynthesis | Bacteriorhodopsins - chemistry | Rhodopsins, Microbial - chemistry | Bacteriorhodopsins - biosynthesis | Bacteriorhodopsins - genetics | Physiological aspects | Opsins | Research
OPTICAL CONTROL | LIGHT-INDUCED ACTIVATION | IN-VIVO CONTROL | REMOTE-CONTROL | GREEN-ALGAE | RESTORES VISUAL RESPONSES | DEEP BRAIN-STIMULATION | NEURAL CIRCUITRY | NEUROSCIENCES | PREFRONTAL CORTEX | VENTRAL TEGMENTAL AREA | Rhodopsins, Microbial - genetics | Neurosciences | Optogenetics - methods | Opsins - genetics | Protein Structure, Secondary | Humans | Opsins - biosynthesis | Optogenetics - trends | Animals | Opsins - chemistry | Photic Stimulation - methods | Light | Rhodopsins, Microbial - biosynthesis | Bacteriorhodopsins - chemistry | Rhodopsins, Microbial - chemistry | Bacteriorhodopsins - biosynthesis | Bacteriorhodopsins - genetics | Physiological aspects | Opsins | Research
Journal Article
Nature Methods, ISSN 1548-7091, 01/2011, Volume 8, Issue 1, pp. 26 - 29
Optogenetics is a technology that allows targeted, fast control of precisely defined events in biological systems as complex as freely moving mammals. By...
PROTEIN | HALOBACTERIUM-HALOBIUM | CHANNEL | IN-VIVO CONTROL | LIGHT | BIOCHEMICAL RESEARCH METHODS | NEURONS | NEURAL CIRCUITRY | BRAIN | Animals | Humans | Light | Gene Expression Regulation - radiation effects | Neurons - metabolism | Genetic Techniques | Neurons - radiation effects | Photic Stimulation | Gene expression | Neurosciences | Research | Optics | Genetics | Research methodology | Technological change | Innovations
PROTEIN | HALOBACTERIUM-HALOBIUM | CHANNEL | IN-VIVO CONTROL | LIGHT | BIOCHEMICAL RESEARCH METHODS | NEURONS | NEURAL CIRCUITRY | BRAIN | Animals | Humans | Light | Gene Expression Regulation - radiation effects | Neurons - metabolism | Genetic Techniques | Neurons - radiation effects | Photic Stimulation | Gene expression | Neurosciences | Research | Optics | Genetics | Research methodology | Technological change | Innovations
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7483, pp. 309 - 317
The recent development of technologies for investigating specific components of intact biological systems has allowed elucidation of the neural circuitry...
OPTOGENETIC CONTROL | CONNECTIVITY | MULTIDISCIPLINARY SCIENCES | LATERAL HABENULA | ANIMAL-MODELS | NETWORKS | DOPAMINERGIC-NEURONS | GAMMA RHYTHM | DEEP BRAIN-STIMULATION | REWARD | AMYGDALA | Mental Disorders - pathology | Animals | Depressive Disorder - pathology | Health | Depressive Disorder - physiopathology | Humans | Deep Brain Stimulation | Behavior - physiology | Neural Pathways | Mental Disorders - physiopathology | Psychological research | Adjustment (Psychology) | Research | Electrodes | Neurosciences | Social research | Brain research | Disease | Anatomy & physiology | Behavior
OPTOGENETIC CONTROL | CONNECTIVITY | MULTIDISCIPLINARY SCIENCES | LATERAL HABENULA | ANIMAL-MODELS | NETWORKS | DOPAMINERGIC-NEURONS | GAMMA RHYTHM | DEEP BRAIN-STIMULATION | REWARD | AMYGDALA | Mental Disorders - pathology | Animals | Depressive Disorder - pathology | Health | Depressive Disorder - physiopathology | Humans | Deep Brain Stimulation | Behavior - physiology | Neural Pathways | Mental Disorders - physiopathology | Psychological research | Adjustment (Psychology) | Research | Electrodes | Neurosciences | Social research | Brain research | Disease | Anatomy & physiology | Behavior
Journal Article
Nature Methods, ISSN 1548-7091, 04/2013, Volume 10, Issue 6, pp. 508 - 513
With potential relevance for brain-mapping work, hydrogel-based structures can now be built from within biological tissue to allow subsequent removal of lipids...
MOUSE-BRAIN | TOMOGRAPHY | ZEBRAFISH | CORTEX | ILLUMINATION | SYNAPTIC PARTNERS | RECONSTRUCTION | LIGHT-SHEET MICROSCOPY | HIGH-RESOLUTION | BIOCHEMICAL RESEARCH METHODS | NEURONS | Diagnostic Imaging - methods | Animals | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Microscopy | Synapses - physiology | Humans | Brain Mapping - methods | Methods | Brain mapping | Research | Neurology | Tissue | Biotechnology | Nervous system | Brain research
MOUSE-BRAIN | TOMOGRAPHY | ZEBRAFISH | CORTEX | ILLUMINATION | SYNAPTIC PARTNERS | RECONSTRUCTION | LIGHT-SHEET MICROSCOPY | HIGH-RESOLUTION | BIOCHEMICAL RESEARCH METHODS | NEURONS | Diagnostic Imaging - methods | Animals | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Microscopy | Synapses - physiology | Humans | Brain Mapping - methods | Methods | Brain mapping | Research | Neurology | Tissue | Biotechnology | Nervous system | Brain research
Journal Article
Nature Reviews Neuroscience, ISSN 1471-003X, 04/2012, Volume 13, Issue 4, pp. 251 - 266
Optogenetic tools have provided a new way to establish causal relationships between brain activity and behaviour in health and disease. Although no animal...
POSTTRAUMATIC-STRESS-DISORDER | TREATMENT-RESISTANT DEPRESSION | NUCLEUS-ACCUMBENS DOPAMINE | IN-VIVO CONTROL | REWARD-SEEKING BEHAVIOR | CONTEXTUAL FEAR | MAJOR DEPRESSION | CONDITIONED FEAR | NEUROSCIENCES | NATIONAL COMORBIDITY SURVEY | PARKINSONS-DISEASE | Neuroimaging - methods | Animals | Nerve Net - physiopathology | Brain Diseases - physiopathology | Neurons - physiology | Disease Models, Animal | Brain | Nervous system diseases | Genetic engineering | Investigations
POSTTRAUMATIC-STRESS-DISORDER | TREATMENT-RESISTANT DEPRESSION | NUCLEUS-ACCUMBENS DOPAMINE | IN-VIVO CONTROL | REWARD-SEEKING BEHAVIOR | CONTEXTUAL FEAR | MAJOR DEPRESSION | CONDITIONED FEAR | NEUROSCIENCES | NATIONAL COMORBIDITY SURVEY | PARKINSONS-DISEASE | Neuroimaging - methods | Animals | Nerve Net - physiopathology | Brain Diseases - physiopathology | Neurons - physiology | Disease Models, Animal | Brain | Nervous system diseases | Genetic engineering | Investigations
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2012, Volume 71, Issue 12, pp. 1030 - 1032
Journal Article
EMBO reports, ISSN 1469-221X, 06/2017, Volume 18, Issue 6, pp. 859 - 860
Karl Deisseroth was awarded the 2017 quadrennial 4 million euro Else Kröner Fresenius Prize today for the “discoveries of optogenetics and of hydrogel‐tissue...
CIRCUIT DYNAMICS | OPTOGENETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCE | SYSTEMS | BRAIN | CELL BIOLOGY | Neurosciences - methods | Psychiatry - methods | Optogenetics - methods | Humans | Neurochemistry | Brain | Hydrogels | Information processing | Genetics | Optics | Mental depression | Psychiatry | Neurological disorders | Structure-function relationships | Neuroscience | S&S: Health & Disease | S&S: Technology | Opinion
CIRCUIT DYNAMICS | OPTOGENETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCE | SYSTEMS | BRAIN | CELL BIOLOGY | Neurosciences - methods | Psychiatry - methods | Optogenetics - methods | Humans | Neurochemistry | Brain | Hydrogels | Information processing | Genetics | Optics | Mental depression | Psychiatry | Neurological disorders | Structure-function relationships | Neuroscience | S&S: Health & Disease | S&S: Technology | Opinion
Journal Article
Nature protocols, ISSN 1754-2189, 2014, Volume 9, Issue 7, pp. 1682 - 1697
CLARITY is a method for chemical transformation of intact biological tissues into a hydrogel-tissue hybrid, which becomes amenable to interrogation with light...
MOUSE-BRAIN | VISUALIZATION | 2-PHOTON EXCITATION | ULTRAMICROSCOPY | PLANE ILLUMINATION MICROSCOPY | RECONSTRUCTION | LIGHT-SHEET MICROSCOPY | BIOCHEMICAL RESEARCH METHODS | MORPHOLOGY | PHOTODAMAGE | CIRCUIT | Brain - metabolism | Microscopy - methods | Animals | Hydrogel, Polyethylene Glycol Dimethacrylate | Brain - pathology | Mice | Optics and Photonics | Tissue Embedding - methods | High resolution spectroscopy | Usage | Research | Tissues | Neurophysiology
MOUSE-BRAIN | VISUALIZATION | 2-PHOTON EXCITATION | ULTRAMICROSCOPY | PLANE ILLUMINATION MICROSCOPY | RECONSTRUCTION | LIGHT-SHEET MICROSCOPY | BIOCHEMICAL RESEARCH METHODS | MORPHOLOGY | PHOTODAMAGE | CIRCUIT | Brain - metabolism | Microscopy - methods | Animals | Hydrogel, Polyethylene Glycol Dimethacrylate | Brain - pathology | Mice | Optics and Photonics | Tissue Embedding - methods | High resolution spectroscopy | Usage | Research | Tissues | Neurophysiology
Journal Article
Nature Reviews Neuroscience, ISSN 1471-003X, 04/2017, Volume 18, Issue 4, pp. 222 - 235
Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring local or global activity in timing, magnitude or individual-cell...
LATERAL HYPOTHALAMUS | TOP-DOWN CONTROL | IN-VIVO CONTROL | HIPPOCAMPAL-PREFRONTAL INPUT | NEURAL ACTIVITY | CIRCUIT ARCHITECTURE | CLOSED-LOOP | INTACT-TISSUE | HIGH-SPEED | NEUROSCIENCES | CELLULAR-RESOLUTION | Neuroimaging - methods | Optogenetics - trends | Animals | Electrophysiology - methods | Optogenetics - methods | Neuroanatomy - methods | Neurosciences - methods | Neurosciences - trends | Human-machine systems | Neurosciences | Innovations
LATERAL HYPOTHALAMUS | TOP-DOWN CONTROL | IN-VIVO CONTROL | HIPPOCAMPAL-PREFRONTAL INPUT | NEURAL ACTIVITY | CIRCUIT ARCHITECTURE | CLOSED-LOOP | INTACT-TISSUE | HIGH-SPEED | NEUROSCIENCES | CELLULAR-RESOLUTION | Neuroimaging - methods | Optogenetics - trends | Animals | Electrophysiology - methods | Optogenetics - methods | Neuroanatomy - methods | Neurosciences - methods | Neurosciences - trends | Human-machine systems | Neurosciences | Innovations
Journal Article
Nature, ISSN 0028-0836, 06/2009, Volume 459, Issue 7247, pp. 698 - 702
Synchronized oscillations and inhibitory interneurons have important and interconnected roles within cortical microcircuits. In particular, interneurons...
SYNCHRONIZATION | NEOCORTEX | PYRAMIDAL CELLS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | POSITIVE INTERNEURONS | CONNECTIONS | OSCILLATIONS | NEURAL CIRCUITRY | MODULATION | TRANSGENIC MICE | Cell Line | Interneurons - physiology | Neocortex - physiology | Signal Transduction | Evoked Potentials | Periodicity | Electrophysiology | Cortical Synchronization | Animals | Cerebral Cortex - physiology | Interneurons - cytology | Mice | Photic Stimulation | Parvalbumins - physiology | Prefrontal Cortex - physiology | Albumin | Physiological aspects | Chemical properties | Neurons | Gamma rays | Standard deviation | Reverse engineering | Information processing
SYNCHRONIZATION | NEOCORTEX | PYRAMIDAL CELLS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | POSITIVE INTERNEURONS | CONNECTIONS | OSCILLATIONS | NEURAL CIRCUITRY | MODULATION | TRANSGENIC MICE | Cell Line | Interneurons - physiology | Neocortex - physiology | Signal Transduction | Evoked Potentials | Periodicity | Electrophysiology | Cortical Synchronization | Animals | Cerebral Cortex - physiology | Interneurons - cytology | Mice | Photic Stimulation | Parvalbumins - physiology | Prefrontal Cortex - physiology | Albumin | Physiological aspects | Chemical properties | Neurons | Gamma rays | Standard deviation | Reverse engineering | Information processing
Journal Article