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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13817 - 13821
The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubuledestabilizing agents. Here, we... 
Microtubules | Drug interactions | Antineoplastics | Ligands | Dimers | Breast cancer | Molecular mechanisms of action | Crystallography | Binding sites | Crystal structure | X-ray crystallography | Microtubule-targeting agents | Drug mechanism | microtubule-targeting agents | BETA-TUBULIN | VINCA-DOMAIN | MAYTANSINE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ANTIMITOTIC AGENTS | MACROCYCLIC LACTONE ANTIBIOTICS | POTENT ANTITUMOR-ACTIVITY | BREAST-CANCER | STRUCTURAL BASIS | RHIZOXIN | drug mechanism | Tubulin Modulators - chemistry | Humans | Polyketides - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Maytansine - therapeutic use | Breast Neoplasms - drug therapy | Tubulin Modulators - therapeutic use | Pyrones - chemistry | Animals | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - therapeutic use | Macrolides - chemistry | Cattle | Maytansine - chemistry | Pyrones - therapeutic use | Female | Microtubules - chemistry | Tubulin - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Macrolides - therapeutic use | Polyketides - therapeutic use | Binding Sites | Clinical Trials, Phase I as Topic | Antimitotic agents | Pharmaceutical research | Physiological aspects | Dosage and administration | Research | Tubulins | Antineoplastic agents | Binding sites (Biochemistry) | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 2/2013, Volume 339, Issue 6119, pp. 587 - 590
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 10/2012, Volume 4, Issue 10, pp. 1032 - 1042
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2008, Volume 105, Issue 26, pp. 9099 - 9104
The psychoactive cannabinoids from Cannabis sativa L. and the arachidonic acid-derived endocannabinoids are nonselective natural ligands for cannabinoid... 
Edema | Receptors | Cannabis | Cannabinoids | Antiinflammatories | Essential oils | Ligands | Agonists | Mice | Cannabinoid receptors | Natural product | CB2 cannabinoid receptor | Foodstuff | Inflammation | DEXTRAN SULFATE SODIUM | 2-ARACHIDONOYLGLYCEROL | ACTIVATION | natural product | CB2 RECEPTOR | PHARMACOLOGICAL CHARACTERIZATION | MULTIDISCIPLINARY SCIENCES | ESSENTIAL OIL | SESQUITERPENE | inflammation | CONTACT-DERMATITIS | MICE | foodstuff | EXPRESSION | Sesquiterpenes - metabolism | Oils, Volatile - chemistry | Receptor, Cannabinoid, CB2 - agonists | Humans | Tumor Necrosis Factor-alpha - blood | JNK Mitogen-Activated Protein Kinases - metabolism | Sesquiterpenes - administration & dosage | Extracellular Signal-Regulated MAP Kinases - metabolism | Interleukin-1beta - blood | Cannabis - chemistry | Binding Sites | Cannabinoids - metabolism | Sesquiterpenes - chemistry | Administration, Oral | Cannabinoids - administration & dosage | Cannabinoids - chemistry | Cells, Cultured | Computational Biology | Enzyme Activation - drug effects | Cannabinoids - pharmacology | Binding, Competitive - drug effects | Edema - metabolism | Monocytes - enzymology | Receptor, Cannabinoid, CB2 - metabolism | Animals | Diet | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Carrageenan | Edema - chemically induced | Sesquiterpenes - pharmacology | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Care and treatment | Cytokines | Physiological aspects | Health aspects | Risk factors | Biological Sciences
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2015, Volume 54, Issue 6, pp. 1937 - 1940
Journal Article
Journal Article
CHIMIA, ISSN 0009-4293, 2017, Volume 71, Issue 10, pp. 646 - 652
Journal Article
Science, ISSN 0036-8075, 05/2017, Volume 356, Issue 6340, pp. 863 - 866
Journal Article