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NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1590 - 15
Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up-or... 
APOPTOSIS | DECAY | NONSENSE | ONCOPROTEIN SRSF1 | MULTIDISCIPLINARY SCIENCES | SR PROTEINS | PROLIFERATION | TRACT BINDING-PROTEIN | REGULATOR RBFOX2 | RECOGNITION MOTIFS | CELL | Alternative splicing | Deregulation | Splicing | Oligonucleotides | Gene expression | Ribonucleic acid--RNA | Splicing factors | Cancer | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2019, Volume 30, Issue 1, pp. 201 - 211.e6
Differential exposure of tumor cells to blood-borne and angiocrine factors results in diverse metabolic microenvironments conducive for non-genetic tumor cell... 
glioblastoma | metabolic compartmentalization | mTOR pathway | blood vessels | tumor microenvironment | tumor vasculature | tumor heterogeneity | CELLS PROMOTE | HOECHST 33342 | GROWTH | ENDOCRINOLOGY & METABOLISM | VASCULAR NICHE | HYPOXIA | EXPRESSION | MTOR | AGE | CELL BIOLOGY | Medical colleges | Chemotherapy | Metabolites | Gliomas | Developmental biology | Molecular biology | Cancer
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2019, Volume 79, Issue 10, pp. 2480 - 2493
Reprogrammed glucose metabolism of enhanced aerobic glycolysis (or the Warburg effect) is known as a hallmark of cancer. The roles of long noncoding RNAs... 
GLYCOLYSIS | METASTASIS | ONCOLOGY | SPLICING FACTOR SF2/ASF | PHOSPHORYLATION | PATHWAY EFFECTOR TCF7L2 | 4E-BP1 | ENERGY-METABOLISM | EXPRESSION | PROMOTES | PROGRESSION
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 21, pp. 11396 - 11404
Abstract The gene encoding the kinase Mnk2 (MKNK2) is alternatively spliced to produce two isoforms-Mnk2a and Mnk2b. We previously showed that Mnk2a is... 
CELLS | CISPLATIN | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOXORUBICIN | PHASE-II | RECEPTOR | MECHANISMS | DRUG-RESISTANCE | INHIBITOR | EIF4E | Index Medicus | Molecular Biology
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2018, Volume 143, Issue 1, pp. 179 - 183
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. BRCA ‐associated PDAC comprises a clinically relevant subtype. A portion of... 
BRCA | treatment resistant | PARP inhibitor | treatment naïve | pancreatic ductal adenocarcinoma | patient‐derived xenograft (PDX) | patient-derived xenograft (PDX) | SURVIVAL | ONCOLOGY | DUCTAL ADENOCARCINOMA | SUBTYPES | RESISTANCE | treatment naive | Genomic Instability | Neoplasm Transplantation | Prognosis | Humans | Drug Resistance, Neoplasm | Homologous Recombination | Pancreatic Neoplasms - genetics | Disease Progression | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Carcinoma, Pancreatic Ductal - genetics | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Whole Genome Sequencing | Pancreatic Neoplasms - drug therapy | Platinum Compounds - therapeutic use | BRCA1 Protein - genetics | Carcinoma, Pancreatic Ductal - drug therapy | Neoplasm Metastasis | Animals | Mice | Mutation | Platinum Compounds - administration & dosage | BRCA2 Protein - genetics | Biotechnology | Pancreatic cancer | Genomics | Therapeutics | Metastasis | Homeopathy | Materia medica and therapeutics | Adenocarcinoma | Sensitivity analysis | Xenotransplantation | Medical treatment | DNA damage | Homologous recombination | Poly(ADP-ribose) polymerase | Homology | Genomes | Breast cancer | Patients | Cisplatin | Mimicry | Metastases | Gene sequencing | Inhibitors | Biopsy | Platinum | Xenografts | Models | Lesions | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
Journal Article
Current Opinion in Genetics & Development, ISSN 0959-437X, 02/2018, Volume 48, pp. 16 - 21
One of the major challenges in cancer treatment today is that many patients develop resistance to the therapeutic agents, resulting in treatment failure.... 
CELLS | INHIBITION | THERAPY | VARIANTS | PATHWAY | PROSTATE-CANCER | GENETICS & HEREDITY | RECEPTOR | MUTATIONS | LEUKEMIA | ENZALUTAMIDE | CELL BIOLOGY | Drug Resistance, Neoplasm | Animals | Alternative Splicing | Neoplasms - genetics | Humans | Neoplasms - drug therapy | Antimitotic agents | Drug resistance | Drug therapy | Antineoplastic agents | Index Medicus
Journal Article
01/2018
An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a... 
WINE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | NUCLEOSIDES | ORGANIC CHEMISTRY | MICROBIOLOGY | SUGARS | NUCLEIC ACIDS | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | NUCLEOTIDES | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | BIOCHEMISTRY | CULTURE MEDIA | DERIVATIVES THEREOF | CHEMISTRY | VINEGAR
Patent
11/2017
An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a... 
WINE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | NUCLEOSIDES | ORGANIC CHEMISTRY | MICROBIOLOGY | SUGARS | NUCLEIC ACIDS | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | NUCLEOTIDES | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | BIOCHEMISTRY | CULTURE MEDIA | DERIVATIVES THEREOF | CHEMISTRY | VINEGAR
Patent
Journal of Dermatological Science, ISSN 0923-1811, 2017, Volume 87, Issue 2, pp. 123 - 129
Journal Article
Cancer research, ISSN 0008-5472, 3/2017, Volume 77, Issue 5, pp. 1155 - 1167
Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA... 
Alternative splicing | MALAT1 | Oncogene | SRSF1 | S6K1
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2016, Volume 6, Issue 1, pp. 31222 - 31222
Journal Article