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1. Full Text Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
by Wain, Louise V and Shrine, Nick R. G and Artigas, Maria Soler and Erzurumluoglu, A Mesut and Noyvert, Boris and Bossini-Castillo, Lara and Obeidat, Ma'en and Henrys, Amanda P and Portelli, Michael A and Hall, Robert J and Billington, Charlotte K and Rimington, Tracy L and Fenech, Anthony G and John, Catherine and Blake, Tineka and Jackson, Victoria E and Allen, Richard J and Prins, Bram P and Campbell, Archie and Porteous, David J and Jarvelin, Marjo-Riitta and Wielscher, Matthias and Jamess, Alan L and Hui, Jennie and Wareham, Nicholas J and Zhao, Jing Hua and Wilson, James F and Joshi, Peter K and Stubbe, Beate and Rawal, Rajesh and Schulz, Holger and Imboden, Medea and Probst-Hensch, Nicole M and Karrasch, Stefan and Gieger, Christian and Deary, Ian J and Harris, Sarah E and Marten, Jonathan and Rudan, Igor and Enroth, Stefan and Gyllensten, Ulf and Kerr, Shona M and Polasek, Ozren and Kahonen, Mika and Surakka, Ida and Vitart, Veronique and Hayward, Caroline and van den Berge, Maarten and Brandsma, Corry-Anke and Trynka, Gosia and Geisinger-Regeneron DiscovEHR and Understanding Soc Sci Grp and Understanding Society Scientific Group and Geisinger-Regeneron DiscovEHR Collaboration
Nature genetics, ISSN 1061-4036, 03/2017, Volume 49, Issue 3, pp. 416 - 425
POPULATION | VARIANTS | GENETICS | SUSCEPTIBILITY | FAM13A | HEALTH | EPIDEMIOLOGY | AIR-FLOW OBSTRUCTION | COPD | HISTORY | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease - genetics | Humans | Middle Aged | Risk Factors | Genetic Loci - genetics | Male | Lung - physiopathology | Asthma - genetics | Epigenesis, Genetic - genetics | Alleles | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Genome-Wide Association Study - methods | Pulmonary Disease, Chronic Obstructive - genetics | Quantitative trait loci | Molecular targeted therapy | Lung diseases, Obstructive | Care and treatment | Innovations | Development and progression | Genetic aspects | Health aspects | Studies | Chronic obstructive pulmonary disease | Genomes | Health risk assessment | Index Medicus
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2. Full Text New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
by Shrine, Nick and Guyatt, Anna L and Erzurumluoglu, A. Mesut and Jackson, Victoria E and Hobbs, Brian D and Melbourne, Carl A and Batini, Chiara and Fawcett, Katherine A and Song, Kijoung and Sakornsakolpat, Phuwanat and Li, Xingnan and Boxall, Ruth and Reeve, Nicola F and Obeidat, Ma’en and Zhao, Jing Hua and Wielscher, Matthias and Weiss, Stefan and Kentistou, Katherine A and Cook, James P and Sun, Benjamin B and Zhou, Jian and Hui, Jennie and Karrasch, Stefan and Imboden, Medea and Harris, Sarah E and Marten, Jonathan and Enroth, Stefan and Kerr, Shona M and Surakka, Ida and Vitart, Veronique and Lehtimäki, Terho and Allen, Richard J and Bakke, Per S and Beaty, Terri H and Bleecker, Eugene R and Bossé, Yohan and Brandsma, Corry-Anke and Chen, Zhengming and Crapo, James D and Danesh, John and DeMeo, Dawn L and Dudbridge, Frank and Ewert, Ralf and Gieger, Christian and Gulsvik, Amund and Hansell, Anna L and Hao, Ke and Hoffman, Joshua D and Hokanson, John E and Homuth, Georg and Joshi, Peter K and Joubert, Philippe and Langenberg, Claudia and Li, Xuan and Li, Liming and Lin, Kuang and Lind, Lars and Locantore, Nicholas and Luan, Jian’an and Mahajan, Anubha and Maranville, Joseph C and Murray, Alison and Nickle, David C and Packer, Richard and Parker, Margaret M and Paynton, Megan L and Porteous, David J and Prokopenko, Dmitry and Qiao, Dandi and Rawal, Rajesh and Runz, Heiko and Sayers, Ian and Sin, Don D and Smith, Blair H and Soler Artigas, María and Sparrow, David and Tal-Singer, Ruth and Timmers, Paul R. H. J and Van den Berge, Maarten and Whittaker, John C and Woodruff, Prescott G and Yerges-Armstrong, Laura M and Troyanskaya, Olga G and Raitakari, Olli T and Kähönen, Mika and Polašek, Ozren and Gyllensten, Ulf and Rudan, Igor and Deary, Ian J and Probst-Hensch, Nicole M and Schulz, Holger and James, Alan L and Wilson, James F and Stubbe, Beate and Zeggini, Eleftheria and Jarvelin, Marjo-Riitta and Wareham, Nick and Silverman, Edwin K and Hayward, Caroline and Morris, Andrew P and ... and Understanding Soc Sci Grp and Understanding Society Scientific Group
Nature genetics, ISSN 1061-4036, 03/2019, Volume 51, Issue 3, pp. 481 - 493
LOCI | GWAS | VARIANTS | HERITABILITY | GENOME-WIDE ASSOCIATION | COPD | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease - genetics | Humans | Middle Aged | Risk Factors | Male | Smoking - genetics | Lung - physiopathology | Case-Control Studies | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Female | Aged | Genome-Wide Association Study - methods | Pulmonary Disease, Chronic Obstructive - genetics | Respiratory function | Lung diseases | Genomes | Gene expression | Studies | Consortia | Pathways | Obstructive lung disease | New combinations | Quality control | Chronic obstructive pulmonary disease | Health risk assessment | Smoking | Index Medicus
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3. Full Text Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
by Artigas, Maria Soler and Wain, Louise V and Miller, Suzanne and Kheirallah, Abdul Kader and Huffman, Jennifer E and Ntalla, Ioanna and Shrine, Nick and Obeidat, Ma'en and Trochet, Holly and McArdle, Wendy L and Alves, Alexessander Couto and Hui, Jennie and Zhao, Jing Hua and Joshi, Peter K and Teumer, Alexander and Albrecht, Eva and Imboden, Medea and Rawal, Rajesh and Lopez, Lorna M and Marten, Jonathan and Enroth, Stefan and Surakka, Ida and Polasek, Ozren and Lyytikainen, Leo-Pekka and Granell, Raquel and Hysi, Pirro G and Flexeder, Claudia and Mahajan, Anubha and Beilby, John and Bosse, Yohan and Brandsma, Corry-Anke and Campbell, Harry and Gieger, Christian and Glaeser, Sven and Gonzalez, Juan R and Grallert, Harald and Hammond, Chris J and Harris, Sarah E and Hartikainen, Anna-Liisa and Heliovaara, Markku and Henderson, John and Hocking, Lynne and Horikoshi, Momoko and Hutri-Kahonen, Nina and Ingelsson, Erik and Johansson, Asa and Kemp, John P and Kolcic, Ivana and Kumar, Ashish and Lind, Lars and UK BiLEVE
Nature communications, ISSN 2041-1723, 12/2015, Volume 6, Issue 1, pp. 8658 - 8658
OBSTRUCTIVE PULMONARY-DISEASE | METAANALYSIS | GENE-EXPRESSION | ARCHITECTURE | MISSING HERITABILITY | SEQUENCE VARIANTS | WIDE ASSOCIATION | SUSCEPTIBILITY LOCUS | SMOKING-BEHAVIOR | FORCED VITAL CAPACITY | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Humans | Middle Aged | Male | Lung - physiopathology | Forced Expiratory Volume | Young Adult | Lung Diseases - genetics | Aged, 80 and over | Adult | Female | Aged | Lung Diseases - physiopathology | Polymorphism, Single Nucleotide | Index Medicus | Medicin och hälsovetenskap
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4. Full Text Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
by Sakornsakolpat, Phuwanat and Prokopenko, Dmitry and Lamontagne, Maxime and Reeve, Nicola F and Guyatt, Anna L and Jackson, Victoria E and Shrine, Nick and Qiao, Dandi and Bartz, Traci M and Kim, Deog Kyeom and Lee, Mi Kyeong and Latourelle, Jeanne C and Li, Xingnan and Morrow, Jarrett D and Obeidat, Ma’en and Wyss, Annah B and Bakke, Per and Barr, R. Graham and Beaty, Terri H and Belinsky, Steven A and Brusselle, Guy G and Crapo, James D and de Jong, Kim and DeMeo, Dawn L and Fingerlin, Tasha E and Gharib, Sina A and Gulsvik, Amund and Hall, Ian P and Hokanson, John E and Kim, Woo Jin and Lomas, David A and London, Stephanie J and Meyers, Deborah A and O’Connor, George T and Rennard, Stephen I and Schwartz, David A and Sliwinski, Pawel and Sparrow, David and Strachan, David P and Tal-Singer, Ruth and Tesfaigzi, Yohannes and Vestbo, J. rgen and Vonk, Judith M and Yim, Jae-Joon and Zhou, Xiaobo and Bossé, Yohan and Manichaikul, Ani and Lahousse, Lies and ter Riet, Gerben and Silverman, Edwin K and Marike Boezen, H and Wain, Louise V and Tobin, Martin D and Hobbs, Brian D and Cho, Michael H and SpiroMeta Consortium and Understanding Soc Sci Grp and Int COPD Genetics Consortium and International COPD Genetics Consortium
Nature genetics, ISSN 1061-4036, 03/2019, Volume 51, Issue 3, pp. 494 - 505
yes | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease - genetics | Gene Expression - genetics | Humans | Middle Aged | Genetic Loci - genetics | Male | Smoking - genetics | Lung - physiopathology | Pulmonary Fibrosis - genetics | Asthma - genetics | Case-Control Studies | Phenotype | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Genome-Wide Association Study - methods | Pulmonary Disease, Chronic Obstructive - genetics | Lung diseases, Obstructive | Care and treatment | Genome-wide association studies | Usage | Genetic susceptibility | Patient outcomes | Genetic aspects | Research | Gene expression | Consortia | Medical colleges | Genomics | Mortality | Genetic research | Genomes | Disease susceptibility | Health aspects | Asthma | Respiratory function | Disease | Pathogenesis | Smooth muscle | Risk | Heterogeneity | Population | Genetics | Chronic obstructive pulmonary disease | Telomerase | Bioinformatics | Phenotypes | Lung diseases | Health risks | Muscles | Loci | Studies | Pulmonary fibrosis | Obstructive lung disease | Fibrosis | Gene loci | Health risk assessment | Smoking | Index Medicus
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5. Full Text Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
by Ferreira, Manuel A and Vonk, Judith M and Baurecht, Hansjörg and Marenholz, Ingo and Tian, Chao and Hoffman, Joshua D and Helmer, Quinta and Tillander, Annika and Ullemar, Vilhelmina and Van Dongen, Jenny and Lu, Yi and Rüschendorf, Franz and Esparza-Gordillo, Jorge and Medway, Chris W and Mountjoy, Edward and Burrows, Kimberley and Hummel, Oliver and Grosche, Sarah and Brumpton, Ben M and Witte, John S and Hottenga, Jouke-Jan and Willemsen, Gonneke and Zheng, Jie and Rodríguez, Elke and Hotze, Melanie and Franke, Andre and Revez, Joana A and Beesley, Jonathan and Matheson, Melanie C and Dharmage, Shyamali C and Bain, Lisa M and Fritsche, Lars G and Gabrielsen, Maiken E and Balliu, Brunilda and Nielsen, Jonas B and Zhou, Wei and Hveem, Kristian and Langhammer, Arnulf and Holmen, Oddgeir L and Løset, Mari and Abecasis, Goncalo R and Willer, Cristen J and Arnold, Andreas and Homuth, Georg and Schmidt, Carsten O and Thompson, Philip J and Martin, Nicholas G and Duffy, David L and Novak, Natalija and Schulz, Holger and Karrasch, Stefan and Gieger, Christian and Strauch, Konstantin and Melles, Ronald B and Hinds, David A and Hübner, Norbert and Weidinger, Stephan and Magnusson, Patrik K. E and Jansen, Rick and Jorgenson, Eric and Lee, Young-Ae and Boomsma, Dorret I and Almqvist, Catarina and Karlsson, Robert and Koppelman, Gerard H and Paternoster, Lavinia and 23andMe Res Team and BIOS consortium and LifeLines Cohort Study and AAGC collaborators and 23andMe Research Team
Nature genetics, ISSN 1061-4036, 12/2017, Volume 49, Issue 12, pp. 1752 - 1757
RHINITIS | ATOPIC-DERMATITIS | VARIANTS | TRANSCRIPTOME | HUMAN-CELLS | COHORT | LD SCORE REGRESSION | IDENTIFICATION | GENOME-WIDE ASSOCIATION | TWIN | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Eczema - genetics | Genetic Predisposition to Disease - genetics | Phenotype | Rhinitis, Allergic, Seasonal - genetics | Humans | Risk Factors | Hypersensitivity - genetics | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Asthma - genetics | Genome-wide association studies | Genetic variation | Eczema | Genetic aspects | Health aspects | Hay-fever | Risk factors | Methods | Asthma | Hay | Disease | Transcription | Rhinitis | Genes | Risk sharing | Genomes | Dermatitis | Immunity | Genetic effects | Atopic dermatitis | Allergic rhinitis | DNA methylation | Skin diseases | Age | CpG islands | Health risks | Risk analysis | Gene expression | Allergies | Biological activity | Hay fever | Studies | Heritability | Methylation | Index Medicus | Medicin och hälsovetenskap
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6. Full Text Accuracy of FENO for diagnosing asthma: a systematic review
by Karrasch, Stefan and Linde, Klaus and Rücker, Gerta and Sommer, Harriet and Karsch-Völk, Marlies and Kleijnen, Jos and Jörres, Rudolf A and Schneider, Antonius
Thorax, ISSN 0040-6376, 02/2017, Volume 72, Issue 2, pp. 109 - 116
YOUNG-ADULTS | SCREENING TOOL | METAANALYSIS | EXERCISE-INDUCED BRONCHOCONSTRICTION | SUSPECTED ASTHMA | GENERAL-PRACTICE | EXHALED NITRIC-OXIDE | CLINICAL-PRACTICE | FLOW VARIABILITY | CHRONIC COUGH | Life Sciences & Biomedicine | Respiratory System | Science & Technology | Asthma - diagnosis | Diagnosis, Differential | Forced Expiratory Volume - physiology | Humans | Bronchial Provocation Tests | Nitric Oxide - analysis | Breath Tests - methods | Index Medicus
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