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Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 06/2009, Volume 13, Issue 6, pp. 1004 - 1033
•  Introduction •  Mitochondria and cell death •  Mitochondrial outer membrane permeabilization (MOMP): point of no return ‐  MOMP by BCL‐2 family proteins ‐ ... 
mitochondrial permeability transition | apoptosis | Bcl‐2 | mitochondrial outer membrane permeabilization | caspases | Bcl-2 | Mitochondrial permeability transition | Caspases | Mitochondrial outer membrane permeabilization | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | PERMEABILITY TRANSITION PORE | APOPTOSIS-INDUCING FACTOR | ADENINE-NUCLEOTIDE TRANSLOCATOR | AMYOTROPHIC-LATERAL-SCLEROSIS | CELL BIOLOGY | PROGRAMMED CELL-DEATH | ELECTRON-TRANSPORT CHAIN | PERIPHERAL BENZODIAZEPINE-RECEPTOR | ETOPOSIDE-INDUCED APOPTOSIS | CYTOCHROME-C RELEASE | BCL-2 FAMILY-MEMBERS | Mitochondrial Diseases - drug therapy | Humans | Mitochondrial Diseases - metabolism | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Signal Transduction - drug effects | Models, Biological | Membrane Potential, Mitochondrial - physiology | Signal Transduction - physiology | Apoptosis - physiology | Mitochondria - physiology | Mitochondrial Diseases - physiopathology | Cytochrome | Regulators | Membranes | Drug delivery systems | Bax protein | Calcium | Peptides | Bcl-2 protein | Pathogenesis | Leukemia | DNA damage | Membrane permeability | Homeostasis | Antisense | Drug delivery | Cyclosporin A | Drug development | Damage prevention | Cytosol | Proteins | Lipophilic | Mitochondria | Reperfusion | Ischemia | Tumor necrosis factor-TNF | Physiology | Deoxyribonucleic acid--DNA | Neurodegenerative diseases | Mortality | Poly(ADP-ribose) polymerase | Caspase | Pharmacology | Chemical compounds | Lymphoma | Diseases | Cytochrome c | Vertebrates | Chemotherapy | Inhibitors | Lymphocytes B | Cell death | Cytochromes | Skin | Preconditioning | Adapter proteins | Reviews
Journal Article
Toxicology Letters, ISSN 0378-4274, 10/2019, Volume 314, pp. 117 - 123
The Threshold of Toxicological Concern (TTC) concept integrates data on exposure, chemical structure, toxicity and metabolism to identify a safe exposure... 
Cramer classification | Threshold of toxicological concern | Globally harmonized system | TTC | Food ingredients | UNCERTAINTY | TOXICOLOGY | RISK-ASSESSMENT | REEVALUATION | Usage | Databases | Safety and security measures | Analysis | Carbamates | Food additives industry | Food
Journal Article
Toxicology, ISSN 0300-483X, 2017, Volume 386, pp. 120 - 132
Abstract Lipid dysregulation is a common hepatic adverse outcome after exposure to toxic drugs and chemicals. A donor-free rat hepatocyte-like (B-13/H) cell... 
Emergency | In vitro and alternatives | AR42J-B13 | T0901317 | LXR | Steatosis | Phospholipidosis | CYTOCHROMES P450 | IN-VITRO | INDUCED PHOSPHOLIPIDOSIS | METHAPYRILENE HYDROCHLORIDE | LIVER CARCINOGENESIS | RELEVANCE | FATTY LIVER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HEPATOTOXICITY | DIFFERENTIATION | RECEPTORS LXR | Benzylamines - toxicity | Hepatocytes - metabolism | Benzylamines - administration & dosage | Dose-Response Relationship, Drug | Hydrocarbons, Fluorinated - administration & dosage | Time Factors | Phospholipids - metabolism | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Hepatocytes - drug effects | Cell Line | Fatty Liver - metabolism | Rats | Liver X Receptors - metabolism | Chemical and Drug Induced Liver Injury - physiopathology | Methapyrilene - toxicity | Benzoates - administration & dosage | Triglycerides - metabolism | Hydrocarbons, Fluorinated - toxicity | Animals | Benzoates - toxicity | Lipid Metabolism - drug effects | Methapyrilene - administration & dosage | Sulfonamides - toxicity | Sulfonamides - administration & dosage | Drugs | Lipids | Corticosteroids | Analysis | Cytochrome P-450 | NASH, non-alcoholic steatohepatitis | LAMP1, lysosome-associated membrane protein 1 | DEX, dexamethasone | PB, phenobarbital | RXR, retinoid X-receptor | DTT, dithiothreitol | DAPI, 4’6’-diamino-2-phenylindole | B-13 | H, AR42J-B-13 cells following treatment with 10 nM dexamethasone for 14 days | PEI, polyethylenimine | LXR, liver X receptor | LPLA2, lysosomal phospholipase A2 | ADFP, adipose differentiation-related protein | CYP, cytochrome P450 | B-13, AR42J-B-13 | PCN, 5-pregnen-3β-ol-20-one-16α-carbonitrile | PXR, pregnane X-receptor
Journal Article
Toxicology Letters, ISSN 0378-4274, 05/2017, Volume 273, pp. 55 - 68
Tartrazine is a food colour that activates the transcriptional function of the human oestrogen receptor alpha in an in vitro cell model. Since oestrogens are... 
oestrogen | NF-κB | Alcohol | E 102 | Liver | Food | ENDOCRINE-DISRUPTING CHEMICALS | CHOLESTASIS | MECHANISMS | IDENTIFICATION | BETA | NF-kappa B | XENOESTROGENS | METABOLISM | STEATOSIS | TOXICOLOGY | EXPRESSION | Liver Function Tests | Cell Line | Ethanol - toxicity | Administration, Oral | Liver - metabolism | Mice, Inbred C57BL | Injections, Intraperitoneal | Male | Mice, Transgenic | Estrogen Receptor beta - metabolism | Tartrazine - toxicity | Animals | Estrogen Receptor alpha - genetics | Estrogen Receptor beta - genetics | Liver - drug effects | NF-kappa B - genetics | Food Coloring Agents - toxicity | Estrogen Receptor alpha - metabolism | Female | Luciferases, Firefly - genetics | Estradiol - pharmacology | Safety and security measures | Phosphatases | Metabolites | Food additives | Food contamination | Estrogen | Monoglycerides | Bile acids | Analysis | Genetic engineering | Index Medicus | ALT, alanine aminotransferase | mER, murine oestrogen receptor | EtOH, ethanol | hER, human oestrogen receptor | PBS, phosphate buffered saline | t, wild type mice | ALP, alkaline phosphatase | OO, olive oil | Tg, Tg(NF-κB) mice | SSY, sunset yellow | SA, sulphanilic acid | SCAP, 1-(4-sulphophenyl)-3-carboxy-4-amino-5-pyrazolone | SA-NAc, sulphanilic acid N-acetate | E2, 17β oestradiol | T, Tartrazine | OSPCA, 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid (a major contaminant of the food additive) | SPH, sulphophenylhydrazine
Journal Article
Analytical Chemistry, ISSN 0003-2700, 03/2008, Volume 80, Issue 6, pp. 2063 - 2068
Journal Article