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Cancer Science, ISSN 1347-9032, 03/2014, Volume 105, Issue 3, pp. 272 - 280
Gallbladder cancer (GBC) is a particularly deadly type of cancer with a 5‐year survival rate of only 10%. New effective therapeutic strategies are greatly... 
Epithelial–mesenchymal transition | matrix metalloproteinase | Smo protein | gallbladder cancer | Hedgehog | Epithelial-mesenchymal transition | Matrix metalloproteinase | Gallbladder cancer | STEM-CELLS | INHIBITION | ONCOLOGY | PANCREATIC-CANCER | GLI1 | CARCINOMA | Neoplasm Transplantation | RNA, Small Interfering - genetics | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Hedgehog Proteins - metabolism | Gene Knockdown Techniques | Matrix Metalloproteinase 9 - metabolism | Smoothened Receptor | Epithelial-Mesenchymal Transition | Gallbladder Neoplasms - metabolism | Veratrum Alkaloids - pharmacology | Female | Antineoplastic Agents - pharmacology | Gallbladder Neoplasms - therapy | Gallbladder - metabolism | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Gallbladder Neoplasms - pathology | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Health aspects | Analysis | Stem cells | Cancer | Cell proliferation | Biotechnology | Phenotypes | Mesenchyme | Invasiveness | Therapeutic applications | siRNA | Metastasis | Cancer therapies | Studies | Proteins | Genotype & phenotype | Signal transduction | Hedgehog protein | Medical prognosis | Xenografts | Gallbladder | Ligands | Tumors | Original
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 10, pp. 1593 - 1599
Yokukansan (YKS) is a traditional Japanese herbal medicine. It has been currently applied for treating behavioral and psychological symptoms of dementia in... 
neurogenesis | yokukansan | myelin sheath | synapse | hippocampus | learning ability | Synapse | Learning ability | Myelin sheath | Yokukansan | Neurogenesis | Hippocampus | DEMENTIA | ADULT NEUROGENESIS | ALZHEIMERS-DISEASE | TRADITIONAL JAPANESE MEDICINE | CELL-PROLIFERATION | PSYCHOLOGICAL SYMPTOMS | MODEL | SAMP8 | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | COGNITIVE DEFICITS | Synapses - drug effects | Alzheimer Disease - complications | Dentate Gyrus - metabolism | Alzheimer Disease - drug therapy | Drugs, Chinese Herbal - pharmacology | Myelin Sheath - drug effects | Neuronal Plasticity - drug effects | Cognition Disorders - metabolism | Male | Hippocampus - drug effects | Random Allocation | Cognition Disorders - drug therapy | Maze Learning - drug effects | Hippocampus - metabolism | Animals | Dentate Gyrus - drug effects | Alzheimer Disease - metabolism | Aging | Mice | Neurogenesis - drug effects | Phytotherapy | Drugs, Chinese Herbal - therapeutic use | Lipofuscin - metabolism | Disease Models, Animal | Cell proliferation | Animal models | Senescence | Cognitive ability | Impairment | Bromodeoxyuridine | Inclusions | Learning | Plasticity (behavioral) | Cell growth | Free water | Aqueous solutions | Sheaths | Dementia disorders | Signs and symptoms | Myelin | Electron microscopy | Disease control | Maze learning | Herbal medicine | Dentate gyrus | Plasticity (synaptic) | Postsynaptic density
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 371, Issue 2, pp. 143 - 150
Highlights • Expression of RBPJ and MAML3 increases under hypoxia but not normoxia conditions. • RBPJ and MAML3 play important roles for hypoxia-induced... 
Hematology, Oncology and Palliative Medicine | Hypoxia | Hedgehog signaling | Smoothened | RBPJ | Pancreatic cancer | Mastermind-like 3 | INHIBITION | ONCOLOGY | PATHWAY | Up-Regulation | Cell Proliferation | Pancreatic Neoplasms - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Transcriptional Activation | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Oxygen - metabolism | Carcinoma, Pancreatic Ductal - genetics | Gene Knockdown Techniques | Cell Hypoxia | DNA-Binding Proteins - metabolism | Heterografts | Transfection | RNA Interference | Time Factors | Smoothened Receptor | Female | Transcription, Genetic | Nuclear Proteins - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | Transcription Factors - genetics | Tumor Burden | DNA-Binding Proteins - genetics | Carcinoma, Pancreatic Ductal - pathology | Transcription Factors - metabolism | Animals | Mice, Nude | Cell Line, Tumor | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Cell Movement | Genetic transcription | Genetic research | DNA microarrays | Analysis | Protein binding | Proteins | Studies | Plasmids | Rodents | Tumorigenesis | Experiments | Deoxyribonucleic acid--DNA
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2016, Volume 139, Issue 2, pp. 433 - 445
The objective of this study was to examine the implication of Y‐box‐binding protein‐1 (YB‐1) for the aggressive phenotypes, prognosis and therapeutic target in... 
SKP2/p27 | MT2‐MMP | antisense oligonucleotide therapy | YB‐1 | pancreatic ductal adenocarcinoma | MT2-MMP | YB-1 | HUMAN BREAST CANCERS | OVARIAN-CANCER | DRUG-RESISTANCE | TRANSLATIONAL ACTIVATION | EPITHELIAL-MESENCHYMAL TRANSITION | GELATINASE-A | ONCOLOGY | TRANSCRIPTION FACTOR YB-1 | PROSTATE-CANCER | IN-VIVO | YE-1 | ANTISENSE OLIGONUCLEOTIDES | Cell Cycle - genetics | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Male | Carcinoma, Pancreatic Ductal - genetics | Gene Knockdown Techniques | Neoplasm Metastasis | Neoplasm Grading | Aged, 80 and over | Carcinoma, Pancreatic Ductal - mortality | Female | Pancreatic Neoplasms - mortality | Y-Box-Binding Protein 1 - genetics | Disease Models, Animal | Carcinoma in Situ - pathology | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Animals | Cell Line, Tumor | Aged | Mice | Neoplasm Staging | Proteins | Immunohistochemistry | Cancer patients | Care and treatment | Growth | Analysis | Pancreatic cancer | Metastasis | Protein binding | Cancer | Protein expression | Kinases | Medical prognosis | Cell cycle | Adenocarcinoma | Cell proliferation | Therapy | Surgical implants | Animal models | Correlation | Matrix metalloproteinases | Liver | Oligonucleotides | In vitro testing | Assaying | Tissues | Accumulation | Western blotting | Metastases | Rodents | Inhibition | Pancreas | Monitoring | Binding | Aggressive behavior | Invasiveness | RNA-mediated interference | Implantation | Antisense oligonucleotides | siRNA | Patients | Nuclear factor I | Polymerase chain reaction | Pancreas transplantation | In vivo methods and tests | Tumors
Journal Article
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 10, pp. 1593 - 1599
Yokukansan (YKS) is a traditional Japanese herbal medicine. It has been currently applied for treating behavioral and psychological symptoms of dementia in... 
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 374, Issue 1, pp. 44 - 53
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 5/2010, Volume 59, Issue 5, pp. 653 - 661
The human immune system consists of a balance between immune surveillance against non-self antigens and tolerance of self-antigens. CD8+ T cells and CD4+... 
Intratumoral FOXP3 + regulatory T cells | Immunology | Medicine & Public Health | CD8 + T cell/FOXP3 + cell ratio | Colorectal cancer | Intratumoral CD8 + T cells | Prognostic factor | Oncology | Cancer Research | t cell/foxp3 | Intratumoral foxp3 | t cells | CD8 | cell ratio | regulatory t cells | Intratumoral cd8 | TGF-BETA | PROGNOSIS | Intratumoral CD8(+) T cells | PERIPHERAL-BLOOD | OVARIAN-CANCER | IMMUNOLOGY | CUTTING EDGE | TUMOR-INFILTRATING LYMPHOCYTES | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | Intratumoral FOXP3(+) regulatory T cells | TRANSCRIPTION FACTOR FOXP3 | REGULATORY T-CELLS | IMMUNOLOGICAL SELF-TOLERANCE | CD8(+) T cell/FOXP3(+) cell ratio | Forkhead Transcription Factors - immunology | Immunohistochemistry | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Prognosis | Humans | Middle Aged | Male | T-Lymphocytes, Regulatory - immunology | Flow Cytometry | Forkhead Transcription Factors - metabolism | Lymphatic Metastasis - pathology | Biomarkers, Tumor - metabolism | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | Cell Separation | Kaplan-Meier Estimate | Lymphatic Metastasis - immunology | Disease-Free Survival | Colorectal Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | Aged | CD8-Positive T-Lymphocytes - immunology | Biomarkers, Tumor - immunology | Transforming Growth Factor beta - metabolism | Lymphocytes, Tumor-Infiltrating - immunology
Journal Article
Anticancer Research, ISSN 0250-7005, 06/2009, Volume 29, Issue 6, pp. 2147 - 2157
The side population (SP) and the CD44 + /CD24 -/low population have been reported in separate studies to include more tumorigenic cells than other populations,... 
Cancer stem cell | Hedgehog signaling | Breast cancer | Carcinoma, Pancreatic Ductal - secondary | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | CD24 Antigen - metabolism | Colonic Neoplasms - drug therapy | Humans | Carcinoma, Pancreatic Ductal - metabolism | Hedgehog Proteins - metabolism | Drug Resistance, Neoplasm | RNA, Messenger - metabolism | Colonic Neoplasms - metabolism | Breast Neoplasms - metabolism | Pancreatic Neoplasms - drug therapy | Adenocarcinoma - metabolism | Flow Cytometry | Hyaluronan Receptors - metabolism | Trans-Activators - genetics | Female | Antineoplastic Agents, Phytogenic - therapeutic use | Signal Transduction | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Adenocarcinoma - secondary | Blotting, Western | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice, Inbred NOD | Trans-Activators - metabolism | Cell Proliferation - drug effects | Mice | Zinc Finger Protein GLI1 | Apoptosis - physiology | Trans-Activators - antagonists & inhibitors
Journal Article
Journal Article