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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2007, Volume 104, Issue 28, pp. 11832 - 11837
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 07/2014, Volume 21, Issue 2, pp. 237 - 250
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2007, Volume 104, Issue 28, p. 11832
  Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated with current chemotherapies for non-small-cell lung cancers... 
Lung cancer | Oncology | Pharmacology | DNA repair | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article
Journal Article
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2013, Volume 12, Issue 10, pp. 2110 - 2120
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. 3781 - 3781
Journal Article
2006, AD-a450 260.
We report the development of mono(arylimino) derivatives of beta-lap as potential prodrugs (Reinicke et al. 2005). They undergo hydrolytic conversion to... 
damage | phenols | assaying | beta-lapachone | death | drugs | stresses | glutathione | therapy | cells(biology) | oxidation | breast cancer | prodrugs | reactivities | ros(reactive oxygen species) | deoxyribonucleic acids | nqo1/dt-diaphorase | pharmacokinetics | comets | oxygen | humans | hydrolysis | conversion | sulfides
Government Document
Cancer Biology & Therapy, ISSN 1538-4047, 03/2003, Volume 2, Issue 2, pp. 141 - 152
β-Lapachone (β-Lap) triggers apoptosis in a number of human breast and prostate cancer cell lines through a unique apoptotic pathway that is dependent upon... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Calpain | β-lapachone | Breast cancer | Apoptosis
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. 2283 - 2283
Journal Article
Cancer Research, ISSN 0008-5472, 07/2007, Volume 67, Issue 14, pp. 6936 - 6945
Commonly used antitumor agents, such as DNA topoisomerase I/II poisons, kill cancer cells by creating nonrepairable DNA double-strand breaks (DSBs). To repair... 
Journal Article
STAR, ISSN 1548-8837, 08/2006, Volume 44, Issue 17
We report the development of mono(arylimino) derivatives of beta-lap as potential prodrugs (Reinicke et al. 2005). They undergo hydrolytic conversion to... 
Journal Article
CANCER BIOLOGY & THERAPY, ISSN 1538-4047, 03/2003, Volume 2, Issue 2, pp. 141 - 152
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2006, Volume 281, Issue 44, pp. 33684 - 33696
After genotoxic stress poly(ADP-ribose) polymerase-1 (PARP-1) can be hyperactivated, causing (ADP-ribosyl)ation of nuclear proteins (including itself),... 
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 07/2007, Volume 104, Issue 28, p. 11832
Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated with current chemotherapies for non-small-cell lung cancers... 
Proteins | Evaluation | Chemotherapy | Cell death | Lung cancer | Quinone | Physiological aspects | Chemical properties | Tumors | Cancer
Journal Article
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