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American Journal of Physiology, ISSN 0363-6135, 01/2014, Volume 306, Issue 1, p. H26
  Targeted disruption of the Alox15 gene makes mice resistant to angiotensin II-, DOCA/salt-, and N...-nitro-l-arginine methyl ester (l-NAME)-induced... 
Hypertension | Metabolites | Rodents | Medical treatment | ACE inhibitors
Journal Article
American Journal of Physiology, ISSN 0363-6135, 02/2013, Volume 304, Issue 3, p. H382
  Arachidonic acid (AA) metabolites mediate endothelium-dependent relaxation in many vascular beds. Previously, we identified the major AA 12/15-lipoxygenase... 
Metabolites | Lipids | Physiology | Gene expression | Cells | Endothelium | Veins & arteries
Journal Article
Endocrinology, ISSN 0013-7227, 01/2018, Volume 159, Issue 1, pp. 217 - 226
Angiotensin II (Ang II) and adrenocorticotropic hormone (ACTH) regulate adrenal vascular tone in vitro through endothelial and zona glomerulosa cell-derived... 
IMIDAZOLE DERIVATIVES | CORTICAL ARTERIES | ENDOCRINOLOGY & METABOLISM | STIMULATE ALDOSTERONE RELEASE | ARACHIDONIC-ACID | SECRETION | EPOXYEICOSATRIENOIC ACIDS | CORONARY-ARTERIES | ENDOTHELIAL NITRIC-OXIDE | ZONA GLOMERULOSA CELLS | ADRENOCORTICOTROPIC HORMONE | Injections, Intravenous | Angiotensin II - administration & dosage | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Adrenocorticotropic Hormone - administration & dosage | Endothelium, Vascular - enzymology | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Receptors, Corticotropin - metabolism | Regional Blood Flow - drug effects | 8,11,14-Eicosatrienoic Acid - pharmacology | Adrenal Glands - drug effects | Adrenocorticotropic Hormone - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptor, Angiotensin, Type 2 - agonists | Angiotensin II - metabolism | Nitric Oxide - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Adrenal Glands - blood supply | Eicosanoids - antagonists & inhibitors | Receptors, Corticotropin - agonists | Eicosanoids - blood | Rats, Sprague-Dawley | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Receptor, Angiotensin, Type 2 - metabolism | Adrenal Glands - metabolism | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Eicosanoids - metabolism | Miconazole - pharmacology | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism | Cytochrome | Adrenal glands | Menopause | Aldosterone | Blood | Arginine | Blood pressure | Adrenal gland | Miconazole | Angiotensin II | Cytochromes P450 | Cytochrome P450 | Ablation | Cholesterol | Blood flow | NG-Nitroarginine methyl ester | Adrenocorticotropic hormone | Inhibitors | Acids | Perfusion | Nitric oxide | Angiotensin | Steroidogenesis | Indomethacin | Mercury
Journal Article
American Journal of Physiology, ISSN 0363-6135, 08/2009, Volume 297, Issue 2, p. H495
  Stimulation of vascular endothelial cells with agonists such as acetylcholine (ACh) or bradykinin or with shear stress activates phospholipases and releases... 
Heart | Metabolites | Blood pressure | Metabolism | Potassium | Cells | Veins & arteries
Journal Article
American Journal of Physiology, ISSN 0363-6135, 07/2008, Volume 295, Issue 1, p. H89
  Arachidonic acid (AA) metabolites from the 15-lipoxygenase-1 (15-LO-1) pathway, trihydroxyeicosatrienoic acids (THETAs) and hydroxy-epoxyeicosatrienoic acids... 
Heart | Rabbits | Nitric oxide | Blood pressure | Veins & arteries
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2012, Volume 302, Issue 11, pp. H2428 - H2438
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2008, Volume 294, Issue 6, pp. 2838 - 2844
Previously, we demonstrated (17) that 11,12- and 14,15-epoxyeicosatrienoic acids (EETs) produce marked reductions in myocardial infarct size. Although it is... 
Epoxyeicosatrienoic acids | Cytochrome P-450 epoxygenase | ATP-sensitive potassium channel opener | Soluble epoxide hydrolase | SIGNALING PATHWAYS | METABOLITES | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | REPERFUSION | ARACHIDONIC-ACID | soluble epoxide hydrolase | epoxyeicosatrienoic acids | CYTOCHROME-P450 EPOXYGENASE CYP2J2 | cytochrome P-450 epoxygenase | EPOXYEICOSATRIENOIC ACIDS EETS | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | MOLECULAR-CLONING | CORONARY-ARTERY-DISEASE | Diazoxide - pharmacology | Mitochondria, Heart - metabolism | Cardiovascular Agents - metabolism | Male | 8,11,14-Eicosatrienoic Acid - metabolism | Mitochondria, Heart - drug effects | Lauric Acids - pharmacology | Dose-Response Relationship, Drug | Potassium Channels - metabolism | Heart Rate - drug effects | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Myocardial Infarction - pathology | Myocardium - metabolism | Female | Myocardial Infarction - physiopathology | Blood Pressure - drug effects | 8,11,14-Eicosatrienoic Acid - pharmacology | Adamantane - analogs & derivatives | Disease Models, Animal | Adamantane - pharmacology | Enzyme Inhibitors - pharmacology | Myocardium - pathology | Myocardial Infarction - metabolism | Potassium Channels - drug effects | Cardiovascular Agents - pharmacology | Myocardium - enzymology | Animals | Dogs | Myocardial Infarction - prevention & control | Coronary Circulation - drug effects | Epoxide Hydrolases - metabolism | Epoxide Hydrolases - antagonists & inhibitors
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2013, Volume 304, Issue 3, pp. H382 - H392
Siangjong L, Gauthier KM, Pfister SL, Smyth EM, Campbell WB. Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse... 
Thromboxane receptors | Arachidonic acid | Lipoxygenase | Vasorelaxation | 12-HETE | arachidonic acid | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | HUMAN-PLATELETS | CORNEAL EPITHELIUM | thromboxane receptors | ARACHIDONIC-ACID | ACID LIPOXYGENASE METABOLITES | VASCULAR-TONE | lipoxygenase | LEUKOTRIENE B-4 RECEPTOR | INDUCED RELAXATIONS | SMOOTH-MUSCLE | vasorelaxation | 12-HYDROXYEICOSATETRAENOIC ACID | PERIPHERAL VASCULAR DISEASE | EPOXYEICOSATRIENOIC ACIDS | Vasoconstrictor Agents - pharmacology | Arachidonic Acid - metabolism | Hydrazines - pharmacology | Vasodilator Agents - pharmacology | Isometric Contraction - drug effects | Humans | Mice, Inbred C57BL | Endothelium, Vascular - drug effects | Male | Mesenteric Arteries - drug effects | Chromatography, High Pressure Liquid | Blotting, Western | Animals | Calcium Signaling - drug effects | Receptors, Leukotriene B4 - drug effects | Receptors, Thromboxane A2, Prostaglandin H2 - drug effects | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | HEK293 Cells | Receptors, Thromboxane - antagonists & inhibitors | Mice | Blood Platelets - drug effects | Receptors, G-Protein-Coupled - drug effects | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - pharmacology | Physiological aspects | Metabolites | Health aspects | Arteries | Endothelium | Vascular Biology and Microcirculation
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 01/2014, Volume 306, Issue 1, pp. H26 - H32
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2011, Volume 300, Issue 3, pp. H725 - H735
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 04/2012, Volume 302, Issue 8, pp. 1574 - 1583
Arachidonic acid is metabolized to four regioisomeric epoxyeicosatrienoic acids (EETs) by cytochrome P-450. 5,6-, 8,9-, 11,12-, and 14,15-EET are equipotent in... 
Epoxyeicosatrienoic acid | Soluble epoxide hydrolase | Arteries | Endothelium-derived hyperpolarizing factor | Vascular relaxation | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | arteries | EPOXYGENASE-DERIVED EICOSANOIDS | DEPENDENT HYPERPOLARIZATION | ARACHIDONIC-ACID | 11,12-EPOXYEICOSATRIENOIC ACID | soluble epoxide hydrolase | endothelium-derived hyperpolarizing factor | 14,15-EET ANALOGS | SMOOTH-MUSCLE | epoxyeicosatrienoic acid | STRUCTURAL REQUIREMENTS | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | vascular relaxation | EPOXYEICOSATRIENOIC ACIDS | Membrane Potentials - drug effects | Coronary Vessels - drug effects | Muscle, Smooth, Vascular - metabolism | Isometric Contraction - drug effects | Rats | Male | Mesenteric Arteries - drug effects | Large-Conductance Calcium-Activated Potassium Channels - drug effects | Potassium Channels - drug effects | Rats, Sprague-Dawley | Coronary Vessels - metabolism | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Patch-Clamp Techniques | Animals | Cattle | Mass Spectrometry | Arachidonic Acid - pharmacology | 8,11,14-Eicosatrienoic Acid - antagonists & inhibitors | Coronary Circulation - drug effects | Muscle Relaxation - drug effects | Vasodilation - drug effects | 8,11,14-Eicosatrienoic Acid - pharmacology | In Vitro Techniques | Muscle, Smooth, Vascular - drug effects | Physiological aspects | Health aspects | Fatty acids | Cytochrome P-450 | Coronary arteries | Vascular Biology and Microcirculation
Journal Article
American Journal of Physiology, ISSN 0363-6135, 05/2007, Volume 292, Issue 5, p. H2265
  Adrenic acid (docosatetraenoic acid), an abundant fatty acid in the vasculature, is produced by a two-carbon chain elongation of arachidonic acid. Despite... 
Proteins | Cattle | Coronary vessels | Metabolism | Fatty acids | Mass spectrometry | Chromatography
Journal Article
American Journal of Physiology, ISSN 0363-6135, 06/2012, Volume 302, Issue 11, p. H2428
In mouse arteries, Alox15 [leukocyte-type 12/15-lipoxygenase (LO)] is assumed to regulate vascular function by metabolizing arachidonic acid (AA) to dilator... 
Proteins | Hypertension | Leucocytes | Metabolites | Rodents | Veins & arteries
Journal Article