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PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, pp. e0184744 - e0184744
The oral thrombin inhibitor ximelagatran was withdrawn in the late clinical trial phase because it adversely affected the liver. In approximately 8% of treated... 
HLA CLASS-II | DIRECT THROMBIN INHIBITOR | RISK-FACTORS | STROKE PREVENTION | MULTIDISCIPLINARY SCIENCES | PEPTIDE REPERTOIRE | GENOME-WIDE | MAJOR HISTOCOMPATIBILITY COMPLEX | DRUG HYPERSENSITIVITY | NONVALVULAR ATRIAL-FIBRILLATION | INDUCED LIVER-INJURY | Lymphocytes - metabolism | Cell Line | HLA-DR7 Antigen - metabolism | HLA-DQ Antigens - metabolism | HLA-DR7 Antigen - genetics | Humans | Mice, Inbred C57BL | Benzylamines - toxicity | Male | Mice, Transgenic | Azetidines - toxicity | Chemical and Drug Induced Liver Injury - immunology | Phenotype | Animals | HLA-DQ Antigens - genetics | Female | Molecular Docking Simulation | Disease Models, Animal | Drugs | Complications and side effects | Histocompatibility antigens | HLA histocompatibility antigens | Physiological aspects | Genetic aspects | Dosage and administration | Models | Research | Ximelagatran | Health aspects | Risk factors | Haplotypes | Health sciences | Animal models | Toxicity | Pathogenesis | DQA1 protein | Liver | Genomics | Transaminase | Thrombin | Homology | Genomes | Molecular weight | Mimicry | Proteins | Toxicology | Histopathology | Immunology | Transgenic animals | Rodents | Hepatology | Drb1 protein | Biocompatibility | Bioindicators | Hepatotoxicity | Antigens | Stroke | Alanine | Transgenic mice | Patients | CD4 antigen | Medicine | Studies | Pathology | Hypotheses | Major histocompatibility complex | Councils | Alanine transaminase | Biomarkers | Ligands | In vivo methods and tests | Mice | Histocompatibility antigen HLA | Histocompatibility | Index Medicus | Basic Medicine | Farmakologi och toxikologi | Medical and Health Sciences | Pharmacology and Toxicology | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 09/2018, Volume 46, Issue 16, pp. 8417 - 8434
Abstract The mutation patterns at Cas9 targeted sites contain unique information regarding the nuclease activity and repair mechanisms in mammalian cells.... 
ADAPTIVE IMMUNITY | HELICASE DOMAIN | COMPLEX | STRAND BREAK REPAIR | RNA | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NHEJ | CLEAVAGE | NUCLEASE | REVEALS | Index Medicus | Molecular Biology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 16, pp. 6603 - 6608
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 03/2013, Volume 102, Issue 3, pp. 1116 - 1124
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2011, Volume 108, Issue 16, pp. 6603 - 6608
Peroxisome proliferator-activated receptor-[gamma] coactivator 1-[alpha] (PGC1[alpha]) is a transcriptional coactivator able to up-regulate mitochondrial... 
Peroxisomes | Energy metabolism | Bioenergetics | Gastrointestinal cancer | Physiological aspects | Mitochondrial DNA | Diagnosis | Fatty acids | Health aspects | Proteins | Signal transduction | Pathogenesis | Metabolism | Cell adhesion & migration | Apoptosis | Cancer
Journal Article
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