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PLoS ONE, ISSN 1932-6203, 02/2018, Volume 13, Issue 2, pp. e0193018 - e0193018
Journal Article
International Journal of Hematology, ISSN 0925-5710, 6/2016, Volume 103, Issue 6, pp. 713 - 717
Journal Article
Internal Medicine, ISSN 0918-2918, 2018, Volume 57, Issue 1, pp. 91 - 95
Journal Article
Respiratory Research, ISSN 1465-9921, 01/2019, Volume 20, Issue 1, pp. 9 - 9
BackgroundWe have shown that phospholipase C epsilon (PLC epsilon), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and... 
Acute respiratory distress syndrome | Acute lung injury | Phospholipase Cϵ | Inflammation | Mouse model | Neutrophil | Nuclear factor-κB | Alveolar epithelial cells | Cxcl5 | KINASE | Phospholipase C epsilon | KAPPA-B | INDUCTION | RESPIRATORY SYSTEM | MICE | TNF-ALPHA | EXPRESSION | Nuclear factor-B | Lipopolysaccharides - toxicity | Mice, Inbred C57BL | Neutrophils - drug effects | Cells, Cultured | Alveolar Epithelial Cells - metabolism | Phosphoinositide Phospholipase C - physiology | Alveolar Epithelial Cells - drug effects | Random Allocation | Mice, Knockout | Chemokine CXCL5 - biosynthesis | Animals | Acute Lung Injury - chemically induced | Acute Lung Injury - metabolism | Mice | Neutrophils - metabolism | Phosphorylation | Pneumonia | Pathogenesis | Epithelial cells | Reverse transcription | Kinases | Dermatitis | Carcinogenesis | Lipopolysaccharides | Proteins | Signal transduction | Carcinogens | Reduction | Bronchoalveolar lavage | Rodents | Tumor necrosis factor-TNF | Alveoli | Trachea | Genotypes | Injury analysis | Thickening | Translocation | Lavage | NF-κB protein | Cytokines | Neutrophils | Organs | Bronchus | Leukocytes (neutrophilic) | Roles | Gene expression | Weight | Nuclear transport | Phospholipase C | Augmentation | Rap1 protein | Polymerase chain reaction | Phospholipase | Respiratory distress syndrome | Lungs | Protein kinase | Ligands | Chemokines | Index Medicus | Phospholipase Cε | Research
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2018, Volume 13, Issue 9, p. e0203211
Background Sphingosine kinase phosphorylates sphingosine to generate sphingosine 1 phosphate (S1P) following stimulation of the five plasma membrane... 
LUNG | BETA-1-ADRENOCEPTORS | ACTIVATION | POLYMORPHISMS | MULTIDISCIPLINARY SCIENCES | SPHINGOSINE-1-PHOSPHATE | AIRWAY INFLAMMATION | ASTHMA | RECEPTORS | EXPRESSION | SPHINGOSINE 1-PHOSPHATE | Lysophospholipids - metabolism | Asthma - metabolism | Chemokine CCL20 - metabolism | Receptors, Lysosphingolipid - antagonists & inhibitors | Epithelial Cells - metabolism | Humans | Bronchi - immunology | Gene Knockdown Techniques | Eosinophilia - pathology | Phosphoserine - analogs & derivatives | Phosphoserine - pharmacology | Bronchi - metabolism | Receptors, Lysosphingolipid - genetics | Female | Sphingosine - metabolism | Eosinophilia - drug therapy | Receptors, Lysosphingolipid - metabolism | Bronchi - pathology | Disease Models, Animal | Receptors, Prostaglandin E, EP4 Subtype - genetics | Cell Line | Gene Expression | Anti-Inflammatory Agents - pharmacology | Receptors, Adrenergic, beta-2 - genetics | Epithelial Cells - pathology | Asthma - drug therapy | Asthma - genetics | Sphingosine - analogs & derivatives | Animals | Epithelial Cells - immunology | Mice | Mice, Inbred BALB C | Care and treatment | Research | Epithelial cells | Health aspects | Sphingosine | Asthma | G protein-coupled receptors | Genes | Kinases | Respiratory tract | Proteins | Receptors | Bronchoalveolar lavage | CCL20 protein | Respiratory tract diseases | Alveoli | University graduates | Ovalbumin | Immunization | Sphingosine kinase | Lymphatic system | Cytokines | Internal medicine | Dendritic cells | Leukocytes (eosinophilic) | Bronchus | Inflammation | siRNA | Gene expression | Membrane proteins | Medicine | Chemokines
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 134, Issue 7, pp. 2004 - 2013
Background & Aims: Chemotherapy with an anticancer agent generally causes gastrointestinal tract disorders such as vomiting and anorexia, but the mechanism... 
Gastroenterology and Hepatology | SEROTONIN RECEPTOR | GHRELIN LEVELS | SYMPTOMS | MICE | EMESIS | GASTROENTEROLOGY & HEPATOLOGY | STOMACH | Receptor, Serotonin, 5-HT2B - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Body Weight - drug effects | Drugs, Chinese Herbal - pharmacology | Male | Stomach - metabolism | Drugs, Chinese Herbal - metabolism | Anorexia - physiopathology | Quinolines - pharmacology | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Serotonin 5-HT2 Receptor Antagonists | Chalcones - pharmacology | Dopamine Antagonists - metabolism | Receptors, Ghrelin - metabolism | Indoles - pharmacology | Stomach - innervation | Stomach - drug effects | Drugs, Chinese Herbal - therapeutic use | Flavones - pharmacology | Acylation | Disease Models, Animal | Antineoplastic Agents | Rats | Thiophenes - pharmacology | Anorexia - metabolism | Dopamine Antagonists - therapeutic use | Receptors, Ghrelin - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Vagotomy | Cisplatin | Ghrelin - metabolism | Eating - drug effects | Gastrointestinal Agents - pharmacology | Ghrelin - blood | Animals | Dopamine Antagonists - pharmacology | Aminopyridines - pharmacology | Serotonin - metabolism | Gastrointestinal Agents - therapeutic use | Anorexia - prevention & control | Hesperidin - pharmacology | Protein Binding | Anorexia - chemically induced | Oligopeptides - pharmacology | Gastrointestinal Agents - metabolism | Medicine, Botanic | Medicine, Herbal
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 05/2019, Volume 20, Issue 10, p. 2589
Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural... 
extracellular vesicles | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | microparticles | ANTIGEN PRESENTATION | CHEMISTRY, MULTIDISCIPLINARY | LAVAGE FLUID EXOSOMES | TISSUE GROWTH-FACTOR | EPITHELIAL-CELLS | exosomes | NEUTRAL SPHINGOMYELINASE | REGULATORY T-CELLS | CELL-DERIVED EXOSOMES | STROMAL CELLS | apoptotic bodies | CLASS-II
Journal Article
International Journal of Hematology, ISSN 0925-5710, 6/2014, Volume 99, Issue 6, pp. 721 - 725
Journal Article
Journal Article
Journal Article
INTERNAL MEDICINE, ISSN 0918-2918, 2019, Volume 58, Issue 10, pp. 1467 - 1471
Journal Article
THERAPEUTICS AND CLINICAL RISK MANAGEMENT, ISSN 1178-203X, 2019, Volume 15, pp. 1283 - 1289
We herein report the case of a 39-year-old Japanese female with eosinophilic pneumonia associated with natalizumab. The patient with bronchial asthma had... 
multiple sclerosis | eosinophilic pneumonia | natalizumab | DISEASE | HEALTH CARE SCIENCES & SERVICES | Drugs | Antigens | Pneumonia | Multiple sclerosis | Immunoglobulins | Internal medicine | Laboratories | Lung diseases | Patients | Asthma | Medicine | Neurology | X rays | Lymphocytes | Medical prognosis | Respiration | University graduates
Journal Article
Respiratory Research, ISSN 1465-9921, 01/2019, Volume 20, Issue 1
We have shown that phospholipase C[epsilon] (PLC[epsilon]), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and... 
Acute respiratory distress syndrome | Cytokines | Analysis | Inflammation | Phospholipases | G proteins | Mitogens | Protein kinases
Journal Article
Internal Medicine, ISSN 0918-2918, 2019
Hypertrophic pulmonary osteoarthropathy (HPO) is a paraneoplastic syndrome characterized by digital clubbing, arthritis, and periostitis. Tumor removal usually... 
crizotinib | hypertrophic pulmonary osteoarthropathy | ROS1-rearranged lung cancer | paraneoplastic syndrome
Journal Article
CANCER MANAGEMENT AND RESEARCH, ISSN 1179-1322, 2019, Volume 11, pp. 3669 - 3679
Background: The combination of gemcitabine (GEM) and paclitaxel (PTX) was appealing for clinical exploration due to different mechanisms of action and... 
APOPTOSIS | ARREST | ONCOLOGY | TAXOL | IC50 | tubulin | HISTONE DEACETYLASE 6 | COMBINATION | combination index | CYCLE | Polymerization | Lung cancer | α-tubulin
Journal Article
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, ISSN 1753-4658, 09/2019, Volume 13, p. 175346661987592
Smoking causes various diseases and is a major public health threat worldwide. Therefore, promoting smoking cessation is the most important intervention... 
nicotine-replacement therapy | EFFICACY | RISK | N-ACETYLCYSTEINE | varenicline | CIGARETTE-SMOKING | NICOTINE PATCH | RESPIRATORY SYSTEM | abstinence | DOUBLE-BLIND | TOBACCO USE | cytokines | PLACEBO-CONTROLLED TRIAL | SUSTAINED-RELEASE BUPROPION | LIFE EXPECTANCY
Journal Article