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Natural product reports, ISSN 0265-0568, 04/2019
Covering: up to 2019Inhibitors of proteases and related enzymes have versatile applications in medicine and other areas. They are used in the clinic e.g. for... 
Journal Article
by Medema, Marnix H and Kottmann, Renzo and Yilmaz, Pelin and Cummings, Matthew and Biggins, John B and Blin, Kai and de Bruijn, Irene and Chooi, Yit Heng and Claesen, Jan and Coates, R Cameron and Cruz-Morales, Pablo and Duddela, Srikanth and Düsterhus, Stephanie and Edwards, Daniel J and Fewer, David P and Garg, Neha and Geiger, Christoph and Gomez-Escribano, Juan Pablo and Greule, Anja and Hadjithomas, Michalis and Haines, Anthony S and Helfrich, Eric J N and Hillwig, Matthew L and Ishida, Keishi and Jones, Adam C and Jones, Carla S and Jungmann, Katrin and Kegler, Carsten and Kim, Hyun Uk and Kötter, Peter and Krug, Daniel and Masschelein, Joleen and Melnik, Alexey V and Mantovani, Simone M and Monroe, Emily A and Moore, Marcus and Moss, Nathan and Nützmann, Hans-Wilhelm and Pan, Guohui and Pati, Amrita and Petras, Daniel and Reen, F Jerry and Rosconi, Federico and Rui, Zhe and Tian, Zhenhua and Tobias, Nicholas J and Tsunematsu, Yuta and Wiemann, Philipp and Wyckoff, Elizabeth and Yan, Xiaohui and Yim, Grace and Yu, Fengan and Xie, Yunchang and Aigle, Bertrand and Apel, Alexander K and Balibar, Carl J and Balskus, Emily P and Barona-Gómez, Francisco and Bechthold, Aneas and Bode, Helge B and Borriss, Rainer and Brady, Sean F and Brakhage, Axel A and Caffrey, Patrick and Cheng, Yi-Qiang and Clardy, Jon and Cox, Russell J and De Mot, René and Donadio, Stefano and Donia, Mohamed S and van der Donk, Wilfred A and Dorrestein, Pieter C and Doyle, Sean and essen, Arnold J M and Ehling-Schulz, Monika and Entian, Karl-Dieter and Fischbach, Michael A and Gerwick, Lena and Gerwick, William H and Gross, Harald and Gust, Bertolt and Hertweck, Christian and Höfte, Monica and Jensen, Susan E and Ju, Jianhua and Katz, Leonard and Kaysser, Leonard and Klassen, Jonathan L and Keller, Nancy P and Kormanec, Jan and Kuipers, Oscar P and Kuzuyama, Tomohisa and Kyrpides, Nikos C and Kwon, Hyung-Jin and Lautru, Sylvie and Lavigne, Rob and Lee, Chia Y and Linquan, Bai and Liu, Xinyu and Liu, Wen and ...
Nature Chemical Biology, ISSN 1552-4469, 08/2015, Volume 11, Issue 9, pp. 625 - 631
Journal Article
Journal Article
BioSpektrum, ISSN 0947-0867, 2017, Volume 23, Issue 1, pp. 41 - 45
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2013, Volume 9, Issue 10, pp. 610 - 615
Journal Article
BIOspektrum, ISSN 0947-0867, 2/2017, Volume 23, Issue 1, pp. 41 - 45
Bacteria are a rich source for small-molecule inhibitors of proteases and protease-like enzymes with various therapeutic applications. These molecules often... 
Life Sciences | Biochemistry, general | Human Genetics | Life Sciences, general | Microbiology | Developmental Biology | Pharmacology/Toxicology
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2017, Volume 56, Issue 23, p. 6665
Belactosins and cystargolides are natural product proteasome inhibitors from Actinobacteria. Both feature dipeptidic backbones and a unique [beta]-lactone... 
Physiological aspects | Amino acids | Biosynthesis | Ligases | Analysis | Cluster analysis | Inhibitors | Gene clusters | Homology | Leucine | Proteasome inhibitors | Feeding
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 10/2014, Volume 53, Issue 41, pp. 11023 - 11026
The vanadium-dependent chloroperoxidase Mcl24 was discovered to mediate a complex series of unprecedented transformations in the biosynthesis of the... 
oxidation | enzymes | ORTHO-CHLORINATION | AROMATIC SERIES | CHEMISTRY, MULTIDISCIPLINARY | chlorine | MARINE NATURAL-PRODUCTS | PHENOLS | REGIOSELECTIVE HALOGENATION | BIOSYNTHESIS | vanadium | HALOPEROXIDASES | SULFURYL CHLORIDE | ACCEPTOR TYPE INTERACTIONS | biomimetic synthesis | BROMOPEROXIDASE
Journal Article
ChemBioChem, ISSN 1439-4227, 05/2016, Volume 17, Issue 9, pp. 792 - 798
Journal Article
Journal Article