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PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179063
Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a... 
FALSE DISCOVERY RATE | DRUG | SALICYLATE | OBESITY | ACIDS | MULTIDISCIPLINARY SCIENCES | Inflammation - pathology | Humans | Hypertension - drug therapy | NLR Proteins - biosynthesis | Metabolic Syndrome - drug therapy | Fatty Acids, Nonesterified - metabolism | Inflammation - drug therapy | Hypertension - genetics | C-Reactive Protein - biosynthesis | PPAR alpha - biosynthesis | Liver - metabolism | Salicylates - administration & dosage | Rats | C-Reactive Protein - genetics | Hypertension - pathology | Animals | Animals, Genetically Modified - genetics | Metabolic Syndrome - genetics | Insulin Resistance - genetics | Lipid Metabolism - drug effects | Inflammation - genetics | Adipose Tissue, Brown - metabolism | Metabolic Syndrome - pathology | Oxidative Stress - drug effects | Tumor Necrosis Factor-alpha - biosynthesis | C-reactive protein | Analysis | Insulin resistance | Inflammation | Dosage and administration | Research | Metabolic syndrome X | Salsalate | Risk factors | Adipose tissue | Pathogenesis | Liver | Body weight | Lipid peroxidation | Glucose | Palmitic acid | Proteins | Signal transduction | Physiology | Lipid metabolism | Adipose tissue (brown) | Drug dosages | Obesity | Gene expression | Metabolism | Insulin | Fatty acids | Strain | Disturbances | Weight reduction | Metabolic disorders | Monocyte chemoattractant protein 1 | Kidney transplantation | Oxidative stress | Transcription | Genes | Kinases | Metabolic syndrome | Pathways | Rodents | Tumor necrosis factor-TNF | Oxidation | Skeleton | Nonsteroidal anti-inflammatory drugs | Lipoproteins (high density) | Food | Hypertension | Retarding | Kidneys | Markers | Muscles | Cholesterol | Skeletal muscle | Medicine | Glucose tolerance | Signaling | Sensitivity | Diabetes
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e101906
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0150924
Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for... 
FALSE DISCOVERY RATE | GLYCATION | METABOLISM | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | METHYLGLYOXAL | Rats, Inbred SHR | AMP-Activated Protein Kinases - metabolism | Gene Expression | Lipolysis - drug effects | Cytokines - metabolism | Rats, Transgenic | Humans | Metformin - pharmacology | Oxidative Stress - genetics | Rats | Male | C-Reactive Protein - genetics | Lipolysis - genetics | Pyruvaldehyde - metabolism | Animals | Myocardium - metabolism | Glucose - metabolism | Heart Ventricles - metabolism | Oxidative Stress - drug effects | C-Reactive Protein - biosynthesis | AMP-Activated Protein Kinases - genetics | Hypertension | Complications and side effects | C-reactive protein | Physiological aspects | Genetic aspects | Dosage and administration | Research | Metformin | Gene expression | Heart | Oxidative stress | Deregulation | Adipose tissue | Syngeneic grafts | Pathogenesis | Oxidative metabolism | Liver | Transgenic | Inflammatory response | AMP-activated protein kinase | Interleukin 6 | Proteins | Glucose metabolism | Hyperglycemia | Metabolites | Rodents | Measurement methods | Physiology | Lipid metabolism | Bioinformatics | Gluconeogenesis | Kidneys | AMP | Diabetes mellitus | Inflammation | Tumor necrosis factor-α | Metabolism | Insulin | Variance analysis | Lipolysis | Strain | Medicine | Signaling | Molecular modelling | Insulin resistance | Diabetes | Dienes | Pyruvaldehyde | Metabolic disorders | Monocyte chemoattractant protein 1 | Kidney transplantation
Journal Article
EBioMedicine, ISSN 2352-3964, 10/2015, Volume 2, Issue 10, pp. 1308 - 1309
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0152708
Metabolic syndrome is a highly prevalent human disease with substantial genomic and environmental components. Previous studies indicate the presence of... 
STRAINS | QUANTITATIVE TRAIT LOCI | GENETIC-DETERMINANTS | MULTIDISCIPLINARY SCIENCES | MECHANISMS | PHENOTYPES | IDENTIFICATION | BLOOD-PRESSURE | GLUCOSE-TOLERANCE | HYPERTENSIVE-RAT | REVEALS | Glucose Tolerance Test | Rats, Inbred BN - genetics | Animals, Congenic - metabolism | Humans | Metabolome | Rats, Inbred SHR - metabolism | Male | Metabolic Syndrome - metabolism | Rats, Inbred BN - metabolism | Animals, Congenic - physiology | Animals | Rats, Inbred BN - physiology | Metabolic Syndrome - genetics | Metabolic Syndrome - physiopathology | Animals, Congenic - genetics | Hemodynamics | Genome | Rats, Inbred SHR - genetics | Chromosomes, Human, Pair 16 - genetics | Rats, Inbred SHR - physiology | Physiological aspects | Genetic aspects | Research | Metabolic syndrome X | Genetic polymorphisms | Risk factors | Genes | Genomics | Synteny | Genomes | Biology | Metabolic syndrome | Adiponectin | Gene sequencing | Missense mutation | Rodents | Interleukin 1 | Genetics | Physiology | Blood pressure | Chromosome 16 | Chromosomes | Deoxyribonucleic acid--DNA | Hypertension | Nucleotide sequence | Rats | Triglycerides | Gene expression | Insulin | Fatty acids | Variance analysis | Cholesterol | Medicine | Studies | Glucose tolerance | Insulin resistance | Diabetes | Mutation | Metabolic disorders | Deoxyribonucleic acid | DNA
Journal Article
Nutrition, ISSN 0899-9007, 2015, Volume 31, Issue 7, pp. 1045 - 1051
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1723
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1722
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e109983
The plasma profile of major lipoprotein classes and its subdivision into particular fractions plays a crucial role in the pathogenesis of atherosclerosis and... 
QUANTITATIVE TRAIT LOCI | METABOLIC SYNDROME | INDUCED HYPERCHOLESTEROLEMIA | SPONTANEOUSLY HYPERTENSIVE-RAT | GENETIC-DETERMINANTS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | LINKAGE ANALYSIS | CORONARY-ARTERY-DISEASE | RECOMBINANT INBRED STRAINS | Cholesterol - chemistry | Genome-Wide Association Study | Animals | Species Specificity | Genomics | Rats | Male | Lipoproteins - chemistry | Polymorphism, Single Nucleotide | Triglycerides - chemistry | Quantitative genetics | Low density lipoproteins | Atherosclerosis | Triglycerides | Single nucleotide polymorphisms | Chromosomes | Cholesterol | Lipoproteins (low density) | Animal models | Adipose tissue | Sucrose | High cholesterol diet | Pathogenesis | Cardiovascular disease | Genomes | Biology | Single-nucleotide polymorphism | Rodents | DNA methylation | Genetics | Inbreeding | Lipoprotein (low density) receptors | Heart diseases | Sugars | Recombinant | Hypertension | Permutations | Microsatellites | Coronary artery | Particulates | Gene expression | LRP1B protein | Coronary artery disease | Loci | Lipoproteins (very low density) | Quantitative trait loci | Medicine | Studies | Genetic markers | Particle size distribution | Lipoproteins | Diet | Arteriosclerosis | Alleles | Receptor density | Determinants | Insulin resistance | Diabetes | Laboratory animals | Metabolic disorders
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122768
Journal Article