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Molecular Cell, ISSN 1097-2765, 02/2017, Volume 65, Issue 3, pp. 377 - 379
Adaptation of CRISPR-Cas9 for genome-editing applications has revolutionized biomedical research. New single-component effector CRISPR systems are emerging... 
C2c3 | CRISPR | C2c2 | C2c1 | type II | Cas | Cpf1 | interference | immunity | Cas9 | Genetic Engineering - methods | Models, Molecular | CRISPR-Associated Proteins - chemistry | Gene Editing - methods | CRISPR-Cas Systems
Journal Article
Methods in Enzymology, ISSN 0076-6879, 01/2019, Volume 616, pp. 27 - 41
Type I CRISPR–Cas, the most prevalent CRISPR system, features a sequential target searching and degradation process. First, the multisubunit surveillance... 
Cas3 | R-loop | CRISPR–Cas | Cascade | CRISPR-Cas
Conference Proceeding
Science, ISSN 0036-8075, 07/2018, Volume 361, Issue 6397, pp. 41 - 41
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7591, pp. 499 - 503
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2011, Volume 286, Issue 35, pp. 30759 - 30768
Journal Article
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, p. 137
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 10/2008, Volume 15, Issue 10, pp. 1076 - 1083
  Three distinct classes of S-adenosyl-L-methionine (SAM)-responsive riboswitches have been identified that regulate bacterial gene expression at the levels of... 
Gene expression | Molecular biology | Alternatives | Binding sites | Crystal structure
Journal Article
Journal Article
Wiley Interdisciplinary Reviews: RNA, ISSN 1757-7004, 09/2018, Volume 9, Issue 5, pp. e1482 - n/a
After remaining an orphan for over a decade, the ykkC riboswitch family (ykkC, mini‐ykkC, and ykkC‐III) was recently characterized as guanidine‐specific... 
microbiology | RNA biology | RNA structure | Riboswitches | BACTERIA | LIGAND-BINDING | RECOGNITION | CANDIDATE STRUCTURED RNAS | BIOCHEMICAL VALIDATION | IDENTIFICATION | CELL BIOLOGY | RNA-mediated interference | Guanidine | Physiology | Regulatory sequences | Intracellular | Ribonucleic acid--RNA
Journal Article
Science, ISSN 0036-8075, 2/2011, Volume 331, Issue 6019, pp. 881 - 886
Cotranslational targeting of membrane and secretory proteins is mediated by the universally conserved signal recognition particle (SRP). Together with its... 
Hydrolysis | Molecules | Receptors | RNA | RESEARCH ARTICLES | Ribosomes | Biochemistry | Cell membranes | Genetic mutation | Freight | Crystal structure | CORE | DOMAIN | SRP GTPASES FFH | CONFORMATIONAL-CHANGES | 4.5S RNA | FTSY | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | NUCLEOTIDE SPECIFICITY | TRANSLATING RIBOSOME | BINDING | Ribosomal Proteins - chemistry | Signal Recognition Particle - metabolism | Protein Multimerization | Bacterial Proteins - chemistry | Ribosomes - metabolism | Crystallography, X-Ray | Guanosine Triphosphate - metabolism | Ribosomal Proteins - metabolism | GTP Phosphohydrolases - chemistry | Base Sequence | Receptors, Cytoplasmic and Nuclear - chemistry | Escherichia coli - metabolism | Guanosine Triphosphate - chemistry | Signal Recognition Particle - chemistry | Nucleic Acid Conformation | Binding Sites | RNA, Bacterial - metabolism | Protein Structure, Tertiary | Crystallization | Guanosine Triphosphate - analogs & derivatives | Models, Molecular | Escherichia coli Proteins - metabolism | Escherichia coli - chemistry | Protein Transport | GTP Phosphohydrolases - metabolism | Hydrogen Bonding | Models, Biological | RNA, Bacterial - chemistry | Hydrophobic and Hydrophilic Interactions | Bacterial Proteins - metabolism | Protein Conformation | Enzyme Activation | Escherichia coli Proteins - chemistry | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Chemical properties | Research | Structure | Guanine | Enzymes | RNA-protein interactions | Molecular biology
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 16
The widespread Mn2+-sensing yybP-ykoY riboswitch controls the expression of bacterial Mn2+ homeostasis genes. Here, we first determine the crystal structure of... 
HETEROGENEITY | MOLECULAR-DYNAMICS | MECHANICS | SINGLE | RNA STRUCTURE | EUBACTERIA SENSE | MULTIDISCIPLINARY SCIENCES | SIMULATIONS | PARAMETERS | BINDING | REVEALS | Adenosine | Core loss | Homeostasis | Ribonucleic acid--RNA | Gene expression | Signal transduction | Aptamers | Ligands | Transduction | Fluorescence resonance energy transfer | Magnesium | Mutation | Crystal structure | Conformation | Metal ions
Journal Article
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 01/2014, Volume 21, Issue 1, pp. 95 - 102
Journal Article