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British Journal of Clinical Pharmacology, ISSN 0306-5251, 08/2016, Volume 82, Issue 2, pp. 561 - 561
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 08/2016, Volume 82, Issue 2, pp. 561 - 561
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2010, Volume 363, Issue 9, pp. 809 - 819
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2011, Volume 364, Issue 26, pp. 2507 - 2516
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2012, Volume 366, Issue 8, pp. 707 - 714
Journal Article
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 596 - 599
B-RAF is the most frequently mutated protein kinase in human cancers(1). The finding that oncogenic mutations in BRAF are common in melanoma(2), followed by... 
ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | MUTATION | KERATOACANTHOMAS | SENSITIVITY | SENESCENCE | SORAFENIB | HUMAN CANCER | PROGRESSION | BRAF(V600E) | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Macaca fascicularis | Melanoma - enzymology | Substrate Specificity | Positron-Emission Tomography | Extracellular Signal-Regulated MAP Kinases - metabolism | Indoles - administration & dosage | Neoplasm Metastasis | Melanoma - genetics | Phosphorylation - drug effects | Mutant Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Sulfonamides - chemistry | Mutant Proteins - genetics | Models, Molecular | Rats | Mutant Proteins - metabolism | Melanoma - pathology | Mutation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Indoles - adverse effects | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mutant Proteins - chemistry | Alleles | Dogs | Sulfonamides - adverse effects | Indoles - therapeutic use | Indoles - chemistry | Sulfonamides - administration & dosage | Control | Gene mutations | Melanoma | Development and progression | Genetic aspects | Research | Health aspects | Protein kinases | Cancer | Proteins | Mutation | Kinases | Rodents | Index Medicus | targeted therapy | melanoma | BRAF | PLX4032 | biomarker | oncogene
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 3, pp. 207 - 215
Patients with melanoma who are treated with a BRAF inhibitor have a high incidence of keratoacanthomas. Most of the tumors have oncogenic mutations in HRAS... 
MEDICINE, GENERAL & INTERNAL | ACTIVATION | MELANOMA | CARCINOGENESIS | PLX4032 | PATHWAY | KINASE | RESISTANCE | PROLIFERATION | LINES | VEMURAFENIB | p53 Protein | MEK inhibitors | Extracellular signal-regulated kinase | MAP kinase | Ras protein | Kinases | Patients | Carcinogenesis | Proteins | Protein kinase | Transcription activation | Rodents | Cell lines | Skin | Mutation | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7574, pp. 583 - 586
Journal Article