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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2008, Volume 18, Issue 3, pp. 973 - 978
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2008, Volume 18, Issue 23, pp. 6104 - 6109
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 2009, Volume 22, Issue 2, pp. 241 - 245
In order to metastasize, tumor cells must adapt to untoward, stressful microenvironments as they disseminate into the systemic circulation and colonize distant... 
Internal Medicine | CANCER-CELLS | APOPTOSIS | DISRUPTION | MACROPHAGES | DISSEMINATION | TUMOR-CELLS | MECHANISMS | INDUCTION | CELL-SURVIVAL | PROGRESSION | CELL BIOLOGY | Inflammation - pathology | Animals | Cell Cycle | Neoplasm Metastasis - pathology | Humans | Anoikis | Autophagy | Necrosis - pathology
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 7, pp. 2279 - 2282
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 01/2010, Volume 20, Issue 2, pp. 755 - 758
We report herein a novel series of difluoropiperidine acetic acids as modulators of g-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was... 
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 04/2010, Volume 20, Issue 7, pp. 2279 - 2282
The development of a novel series of purines as g-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein.... 
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 01/2011, Volume 22, Issue 2, pp. 165 - 178
The protumorigenic functions for autophagy are largely attributed to its ability to promote cancer cell survival in response to diverse stresses. Here we... 
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2014, Volume 5, Issue 4, pp. 340 - 345
The identification and in vitro and in vivo characterization of a potent SHI-1:2 are described. Kinetic analysis indicated that biaryl inhibitors exhibit slow... 
Histone acetylation | kinetics | isoform selectivity | histone deacetylase inhibitor | MGCD0103 | CHEMISTRY, MEDICINAL | DEACETYLASE INHIBITORS | DISCOVERY | HDAC
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2016, Volume 129, Issue 20, pp. 3685 - 3693
Autophagy, a pathway for lysosomal-mediated cellular degradation, has recently been described as a regulator of cell migration. Although the molecular... 
Autophagy | Migration | Focal adhesion | NBR1 | PAXILLIN | MICROTUBULES | PHOSPHORYLATION | UBIQUITIN | KINASE | CELL BIOLOGY | PINK1 | CELL-MIGRATION | DEGRADATION | TALIN | PROMOTES | Animals | Focal Adhesions - metabolism | Humans | Cell Adhesion | Integrins - metabolism | Cell Movement | Protein Transport | 131
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2016, Volume 30, Issue 2, pp. 189 - 191
Pre-Metastatic Niches (PMNs) result from communications between primary tumors and the microenvironment of future distant metastasis via tumor-derived factors.... 
NEUTROPHILS | ONCOLOGY | MYELOID CELLS | INITIATE | CELL BIOLOGY | Neoplasm Metastasis | Humans | Lung | Tumor Microenvironment | Epithelial Cells | Neoplasms | RNA, Neoplasm | Metastasis | Developmental biology
Journal Article