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Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 25057 - 25073
Resistance to cell death is a hallmark of cancer. Autophagy is a survival mechanism activated in response to nutrient deprivation; however, excessive autophagy... 
MACROPHAGE INFILTRATION | CARCINOMA-CELLS | ACTIVATION | INDUCED APOPTOSIS | PATHWAY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | BONE | MACROAUTOPHAGY | Prostatic Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Multiprotein Complexes | Culture Media, Serum-Free | Male | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Proteins | Prostatic Neoplasms - genetics | Chemokine CCL2 - metabolism | Autophagy - genetics | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - genetics | Inhibitor of Apoptosis Proteins | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Cell Survival | Enzyme Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Chemokine CCL2 - genetics | Transcription Factors - antagonists & inhibitors | Up-Regulation - genetics | Transcription Factors - genetics | Sirolimus - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Transcription Factors - metabolism | Up-Regulation - drug effects | Chemokine CCL2 - pharmacology | Cell Line, Tumor | TOR Serine-Threonine Kinases | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mechanisms of Signal Transduction
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2008, Volume 105, Issue 10, pp. 3933 - 3938
We have designed MI-219 as a potent, highly selective and orally active small-molecule inhibitor of the MDM2-p53 interaction. MI-219 binds to human MDM2 with a... 
Up regulation | Laboratory staining techniques | Cell growth | Drug interactions | Cell cycle | Cell lines | Heterologous transplantation | Tumors | Apoptosis | Cancer | Selective toxicity to tumors | Small-molecule inhibitor | Cancer therapy | MDM2-p53 protein-protein interaction | APOPTOSIS | CELLS | ONCOPROTEIN | MULTIDISCIPLINARY SCIENCES | small-molecule inhibitor | RESTORATION | CANCER-THERAPY | cancer therapy | PATHWAY | P53-MDM2 | IN-VIVO | selective toxicity to tumors | SMALL-MOLECULE ANTAGONISTS | STRUCTURE-BASED DESIGN | Apoptosis - drug effects | Humans | Spiro Compounds - administration & dosage | Antineoplastic Agents - administration & dosage | Indoles - administration & dosage | Time Factors | Protein Binding - drug effects | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Spiro Compounds - chemistry | Administration, Oral | Indoles - blood | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Animals | Spiro Compounds - blood | Antineoplastic Agents - blood | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Cell Cycle - drug effects | Neoplasms - pathology | Indoles - chemistry | Spiro Compounds - pharmacology | Care and treatment | Influence | Tumor suppressor genes | Research | DNA binding proteins | Properties | Protein-protein interactions | Index Medicus | Biological Sciences | MDM2–p53 protein–protein interaction
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2008, Volume 283, Issue 7, pp. 4283 - 4294
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e76773
Cell plasticity regulated by the balance between the mesenchymal to epithelial transition (MET) and the opposite program, EMT, is critical in the metastatic... 
PATHWAYS | CELLS | INVASION | ZEB1 | GENE | RNA-SEQ | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | TUMOR-METASTASIS | MIR-200 FAMILY | EXPRESSION | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Coculture Techniques | Humans | Male | Gene Expression Profiling | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Neoplasm Metastasis | RNA Splicing | Heterografts | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Epithelial-Mesenchymal Transition | Female | Transcription, Genetic | Disease Models, Animal | Prostatic Neoplasms - pathology | Neoplasm Invasiveness | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Mice | Neoplasms - pathology | Cluster Analysis | RNA | Analysis | Stem cells | Research | DNA binding proteins | Metastasis | Prostate cancer | Cancer | Regulators | Animal models | Transcription factors | Mesenchyme | Feedback loops | Urology | Metastases | Proteins | Genotype & phenotype | Plasticity | Bioinformatics | Inducers | Internal medicine | Splicing | Breast cancer | Tumor cell lines | Gene expression | Medicine | Microscopy | MicroRNAs | Morphology | Cell lines | Plastic properties | Control theory | Prostate
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e69239
Journal Article
Journal Article
Current Pathobiology Reports, ISSN 2167-485X, 12/2018, Volume 6, Issue 4, pp. 209 - 218
Here we connect theories of diet choice, patch use, and habitat selection with cancer biology. Key and only partially answered questions include: Do cancer... 
Pathology | Metabolomics | Medicine & Public Health | Consumer-resource dynamics | Diet choice | Habitat selection | Tumor ecosystems | Patch use | Cancer | Foraging ecology
Journal Article
亚洲男性学杂志:英文版, ISSN 1008-682X, 2015, Issue 6, pp. 936 - 938
Metastatic prostate cancer continues to kill approximately 30,000 men per year. Since 2010, five new therapeutic agents have been Food and Drug Administration... 
治疗药物 | 临床医生 | 前列腺癌 | 转移性 | 症状 | 决策过程 | 治疗方案 | 去势
Journal Article
Science, ISSN 0036-8075, 10/2005, Volume 310, Issue 5748, pp. 644 - 648
Journal Article