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by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
Journal Article
by Cacheiro, P and Munoz-Fuentes, V and Murray, SA and Dickinson, ME and Bucan, M and Nutter, LMJ and Peterson, KA and Haselimashhadi, H and Flenniken, AM and Morgan, H and Westerberg, H and Konopka, T and Hsu, CW and Christiansen, A and Lanza, DG and Beaudet, AL and Heaney, JD and Fuchs, H and Gailus-Durner, V and Sorg, T and Prochazka, J and Novosadova, V and Lelliott, CJ and Wardle-Jones, H and Wells, S and Teboul, L and Cater, H and Stewart, M and Hough, T and Wurst, W and Sedlacek, R and Adams, DJ and Seavitt, JR and Tocchini-Valentini, G and Mammano, F and Braun, RE and McKerlie, C and Herault, Y and de Angelis, MH and Mallon, AM and Lloyd, KCK and Brown, SDM and Parkinson, H and Meehan, TF and Smedley, D and Ambrose, JC and Arumugam, P and Baple, EL and Bleda, M and Boardman-Pretty, F and Boissiere, JM and Boustred, CR and Brittain, H and Caulfield, MJ and Chan, GC and Craig, CEH and Daugherty, LC and de Burca, A and Devereau, A and Elgar, G and Foulger, RE and Fowler, T and Furio-Tari, P and Hackett, JM and Halai, D and Hamblin, A and Henderson, S and Holman, JE and Hubbard, TJP and Ibanez, K and Jackson, R and Jones, LJ and Kasperaviciute, D and Kayikci, M and Lahnstein, L and Lawson, K and Leigh, SEA and Leong, IUS and Lopez, FJ and Maleady-Crowe, F and Mason, J and McDonagh, EM and Moutsianas, L and Mueller, M and Murugaesu, N and Need, AC and Odhams, CA and Patch, C and Perez-Gil, D and Polychronopoulos, D and Pullinger, J and Rahim, T and Rendon, A and Riesgo-Ferreiro, P and Rogers, T and Ryten, M and Savage, K and Sawant, K and Scott, RH and Siddiq, A and ... and Genomics England Res Consortium and Int Mouse Phenotyping Consortium and Genomics England Research Consortium and International Mouse Phenotyping Consortium and The Genomics England Research Consortium and The International Mouse Phenotyping Consortium
NATURE COMMUNICATIONS, ISSN 2041-1723, 01/2020, Volume 11, Issue 1, pp. 655 - 655
The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge.... 
R/BIOCONDUCTOR PACKAGE | DATABASE | VARIANTS | IMPC | MULTIDISCIPLINARY SCIENCES | UPDATE | GENOME | Animals | Disease - genetics | Genomics | Humans | Genetic Association Studies - methods | Mice | Genes, Essential | Mice, Knockout | Biological properties | Cell survival | Disease | Genes | Disorders | Genomes | Gene sequencing | Consortia | Intolerance | Species classification | Phenotyping | Cell lines | Viability | Index Medicus
Journal Article
by Bradley, Allan and Anastassiadis, Konstantinos and Ayadi, Abdelkader and Battey, James and Bell, Cindy and Birling, Marie-Christine and Bottomley, Joanna and Brown, Steve and Bürger, Friederike and Bult, Carol and Bushell, Wendy and Collins, Francis and Desaintes, Christian and Doe, Brendan and Aris, Economides and Eppig, Janan and Finnell, Richard and Fletcher, Colin and Fray, Martin and Frendewey, David and Friedel, Roland and Grosveld, Frank and Hansen, J and Hérault, Yann and Hicks, Geoffrey and Hörlein, Aneas and Houghton, Catherine and Hrabé De Angelis, Martin and Huylebroeck, Danny and Iyer, Vivek and Jong, Pieter and Kadin, James and Kaloff, Cornelia and Kennedy, Karen and Koutsourakis, Manousos and Kent Lloyd, K.C and Marschall, Susan and Mason, Jeremy and McKerlie, Colin and McLeod, Michael and Melchner, Harald and Moore, Matt and Mujica, Alejano and Nagy, Anas and Nefedov, Mikhail and Nutter, Lauryl and Pavlovic, Guillaume and Peterson, Jane and Pollock, I and Ramirez-Solis, Ramiro and Rancourt, Derrick and Raspa, Marcello and Remacle, Jacques and Ringwald, Martin and Rosen, Barry and Rosenthal, Nadia and Rossant, Janet and Ruiz Noppinger, Patricia and Ryder, S and Schick, Joel Zupicich and Schnütgen, Frank and Schofield, Christopher and Seisenberger, Claudia and Selloum, Mohammed and Simpson, Elizabeth and Skarnes, William and Smedley, Damian and Stanford, William and Stewart, Francis and Stone, Kevin and Swan, Kate and Tadepally, Hamsa and Teboul, Jean Louis and Tocchini-Valentini, Glauco and Valenzuela, David and West, Anthony and Yamamura, Ken-Ichi and Yoshinaga, Yuko and Wurst, Martin
Mammalian Genome, ISSN 0938-8990, 10/2012, Volume 23, Issue 9-10, pp. 580 - 586
textabstractIn 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene... 
Life Sciences | Anatomy | Zoology | Cell Biology | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | Mice, Knockout - genetics | Mice | Animals | Internet | Internationality
Journal Article
by Mark B. Gerstein and Zhi John Lu and Eric L. Van Nostrand and Chao Cheng and Bradley I. Arshinoff and Tao Liu and Kevin Y. Yip and Rebecca Robilotto and Andreas Rechtsteiner and Kohta Ikegami and Pedro Alves and Aurelien Chateigner and Marc Perry and Mitzi Morris and Raymond K. Auerbach and Xin Feng and Jing Leng and Anne Vielle and Wei Niu and Kahn Rhrissorrakrai and Ashish Agarwal and Roger P. Alexander and Galt Barber and Cathleen M. Brdlik and Jennifer Brennan and Jeremy Jean Brouillet and Adrian Carr and Ming-Sin Cheung and Hiram Clawson and Sergio Contrino and Luke O. Dannenberg and Abby F. Dernburg and Arshad Desai and Lindsay Dick and Andréa C. Dosé and Jiang Du and Thea Egelhofer and Sevinc Ercan and Ghia Euskirchen and Brent Ewing and Elise A. Feingold and Reto Gassmann and Peter J. Good and Phil Green and Francois Gullier and Michelle Gutwein and Mark S. Guyer and Lukas Habegger and Ting Han and Jorja G. Henikoff and Stefan R. Henz and Angie Hinrichs and Heather Holster and Tony Hyman and A. Leo Iniguez and Judith Janette and Morten Jensen and Masaomi Kato and W. James Kent and Ellen Kephart and Vishal Khivansara and Ekta Khurana and John K. Kim and Paulina Kolasinska-Zwierz and Eric C. Lai and Isabel Latorre and Amber Leahey and Suzanna Lewis and Paul Lloyd and Lucas Lochovsky and Rebecca F. Lowdon and Yaniv Lubling and Rachel Lyne and Michael MacCoss and Sebastian D. Mackowiak and Marco Mangone and Sheldon McKay and Desirea Mecenas and Gennifer Merrihew and David M. Miller and Andrew Muroyama and John I. Murray and Siew-Loon Ooi and Hoang Pham and Taryn Phippen and Elica A. Preston and Nikolaus Rajewsky and Gunnar Rätsch and Heidi Rosenbaum and Joel Rozowsky and Kim Rutherford and Peter Ruzanov and Mihail Sarov and Rajkumar Sasidharan and Andrea Sboner and Paul Scheid and Eran Segal and Hyunjin Shin and Chong Shou and Frank J. Slack and ... and modENCODE Consortium
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6012, pp. 1775 - 1787
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2017, Volume 49, Issue 8, pp. 1231 - 1238
Journal Article
Cancer research, ISSN 0008-5472, 2017, Volume 77, Issue 21, pp. e62 - e66
Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug... 
DATABASE | ONCOLOGY | PROMISE | Animals | Neoplasms - genetics | Humans | Mice | Xenograft Model Antitumor Assays - statistics & numerical data | Patients | Databases as Topic | Disease Models, Animal | Neoplasms - drug therapy | Medical research | Quality assurance | Animal models | Reproducibility | Quality control | Xenografts | Implantation | Standards | Tumors | Cancer
Journal Article
by Sushmita Roy and Jason Ernst and Peter V. Kharchenko and Pouya Kheradpour and Nicolas Negre and Matthew L. Eaton and Jane M. Landolin and Christopher A. Bristow and Lijia Ma and Michael F. Lin and Stefan Washietl and Bradley I. Arshinoff and Ferhat Ay and Patrick E. Meyer and Nicolas Robine and Nicole L. Washington and Luisa Di Stefano and Eugene Berezikov and Christopher D. Brown and Rogerio Candeias and Joseph W. Carlson and Adrian Carr and Irwin Jungreis and Daniel Marbach and Rachel Sealfon and Michael Y. Tolstorukov and Sebastian Will and Artyom A. Alekseyenko and Carlo Artieri and Benjamin W. Booth and Angela N. Brooks and Qi Dai and Carrie A. Davis and Michael O. Duff and Xin Feng and Andrey A. Gorchakov and Tingting Gu and Jorja G. Henikoff and Philipp Kapranov and Renhua Li and Heather K. MacAlpine and John Malone and Aki Minoda and Jared Nordman and Katsutomo Okamura and Marc Perry and Sara K. Powell and Nicole C. Riddle and Akiko Sakai and Anastasia Samsonova and Jeremy E. Sandler and Yuri B. Schwartz and Noa Sher and Rebecca Spokony and David Sturgill and Marijke van Baren and Kenneth H. Wan and Li Yang and Charles Yu and Elise Feingold and Peter Good and Mark Guyer and Rebecca Lowdon and Kami Ahmad and Justen Andrews and Bonnie Berger and Steven E. Brenner and Michael R. Brent and Lucy Cherbas and Sarah C. R. Elgin and Thomas R. Gingeras and Robert Grossman and Roger A. Hoskins and Thomas C. Kaufman and William Kent and Mitzi I. Kuroda and Terry Orr-Weaver and Norbert Perrimon and Vincenzo Pirrotta and James W. Posakony and Bing Ren and Steven Russell and Peter Cherbas and Brenton R. Graveley and Suzanna Lewis and Gos Micklem and Brian Oliver and Peter J. Park and Susan E. Celniker and Steven Henikoff and Gary H. Karpen and Eric C. Lai and David M. MacAlpine and Lincoln D. Stein and Kevin P. White and Manolis Kellis and modENCODE Consortium and The modENCODE Consortium
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6012, pp. 1787 - 1797
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 12/2011, Volume 1245, Issue 1, pp. 24 - 26
Journal Article