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Protein Science, ISSN 0961-8368, 02/2019, Volume 28, Issue 2, pp. 313 - 328
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 2009, Volume 38, Issue 2, pp. 338 - 351
This tutorial review outlines the modern ligation methods that enable the efficient total chemical synthesis of enzymes and other protein molecules. Key to... 
ENZYME | CRYSTAL-STRUCTURE | ENANTIOMERS | X-RAY-STRUCTURE | LIGATION | HIV-1 PROTEASE | RESIDUES | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE
Journal Article
Chemical Society reviews, ISSN 0306-0012, 02/2009, Volume 38, Issue 2, pp. 338 - 351
This tutorial review outlines the modern ligation methods that enable the efficient total chemical synthesis of enzymes and other protein molecules. Key to... 
Magnetic Resonance Spectroscopy | Humans | Mass Spectrometry | Crystallography, X-Ray | Protein Conformation | Proteins - classification | Cysteine - chemistry | Proteins - chemistry | Proteins - chemical synthesis | Proteins - isolation & purification
Journal Article
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 97, pp. 13979 - 13982
Under suitable conditions, trifluoromethanesulfonic acid performs comparably to hydrogen fluoride for the on-resin global deprotection of peptides prepared by... 
Synthesis (chemistry) | Hydrogen fluoride | Peptides | Solid phases
Journal Article
Organic Letters, ISSN 1523-7060, 07/2015, Volume 17, Issue 14, pp. 3521 - 3523
The solubility-enhancing power of covalent attachment to solvent-swollen cross-linked resin supports was illustrated by syntheses of the highly aggregating... 
CHEMISTRY | CHEMISTRY, ORGANIC | CHEMICAL-SYNTHESIS
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 2009, Volume 131, Issue 44, pp. 16313 - 16318
Here we report a proof-of-principle study demonstrating the efficient folding, with concomitant formation of the correct disulfides, of an isolated polypeptide... 
ANALOG | A-CHAIN | CONVERSION | COMBINATION | PROTEINS | PRECURSORS | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | Oximes - chemistry | Insulin - chemical synthesis | Disulfides | Hypoglycemic Agents - chemical synthesis | Proinsulin - chemical synthesis | Insulin - analogs & derivatives | Insulin Lispro
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2014, Volume 53, Issue 18, pp. 4662 - 4666
The enzyme sortase A is a ligase which catalyzes transpeptidation reactions.1, 2 Surface proteins, including virulence factors, that have a C terminal... 
sortase A | enzyme catalysis | convergent synthesis | chemical ligation | chemical protein synthesis | sortase A
Journal Article
ISSN 1359-7345, 11/2016, Volume 52, Issue 97, pp. 13979 - 13982
Under suitable conditions, trifluoromethanesulfonic acid performs comparably to hydrogen fluoride for the on-resin global deprotection of peptides prepared by... 
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 37, pp. 8804 - 8814
In this paper, we have used total chemical synthesis of RNase A analogues in order to probe the molecular basis of enzyme catalysis. Our goal was to obligately... 
SITE | URIDINE-VANADATE | X-RAY-STRUCTURE | PHOSPHATE-ESTERS | RESOLUTION | HYDROLYSIS | LIGATION | CHEMISTRY, ORGANIC | DIFFRACTION | BOVINE PANCREATIC RIBONUCLEASE | PHASE PEPTIDE-SYNTHESIS
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 09/2016, Volume 14, Issue 37, pp. 8804 - 8814
In this paper, we have used total chemical synthesis of RNase A analogues in order to probe the molecular basis of enzyme catalysis. Our goal was to obligately... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 10, p. E1857
  Voltage-gated sodium channels (Navs) play crucial roles in excitable cells. Although vertebrate Nav function has been extensively studied, the detailed... 
Frogs | Sodium | Rodents | Toxins | Cells | Binding sites
Journal Article
ISSN 1477-0520, 9/2016, Volume 14, Issue 37, pp. 884 - 8814
In this paper, we have used total chemical synthesis of RNase A analogues in order to probe the molecular basis of enzyme catalysis. Our goal was to obligately... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 9, p. 2241
  The burial of hydrophobic side chains in a protein core generally is thought to be the major ingredient for stable, cooperative folding. Here, we show that,... 
Temperature | Protein folding | Arthropods | Entropy | Hydrophobic surfaces
Journal Article
Angewandte Chemie, ISSN 1433-7851, 04/2014, Volume 53, Issue 18, p. 4662
  The enzyme sortaseA is a ligase which catalyzes transpeptidation reactions.1,2 Surface proteins, including virulence factors, that have a C terminal... 
Enzymes | Medical research | Polypeptides | Gram-positive bacteria
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2014, Volume 106, Issue 2, pp. 133a - 133a
Journal Article
TETRAHEDRON LETTERS, ISSN 0040-4039, 03/2007, Volume 48, Issue 10, pp. 1795 - 1799
Modification of a peptide-(alpha)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a... 
COLI DIACYLGLYCEROL KINASE | thioester | TERMINAL DOMAIN | ESCHERICHIA-COLI | TRANSMEMBRANE PEPTIDES | LIGATION | CHEMISTRY, ORGANIC | diacylglycerol kinase | LIQUID-CHROMATOGRAPHIC PURIFICATION | integral membrane proteins | CHANNELS | VPU | native chemical ligation | chemical protein synthesis
Journal Article