International Journal of Clinical Oncology, ISSN 1341-9625, 2/2018, Volume 23, Issue 1, pp. 1 - 34
Japanese mortality due to colorectal cancer is on the rise, surpassing 49,000 in 2015. Many new treatment methods have been developed during recent decades....
Chemotherapy | Medicine & Public Health | Surgery | Colorectal cancer | Oncology | Cancer Research | Guideline | Endoscopy | Radiotherapy | Surgical Oncology | INTENSIVE FOLLOW-UP | FLUOROURACIL PLUS LEUCOVORIN | INTERVAL HEPATIC RESECTION | WILD-TYPE KRAS | FRAIL ELDERLY-PATIENTS | TOTAL MESORECTAL EXCISION | SINGLE-AGENT PANITUMUMAB | PHASE-III TRIAL | LYMPH-NODE METASTASIS | ONCOLOGY | HIGH-DOSE LEUCOVORIN | Practice guidelines (Medicine) | Care and treatment | Cancer | Special
Chemotherapy | Medicine & Public Health | Surgery | Colorectal cancer | Oncology | Cancer Research | Guideline | Endoscopy | Radiotherapy | Surgical Oncology | INTENSIVE FOLLOW-UP | FLUOROURACIL PLUS LEUCOVORIN | INTERVAL HEPATIC RESECTION | WILD-TYPE KRAS | FRAIL ELDERLY-PATIENTS | TOTAL MESORECTAL EXCISION | SINGLE-AGENT PANITUMUMAB | PHASE-III TRIAL | LYMPH-NODE METASTASIS | ONCOLOGY | HIGH-DOSE LEUCOVORIN | Practice guidelines (Medicine) | Care and treatment | Cancer | Special
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Functional salivary gland regeneration by transplantation of a bioengineered organ germ
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2498
Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiation therapy for head cancer, Sjogren's syndrome or aging, and can cause a...
HEAD | STEM-CELLS | ORIGIN | STIMULATION | RESCUE | MULTIDISCIPLINARY SCIENCES | CELL THERAPY | Embryonic Stem Cells - cytology | Embryo, Mammalian | Mice, Inbred C57BL | Epithelial Cells - pathology | Submandibular Gland - innervation | Xerostomia - surgery | Citric Acid - pharmacology | Recovery of Function | Transplantation, Homologous | Stem Cell Transplantation | Regeneration | Mesenchymal Stromal Cells - cytology | Submandibular Gland - pathology | Xerostomia - pathology | Animals | Pilocarpine - pharmacology | Graft Survival - physiology | Xerostomia - therapy | Mice | Submandibular Gland - surgery | Tissue Engineering
HEAD | STEM-CELLS | ORIGIN | STIMULATION | RESCUE | MULTIDISCIPLINARY SCIENCES | CELL THERAPY | Embryonic Stem Cells - cytology | Embryo, Mammalian | Mice, Inbred C57BL | Epithelial Cells - pathology | Submandibular Gland - innervation | Xerostomia - surgery | Citric Acid - pharmacology | Recovery of Function | Transplantation, Homologous | Stem Cell Transplantation | Regeneration | Mesenchymal Stromal Cells - cytology | Submandibular Gland - pathology | Xerostomia - pathology | Animals | Pilocarpine - pharmacology | Graft Survival - physiology | Xerostomia - therapy | Mice | Submandibular Gland - surgery | Tissue Engineering
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Mechanisms of Development, ISSN 0925-4773, 07/2017, Volume 145, pp. S77 - S77
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Development, Growth & Differentiation, ISSN 0012-1592, 06/2018, Volume 60, Issue 5, pp. 291 - 299
A Merkel cell‐neurite complex is a touch receptor composed of specialized epithelial cells named Merkel cells and peripheral sensory nerves in the skin. Merkel...
Merkel cell‐neurite complex | trigeminal ganglion | organotypic culture | somatosensory system | whisker | Merkel cell-neurite complex | TRANSCRIPTION | PATTERNS | PROLIFERATION | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | GROWTH | NEURONS | SKIN | RECEPTORS | EXPRESSION | CULTURES | Embryonic development | Analysis | Skin | Cytokeratin | Cell culture | Nestin | Epithelial cells | Schwann cells | Follicles | Sox10 protein | Fibers | Morphogenesis | Embryogenesis | Trigeminal nerve | Sensory neurons | Trigeminal ganglion
Merkel cell‐neurite complex | trigeminal ganglion | organotypic culture | somatosensory system | whisker | Merkel cell-neurite complex | TRANSCRIPTION | PATTERNS | PROLIFERATION | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | GROWTH | NEURONS | SKIN | RECEPTORS | EXPRESSION | CULTURES | Embryonic development | Analysis | Skin | Cytokeratin | Cell culture | Nestin | Epithelial cells | Schwann cells | Follicles | Sox10 protein | Fibers | Morphogenesis | Embryogenesis | Trigeminal nerve | Sensory neurons | Trigeminal ganglion
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Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2497
The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease,...
CORNEAL | STEM-CELLS | ORIGIN | REPAIR | ACINAR | DRY EYE | MULTIDISCIPLINARY SCIENCES | MECHANISMS | MODEL | TEAR SECRETION | Embryonic Stem Cells - cytology | Embryo, Mammalian | Harderian Gland - transplantation | Mice, Inbred C57BL | Lacrimal Apparatus - surgery | Dry Eye Syndromes - surgery | Epithelial Cells - pathology | Graft Survival | Recovery of Function | Transplantation, Homologous | Dry Eye Syndromes - pathology | Regeneration | Animals | Polyglycolic Acid - chemistry | Tears - secretion | Dry Eye Syndromes - therapy | Cornea - pathology | Mice | Lacrimal Apparatus - pathology | Tissue Engineering
CORNEAL | STEM-CELLS | ORIGIN | REPAIR | ACINAR | DRY EYE | MULTIDISCIPLINARY SCIENCES | MECHANISMS | MODEL | TEAR SECRETION | Embryonic Stem Cells - cytology | Embryo, Mammalian | Harderian Gland - transplantation | Mice, Inbred C57BL | Lacrimal Apparatus - surgery | Dry Eye Syndromes - surgery | Epithelial Cells - pathology | Graft Survival | Recovery of Function | Transplantation, Homologous | Dry Eye Syndromes - pathology | Regeneration | Animals | Polyglycolic Acid - chemistry | Tears - secretion | Dry Eye Syndromes - therapy | Cornea - pathology | Mice | Lacrimal Apparatus - pathology | Tissue Engineering
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 32, pp. 13475 - 13480
Current approaches to the development of regenerative therapies have been influenced by our understanding of embryonic development stem cell biology, and...
Bioengineering | Tissue engineering | Epithelial cells | Mechanical stress | Biomedical technology | Teeth | Stem cells | Bones | Transplantation | Orthodontics | Regenerative therapy | MORPHOGENESIS | STEM-CELLS | REPAIR | REGENERATION | RECONSTRUCTION | MULTIDISCIPLINARY SCIENCES | regenerative therapy | transplantation | BONE CONSTRUCTS | TEETH | MECHANISMS | CHALLENGES | Tooth Eruption - physiology | Mice, Inbred C57BL | Stress, Mechanical | Regenerative Medicine | Hardness | Pain - pathology | Bioartificial Organs | Animals | Neurons - physiology | Tooth - physiopathology | Mastication - physiology | Tooth - physiology | Mice | Tissue Engineering | Transplantation of organs, tissues, etc | Models | Research | Regenerative medicine | Biological Sciences
Bioengineering | Tissue engineering | Epithelial cells | Mechanical stress | Biomedical technology | Teeth | Stem cells | Bones | Transplantation | Orthodontics | Regenerative therapy | MORPHOGENESIS | STEM-CELLS | REPAIR | REGENERATION | RECONSTRUCTION | MULTIDISCIPLINARY SCIENCES | regenerative therapy | transplantation | BONE CONSTRUCTS | TEETH | MECHANISMS | CHALLENGES | Tooth Eruption - physiology | Mice, Inbred C57BL | Stress, Mechanical | Regenerative Medicine | Hardness | Pain - pathology | Bioartificial Organs | Animals | Neurons - physiology | Tooth - physiopathology | Mastication - physiology | Tooth - physiology | Mice | Tissue Engineering | Transplantation of organs, tissues, etc | Models | Research | Regenerative medicine | Biological Sciences
Journal Article
Breast Cancer Research, ISSN 1465-5411, 09/2015, Volume 17, Issue 1, p. 124
Introduction: The status of tumor-infiltrating lymphocytes (TILs) has been recently proposed to predict clinical outcome of patients with breast cancer. We...
SURVIVAL | RESPONSES | ONCOLOGY | SAFETY | MARKER | POOR-PROGNOSIS | REGULATORY T-CELLS | RECEPTOR | ANTIBODY | ANTI-PD-1 | CARCINOMA | Neoplasm, Residual - pathology | CD8-Positive T-Lymphocytes - pathology | Lymph Nodes - pathology | Neoplasm, Residual - metabolism | Prognosis | Humans | Middle Aged | Lymph Nodes - metabolism | Lymphocytes, Tumor-Infiltrating - drug effects | Triple Negative Breast Neoplasms - drug therapy | Disease-Free Survival | CD8 Antigens - metabolism | Lymphocytes, Tumor-Infiltrating - pathology | Forkhead Transcription Factors - metabolism | Triple Negative Breast Neoplasms - metabolism | CD8-Positive T-Lymphocytes - drug effects | Neoadjuvant Therapy - methods | Neoplasm, Residual - drug therapy | Triple Negative Breast Neoplasms - pathology | CD8-Positive T-Lymphocytes - metabolism | Female | Lymph Nodes - drug effects | Lymphocytes, Tumor-Infiltrating - metabolism | Retrospective Studies | Immunohistochemistry | Cancer patients | Lymphocytes | Analysis | Oncology, Experimental | Adjuvant treatment | Breast cancer | Research | Cancer
SURVIVAL | RESPONSES | ONCOLOGY | SAFETY | MARKER | POOR-PROGNOSIS | REGULATORY T-CELLS | RECEPTOR | ANTIBODY | ANTI-PD-1 | CARCINOMA | Neoplasm, Residual - pathology | CD8-Positive T-Lymphocytes - pathology | Lymph Nodes - pathology | Neoplasm, Residual - metabolism | Prognosis | Humans | Middle Aged | Lymph Nodes - metabolism | Lymphocytes, Tumor-Infiltrating - drug effects | Triple Negative Breast Neoplasms - drug therapy | Disease-Free Survival | CD8 Antigens - metabolism | Lymphocytes, Tumor-Infiltrating - pathology | Forkhead Transcription Factors - metabolism | Triple Negative Breast Neoplasms - metabolism | CD8-Positive T-Lymphocytes - drug effects | Neoadjuvant Therapy - methods | Neoplasm, Residual - drug therapy | Triple Negative Breast Neoplasms - pathology | CD8-Positive T-Lymphocytes - metabolism | Female | Lymph Nodes - drug effects | Lymphocytes, Tumor-Infiltrating - metabolism | Retrospective Studies | Immunohistochemistry | Cancer patients | Lymphocytes | Analysis | Oncology, Experimental | Adjuvant treatment | Breast cancer | Research | Cancer
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Nature Methods, ISSN 1548-7091, 03/2007, Volume 4, Issue 3, pp. 227 - 230
To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ...
TEETH | MORPHOGENESIS | TOOTH DEVELOPMENT | BIOCHEMICAL RESEARCH METHODS | Organ Culture Techniques - methods | Tissue Engineering - methods | Cells, Cultured | Bioartificial Organs | Epithelial Cells - physiology | Mesenchymal Stromal Cells - cytology | Animals | Tooth - cytology | Cell Differentiation | Mice | Organogenesis - physiology | Vibrissae - cytology | Biomedical Engineering - methods | Biotechnology | Cell culture | Skin | Transplants & implants | Research methodology | Teeth
TEETH | MORPHOGENESIS | TOOTH DEVELOPMENT | BIOCHEMICAL RESEARCH METHODS | Organ Culture Techniques - methods | Tissue Engineering - methods | Cells, Cultured | Bioartificial Organs | Epithelial Cells - physiology | Mesenchymal Stromal Cells - cytology | Animals | Tooth - cytology | Cell Differentiation | Mice | Organogenesis - physiology | Vibrissae - cytology | Biomedical Engineering - methods | Biotechnology | Cell culture | Skin | Transplants & implants | Research methodology | Teeth
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 02/2015, Volume 137, Issue 6, pp. 2295 - 2302
We report synthesis of novel macrocyclic molecules and their metal complexes as well as their thermotropic columnar liquid-crystalline behavior. The...
HYDROGEN | ORDER | SCHIFF-BASE MACROCYCLES | ALIGNMENT | IMINES | CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | Copper compounds | Nickel compounds | Chemical properties | Chemical synthesis | Analysis | Electric properties
HYDROGEN | ORDER | SCHIFF-BASE MACROCYCLES | ALIGNMENT | IMINES | CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | Copper compounds | Nickel compounds | Chemical properties | Chemical synthesis | Analysis | Electric properties
Journal Article
Virchows Archiv, ISSN 0945-6317, 1/2011, Volume 458, Issue 1, pp. 65 - 72
We attempted to subclassify triple negative breast cancer (TNBC) cases into subgroups according to clinical outcome or prognosis of TNBC patients using...
Pathology | Ki-67 | Histopathology | Prognosis | Medicine & Public Health | MVD | Basal-like | Triple negative breast cancer | FACTOR VEGF | MARKERS | MICROVESSEL DENSITY | TUMOR ANGIOGENESIS | PATHOLOGY | BASAL-LIKE SUBTYPE | CARCINOMAS | INHIBITORS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Breast Neoplasms - classification | Severity of Illness Index | Receptors, Estrogen - metabolism | Humans | Japan | Middle Aged | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Survival Rate | Receptors, Progesterone - metabolism | Disease-Free Survival | Microcirculation | Receptor, Epidermal Growth Factor - metabolism | Breast Neoplasms - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Aged | Breast Neoplasms - diagnosis | Retrospective Studies | Immunohistochemistry | Breast cancer | Epidermal growth factor | Progesterone | Analysis | Estrogen
Pathology | Ki-67 | Histopathology | Prognosis | Medicine & Public Health | MVD | Basal-like | Triple negative breast cancer | FACTOR VEGF | MARKERS | MICROVESSEL DENSITY | TUMOR ANGIOGENESIS | PATHOLOGY | BASAL-LIKE SUBTYPE | CARCINOMAS | INHIBITORS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Breast Neoplasms - classification | Severity of Illness Index | Receptors, Estrogen - metabolism | Humans | Japan | Middle Aged | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Survival Rate | Receptors, Progesterone - metabolism | Disease-Free Survival | Microcirculation | Receptor, Epidermal Growth Factor - metabolism | Breast Neoplasms - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Aged | Breast Neoplasms - diagnosis | Retrospective Studies | Immunohistochemistry | Breast cancer | Epidermal growth factor | Progesterone | Analysis | Estrogen
Journal Article
Development, Growth & Differentiation, ISSN 0012-1592, 02/2019, Volume 61, Issue 2, pp. 141 - 149
Selective cell death by apoptosis plays important roles in organogenesis. Apoptotic cells are observed in the developmental and homeostatic processes of...
Wnt/β‐catenin signaling | bioengineered skin | selective cell death | caspase | cavitation | Wnt/β-catenin signaling | APOPTOSIS | MECHANISMS | DEVELOPMENTAL BIOLOGY | Wnt/beta-catenin signaling | BETA-CATENIN | ORGANOGENESIS | CELL BIOLOGY | MORPHOGENESIS | ARCHITECTURE | Skin | Biochemistry | Cell death | Analysis | Cell culture | Wnt protein | Mesenchyme | Epithelial cells | Organogenesis | Morphogenesis | Feathers | Mammary gland | Caspase inhibitors | Buds | Catenin | Apoptosis
Wnt/β‐catenin signaling | bioengineered skin | selective cell death | caspase | cavitation | Wnt/β-catenin signaling | APOPTOSIS | MECHANISMS | DEVELOPMENTAL BIOLOGY | Wnt/beta-catenin signaling | BETA-CATENIN | ORGANOGENESIS | CELL BIOLOGY | MORPHOGENESIS | ARCHITECTURE | Skin | Biochemistry | Cell death | Analysis | Cell culture | Wnt protein | Mesenchyme | Epithelial cells | Organogenesis | Morphogenesis | Feathers | Mammary gland | Caspase inhibitors | Buds | Catenin | Apoptosis
Journal Article
Development, Growth & Differentiation, ISSN 0012-1592, 04/2016, Volume 58, Issue 3, pp. 303 - 314
Various kinds of in vitro culture systems of tissues and organs have been developed, and applied to understand multicellular systems during embryonic...
feather bud development | self‐organization | organ germ method | epithelial‐mesenchymal interaction | skin regeneration | Epithelial-mesenchymal interaction | Skin regeneration | Feather bud development | Organ germ method | Self-organization | epithelial-mesenchymal interaction | self-organization | GLAND REGENERATION | DEVELOPMENTAL BIOLOGY | AVIAN SKIN | TRANSPLANTATION | CELL BIOLOGY | MORPHOGENESIS | MODULE | ORGAN GERM | Skin - cytology | Microscopy, Phase-Contrast | Tissue Culture Techniques | Cells, Cultured | Feathers - embryology | Signal Transduction - genetics | Chick Embryo | Bioengineering - methods | Blood Vessels - embryology | Skin - blood supply | Epithelial Cells - physiology | Mesenchymal Stromal Cells - cytology | Animals | In Situ Hybridization | Time Factors | Gene Expression Regulation, Developmental | Chorioallantoic Membrane - cytology | Chorioallantoic Membrane - embryology | Epithelial Cells - cytology | Mesenchymal Stromal Cells - physiology | Microscopy, Fluorescence | Avian Proteins - genetics | Chorioallantoic Membrane - blood supply | Skin - embryology | Bone morphogenetic proteins | Fibroblast growth factors | Skin | Stem cells
feather bud development | self‐organization | organ germ method | epithelial‐mesenchymal interaction | skin regeneration | Epithelial-mesenchymal interaction | Skin regeneration | Feather bud development | Organ germ method | Self-organization | epithelial-mesenchymal interaction | self-organization | GLAND REGENERATION | DEVELOPMENTAL BIOLOGY | AVIAN SKIN | TRANSPLANTATION | CELL BIOLOGY | MORPHOGENESIS | MODULE | ORGAN GERM | Skin - cytology | Microscopy, Phase-Contrast | Tissue Culture Techniques | Cells, Cultured | Feathers - embryology | Signal Transduction - genetics | Chick Embryo | Bioengineering - methods | Blood Vessels - embryology | Skin - blood supply | Epithelial Cells - physiology | Mesenchymal Stromal Cells - cytology | Animals | In Situ Hybridization | Time Factors | Gene Expression Regulation, Developmental | Chorioallantoic Membrane - cytology | Chorioallantoic Membrane - embryology | Epithelial Cells - cytology | Mesenchymal Stromal Cells - physiology | Microscopy, Fluorescence | Avian Proteins - genetics | Chorioallantoic Membrane - blood supply | Skin - embryology | Bone morphogenetic proteins | Fibroblast growth factors | Skin | Stem cells
Journal Article
Retina, ISSN 0275-004X, 07/2017, Volume 37, Issue 7, pp. 1393 - 1399
Purpose: To compare the retinal blood flow velocity using laser speckle flowgraphy (LSFG) and a retinal function imager (RFI) in healthy Japanese subjects....
retinal function imager | laser speckle flowgraphy | retinal blood flow velocity | PRESSURE | YOUNG | OPHTHALMOLOGY | MICROCIRCULATION | GLAUCOMA | ASSOCIATION | FLUORESCEIN | REPRODUCIBILITY | AGE | Prospective Studies | Follow-Up Studies | Retinal Vein - diagnostic imaging | Humans | Male | Laser-Doppler Flowmetry | Healthy Volunteers | Optic Disk - blood supply | Retinal Vein - physiology | Retinal Artery - physiology | Adult | Female | Retinal Artery - diagnostic imaging | Regional Blood Flow - physiology | Blood Flow Velocity - physiology
retinal function imager | laser speckle flowgraphy | retinal blood flow velocity | PRESSURE | YOUNG | OPHTHALMOLOGY | MICROCIRCULATION | GLAUCOMA | ASSOCIATION | FLUORESCEIN | REPRODUCIBILITY | AGE | Prospective Studies | Follow-Up Studies | Retinal Vein - diagnostic imaging | Humans | Male | Laser-Doppler Flowmetry | Healthy Volunteers | Optic Disk - blood supply | Retinal Vein - physiology | Retinal Artery - physiology | Adult | Female | Retinal Artery - diagnostic imaging | Regional Blood Flow - physiology | Blood Flow Velocity - physiology
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