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Chemical Reviews, ISSN 0009-2665, 01/2019, Volume 119, Issue 2, pp. 1519 - 1624
Journal Article
Chemical Science, ISSN 2041-6520, 06/2014, Volume 5, Issue 8, pp. 2925 - 2932
NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer and has recently been studied successfully in a... 
Tyrosine | Drugs | Cellular | Sodium | Tumours | Activation | Kinases | Ruthenium compounds
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 2/2018, Volume 47, Issue 3, pp. 99 - 928
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 10
We have recently demonstrated that riboflavin (Rf) functions as unconventional bioorthogonal photocatalyst for the activation of PtIV prodrugs. In this study,... 
Phosphorylation | Prodrugs | Photodynamic therapy | Nuclear magnetic resonance--NMR | Photoactivation | DNA damage | Riboflavin | Mass spectroscopy | Cisplatin | Biological activity | Circular dichroism | Ammonia | Cell activation | Microscopy | Cell death | Pancreatic cancer | Carboplatin | Hypoxia | Immunofluorescence | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2019, Volume 58, Issue 24, pp. 8007 - 8012
Metal‐driven self‐assembly afforded a multitude of fascinating supramolecular coordination complexes (SCCs) with applications as catalysts, host–guest, and... 
platinum | SCC | subcellular localization | metallacycle | G-quadruplex | Viral antibodies | Squamous cell carcinoma | Chromatin | DNA | Fluorescence | Antibodies | Antigenic determinants | Profiling | Tracking | Catalysts | Organometallic compounds | Epitopes | Nucleoli | Nuclei (cytology) | Coordination compounds | Deoxyribonucleic acid--DNA | Photobleaching | Communications | Communication
Journal Article
Science of the Total Environment, ISSN 0048-9697, 03/2019, Volume 656, pp. 952 - 958
The present study elucidates the role of natural iron fertilization of the coastal ocean by so-called “blackwater rivers”. Areas of marsh, fen, peatland,... 
Marine CO2 sinks | Marine phytoplankton | Humic substances | Global iron cycle | Peatlands | sinks | Marine CO
Journal Article
SCIENCE OF THE TOTAL ENVIRONMENT, ISSN 0048-9697, 03/2019, Volume 656, pp. 952 - 958
The present study elucidates the role of natural iron fertilization of the coastal ocean by so-called "blackwater rivers". Areas of marsh, fen, peatland,... 
Marine phytoplankton | SOUTHERN-OCEAN | Global iron cycle | Peatlands | COMPLEXES | Marine CO2 sinks | Humic substances | SOLUBILITY | PHYTOPLANKTON BLOOM | ENVIRONMENTAL SCIENCES | GROWTH | CHEMISTRY | DISSOLVED ORGANIC-MATTER | BOG | LIMITATION | Ethylenediaminetetraacetic acid | Analysis | Phytochemistry | Physiological aspects | Contract manufacturing | Photosynthesis | Peat | Sea-water | Humic acid | Peat-bogs
Journal Article
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 3, pp. 2241 - 2250
The design of targeted platinum(IV) prodrugs is a very promising approach to enhance the low selectivity of platinum(II) drugs towards cancerous tissue in... 
PT(IV) PRODRUGS | BREAST-CANCER | CARBOPLATIN | CISPLATIN | DRUG-DELIVERY | SERUM-ALBUMIN | BIOLOGICAL-ACTIVITY | RESISTANCE | PLATINUM(IV) COMPLEXES | CHEMISTRY, MULTIDISCIPLINARY | HYDROGEN-PEROXIDE OXIDATION | Drugs | In vivo methods and tests | Mice | Derivatives | Chemical compounds | Half life | Tumors | Anticancer properties
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 11/2018, Volume 410, Issue 27, pp. 7211 - 7220
Quantitative screening for potential drug–protein binding is an essential step in developing novel metal-based anticancer drugs. ICP–MS approaches are at the... 
Biochemistry, general | High-throughput | Chemistry | Analytical Chemistry | Food Science | Monitoring/Environmental Analysis | Characterization and Evaluation of Materials | Laboratory Medicine | Metal-based anticancer drugs | ICP–MS | Elemental speciation analysis | Metal–protein interaction | POLYMERS | CHEMISTRY, ANALYTICAL | HUMAN SERUM-ALBUMIN | COMPLEXES | BIOCHEMICAL RESEARCH METHODS | METALLOMICS | PLASMA | Metal-protein interaction | TURBULENT-FLOW CHROMATOGRAPHY | ICP-MS | SIZE-EXCLUSION CHROMATOGRAPHY | METAL-BASED DRUGS | SPECIATION ANALYSIS | Chromatography, Gel - methods | Chromatography, High Pressure Liquid - methods | Humans | Ultrafiltration - methods | Metals - analysis | Antineoplastic Agents - analysis | Blood Proteins - metabolism | Antineoplastic Agents - metabolism | Blood Proteins - analysis | Metals - metabolism | Organoplatinum Compounds - metabolism | Protein Binding | Flow Injection Analysis - methods | Organoplatinum Compounds - analysis | Mass Spectrometry - methods | Antimitotic agents | Drug interactions | Dosage and administration | Observations | Antineoplastic agents | Mass spectrometry | Methods | Protein binding | Binding | Drugs | Size exclusion chromatography | Turbulent flow | Flow injection analysis | Fluid dynamics | Protein purification | Metals | Mass spectroscopy | Serum proteins | Drug development | Chromatography | Proteins | Screening | Protein adducts | Inductively coupled plasma | Ultrafiltration | Antitumor agents | Measurement methods | Cancer | Adducts | Research Paper
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 07/2019, Volume 141, Issue 26, pp. 10205 - 10213
The proto-oncogene KIT encodes for a tyrosine kinase receptor, which is a clinically validated target for treating gastrointestinal stromal tumors. The KIT... 
DNA-STRUCTURE | FORMING REGION | RECOGNITION | MOLECULE | STABILITY | TRANSCRIPTION FACTOR | BINDING | MOTIF | EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | PARALLEL
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2019, Volume 58, Issue 22, pp. 7464 - 7469
Due to their high kinetic inertness and consequently reduced side reactions with biomolecules, PtIV complexes are considered to define the future of anticancer... 
prodrugs | reduction | platinum(IV) complexes | hydrolysis | antitumor agents | Antimitotic agents | Hydrolysis | Physiological aspects | Antineoplastic agents | Drugs | Cell culture | Biotechnology | Side reactions | Drug development | Organic chemistry | Oxaliplatin | Antitumor agents | Platinum | Reaction kinetics | Biomolecules | Kinetics | Coordination compounds | Cancer | Communications | Communication
Journal Article
Chemical Science, ISSN 2041-6520, 04/2015, Volume 6, Issue 4, pp. 2449 - 2456
The clinical development of anticancer metallodrugs is often hindered by the elusive nature of their molecular targets. To identify the molecular targets of an... 
ORGANOMETALLIC RUTHENIUM(II) | IN-VITRO | DRUG DISCOVERY | COMPOUND | ANTICANCER METALLODRUGS | REACTIVITY | ICP-MS | BINDING | CHEMISTRY, MULTIDISCIPLINARY | MIDKINE | PROTEIN ADDUCTS | Proteins | Antiproliferatives | Proteomics | Histones | Fibroblasts | Guanines | Ruthenium organometallic complexes | Cancer
Journal Article
Inorganica Chimica Acta, ISSN 0020-1693, 06/2019, Volume 491, pp. 76 - 83
A series of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes as well as an ethylamine analog were synthesized. The compounds are either... 
Cytotoxicity | Synthesis | Anticancer agents | NMR spectroscopy | Platinum | TETRACARBOXYLATOPLATINUM(IV) COMPLEXES | CHEMISTRY, INORGANIC & NUCLEAR | REDUCTION | CISPLATIN | LIGANDS | EQUATORIAL | DRUGS | AGENTS | PLATINUM(IV) | Chemical analysis | Succinic acid | Ligands | Colon | Mass spectrometry | Lipophilicity
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2016, Volume 55, Issue 22, pp. 6417 - 6422
Humic substances (HS) are important iron chelators responsible for the transport of iron from freshwater systems to the open sea, where iron is essential for... 
dissolved organic matter | Fe K-edge | natural organic matter | complexed iron | iron chelator agents | FINE-STRUCTURE | XAFS ANALYSIS | X-RAY-ABSORPTION | COORDINATION | SEAWATER | CHEMISTRY, MULTIDISCIPLINARY | IN-VIVO | STRUCTURE SPECTROSCOPY | NEAR-EDGE STRUCTURE | COASTAL WATERS | METAL-COMPLEXES | Marine biology | Biogeochemistry | Analysis | Terrigenous sediments | Humic acid
Journal Article