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Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2008, Volume 105, Issue 44, pp. 17079 - 17084
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2017, Volume 23, Issue 22, pp. 7020 - 7033
Purpose: We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse.Experimental... 
Drugs | BRCA1 protein | Tumor cells | p53 Protein | Alkylating agents | Fluorescence | Crosslinking | Breast cancer | Gene deletion | Cisplatin | Alkylation | Ubiquitination | Clonal deletion | Restoration | Experimental design | Platinum | Drug tolerance | Deletion | Genetic engineering | Deoxyribonucleic acid--DNA | Tumors | Cancer
Journal Article
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 4190 - 14
The KRAS oncoprotein, a critical driver in 33% of lung adenocarcinoma (LUAD), has remained an elusive clinical target due to its perceived undruggable nature.... 
P-31 NMR | SERINE BIOSYNTHESIS | CELLS-OF-ORIGIN | NRF2 | MULTIDISCIPLINARY SCIENCES | 6-AMINONICOTINAMIDE | KEAP1 | DRIVEN | IDENTIFICATION | CANCER | EXPRESSION | Antioxidants | Adenocarcinoma | Heterogeneity | Pentose phosphate | Lung cancer | Pentose | Pentose phosphate pathway | Mutation | Macrophages | Alveoli | Tumors
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2018, Volume 27, Issue 4, pp. 935 - 943.e4
The lung presents a highly oxidative environment, which is tolerated through engagement of tightly controlled stress response pathways. A critical stress... 
Keap1 | PD-L1 | Pten | Nrf2 | Taldo1 | non-small-cell lung cancer | STEM-CELLS | ORIGIN | NRF2 | LANDSCAPE | ADENOCARCINOMA | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | BLOCKADE | CARCINOMA | EXPRESSION | DELETION | CELL BIOLOGY | Phosphates | Respiratory agents | Metabolites | Lung cancer, Non-small cell | Stem cells
Journal Article
Cancer Research, ISSN 0008-5472, 2019, Volume 79, Issue 3, pp. 452 - 460
The defect in homologous recombination (HR) found in BRCA1-associated cancers can be therapeutically exploited by treatment with DNA-damaging agents and PARP... 
SENSITIVITY | MAMMARY-TUMORS | BRCA1 | ONCOLOGY | RESECTION | 53BP1
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2018, Volume 33, Issue 6, pp. 1078 - 1093.e12
Journal Article
Journal Article