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by Surakka, Ida and Horikoshi, Momoko and Mägi, Reedik and Sarin, Antti-Pekka and Mahajan, Anubha and Lagou, Vasiliki and Marullo, Letizia and Ferreira, Teresa and Miraglio, Benjamin and Timonen, Sanna and Kettunen, Johannes and Pirinen, Matti and Karjalainen, Juha and Thorleifsson, Gudmar and Hägg, Sara and Hottenga, Jouke-Jan and Isaacs, Aaron and Ladenvall, Claes and Beekman, Marian and Esko, Tõnu and Ried, Janina S and Nelson, Christopher P and Willenborg, Christina and Gustafsson, Stefan and Westra, Harm-Jan and Blades, Matthew and de Craen, Anton J M and de Geus, Eco J and Deelen, Joris and Grallert, Harald and Hamsten, Anders and Havulinna, Aki S and Hengstenberg, Christian and Houwing-Duistermaat, Jeanine J and Hyppönen, Elina and Karssen, Lennart C and Lehtimäki, Terho and Lyssenko, Valeriya and Magnusson, Patrik K E and Mihailov, Evelin and Müller-Nurasyid, Martina and Mpindi, John-Patrick and Pedersen, Nancy L and Penninx, Brenda W J H and Perola, Markus and Pers, Tune H and Peters, Annette and Rung, Johan and Smit, Johannes H and Steinthorsdottir, Valgerdur and Tobin, Martin D and Tsernikova, Natalia and van Leeuwen, Elisabeth M and Viikari, Jorma S and Willems, Sara M and Willemsen, Gonneke and Schunkert, Heribert and Erdmann, Jeanette and Samani, Nilesh J and Kaprio, Jaakko and Lind, Lars and Gieger, Christian and Metspalu, Andres and Slagboom, P Eline and Groop, Leif and van Duijn, Cornelia M and Eriksson, Johan G and Jula, Antti and Salomaa, Veikko and Boomsma, Dorret I and Power, Christine and Raitakari, Olli T and Ingelsson, Erik and Järvelin, Marjo-Riitta and Thorsteinsdottir, Unnur and Franke, Lude and Ikonen, Elina and Kallioniemi, Olli and Pietiäinen, Vilja and Lindgren, Cecilia M and Stefansson, Kari and Palotie, Aarno and McCarthy, Mark I and Morris, Andrew P and Prokopenko, Inga and Ripatti, Samuli and ENGAGE Consortium
Nature genetics, ISSN 1546-1718, 2015, Volume 47, Issue 6, pp. 589 - 597
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2016, Volume 67, Issue 10, pp. 1200 - 1210
Abstract Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty... 
Cardiovascular | Internal Medicine | drug development | Mendelian randomization | metabolomics | cholesterol lowering | lipoproteins | COHORT PROFILE | CARDIAC & CARDIOVASCULAR SYSTEMS | BIOMARKER | VARIANTS | FATTY-ACID-COMPOSITION | RISK | TRIGLYCERIDES | LDL CHOLESTEROL | CORONARY-HEART-DISEASE | ASSOCIATION | EPIDEMIOLOGY | Hydroxymethylglutaryl CoA Reductases - drug effects | Mendelian Randomization Analysis - methods | Magnetic Resonance Spectroscopy - methods | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | United Kingdom | Cardiovascular Diseases - genetics | Forecasting | Metabolomics - methods | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Finland | Cardiovascular Diseases - blood | Adult | Female | Retrospective Studies | Hydroxymethylglutaryl CoA Reductases - blood | Hydroxymethylglutaryl CoA Reductases - genetics | Medical colleges | Metabolites | Pharmacy | Genomics | Genetic research | Drugstores | Fatty acids | Epidemiology | Statins | Public health | Cardiovascular agents | Lipids | Cholesterol | LDL-C, low-density lipoprotein cholesterol | CVD, cardiovascular disease | IDL, intermediate-density lipoprotein | VLDL, very-low-density lipoprotein | HMGCR, HMG-CoA reductase | NMR, nuclear magnetic resonance | HDL, high-density lipoprotein | Original Investigation
Journal Article
PLoS medicine, ISSN 1549-1676, 2014, Volume 11, Issue 2, p. e1001606
Journal Article
by Peters, Marjolein J and Joehanes, Roby and Pilling, Luke C and Schurmann, Claudia and Conneely, Karen N and Powell, Joseph and Reinmaa, Eva and Sutphin, George L and Zhernakova, Alexandra and Schramm, Katharina and Wilson, Yana A and Kobes, Sayuko and Tukiainen, Taru and Ramos, Yolande F and Göring, Harald H. H and Fornage, Myriam and Liu, Yongmei and Gharib, Sina A and Stranger, Barbara E and De Jager, Philip L and Aviv, Abraham and Levy, Daniel and Murabito, Joanne M and Munson, Peter J and Huan, Tianxiao and Hofman, Albert and Uitterlinden, André G and Rivadeneira, Fernando and van Rooij, Jeroen and Stolk, Lisette and Broer, Linda and Verbiest, Michael M. P. J and Jhamai, Mila and Arp, Pascal and Metspalu, Andres and Tserel, Liina and Milani, Lili and Samani, Nilesh J and Peterson, Pärt and Kasela, Silva and Codd, Veryan and Peters, Annette and Ward-Caviness, Cavin K and Herder, Christian and Waldenberger, Melanie and Roden, Michael and Singmann, Paula and Zeilinger, Sonja and Illig, Thomas and Homuth, Georg and Grabe, Hans-Jörgen and Völzke, Henry and Steil, Leif and Kocher, Thomas and Murray, Anna and Melzer, David and Yaghootkar, Hanieh and Bandinelli, Stefania and Moses, Eric K and Kent, Jack W and Curran, Joanne E and Johnson, Matthew P and Williams-Blangero, Sarah and Westra, Harm-Jan and McRae, Allan F and Smith, Jennifer A and Kardia, Sharon L. R and Hovatta, Iiris and Perola, Markus and Ripatti, Samuli and Salomaa, Veikko and Henders, Anjali K and Martin, Nicholas G and Smith, Alicia K and Mehta, Divya and Binder, Elisabeth B and Nylocks, K Maria and Kennedy, Elizabeth M and Klengel, Torsten and Ding, Jingzhong and Suchy-Dicey, Astrid M and Enquobahrie, Daniel A and Brody, Jennifer and Rotter, Jerome I and Chen, Yii-Der I and Houwing-Duistermaat, Jeanine and Kloppenburg, Margreet and Slagboom, P. Eline and Helmer, Quinta and den Hollander, Wouter and Bean, Shannon and Raj, Towfique and Bakhshi, Noman and Wang, Qiao Ping and Oyston, Lisa J and Psaty, Bruce M and Tracy, Russell P and Montgomery, Grant W and Turner, Stephen T and Blangero, John and ... and NABEC/UKBEC Consortium and NABEC UKBEC Consortium
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 8570
textabstractDisease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately... 
LIFE-SPAN | OXIDATIVE STRESS | METHYLATION | PROFILES | GLYCOSAMINOGLYCANS | HUMAN LONGEVITY | DROSOPHILA-MELANOGASTER | MULTIDISCIPLINARY SCIENCES | PATTERNS | GENE-EXPRESSION CHANGES | GENOME-WIDE ASSOCIATION | Aging - blood | DNA Methylation | Humans | Transcriptome | European Continental Ancestry Group | Gene Expression Profiling | Biomarkers - blood
Journal Article
Journal Article
by Thorgeirsson, Thorgeir E and Gudbjartsson, Daniel F and Surakka, Ida and Vink, Jacqueline M and Amin, Najaf and Geller, Frank and Sulem, Patrick and Rafnar, Thorunn and Esko, Tõnu and Walter, Stefan and Gieger, Christian and Rawal, Rajesh and Mangino, Massimo and Prokopenko, Inga and Mägi, Reedik and Keskitalo, Kaisu and Gudjonsdottir, Iris H and Gretarsdottir, Solveig and Stefansson, Hreinn and Thompson, John R and Aulchenko, Yurii S and Nelis, Mari and Aben, Katja K and den Heijer, Martin and Dirksen, Asger and Ashraf, Haseem and Soranzo, Nicole and Valdes, Ana M and Steves, Claire and Uitterlinden, André G and Hofman, Albert and Tönjes, Anke and Kovacs, Peter and Hottenga, Jouke Jan and Willemsen, Gonneke and Vogelzangs, Nicole and Döring, Angela and Dahmen, Norbert and Nitz, Barbara and Pergadia, Michele L and Saez, Berta and De Diego, Veronica and Lezcano, Victoria and Garcia-Prats, Maria D and Ripatti, Samuli and Perola, Markus and Kettunen, Johannes and Hartikainen, Anna-Liisa and Pouta, Anneli and Laitinen, Jaana and Isohanni, Matti and Huei-Yi, Shen and Allen, Maxine and Krestyaninova, Maria and Hall, Alistair S and Jones, Gregory T and van Rij, Andre M and Mueller, Thomas and Dieplinger, Benjamin and Haltmayer, Meinhard and Jonsson, Steinn and Matthiasson, Stefan E and Oskarsson, Hogni and Tyrfingsson, Thorarinn and Kiemeney, Lambertus A and Mayordomo, Jose I and Lindholt, Jes S and Pedersen, Jesper Holst and Franklin, Wilbur A and Wolf, Holly and Montgomery, Grant W and Heath, Andrew C and Martin, Nicholas G and Madden, Pamela A F and Giegling, Ina and Rujescu, Dan and Järvelin, Marjo-Riitta and Salomaa, Veikko and Stumvoll, Michael and Spector, Tim D and Wichmann, H-Erich and Metspalu, Andres and Samani, Nilesh J and Penninx, Brenda W and Oostra, Ben A and Boomsma, Dorret I and Tiemeier, Henning and van Duijn, Cornelia M and Kaprio, Jaakko and Gulcher, Jeffrey R and McCarthy, Mark I and Peltonen, Leena and Thorsteinsdottir, Unnur and Stefansson, Kari and The ENGAGE Consortium and ENGAGE Consortium
Nature genetics, ISSN 1546-1718, 2010, Volume 42, Issue 5, pp. 448 - 453
Journal Article
Molecular systems biology, ISSN 1744-4292, 2010, Volume 6, Issue 1, pp. 441 - n/a
Journal Article
BMC genomics, ISSN 1471-2164, 2016, Volume 17, Issue 1, p. 874
Background: Complex diseases are characterized by multiple subtle perturbations to biological processes. New omics platforms can detect these perturbations,... 
Blood glucose | Gene networks | Key drivers | Mergeomics | Integrative genomics | Cholesterol | Functional genomics | Multidimensional data integration | MOUSE | LOCI | SET ENRICHMENT ANA