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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2008, Volume 52, Issue 12, pp. 4432 - 4441
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4401 - 4410
Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we... 
CFI-402257 | POTENT | CHEMISTRY, MEDICINAL | CHECKPOINT | MPS1 | DISCOVERY
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2020, Volume 28, Issue 1, p. 115232
[Display omitted] Glucose flux through glucokinase (GK) controls insulin release from the pancreas in response to high levels of glucose. Flux through GK is... 
S0.5 | Glucokinase activator | Structure-aided design | Glucokinase | Structure-based design | Vmax | Type II diabetes | Diabetes | OGTT | ob/ob mouse | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | GLUCOSE | REGULATORY PROTEIN | S-0.5 | V-max
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2014, Volume 57, Issue 19, pp. 8180 - 8186
Glucokinase (GK) is the rate-limiting step for insulin release from the pancreas in response to high levels of glucose. Flux through GK also contributes to... 
TYPE-2 DIABETES-MELLITUS | CHEMISTRY, MEDICINAL | THERAPY | Enzyme Activators - pharmacology | Glucose Tolerance Test | Animals | Mice, Inbred C57BL | Urea - analogs & derivatives | Pyridines - chemical synthesis | Pyridines - pharmacology | Glucokinase - metabolism | Drug Discovery | Enzyme Activators - chemical synthesis
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/1997, Volume 119, Issue 42, pp. 10147 - 10152
The transition structures for the epoxidations of ethylene by performic acid, dioxirane, oxaziridine, and peroxynitrous acid have been located with density... 
CARBONYL OXIDE | ALKENES | ENANTIOSELECTIVE EPOXIDATION | MECHANISM | ASYMMETRIC EPOXIDATION | OXYGEN-TRANSFER | DIOXIRANES | CHEMISTRY | OLEFINS | K DY CHEMISTRY | OXAZIRIDINE | Density functionals | Usage | Research | Catalysts | Radioactivation analysis
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2016, Volume 7, Issue 7, pp. 714 - 718
Glucokinase (GK) catalyzes the phosphorylation of glucose to glucose-6-phosphate. We present the structure–activity relationships leading to the discovery of... 
Glucokinase activator | GKA | AM-2394 | CHEMISTRY, MEDICINAL | THERAPY | GLUCOSE | TYPE-2 DIABETES-MELLITUS
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/1996, Volume 118, Issue 51, pp. 13002 - 13006
The mechanisms of oxidations of amines, sulfides, and alkenes by peroxynitrous acid, as well as the mechanism for the conversion of peroxynitrous acid to... 
Sulfides | Oxidation-reduction reaction | Amines | Research | Olefins
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2008, Volume 18, Issue 6, pp. 2206 - 2210
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2014, Volume 5, Issue 12, pp. 1284 - 1289
Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose... 
Type 2 diabetes | glucokinase activator | GKA | methyl urea-substituted pyridines | CHEMISTRY, MEDICINAL | PLASMA-GLUCOSE | RISK | TYPE-2 | DISCOVERY | PATHOPHYSIOLOGY
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/1995, Volume 117, Issue 11, pp. 3057 - 3083
A synthetic route to the cembranoid natural product (+/-)-7,8-epoxy-4-basmen-6-one (1) is described employing as key steps the cationic macrocyclization of the... 
INTRAMOLECULAR ALKYLATION | ORGANIC-SYNTHESIS | ORGANOSELENIUM CHEMISTRY | RADICAL CYCLIZATIONS | CHEMISTRY | ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS | BETA-KETO-ESTERS | BASMANE DITERPENES | RING-CLOSURE | STEREOSELECTIVE SYNTHESIS | SUBSTITUTED HEX-5-ENYL | Ring formation (Chemistry) | Research | Stereochemistry
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 05/1998, Volume 63, Issue 10, pp. 3196 - 3203
The selectivities of nucleophilic additions of ethyl, vinyl, and ethynyllithium and Grignard reagents to a 2-(3‘-phenylpropyl)cycloheptanone were investigated... 
KETONES | SUBSTITUTION | ALKENES | HYDRIDE REDUCTIONS | MODELS | TRANSITION STRUCTURES | STEREOCHEMISTRY | CYCLOHEXANONE | CHEMISTRY, ORGANIC | SYSTEMS | ION | Cyclic compounds | Addition polymerization | Research
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 11/1994, Volume 59, Issue 23, pp. 6879 - 6881
Intermolecular Diels-Alder reaction of a monoprotected bis-diene with a bis-dienophile, followed by deprotection on the second diene moeity and a second... 
CHEMISTRY, ORGANIC | ALKYLATION REACTIONS | Synthesis | Research | Diels-Alder reaction | Cyclic compounds | Organic compounds
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/1997, Volume 119, Issue 12, p. 2964
Journal Article
12/2019
compostos macrocíclicos como inibidores de trk quinase, composição farmacêutica, uso de um composto de fórmula i ou um sal farmaceuticamente aceitável do... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
09/2019
Compounds of Formula I : and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R 2 , R 2a , R 3 , R 3a , and Z are as defined herein,... 
Patent
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