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1. Full Text An Anti-Opioid System, Courtesy of a Worm Model
by Kieffer, Brigitte L
The New England Journal of Medicine, ISSN 0028-4793, 11/2019, Volume 381, Issue 21, pp. 2067 - 2069
A forward genetic screen using the worm Caenorhabditis elegans implicated the G protein–coupled receptor 139 in suppressing signaling by the mu opioid... 
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2. Full Text The Control of Reward Seeking
by Darcq, Emmanuel and Kieffer, Brigitte L
Biological Psychiatry, ISSN 0006-3223, 06/2018, Volume 83, Issue 12, pp. 981 - 983
Basal Forebrain | Reward | Neurons | Habenula
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3. Full Text Drug discovery: Designing the ideal opioid
by Kieffer, Brigitte L
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 170 - 171
RECEPTOR | GENE | MULTIDISCIPLINARY SCIENCES | ANALGESIA | Receptors, Opioid, mu | Analgesics, Opioid | Drug Discovery | Humans | Receptors, Opioid | Pharmaceutical research | Drug metabolism | Research | Bioavailability | Opioids
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4. Full Text Deficit in Attachment Behavior in Mice Lacking the μ-Opioid Receptor Gene
by Anna Moles and Brigitte L. Kieffer and Francesca R. D'Amato
Science, ISSN 0036-8075, 6/2004, Volume 304, Issue 5679, pp. 1983 - 1986
Endogenous opioid binding to μ receptors is hypothesized to mediate natural rewards and has been proposed to be the basis of infant attachment behavior. Here,... 
Animal nesting | Receptors | Odors | Neurons | Attachment behavior | Reports | Mothers | Velocity | Pups | Genotypes | Ultrasonics
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5. Full Text Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson's disease
by Sikora, Joanna and Kieffer, Brigitte L and Paoletti, Pierre and Ouagazzal, Abdel-Mouttalib
Neurobiology of Disease, ISSN 0969-9961, 02/2020, Volume 134, p. 104681
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6. Full Text Differential impact of two critical respiratory centres in opioid‐induced respiratory depression in awake mice
by Varga, Adrienn G and Reid, Brandon T and Kieffer, Brigitte L and Levitt, Erica S
The Journal of Physiology, ISSN 0022-3751, 11/2019
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7. Full Text Designing the ideal opioid
by Kieffer, Brigitte L
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7619, pp. 170 - 171
Opium has been used medicinally and recreationally for more than 4,000 years because of its remarkable pain-relieving and euphoria-inducing properties1. Today,... 
Drugs | Proteins | Pharmacology | Pain | Narcotics | Research & development--R&D
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8. Full Text Opioid receptors: distinct roles in mood disorders
by Lutz, Pierre-Eric and Kieffer, Brigitte L
Trends in Neurosciences, ISSN 0166-2236, 2012, Volume 36, Issue 3, pp. 195 - 206
The roles of opioid receptors in pain and addiction have been extensively studied, but their function in mood disorders has received less attention.... 
Neurology | delta opioid receptor | depression | kappa opioid receptor | mood | mu opioid receptor | Depression | Mood | Delta opioid receptor | Mu opioid receptor | Kappa opioid receptor | SPRAGUE-DAWLEY RATS | MESSENGER-RNA EXPRESSION | ANTIDEPRESSANT-LIKE ACTIVITIES | CONDITIONED PLACE PREFERENCE | ADULT HIPPOCAMPAL NEUROGENESIS | MORPHINE-INDUCED INCREASES | FORCED SWIM TEST | NEUROSCIENCES | LEARNED HELPLESSNESS MODEL | CENTRAL-NERVOUS-SYSTEM | DORSAL RAPHE NUCLEUS | Mood Disorders - drug therapy | Receptors, Opioid - agonists | Prenatal Exposure Delayed Effects | Opioid Peptides - physiology | Humans | Analgesics, Opioid - pharmacology | Neuronal Plasticity - drug effects | Male | Receptors, Opioid - physiology | Neuronal Plasticity - physiology | Brain-Derived Neurotrophic Factor - physiology | Social Behavior | Receptors, Opioid - deficiency | Female | Antidepressive Agents - pharmacology | Neurogenesis - drug effects | Neurotransmitter Agents - physiology | Affect - drug effects | Nerve Tissue Proteins - physiology | Comorbidity | Affect - physiology | Maternal Behavior - physiology | Maternal Behavior - drug effects | Substance-Related Disorders - physiopathology | Mice, Knockout | Antidepressive Agents - therapeutic use | Pregnancy | Animals | Neurogenesis - physiology | Narcotic Antagonists - pharmacology | Brain Chemistry | Mice | Models, Neurological | Reward | Substance-Related Disorders - drug therapy | Mood Disorders - physiopathology | Mood Disorders - metabolism | Antidepressants | Development and progression | Depression, Mental
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9. Opioid receptors: distinct roles in mood disorders
by Pierre-Eric Lutz and Brigitte L Kieffer
Trends in Neurosciences, ISSN 0166-2236, 03/2013, Volume 36, Issue 3, p. 195
  The roles of opioid receptors in pain and addiction have been extensively studied, but their function in mood disorders has received less attention.... 
Brain | Emotional disorders | Neurobiology | T cell receptors
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10. Full Text PI 3K signaling in the locus coeruleus: a new molecular pathway for ADHD  research
by Darcq, Emmanuel and Kieffer, Brigitte L
EMBO Molecular Medicine, ISSN 1757-4676, 07/2015, Volume 7, Issue 7, pp. 859 - 861
Attention‐deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has... 
Attention deficit disorder | Neurosciences | Animal models | Substance abuse treatment | Hyperactivity | Memory | Genes | Neurobiology | Homeostasis | Kinases | Flexibility | Genotype & phenotype | Signal transduction | Rodents | Addictive behaviors | Behavior | Locus coeruleus | Impulsivity | Dopamine | Neurons | Attention deficit hyperactivity disorder | Environmental factors | Brain research | Molecular modelling | Norepinephrine
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11. Full Text Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol
: Abstinence across drugs
by Becker, Jérôme A.J and Kieffer, Brigitte L and Le Merrer, Julie
Addiction Biology, ISSN 1355-6215, 09/2017, Volume 22, Issue 5, pp. 1205 - 1217
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12. Full Text PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research
by Darcq, Emmanuel and Kieffer, Brigitte L
EMBO Molecular Medicine, ISSN 1757-4676, 07/2015, Volume 7, Issue 7, pp. 859 - 861
Attention‐deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has... 
Animals | Adrenergic Neurons - pathology | Signal Transduction | Locus Coeruleus - pathology | Class Ib Phosphatidylinositol 3-Kinase - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Attention Deficit Disorder with Hyperactivity - pathology | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Development and progression | Analysis | Attention-deficit hyperactivity disorder | Closeup
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13. Full Text Reward Processing by the Opioid System in the Brain
by Julie Le Merrer and Jérôme A. J. Becker and Katia Befort and Brigitte L. Kieffer
Physiological Reviews, ISSN 0031-9333, 10/2009, Volume 89, Issue 4, pp. 1379 - 1412
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors,... 
MEDIAL PREOPTIC AREA | PHYSIOLOGY | PROGRESSIVE RATIO SCHEDULE | CHRONIC MORPHINE EXPOSURE | NICOTINE-INDUCED ANTINOCICEPTION | CONDITIONED PLACE PREFERENCE | RECEPTOR MESSENGER-RNA | PROOPIOMELANOCORTIN GENE-EXPRESSION | NUCLEUS-ACCUMBENS SHELL | DORSAL PERIAQUEDUCTAL GRAY | VENTRAL TEGMENTAL AREA | Endorphins - physiology | Endorphins - genetics | Receptors, Opioid - genetics | Substance-Related Disorders - metabolism | Brain - anatomy & histology | Humans | RNA, Messenger - genetics | Reinforcement (Psychology) | Brain - physiology | RNA, Messenger - biosynthesis | Animals | Receptors, Opioid - biosynthesis | Reward | Receptors | Messenger RNA | Brain research | Analysis | Opioids | Research | Gene expression | Index Medicus
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14. Full Text Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in μ-opioid receptor knock-out mice
by Berrendero, Fernando and Kieffer, Brigitte L and Maldonado, Rafael
Journal of Neuroscience, ISSN 0270-6474, 12/2002, Volume 22, Issue 24, pp. 10935 - 10940
The involvement of μ-opioid receptors in different behavioral responses elicited by nicotine was explored by using μ-opioid receptor knock-out mice. The acute... 
Opioid | Reward | Knock-out mice | Withdrawal | Conditioning place preference | Nicotine | reward | ARTICLE | nicotine | opioid | conditioning place preference | withdrawal | knock-out mice
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15. Full Text 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse
by Charbogne, Pauline and Kieffer, Brigitte L and Befort, Katia
Neuropharmacology, ISSN 0028-3908, 01/2014, Volume 76, Issue 0, pp. 204 - 217
The endogenous opioid system is expressed throughout the brain reinforcement circuitry, and plays a major role in reward processing, mood control and the... 
Opioid peptides | Knockout mice | Drugs of abuse | Reward | Opioid receptors | Addiction | SUBSTANCE USE DISORDERS | PROTEIN-KINASE-C | CANNABINOID WITHDRAWAL SYNDROME | CONDITIONED PLACE PREFERENCE | EVOKED DOPAMINERGIC NEUROTRANSMISSION | BETA-ENDORPHIN-DEFICIENT | NICOTINIC ACETYLCHOLINE-RECEPTORS | NEUROSCIENCES | INDUCED BEHAVIORAL SENSITIZATION | MICE LACKING | VENTRAL TEGMENTAL AREA | PHARMACOLOGY & PHARMACY | Receptors, Opioid - genetics | History, 21st Century | History, 20th Century | Humans | Opioid Peptides - deficiency | Biomedical Research - history | Substance-Related Disorders - genetics | Substance-Related Disorders - history | Mice, Knockout | Animals | Opioid Peptides - genetics | Receptors, Opioid - deficiency | Mice | Disease Models, Animal | Drug abuse | Image processing | Illegal drugs | Morphine | Equipment and supplies | Cocaine | Beta-endorphin | Intermedin | opioid receptors | drugs of abuse | reward | knockout mice | opioid peptides | addiction
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16. Molecular and biophysical mechanisms of arousal, alertness, and attention
by Pfaff, Donald W and Kieffer, Brigitte L and New York Academy of Sciences
2008, Annals of the New York Academy of Sciences, ISBN 1573317039, Volume 1129., xi, 372
Molecular neurobiology | Neurogenetics | Arousal (Physiology) | Attention
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17. Full Text Ligand‐directed signalling within the opioid receptor family
by Pradhan, Amynah A and Smith, Monique L and Kieffer, Brigitte L and Evans, Christopher J
British Journal of Pharmacology, ISSN 0007-1188, 11/2012, Volume 167, Issue 5, pp. 960 - 969
The classic model of GPCR activation proposed that all agonists induce the same active receptor conformation. However, research over the last decade has shown... 
reward | GPCR | pain | receptor biology | functional selectivity | SPRAGUE-DAWLEY RATS | ALKALOID AGONISTS | PHARMACOLOGICAL CHARACTERIZATION | N-TERMINAL KINASE | NEUROPATHIC PAIN | 7-TRANSMEMBRANE RECEPTORS | IN-VIVO | PHARMACOLOGY & PHARMACY | ANALGESIC TOLERANCE | CHRONIC INFLAMMATION | Receptors, Opioid - agonists | Receptors, Opioid - physiology | Ligands | Animals | Signal Transduction | Humans | Reviews
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