The New England Journal of Medicine, ISSN 0028-4793, 11/2019, Volume 381, Issue 21, pp. 2067 - 2069
A forward genetic screen using the worm Caenorhabditis elegans implicated the G protein–coupled receptor 139 in suppressing signaling by the mu opioid...
Journal Article
Biological Psychiatry, ISSN 0006-3223, 06/2018, Volume 83, Issue 12, pp. 981 - 983
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 170 - 171
Journal Article
Science, ISSN 0036-8075, 6/2004, Volume 304, Issue 5679, pp. 1983 - 1986
Endogenous opioid binding to μ receptors is hypothesized to mediate natural rewards and has been proposed to be the basis of infant attachment behavior. Here,...
Animal nesting | Receptors | Odors | Neurons | Attachment behavior | Reports | Mothers | Velocity | Pups | Genotypes | Ultrasonics
Animal nesting | Receptors | Odors | Neurons | Attachment behavior | Reports | Mothers | Velocity | Pups | Genotypes | Ultrasonics
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 02/2020, Volume 134, p. 104681
Journal Article
The Journal of Physiology, ISSN 0022-3751, 11/2019
Journal Article
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7619, pp. 170 - 171
Opium has been used medicinally and recreationally for more than 4,000 years because of its remarkable pain-relieving and euphoria-inducing properties1. Today,...
Drugs | Proteins | Pharmacology | Pain | Narcotics | Research & development--R&D
Drugs | Proteins | Pharmacology | Pain | Narcotics | Research & development--R&D
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 2012, Volume 36, Issue 3, pp. 195 - 206
The roles of opioid receptors in pain and addiction have been extensively studied, but their function in mood disorders has received less attention....
Neurology | delta opioid receptor | depression | kappa opioid receptor | mood | mu opioid receptor | Depression | Mood | Delta opioid receptor | Mu opioid receptor | Kappa opioid receptor | SPRAGUE-DAWLEY RATS | MESSENGER-RNA EXPRESSION | ANTIDEPRESSANT-LIKE ACTIVITIES | CONDITIONED PLACE PREFERENCE | ADULT HIPPOCAMPAL NEUROGENESIS | MORPHINE-INDUCED INCREASES | FORCED SWIM TEST | NEUROSCIENCES | LEARNED HELPLESSNESS MODEL | CENTRAL-NERVOUS-SYSTEM | DORSAL RAPHE NUCLEUS | Mood Disorders - drug therapy | Receptors, Opioid - agonists | Prenatal Exposure Delayed Effects | Opioid Peptides - physiology | Humans | Analgesics, Opioid - pharmacology | Neuronal Plasticity - drug effects | Male | Receptors, Opioid - physiology | Neuronal Plasticity - physiology | Brain-Derived Neurotrophic Factor - physiology | Social Behavior | Receptors, Opioid - deficiency | Female | Antidepressive Agents - pharmacology | Neurogenesis - drug effects | Neurotransmitter Agents - physiology | Affect - drug effects | Nerve Tissue Proteins - physiology | Comorbidity | Affect - physiology | Maternal Behavior - physiology | Maternal Behavior - drug effects | Substance-Related Disorders - physiopathology | Mice, Knockout | Antidepressive Agents - therapeutic use | Pregnancy | Animals | Neurogenesis - physiology | Narcotic Antagonists - pharmacology | Brain Chemistry | Mice | Models, Neurological | Reward | Substance-Related Disorders - drug therapy | Mood Disorders - physiopathology | Mood Disorders - metabolism | Antidepressants | Development and progression | Depression, Mental
Neurology | delta opioid receptor | depression | kappa opioid receptor | mood | mu opioid receptor | Depression | Mood | Delta opioid receptor | Mu opioid receptor | Kappa opioid receptor | SPRAGUE-DAWLEY RATS | MESSENGER-RNA EXPRESSION | ANTIDEPRESSANT-LIKE ACTIVITIES | CONDITIONED PLACE PREFERENCE | ADULT HIPPOCAMPAL NEUROGENESIS | MORPHINE-INDUCED INCREASES | FORCED SWIM TEST | NEUROSCIENCES | LEARNED HELPLESSNESS MODEL | CENTRAL-NERVOUS-SYSTEM | DORSAL RAPHE NUCLEUS | Mood Disorders - drug therapy | Receptors, Opioid - agonists | Prenatal Exposure Delayed Effects | Opioid Peptides - physiology | Humans | Analgesics, Opioid - pharmacology | Neuronal Plasticity - drug effects | Male | Receptors, Opioid - physiology | Neuronal Plasticity - physiology | Brain-Derived Neurotrophic Factor - physiology | Social Behavior | Receptors, Opioid - deficiency | Female | Antidepressive Agents - pharmacology | Neurogenesis - drug effects | Neurotransmitter Agents - physiology | Affect - drug effects | Nerve Tissue Proteins - physiology | Comorbidity | Affect - physiology | Maternal Behavior - physiology | Maternal Behavior - drug effects | Substance-Related Disorders - physiopathology | Mice, Knockout | Antidepressive Agents - therapeutic use | Pregnancy | Animals | Neurogenesis - physiology | Narcotic Antagonists - pharmacology | Brain Chemistry | Mice | Models, Neurological | Reward | Substance-Related Disorders - drug therapy | Mood Disorders - physiopathology | Mood Disorders - metabolism | Antidepressants | Development and progression | Depression, Mental
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 03/2013, Volume 36, Issue 3, p. 195
The roles of opioid receptors in pain and addiction have been extensively studied, but their function in mood disorders has received less attention....
Brain | Emotional disorders | Neurobiology | T cell receptors
Brain | Emotional disorders | Neurobiology | T cell receptors
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 07/2015, Volume 7, Issue 7, pp. 859 - 861
Attention‐deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has...
Attention deficit disorder | Neurosciences | Animal models | Substance abuse treatment | Hyperactivity | Memory | Genes | Neurobiology | Homeostasis | Kinases | Flexibility | Genotype & phenotype | Signal transduction | Rodents | Addictive behaviors | Behavior | Locus coeruleus | Impulsivity | Dopamine | Neurons | Attention deficit hyperactivity disorder | Environmental factors | Brain research | Molecular modelling | Norepinephrine
Attention deficit disorder | Neurosciences | Animal models | Substance abuse treatment | Hyperactivity | Memory | Genes | Neurobiology | Homeostasis | Kinases | Flexibility | Genotype & phenotype | Signal transduction | Rodents | Addictive behaviors | Behavior | Locus coeruleus | Impulsivity | Dopamine | Neurons | Attention deficit hyperactivity disorder | Environmental factors | Brain research | Molecular modelling | Norepinephrine
Journal Article
Addiction Biology, ISSN 1355-6215, 09/2017, Volume 22, Issue 5, pp. 1205 - 1217
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 07/2015, Volume 7, Issue 7, pp. 859 - 861
Attention‐deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has...
Animals | Adrenergic Neurons - pathology | Signal Transduction | Locus Coeruleus - pathology | Class Ib Phosphatidylinositol 3-Kinase - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Attention Deficit Disorder with Hyperactivity - pathology | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Development and progression | Analysis | Attention-deficit hyperactivity disorder | Closeup
Animals | Adrenergic Neurons - pathology | Signal Transduction | Locus Coeruleus - pathology | Class Ib Phosphatidylinositol 3-Kinase - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Attention Deficit Disorder with Hyperactivity - pathology | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Development and progression | Analysis | Attention-deficit hyperactivity disorder | Closeup
Journal Article
Physiological Reviews, ISSN 0031-9333, 10/2009, Volume 89, Issue 4, pp. 1379 - 1412
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors,...
MEDIAL PREOPTIC AREA | PHYSIOLOGY | PROGRESSIVE RATIO SCHEDULE | CHRONIC MORPHINE EXPOSURE | NICOTINE-INDUCED ANTINOCICEPTION | CONDITIONED PLACE PREFERENCE | RECEPTOR MESSENGER-RNA | PROOPIOMELANOCORTIN GENE-EXPRESSION | NUCLEUS-ACCUMBENS SHELL | DORSAL PERIAQUEDUCTAL GRAY | VENTRAL TEGMENTAL AREA | Endorphins - physiology | Endorphins - genetics | Receptors, Opioid - genetics | Substance-Related Disorders - metabolism | Brain - anatomy & histology | Humans | RNA, Messenger - genetics | Reinforcement (Psychology) | Brain - physiology | RNA, Messenger - biosynthesis | Animals | Receptors, Opioid - biosynthesis | Reward | Receptors | Messenger RNA | Brain research | Analysis | Opioids | Research | Gene expression | Index Medicus
MEDIAL PREOPTIC AREA | PHYSIOLOGY | PROGRESSIVE RATIO SCHEDULE | CHRONIC MORPHINE EXPOSURE | NICOTINE-INDUCED ANTINOCICEPTION | CONDITIONED PLACE PREFERENCE | RECEPTOR MESSENGER-RNA | PROOPIOMELANOCORTIN GENE-EXPRESSION | NUCLEUS-ACCUMBENS SHELL | DORSAL PERIAQUEDUCTAL GRAY | VENTRAL TEGMENTAL AREA | Endorphins - physiology | Endorphins - genetics | Receptors, Opioid - genetics | Substance-Related Disorders - metabolism | Brain - anatomy & histology | Humans | RNA, Messenger - genetics | Reinforcement (Psychology) | Brain - physiology | RNA, Messenger - biosynthesis | Animals | Receptors, Opioid - biosynthesis | Reward | Receptors | Messenger RNA | Brain research | Analysis | Opioids | Research | Gene expression | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2002, Volume 22, Issue 24, pp. 10935 - 10940
The involvement of μ-opioid receptors in different behavioral responses elicited by nicotine was explored by using μ-opioid receptor knock-out mice. The acute...
Opioid | Reward | Knock-out mice | Withdrawal | Conditioning place preference | Nicotine | reward | ARTICLE | nicotine | opioid | conditioning place preference | withdrawal | knock-out mice
Opioid | Reward | Knock-out mice | Withdrawal | Conditioning place preference | Nicotine | reward | ARTICLE | nicotine | opioid | conditioning place preference | withdrawal | knock-out mice
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2014, Volume 76, Issue 0, pp. 204 - 217
The endogenous opioid system is expressed throughout the brain reinforcement circuitry, and plays a major role in reward processing, mood control and the...
Opioid peptides | Knockout mice | Drugs of abuse | Reward | Opioid receptors | Addiction | SUBSTANCE USE DISORDERS | PROTEIN-KINASE-C | CANNABINOID WITHDRAWAL SYNDROME | CONDITIONED PLACE PREFERENCE | EVOKED DOPAMINERGIC NEUROTRANSMISSION | BETA-ENDORPHIN-DEFICIENT | NICOTINIC ACETYLCHOLINE-RECEPTORS | NEUROSCIENCES | INDUCED BEHAVIORAL SENSITIZATION | MICE LACKING | VENTRAL TEGMENTAL AREA | PHARMACOLOGY & PHARMACY | Receptors, Opioid - genetics | History, 21st Century | History, 20th Century | Humans | Opioid Peptides - deficiency | Biomedical Research - history | Substance-Related Disorders - genetics | Substance-Related Disorders - history | Mice, Knockout | Animals | Opioid Peptides - genetics | Receptors, Opioid - deficiency | Mice | Disease Models, Animal | Drug abuse | Image processing | Illegal drugs | Morphine | Equipment and supplies | Cocaine | Beta-endorphin | Intermedin | opioid receptors | drugs of abuse | reward | knockout mice | opioid peptides | addiction
Opioid peptides | Knockout mice | Drugs of abuse | Reward | Opioid receptors | Addiction | SUBSTANCE USE DISORDERS | PROTEIN-KINASE-C | CANNABINOID WITHDRAWAL SYNDROME | CONDITIONED PLACE PREFERENCE | EVOKED DOPAMINERGIC NEUROTRANSMISSION | BETA-ENDORPHIN-DEFICIENT | NICOTINIC ACETYLCHOLINE-RECEPTORS | NEUROSCIENCES | INDUCED BEHAVIORAL SENSITIZATION | MICE LACKING | VENTRAL TEGMENTAL AREA | PHARMACOLOGY & PHARMACY | Receptors, Opioid - genetics | History, 21st Century | History, 20th Century | Humans | Opioid Peptides - deficiency | Biomedical Research - history | Substance-Related Disorders - genetics | Substance-Related Disorders - history | Mice, Knockout | Animals | Opioid Peptides - genetics | Receptors, Opioid - deficiency | Mice | Disease Models, Animal | Drug abuse | Image processing | Illegal drugs | Morphine | Equipment and supplies | Cocaine | Beta-endorphin | Intermedin | opioid receptors | drugs of abuse | reward | knockout mice | opioid peptides | addiction
Journal Article
2008, Annals of the New York Academy of Sciences, ISBN 1573317039, Volume 1129., xi, 372
Book
British Journal of Pharmacology, ISSN 0007-1188, 11/2012, Volume 167, Issue 5, pp. 960 - 969
The classic model of GPCR activation proposed that all agonists induce the same active receptor conformation. However, research over the last decade has shown...
reward | GPCR | pain | receptor biology | functional selectivity | SPRAGUE-DAWLEY RATS | ALKALOID AGONISTS | PHARMACOLOGICAL CHARACTERIZATION | N-TERMINAL KINASE | NEUROPATHIC PAIN | 7-TRANSMEMBRANE RECEPTORS | IN-VIVO | PHARMACOLOGY & PHARMACY | ANALGESIC TOLERANCE | CHRONIC INFLAMMATION | Receptors, Opioid - agonists | Receptors, Opioid - physiology | Ligands | Animals | Signal Transduction | Humans | Reviews
reward | GPCR | pain | receptor biology | functional selectivity | SPRAGUE-DAWLEY RATS | ALKALOID AGONISTS | PHARMACOLOGICAL CHARACTERIZATION | N-TERMINAL KINASE | NEUROPATHIC PAIN | 7-TRANSMEMBRANE RECEPTORS | IN-VIVO | PHARMACOLOGY & PHARMACY | ANALGESIC TOLERANCE | CHRONIC INFLAMMATION | Receptors, Opioid - agonists | Receptors, Opioid - physiology | Ligands | Animals | Signal Transduction | Humans | Reviews
Journal Article