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Neurobiology of disease, ISSN 0969-9961, 02/2020, Volume 134, p. 104681
Hyperactivity of glutamatergic corticostrial pathways is recognized as a key pathophysiological mechanism contributing to development of PD symptoms and... 
Journal Article
The Journal of Physiology, ISSN 0022-3751, 01/2020, Volume 598, Issue 1, pp. 189 - 205
Key points The main cause of death from opioid overdose is respiratory depression due to the activation of µ‐opioid receptors (MORs). We conditionally deleted... 
respiratory depression | pre‐Bötzinger complex | Kolliker‐Fuse nucleus | mu‐opioid receptors | MOR conditional knockout | morphine | SLEEP | PHYSIOLOGY | INTRAVENOUS REMIFENTANIL | MECHANISMS | NEUROSCIENCES | PREBOTZINGER COMPLEX | Kolliker-Fuse nucleus | KOLLIKER-FUSE NEURONS | mu-opioid receptors | MEDULLARY | NUCLEUS | pre-Botzinger complex | RECEPTORS
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2019, Volume 87, Issue 1, pp. 54 - 63
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2019, Volume 381, Issue 21, pp. 2067 - 2069
A forward genetic screen using the worm Caenorhabditis elegans implicated the G protein–coupled receptor 139 in suppressing signaling by the mu opioid... 
MEDICINE, GENERAL & INTERNAL | Caenorhabditis elegans | Usage | Receptors | Control | Animal models in research | Opioids | Genetic aspects | Genetic screening | Methods | Testing
Journal Article
ACS Pharmacology & Translational Science, ISSN 2575-9108, 08/2019, Volume 2, Issue 4, pp. 264 - 274
Journal Article
Die Welt, 05/2019
Newspaper Article
iScience, ISSN 2589-0042, 04/2019, Volume 14, pp. 47 - 57
G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals. The concept of ligand-dependent biased signaling raises the... 
Bioengineering | Biological Sciences | Neuroscience | Physiology | Molecular Biology | Cell Biology | PROTEIN | LIGANDS | MULTIDISCIPLINARY SCIENCES | DISCOVERY
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 04/2019, Volume 23, Issue 4, pp. 315 - 326
Introduction: Pain relief remains a major public health challenge. The most efficient available painkillers are opioids targeting the mu opioid receptor (MOR).... 
allosteric | pain | heteromer | Opioid receptor | addiction | peripherally limited opioid | pH-dependent agonist and endogenous opioid | analogue | biased agonism | opiate | drug | discovery | GPCR | MODERATE | TOXIN | ANTINOCICEPTION | PEPTIDE | PNPP-19 | BUPRENORPHINE | DOPAMINE | NEURONS | PHARMACOLOGY & PHARMACY | ETHNOPHARMACOLOGY
Journal Article
Addiction Biology, ISSN 1355-6215, 01/2019, Volume 24, Issue 1, pp. 28 - 39
Journal Article
FRONTIERS IN PSYCHIATRY, ISSN 1664-0640, 12/2018, Volume 9, p. 643
Mu opioid receptor (MOR) activation facilitates reward processing and reduces pain, and brain networks underlying these effects are under intense... 
in-vivo | MRI | PSYCHIATRY | mu opioid receptor | VOLUME | NEUROANATOMICAL DIFFERENCES | DISTINCT ROLES | mice | MOUSE MODELS | HEROIN | LACKING | PAIN | GENE | anatomical | structural change | ANALGESIA | Brain | Usage | Receptors | Morphometrics (Biology) | Magnetic resonance imaging | Opioids | Research | Health aspects
Journal Article
Communications biology, ISSN 2399-3642, 08/2018, Volume 1, Issue 1, pp. 102 - 14
Orphan G-protein-coupled receptors (oGPCRs) possess untapped potential for drug discovery. In the brain, oGPCRs are generally expressed at low abundance and... 
INTERNATIONAL UNION | RNA | TRANSCRIPTOME | PROTEIN-COUPLED RECEPTOR | GPR88 | BIOLOGY | NEURONS | DOPAMINE | NEURAL CIRCUITS | REWARD | DISCOVERY
Journal Article