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Pediatric Blood & Cancer, ISSN 1545-5009, 01/2015, Volume 62, Issue 1, pp. 3 - 4
Journal Article
Neuro-Oncology, ISSN 1522-8517, 08/2017, Volume 19, Issue 8, pp. 1017 - 1018
Journal Article
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 12/2006, Volume 5, Issue 12, pp. 1640 - 1646
Journal Article
Current cancer drug targets, 2018, Volume 18, Issue 1, p. 57
Central nervous system (CNS) tumors represent the second most prevalent group of cancers in children and adolescents, yet account for the majority of childhood... 
Brain Neoplasms - prevention & control | DNA Methylation | Epigenesis, Genetic | Humans | Adolescent | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Brain Neoplasms - genetics | Disease Management | Child
Journal Article
Nature Nanotechnology, ISSN 1748-3387, 2014, Volume 9, Issue 8, pp. 648 - 655
Journal Article
by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Schmidt, Sabine and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Olaf and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and ICGC PedBrain Tumor Project
Cancer Cell, ISSN 1535-6108, 03/2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
NERVOUS-SYSTEM | TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | PEDIATRIC MEDULLOBLASTOMA | CANCER | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing | Index Medicus
Journal Article
by Jones, David T. W and Hutter, Barbara and Jäger, Natalie and Korshunov, Aney and Kool, Marcel and Warnatz, Hans-Jörg and Zichner, Thomas and Lambert, Sally R and Ryzhova, Marina and Quang, Dong Anh Khuong and Fontebasso, Adam M and Stütz, Aian M and Hutter, Sonja and Zuckermann, Marc and Sturm, Dominik and Gronych, Jan and Lasitschka, Bärbel and Schmidt, Sabine and Seker-Cin, Huriye and Witt, Henik and Sultan, Marc and Ralser, Meryem and Northcott, Paul A and Hovestadt, Volker and Bender, Sebastian and Pfaff, Elke and Stark, Sebastian and Faury, Damien and Schwartzentruber, Jeremy and Majewski, Jacek and Weber, Ursula D and Zapatka, Marc and Raeder, Benjamin and Schlesner, Matthias and Worth, Catherine L and Bartholomae, Cynthia C and von Kalle, Christof and Imbusch, Charles D and Radomski, Sylwester and Lawerenz, Chris and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Versteeg, Rogier and Lehrach, Hans and Monoranu, Camelia and Winkler, Beate and Unterberg, Aneas and Herold-Mende, Christel and Milde, Till and Kulozik, Aneas E and Ebinger, Martin and Schuhmann, Martin U and Cho, Yoon-Jae and Pomeroy, Scott L and von Deimling, Aneas and Witt, Olaf and Taylor, Michael D and Wolf, Stephan and Karajannis, Matthias A and Eberhart, Charles G and Scheurlen, Wolfram and Hasselblatt, Martin and Ligon, Keith L and Kieran, Mark W and Korbel, Jan O and Yaspo, Marie-Laure and Brors, Benedikt and Felsberg, Jörg and Reifenberger, Guido and Collins, V. Peter and Jabado, Nada and Eils, Roland and Lichter, Peter and Pfister, Stefan M and Int Canc Genome Consortium and International Cancer Genome Consortium PedBrain Tumor Project and the International Cancer Genome Consortium PedBrain Tumor Project
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 8, pp. 927 - 932
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i110 - i110
Abstract Abnormal signaling of the RAS/RAF pathway predominates in pediatric low-grade gliomas (PLGGs). Most (85%) non-NF1 low-grade gliomas have... 
Abstracts
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2013, Volume 110, Issue 16, pp. 6530 - 6535
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 2014, Volume 20, Issue 4, pp. 912 - 925
Journal Article
Journal of pediatric hematology/oncology, ISSN 1077-4114, 06/2019, p. 1
Infantile hepatic hemangioendothelioma (IHHE) is the most common hepatic vascular tumor in children. We report on the treatment outcome of our large... 
Journal Article
Circulation, ISSN 0009-7322, 07/2014, Volume 130, Issue 1, pp. 27 - 34
Background-Hutchinson-Gilford progeria syndrome is an ultrarare segmental premature aging disease resulting in early death from heart attack or stroke. There... 
Prenylation | Lonafarnib | Progeria | Atherosclerosis | Aging | Lamins | Kaplan-Meier estimate | atherosclerosis | SYNDROME MUTATION | LONG-TERM | FARNESYLTRANSFERASE INHIBITOR | CARDIAC & CARDIOVASCULAR SYSTEMS | lamins | PROTEIN | lonafarnib | PHENOTYPE | progeria | ZOLEDRONIC ACID | MOUSE MODEL | DISEASE | prenylation | PERIPHERAL VASCULAR DISEASE | aging | OF-THE-LITERATURE | MUTANT LAMIN-A | Atherosclerosis - genetics | Humans | Alkyl and Aryl Transferases - antagonists & inhibitors | Child, Preschool | Male | Young Adult | Piperidines - pharmacology | Nuclear Proteins - deficiency | Diphosphonates - therapeutic use | Imidazoles - therapeutic use | Child | Pravastatin - therapeutic use | Multicenter Studies as Topic - statistics & numerical data | Piperidines - administration & dosage | Progeria - mortality | Pyridines - administration & dosage | Lamin Type A | Genotype | Diphosphonates - administration & dosage | Imidazoles - pharmacology | Protein Precursors - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Pravastatin - administration & dosage | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Adolescent | Progeria - complications | Cohort Studies | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Clinical Trials as Topic - statistics & numerical data | Imidazoles - administration & dosage | Cause of Death | Progeria - drug therapy | Atherosclerosis - etiology | Genes, Dominant | Adult | Female | Drug Therapy, Combination | Nuclear Proteins - genetics | Pyridines - therapeutic use | Pravastatin - pharmacology | Protein Prenylation - drug effects | Protein Precursors - genetics | Kaplan-Meier Estimate | Proportional Hazards Models | Nuclear Proteins - metabolism | Treatment Outcome | Protein Precursors - deficiency | Piperidines - therapeutic use | Dimethylallyltranstransferase - antagonists & inhibitors | Pyridines - pharmacology | Atherosclerosis - prevention & control | Diphosphonates - pharmacology | Care and treatment | Usage | Enzyme inhibitors | Patient outcomes | Genetic aspects | Health aspects | Index Medicus | Abridged Index Medicus | farnesylation | lamin | Hutchinson-Gilford progeria syndrome | FTI
Journal Article