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Molecular Cell, ISSN 1097-2765, 09/2016, Volume 63, Issue 6, pp. 951 - 964
Huntington’s disease is one of several neurodegenerative disorders characterized by the aggregation of polyglutamine (polyQ)-expanded mutant protein. How polyQ... 
POLYGLUTAMINE | PROTEIN | FUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | PHASE-TRANSITION | DISEASE | MUTATIONS | INCLUSION-BODY FORMATION | AGGREGATION | PROTEOSTASIS | CELL BIOLOGY | Protein Aggregates | Neurons - pathology | Humans | Protein Multimerization | Peptides - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Ribosomal Proteins - metabolism | Peptides - metabolism | Neurons - metabolism | Gene Ontology | Green Fluorescent Proteins - metabolism | Gene Expression | HSP40 Heat-Shock Proteins - metabolism | HSP40 Heat-Shock Proteins - genetics | Peptides - chemistry | Ribosomal Proteins - genetics | Huntingtin Protein - metabolism | Molecular Sequence Annotation | Bacterial Proteins - genetics | Solubility | Spectrometry, Fluorescence | Single Molecule Imaging - methods | Protein Interaction Mapping | Animals | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | HeLa Cells | Huntingtin Protein - genetics | Mutation | Luminescent Proteins - metabolism | Ubiquitin | Fluorescence spectroscopy | Nervous system diseases | RNA | Heat shock proteins | Fluorescence | Biosynthesis | Genetic transcription | Oligomers | Analysis | Cellular signal transduction | Research institutes | Binding proteins | Protein binding
Journal Article
01/2019, ISBN 9781392057384
Microsatellite repeat mutations are long expansions of repetitive DNA in the genome. Two Dozen of devastating neurological disorders are associated with the... 
Medicine | Neurosciences | Physiology | Bioinformatics
Dissertation
Annual Review of Biochemistry, ISSN 0066-4154, 01/2013, Volume 82, p. 323
  The biological functions of proteins are governed by their three-dimensional fold. Protein folding, maintenance of proteome integrity, and protein... 
Polypeptides | Protein folding | Pathogenesis | Proteomics | Homeostasis | Biochemistry
Journal Article
Database, ISSN 1758-0463, 2013, Volume 2013, p. bat045
High content studies that profile mouse and human embryonic stem cells (m/hESCs) using various genome-wide technologies such as transcriptomics and proteomics... 
WEB | MATHEMATICAL & COMPUTATIONAL BIOLOGY | RESOURCE | Biomarkers - metabolism | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Publications | Humans | Databases as Topic | Pluripotent Stem Cells - metabolism | Cell Lineage | Animals | High-Throughput Screening Assays | Search Engine | Mice
Journal Article
Journal of molecular biology, ISSN 0022-2836, 7/2009, Volume 390, Issue 3, pp. 516 - 529
The pathological and physiological hallmarks of the protein α-synuclein are its misfolding into cytotoxic aggregates and its binding to synaptic vesicles,... 
sodium lauroyl sarcosinate | membrane proteins | NMR spectroscopy | protein misfolding | α-synuclein
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 07/2009, Volume 390, Issue 3, p. 516
The pathological and physiological hallmarks of the protein [alpha]-synuclein (aS) are its misfolding into cytotoxic aggregates and its binding to synaptic... 
Surface active agents | Physiological aspects | Nuclear magnetic resonance spectroscopy | Sport-utility vehicles | Chemical properties | Membrane proteins
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 10, pp. 8188 - 8196
Huntington disease results from an expanded polyglutamine region in the N terminus of the huntingtin protein. HD pathology is characterized by neuronal... 
Neurotoxicity | Polyglutamine | Huntingtin | Exons | Toxicity | Antibodies | Data processing | Degeneration | Huntington's disease | Hydrogen bonding | Mammalian cells
Journal Article
01/2009, ISBN 1109561628
The interaction between proteins and membranes underlies many important biological processes. Proteins influence the structure and fluidity of membranes and... 
Neurosciences | Biochemistry | Biophysics | Molecular biology
Dissertation
論文提要內容:《奎章全韻》(以下簡稱《奎章》)書成於韓國朝鮮正祖 十六年( 1792)。全書共二卷一冊,原刊本藏於奎章閣與藏書閣。書中 表現的『華音』之音韻現象,顯示它是一部北方官話的韻書。本論主旨在 藉著對《奎章》『華音』之研究,盼能更進一步地了解漢語由中古至現代... 
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Dissertation
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