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Journal of Hypertension, ISSN 0263-6352, 09/2016, Volume 34 Suppl 1 - ISH 2016 Abstract Book, pp. e367 - e367
There is accumulating evidence that RAS inhibitors not only reduce blood pressure, but also exert pleiotropic effects, including a renoprotective effect,... 
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2012, Volume 59, Issue 3, pp. 265 - 276
Journal Article
Journal of Hypertension, ISSN 0263-6352, 09/2016, Volume 34 Suppl 1 - ISH 2016 Abstract Book, pp. e390 - e391
OBJECTIVE:Although hypertensive patients show significant elevation of blood pressure (BP) in acute phase after cerebral infarction, it is still unknown how it... 
Journal Article
American Journal of Medicine, The, ISSN 0002-9343, 2012, Volume 125, Issue 10, pp. 981 - 990
Abstract Background It is unknown whether high-dose angiotensin II receptor blocker therapy or angiotensin II receptor blocker + calcium channel blocker... 
Internal Medicine | Hypertension | Type 2 diabetes | Clinical trials | Cardiovascular disease | Combination therapy | High-dose angiotensin II receptor blocker | Elderly | CALCIUM-CHANNEL BLOCKER | OLMESARTAN MEDOXOMIL | MONOTHERAPY | AZELNIDIPINE | RANDOMIZED-TRIAL | BLOOD-PRESSURE | AMLODIPINE | MEDICINE, GENERAL & INTERNAL | DOUBLE-BLIND | VALSARTAN | Single-Blind Method | Prospective Studies | Follow-Up Studies | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Cardiovascular Diseases - drug therapy | Cardiovascular Diseases - prevention & control | Humans | Calcium Channel Blockers - therapeutic use | Hypertension - drug therapy | Male | Azetidinecarboxylic Acid - analogs & derivatives | Cardiovascular Diseases - complications | Azetidinecarboxylic Acid - therapeutic use | Aged, 80 and over | Cardiovascular Diseases - mortality | Female | Hypertension - mortality | Imidazoles - therapeutic use | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications | Drug Administration Schedule | Japan | Treatment Outcome | Amlodipine - therapeutic use | Dihydropyridines - therapeutic use | Survival Analysis | Hypertension - complications | Tetrazoles - therapeutic use | Aged | Prevention | Safety and security measures | Demographic aspects | Angiotensin II receptor blockers | Dosage and administration | Research | Drug therapy, Combination | Drug therapy | Cardiovascular diseases | Older people | Medical treatment | Asians | Index Medicus | Abridged Index Medicus | Calcium | Diabetes mellitus | Mortality | Blood pressure
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2011, Volume 57, Issue 7, pp. 861 - 869
Journal Article
Kidney International, ISSN 0085-2538, 04/2013, Volume 83, Issue 4, pp. 582 - 592
The accumulation of -cresyl sulfate (PCS), a uremic toxin, is associated with the mortality rate of chronic kidney disease patients; however, the biological... 
p-cresyl sulfate | chronic kidney disease | uremic toxins | indoxyl sulfate | NADPH oxidase | oxidative stress | KAPPA-B | ORGANIC ANION TRANSPORTERS | FAILURE | CRESYLSULPHATE | ENDOTHELIAL-CELLS | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | CHRONIC KIDNEY-DISEASE | EXPRESSION | Cresols - toxicity | Reactive Oxygen Species - metabolism | Epithelial Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | NADPH Oxidases - metabolism | Male | Sulfuric Acid Esters - toxicity | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Transfection | Nephrectomy | RNA Interference | Inflammation Mediators - metabolism | Renal Insufficiency, Chronic - genetics | NADPH Oxidases - genetics | Kidney Tubules, Proximal - enzymology | Cytokines - genetics | Cell Line | Cell Survival - drug effects | Kidney Tubules, Proximal - pathology | Collagen Type I - metabolism | Cytokines - metabolism | Probenecid - pharmacology | Rats | Epithelial Cells - pathology | NADPH Oxidase 4 | Renal Insufficiency, Chronic - enzymology | Rats, Sprague-Dawley | Renal Insufficiency, Chronic - pathology | Animals | Epithelial Cells - enzymology | Fibrosis | Enzyme Activation | Oxidative Stress - drug effects | Renal Insufficiency, Chronic - chemically induced | Kidney Tubules, Proximal - drug effects | Index Medicus
Journal Article
Cardiovascular diabetology, ISSN 1475-2840, 2014, Volume 13, Issue 1, pp. 148 - 148
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 05/2019, Volume 69, Issue 1, pp. 297 - 309
 Alzheimer’s disease (AD) is increasingly viewed as a neurological disease accompanied by a systemic disorder. Accumulating evidence supports that angiotensin... 
Heart | Brain | Peptides | Cognitive ability | Eutrophication | Atrophy | Nest building | Infusion | Head injuries | Cerebral blood flow | Amyloid | Blood pressure | Gastrocnemius muscle | Angiotensin II | Alzheimer's disease | Hypertension | Cortex | Organs | Muscles | Skeletal muscle | Blood flow | Neurological diseases | Musculoskeletal system | Injury prevention | Angiotensin | Mice | Ventricle | Brain injury | Hippocampus
Journal Article
Cardiovascular Diabetology, ISSN 1475-2840, 11/2016, Volume 15, Issue 1, pp. 157 - 157
Background: The potential benefit of SGLT2 inhibitors in metabolic syndrome is with prediabetic stage unclear. This work was undertaken to investigate the... 
Cardiac protection | Oxidative stress | Adipose tissue | Inflammation | Natriuresis | Metabolic syndrome | Prediabetes | SELECTIVE SGLT2 INHIBITOR | GLYCEMIC CONTROL | CARDIAC & CARDIOVASCULAR SYSTEMS | COTRANSPORTER 2 INHIBITORS | BLOOD-PRESSURE | CONSCIOUS RATS | CARDIOVASCULAR INJURY | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | TYPE-2 DIABETES-MELLITUS | BARORECEPTOR REFLEX SENSITIVITY | Prediabetic State - metabolism | Intra-Abdominal Fat - physiopathology | Biomarkers - urine | Cardiomegaly - pathology | Male | Metabolic Syndrome - metabolism | Water-Electrolyte Balance - drug effects | Prediabetic State - drug therapy | Metabolic Syndrome - drug therapy | Adipocytes, White - drug effects | Time Factors | Metabolic Syndrome - physiopathology | Weight Gain - drug effects | Intra-Abdominal Fat - drug effects | Prediabetic State - pathology | Disease Models, Animal | Rats, Inbred SHR | Glucosides - pharmacology | Adiposity - drug effects | Sodium-Glucose Transporter 2 - metabolism | Cardiomegaly - physiopathology | Biomarkers - blood | Intra-Abdominal Fat - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Diuresis - drug effects | Adipocytes, White - pathology | Animals | Cardiomegaly - prevention & control | Prediabetic State - physiopathology | Benzhydryl Compounds - pharmacology | Hemodynamics - drug effects | Intra-Abdominal Fat - pathology | Metabolic Syndrome - pathology | Oxidative Stress - drug effects | Adipocytes, White - metabolism | Cardiomegaly - metabolism | Hypertrophy | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2005, Volume 129, Issue 3, pp. 969 - 984
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 11/2017, Volume 61, Issue 1, pp. 259 - 263
To examine the role of ASK1 in Alzheimer’s disease (AD), we generated 5XFAD mice deficient in ASK1 and investigated the characteristics of old 5XFAD and... 
Brain | Reduction | Neurodegenerative diseases | Pathogenesis | Rodents | Cognitive ability | Acetazolamide | Aging | MAP kinase | Mice | Alzheimer's disease
Journal Article
Hypertension Research, ISSN 0916-9636, 01/2014, Volume 37, Issue 1, pp. 1 - 3
Journal Article
Hypertension Research, ISSN 0916-9636, 2019, Volume 42, Issue 6, pp. 883 - 891
To investigate whether anemia is an independent risk factor for cardiovascular and renal events in hypertensive outpatients, we performed a subgroup analysis... 
cardiovascular disease | Anemia | hypertension | hemoglobin | renal disease | Hypertension | Hemoglobin | Blood pressure | Risk factors
Journal Article