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Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2787 - 2794
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 06/2018, Volume 122, Issue 6, pp. 577 - 587
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0122197
Journal Article
Toxicological Sciences, ISSN 1096-6080, 07/2019, Volume 170, Issue 1, pp. 223 - 233
Abstract Accumulation of toxic endogenous and/or exogenous substances can trigger tissue injury. Multidrug and toxin extrusion proteins (MATEs) are... 
METFORMIN | PYRIMETHAMINE | SALT EXPORT PUMP | TOXIN | PREDICTION | RENAL SECRETION | nephrotoxicity | LIVER-INJURY | transporter-related toxicity | MULTIDRUG | MATE1 inhibition | TRANSPORTER 1 | TOXICOLOGY | mitochondrial toxicity | CELL | cytotoxicity
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 03/2018, Volume 46, Issue 3, pp. 204 - 213
N-{4-Chloro-2-[(1-oxidopyridin-4-yl)carbonyl]phenyl}-4-(propan-2-yloxy)benzenesulfonamide (MLN3126) is an orally available chemokine C-C motif receptor 9... 
INTESTINAL-MUCOSA | PHARMACOLOGY & PHARMACY | GENERATION | PROTEIN | METABOLISM | DISEASE
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2018, Volume 497, Issue 1, pp. 207 - 213
This study aimed to evaluate the effects of combination therapy with a dipeptidyl peptidase-4 inhibitor, alogliptin, and a peroxisome proliferator-activated... 
Hepatic fibrosis | Alogliptin | Nonalcoholic steatohepatitis | Combination therapy | Pioglitazone | DIPEPTIDYL PEPTIDASE-4 INHIBITOR | ACTIVATION | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SITAGLIPTIN | RECEPTOR | BIOPHYSICS | IMPROVES GLYCEMIC CONTROL | INFLAMMATION | OB/OB MICE | LIPID PROFILES | TYPE-2 DIABETES-MELLITUS
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 06/2019, Volume 83, Issue 6, pp. 1000 - 1010
Pulmonary hypertension (PH) is a life-threatening lung disease. PH with concomitant lung diseases, e.g., idiopathic pulmonary fibrosis, is associated with poor... 
cAMP | cGMP | rat model of monocrotaline-induced pulmonary hypertension | FIBROSIS | SILDENAFIL | SMAD3 | PHOSPHODIESTERASE-4 INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | THERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CHEMISTRY, APPLIED | ROFLUMILAST
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2017, Volume 484, Issue 2, pp. 358 - 364
Journal Article
Pharmaceutical research, 04/2019, Volume 36, Issue 5, p. 76
Intranasal administration enhances drug delivery to the brain by allowing targeted-drug delivery. Here, we investigated the properties that render a compound... 
Journal Article