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1. Full Text Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors and Stroke
by Kimura, Genjiro
Circulation Journal, ISSN 1346-9843, 2017
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2. Full Text Diuretic Action of Sodium-Glucose Cotransporter 2 Inhibitors and Its Importance in the Management of Heart Failure
by Kimura, Genjiro
Circulation Journal, ISSN 1346-9843, 2016
Primarily, the sodium-glucose cotransporter 2 (SGLT2) inhibitors suppress the cotransport of glucose and sodium from the tubular lumen of the proximal tubules... 
Heart failure | Loop diuretics | Sodium balance | Diabetes | Aldosterone
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3. Full Text Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors and Stroke
by Kimura, Genjiro
Circulation Journal, ISSN 1346-9843, 2017, Volume 81, Issue 6, pp. 898 - 898
CARDIAC & CARDIOVASCULAR SYSTEMS | EMPA-REG OUTCOME(R) | METAANALYSIS | EMPAGLIFLOZIN | HEART-FAILURE | DISEASE | Diuretics - therapeutic use | Stroke - drug therapy | Stroke - chemically induced | Humans | Diuretics - adverse effects | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Index Medicus
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4. Full Text Kidney and Circadian Blood Pressure Rhythm
by Kimura, Genjiro
Hypertension, ISSN 0194-911X, 04/2008, Volume 51, Issue 4, pp. 827 - 828
SODIUM SENSITIVITY | PERIPHERAL VASCULAR DISEASE | NATRIURESIS | ESSENTIAL-HYPERTENSION | NONDIPPER | Kidney - physiology | Circadian Rhythm - physiology | Hypertension, Renal - physiopathology | Humans | Index Medicus
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5. Importance of inhibiting sodium-glucose co-transporter and its compelling indication in type 2 diabetes-pathophysiology and thrifty genotype hypothesis
by Kimura, Genjiro
Respiration and Circulation, ISSN 0452-3458, 01/2016, Volume 64, Issue 1, pp. 89 - 97
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6. Full Text Response to Wang et al.: Mechanisms for catheter-based renal denervation to lower blood pressure: Personal speculation
by Kimura, Genjiro
Hypertension Research, ISSN 0916-9636, 11/2013, Volume 36, Issue 11, pp. 1008 - 1008
PERIPHERAL VASCULAR DISEASE | PATIENT | FUTURE | HYPERTENSION | NATRIURESIS RELATIONSHIP | SYMPATHETIC-NERVE ABLATION | Sympathetic Nervous System - surgery | Sympathectomy | Humans | Catheter Ablation | Female | Kidney - innervation | Male | Blood Pressure - physiology | Hypertension - surgery | Index Medicus
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7. Nocturnal hypertension and cardio-renal association
by Kimura, Genjiro
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 2014, Volume 72, Issue 8, pp. 1404 - 1409
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8. Full Text The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2014)
by Shimamoto, Kazuaki and Ando, Katsuyuki and Fujita, Toshiro and Hasebe, Naoyuki and Higaki, Jitsuo and Horiuchi, Masatsugu and Imai, Yutaka and Imaizumi, Tsutomu and Ishimitsu, Toshihiko and Ito, Masaaki and Ito, Sadayoshi and Itoh, Hiroshi and Iwao, Hiroshi and Kai, Hisashi and Kario, Kazuomi and Kashihara, Naok and Kawano, Yuhei and Kim-Mitsuyama, Shokei and Kimura, Genjiro and Kohara, Katsuhiko and Komuro, Issei and Kumagai, Hiroo and Matsuura, Hideo and Miura, Katsuyuki and Morishita, Ryuichi and Naruse, Mitsuhide and Node, Koichi and Ohya, Yusuke and Rakugi, Hiromi and Saito, Ikuo and Saitoh, Shigeyuki and Shimada, Kazuyuki and Shimosawa, Tatsuo and Suzuki, Hiromichi and Tamura, Kouichi and Tanahashi, Norio and Tsuchihashi, Takuya and Uchiyama, Makoto and Ueda, Shinichiro and Umemura, Satoshi and Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
Hypertension Research, ISSN 0916-9636, 2014, Volume 37, Issue 4, pp. 253 - 390
Hypertension - drug therapy | Hypertension - therapy | Antihypertensive Agents - therapeutic use | Humans | Index Medicus
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9. Full Text Future of catheter-based renal denervation: Key issues to solve
by Kimura, Genjiro
Hypertension Research, ISSN 0916-9636, 06/2013, Volume 36, Issue 6, pp. 492 - 493
CONTROLLED-TRIAL | PRESSURE | PHYSIOLOGY | SYMPATHETIC DENERVATION | RESISTANT HYPERTENSION | PERIPHERAL VASCULAR DISEASE | PATIENT | NERVE ABLATION | DIFFICULT-TO-CONTROL | Sympathetic Nervous System - surgery | Sympathectomy | Humans | Catheter Ablation | Female | Kidney - innervation | Male | Blood Pressure - physiology | Hypertension - surgery | Index Medicus
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10. Full Text The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)
by Ogihara, Toshio and Kikuchi, Kenjiro and Matsuoka, Hiroaki and Fujita, Toshiro and Higaki, Jitsuo and Horiuchi, Masatsugu and Imai, Yutaka and Imaizumi, Tsutomu and Ito, Sadayoshi and Iwao, Hiroshi and Kario, Kazuomi and Kawano, Yuhei and Kim-Mitsuyama, Shokei and Kimura, Genjiro and Matsubara, Hiroaki and Matsuura, Hideo and Naruse, Mitsuhide and Saito, Ikuo and Shimada, Kazuyuki and Shimamoto, Kazuaki and Suzuki, Hiromichi and Takishita, Shuichi and Tanahashi, Norio and Tsuchihashi, Takuya and Uchiyama, Makoto and Ueda, Shinichiro and Ueshima, Hirotsugu and Umemura, Satoshi and Ishimitsu, Toshihiko and Rakugi, Hiromi and Japanese Society of Hypertension Committee
Hypertension Research, ISSN 0916-9636, 2009, Volume 32, Issue 1, pp. 3 - 107
Japan - epidemiology | Life Style | Humans | Hypertension - drug therapy | Antihypertensive Agents - therapeutic use | Hypertension - pathology | Antihypertensive Agents - adverse effects | Hypertension - complications | Adult | Aged | Blood Pressure - drug effects | Blood Pressure - physiology | Hypertension - epidemiology | Hypertension - therapy | Child | Patient Education as Topic | Index Medicus
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11. Full Text 110th Scientific Meeting of the Japanese Society of Internal Medicine: Educational lecture: 9. How to use diuretics based on pathophysiology?
by Kimura, Genjiro
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, ISSN 0021-5384, 09/2013, Volume 102, Issue 9, pp. 2413 - 2417
Kidney Tubules - physiopathology | Diuretics - administration & dosage | Sodium Chloride Symporter Inhibitors - pharmacology | Diuretics - pharmacology | Humans | Index Medicus
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12. Full Text Salt sensitivity and circadian rhythm of blood pressure: the keys to connect CKD with cardiovasucular events
by Kimura, Genjiro and Dohi, Yasuaki and Fukuda, Michio
Hypertension Research, ISSN 0916-9636, 06/2010, Volume 33, Issue 6, pp. 515 - 520
In healthy subjects, blood pressure (BP) drops by 10-20% during the night. Conversely, in patients with the salt-sensitive type of hypertension or chronic... 
Salt | Circadian rhythm | Natriuresis | Non-dipper | Kidney | natriuresis | salt | non-dipper | PRIMARY ALDOSTERONISM | kidney | GLOMERULAR-FILTRATION-RATE | DIETARY-SODIUM RESTRICTION | INSULIN-RESISTANCE | circadian rhythm | PERIPHERAL VASCULAR DISEASE | ESSENTIAL-HYPERTENSION | CHRONIC KIDNEY-DISEASE | WATER TANK MODEL | NATRIURESIS RELATIONSHIP | CHRONIC-RENAL-FAILURE | CARDIOVASCULAR RISK-FACTORS
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13. Full Text 9. How to Use Diuretics Based on Pathophysiology?
by Kimura, Genjiro
Nihon Naika Gakkai Zasshi, ISSN 0021-5384, 2013, Volume 102, Issue Suppl, pp. 132 - 132b
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14. Full Text 110th Scientific Meeting of the Japanese Society of Internal Medicine: Educational lecture: 9. How to use diuretics based on pathophysiology?
by Kimura, Genjiro
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, ISSN 0021-5384, 2013, Volume 102, Issue 9, pp. 2413 - 2417
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15. Full Text 9. How to Use Diuretics Based on Pathophysiology?
by Kimura, Genjiro
Nihon Naika Gakkai Zasshi, ISSN 0021-5384, 2013, Volume 102, Issue 9, pp. 2413 - 2417
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16. Full Text Diuretics shift circadian rhythm of blood pressure from nondipper to dipper in essential hypertension
by Uzu, Takashi and Kimura, Genjiro
Circulation, ISSN 0009-7322, 10/1999, Volume 100, Issue 15, pp. 1635 - 1638
Background-Recently, we found that sodium restriction shifted the circadian rhythm of blood pressure from nondipper to dipper in patients with the... 
Diuretics | Blood pressure | Circadian rhythm | Kidney | DIABETES-MELLITUS | blood pressure | kidney | DIETARY-SODIUM RESTRICTION | CARDIAC & CARDIOVASCULAR SYSTEMS | NOCTURNAL DECLINE | REDUCTION | diuretics | circadian rhythm | SENSITIVITY | PERIPHERAL VASCULAR DISEASE | CHRONIC-RENAL-FAILURE | Index Medicus | Abridged Index Medicus
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17. Full Text Uric Acid Levels Predict Future Development of Chronic Kidney Disease
by Sonoda, Hiroo and Takase, Hiroyuki and Dohi, Yasuaki and Kimura, Genjiro
American Journal of Nephrology, ISSN 0250-8095, 04/2011, Volume 33, Issue 4, pp. 352 - 357
Aims: Increased uric acid levels are associated with kidney dysfunction. We tested the hypothesis that uric acid level predicts future development of chronic... 
Original Report: Patient-Oriented, Translational Research | Observational study | Chronic kidney disease | Uric acid | Glomerular filtration rate | OXIDATION | MORTALITY | POPULATION | RENAL-DISEASE | PREVALENCE | HYPERURICEMIA | RISK-FACTOR | CARDIOVASCULAR-DISEASE | UROLOGY & NEPHROLOGY | COHORT | PROGRESSION | Body Mass Index | Glomerular Filtration Rate | Kidney Failure, Chronic - diagnosis | Prospective Studies | Humans | Middle Aged | Risk Factors | Male | Renal Insufficiency, Chronic - blood | Regression Analysis | Dyslipidemias - blood | Kidney Failure, Chronic - blood | Time Factors | Female | Renal Insufficiency, Chronic - diagnosis | Aged | Uric Acid - blood | Index Medicus
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18. Full Text Angiotensin receptor blockers shift the circadian rhythm of blood pressure by suppressing tubular sodium reabsorption
by Michio Fukuda and Tamaki Wakamatsu-Yamanaka and Masashi Mizuno and Toshiyuki Miura and Tatsuya Tomonari and Yoko Kato and Tadashi Ichikawa and Sota Miyagi and Yuichi Shirasawa and Akinori Ito and Atsuhiro Yoshida and Genjiro Kimura
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 11/2011, Volume 301, Issue 5, pp. 953 - 957
Recently, we found that an angiotensin II receptor blocker (ARB) restored the circadian rhythm of the blood pressure (BP) from a nondipper to a dipper pattern,... 
Salt | Glomerulotubular balance | Olmesartan | Nondipper | Chronic kidney disease (CKD) | PHYSIOLOGY | salt | olmesartan | nondipper | SENSITIVITY | RESTRICTION | chronic kidney disease (CKD) | glomerulotubular balance | DIABETIC NEPHROPATHY | TYPE-2 DIABETES | UROLOGY & NEPHROLOGY | ESSENTIAL-HYPERTENSION | ANTIHYPERTENSIVE THERAPY | IRBESARTAN | DIURETICS | NATRIURESIS RELATIONSHIP | Tetrazoles - pharmacology | Kidney Tubules - drug effects | Natriuresis - drug effects | Humans | Middle Aged | Male | Imidazoles - pharmacology | Sodium - metabolism | Creatinine - urine | Angiotensin II Type 2 Receptor Blockers - pharmacology | Kidney Function Tests | Young Adult | Sodium - urine | Adolescent | Adult | Female | Aged | Blood Pressure - drug effects | Glomerular Filtration Barrier - drug effects | Kidney Tubules - metabolism | Circadian Rhythm - drug effects | Kidney Diseases - metabolism | Circadian rhythms | Receptors | Angiotensin | Physiological aspects | Sodium in the body | Blood pressure | Hemodynamics | Research | Health aspects | Circadian rhythm | Kidney diseases | Sodium | ACE inhibitors | Index Medicus
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19. Full Text Increased double product on Monday morning during work
by Kimura, Genjiro and Inoue, Nobutaka and Mizuno, Hiroumi and Izumi, Masaaki and Nagatoya, Katsuyuki and Ohtahara, Akira and Munakata, Masanori and Takano, H and Sameshima, M and Sakihara, T and Sasaki, T and Munakata, M and Konno, S and Yoshinari, K and Okubo, S and Yamanouchi, M and Kondo, T and Omura, M and Sugisawa, C and Sasagawa, T and Sato, N and Kinuno, H and Shinoda, E and Makino, Y and Uetani, T and Kato, M and Mizuno, H and Nagatoya, K and Izumi, M and Inoue, N and Hayashi, Y and Ohtahara, A and Nanba, S and Hondo, T and Seki, K and Satoh, A and Iwata, Y and Kuroda, T and Takatsu, Takatsu and Yamasa, T and Matsumura, T and Workplace Hypertension Co-Operativ and Workplace Hypertension Co-operative Study by 29 Rosai Hospitals belonging to the Japan Organization of Occupational Health and Safety
Hypertension Research, ISSN 0916-9636, 07/2017, Volume 40, Issue 7, pp. 671 - 674
It has been reported that cardiovascular events often occur on Monday morning, especially in the young working population. Because hypertension is a major... 
blood pressure | stress | heart rate | workplace hypertension | cardiovascular event | double product | POPULATION | METAANALYSIS | RISK | BLOOD-PRESSURE | DISEASES | ACUTE MYOCARDIAL-INFARCTION | GENDER | PERIPHERAL VASCULAR DISEASE | EXCESS CARDIAC MORTALITY | BURDEN | Blood Pressure | Heart Rate | Humans | Middle Aged | Female | Male | Occupational Stress - physiopathology | Circadian Rhythm | Health risk assessment | Blood pressure | Index Medicus | cardiovascular event; workplace hypertension | Original
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20. Full Text Distribution of central blood pressure values estimated by Omron HEM-9000AI in the Japanese general population
by Takase, Hiroyuki and Dohi, Yasuaki and Kimura, Genjiro
Hypertension Research, ISSN 0916-9636, 01/2013, Volume 36, Issue 1, pp. 50 - 57
Central blood pressure is more closely associated with cardiovascular events and target organ damage than peripheral blood pressure measured over the brachium... 
arterial stiffness | cardiovascular risk | tonometer | pressure waveform | MORTALITY | METAANALYSIS | CARDIOVASCULAR EVENTS | WAVE REFLECTION | CENTRAL AORTIC PRESSURE | ALL-CAUSE | PULSE | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | CLINICAL-OUTCOMES | Japan - epidemiology | Humans | Middle Aged | Blood Pressure Determination - instrumentation | Oscillometry - instrumentation | Male | Risk Management | Young Adult | Manometry - instrumentation | Pulsatile Flow - physiology | Aged, 80 and over | Adult | Female | Blood Pressure - physiology | Hypertension - diagnosis | Radial Artery - physiology | Cross-Sectional Studies | Oscillometry - methods | Hypertension - physiopathology | Blood Pressure Determination - methods | Hypertension - ethnology | Vascular Stiffness - physiology | Aged | Asian Continental Ancestry Group - statistics & numerical data | Brachial Artery - physiology | Manometry - methods | Index Medicus
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