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1. Full Text The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)
by Yamagami, Keitaro and Kurogi, Ryota and Kurogi, Ai and Nishimura, Kunihiro and Onozuka, Daisuke and Ren, Nice and Kada, Akiko and Nishimura, Ataru and Arimura, Koichi and Ido, Keisuke and Mizoguchi, Masahiro and Sakamoto, Tetsuya and Kayama, Takamasa and Suzuki, Michiyasu and Arai, Hajime and Hagihara, Akihito and Iihara, Koji and Masayoshi, Takigami and Kenji, Kamiyama and Kiyohiro, Houkin and Shougo, Nishi and Tetsuyuki, Yoshimoto and Sadao, Kaneko and Koji, Oka and Hiroshi, Ooyama and Kyousuke, Kamada and Kenichi, Makino and Naoki, Tokumitsu and Kazuhiro, Sako and Susumu, Suzuki and Nozomi, Suzuki and Naoto, Izumi and Kazumi, Nitta and Masahumi, Ootaki and Masanori, Isobe and Mikio, Nishiya and Takaaki, Yamazaki and Syouji, Mabuchi and Kuniaki, Ogasawara and Naohiko, Kubo and Yukihiko, Shimizu and Keiichi, Saito and Tatumi, Yamanome and Atsuo, Yoshino and Mitsuyuki, Fujitsuka and Masaaki, Takami and Hirotoshi, Ohtaka and Teruyuki, Hirano and Yosiaki, Shiokawa and Takaharu, Okada and Ichiro, Suzuki and Michihiro, Kohno and Jou, Haraoka and Yoshinori, Arai and Noriyoshi, Kawamura and Akira, Isoshima and Masaharu, Yasue and Mitsuhiko, Hokari and Takayoshi, Kobayashi and Kensuke, Kawai and Taketoshi, Maehara and Hajime, Arai and Makoto, Noguchi and Haruhiko, Hoshino and Hirofumi, Hiyama and Kensaku, Yoshida and Osamu, Utsugi and Yasuaki, Takeda and Kouichi, Tamaki and Hirohide, Karasudani and Takao, Urabe and Shiro, Kobayashi and Michio, Nakamura and Yorio, Koguchi and Junichi, Ono and Sumio, Suda and Hiromu, Hadeishi and Toshio, Fukutake and Kenji, Wakui and Hirokazu, Tanno and Naoki, Ishige and Takashi, Ohasi and Hideki, Sakai and Yasuaki, Nishimura and Takayuki, Watanabe and Takashi, Matsumoto and Naoki, Koketsu and Yuichi, Hirose and Manabu, Doyu and Toshinori, Hasegawa and Naoto, Kuwayama and Shinichi, Terao and Nobuhiko, Mizutani and Noriyuki, Suzaki and Satoshi, Okuda and Keizo, Yasui and Yukio, Seki and Yasuhiro, Hasegawa and Akira, Ikeda and Youtarou, Takeuchi and ... and J-ASPECT Study Collaborators
World Neurosurgery, ISSN 1878-8750, 2019
Background: The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging... 
Aging | Hospital mortality | Prognosis | Traumatic brain injury | Subdural hematoma | Index Medicus
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2. Full Text Japanese nationwide surveillance in 2011 of antibacterial susceptibility patterns of clinical isolates from complicated urinary tract infection cases
by Ishikawa, Kiyohito and Hamasuna, Ryoichi and Uehara, Shinya and Yasuda, Mitsuru and Yamamoto, Shingo and Hayami, Hiroshi and Takahashi, Satoshi and Matsumoto, Tetsuro and Minamitani, Shinichi and Kadota, Jun-ichi and Iwata, Satoshi and Kaku, Mitsuo and Watanabe, Akira and Sunakawa, Keisuke and Sato, Junko and Hanaki, Hideaki and Tsukamoto, Taiji and Kiyota, Hiroshi and Egawa, Shin and Deguchi, Takashi and Matsumoto, Minori and Tanaka, Kazushi and Arakawa, Soichi and Fujisawa, Masato and Kumon, Hiromi and Kobayashi, Kanao and Matsubara, Akio and Wakeda, Hironobu and Amemoto, Yoshinosuke and Onodera, Shoichi and Goto, Hirokazu and Komeda, Hisao and Yamashita, Masuo and Takenaka, Tadasu and Fujimoto, Yoshinori and Tsugawa, Masaya and Takahashi, Yoshito and Maeda, Hiroshi and Onishi, Hiroyuki and Ishitoya, Satoshi and Nishimura, Kazuo and Mitsumori, Kenji and Ito, Toru and Togo, Yoshikazu and Nakamura, Ichiro and Ito, Noriyuki and Kanamaru, Sojun and Hirose, Takaoki and Muranaka, Takashi and Yamada, Daisuke and Ishihara, Satoshi and Oka, Hiroya and Inatomi, Hisato and Matsui, Takashi and Kobuke, Makoto and Kunishima, Yasuharu and Kimura, Takahiro and Ichikawa, Takaharu and Kagara, Ichiro and Matsukawa, Masanori and Takahashi, Koichi and Mita, Koji and Kato, Masao and Okumura, Kazuhiro and Kawanishi, Hiroaki and Hashimura, Takayuki and Aoyama, Teruyoshi and Shigeta, Masanobu and Koda, Shuntaro and Taguchi, Keisuke and Matsuda, Yohei
Journal of Infection and Chemotherapy, ISSN 1341-321X, 2015, Volume 21, Issue 9, pp. 623 - 633
Abstract To investigate antimicrobial susceptibility patterns of various bacterial pathogens isolated from complicated urinary tract infection (UTI) cases, the... 
Hematology, Oncology and Palliative Medicine | Surveillance | Complicated urinary tract infection | Susceptibility | INFECTIOUS DISEASES | RISK-FACTORS | METAANALYSIS | ACUTE UNCOMPLICATED CYSTITIS | PYELONEPHRITIS | MINIMUM INHIBITORY CONCENTRATION | STAPHYLOCOCCUS-AUREUS INFECTIONS | RESISTANT ESCHERICHIA-COLI | PHARMACOLOGY & PHARMACY | SPECTRUM BETA-LACTAMASES | OUTCOMES | ASSOCIATION | Enterococcus faecalis - drug effects | Klebsiella pneumoniae - drug effects | Serratia marcescens - drug effects | Escherichia coli - drug effects | Humans | Middle Aged | Male | Microbial Sensitivity Tests | Drug Resistance, Multiple, Bacterial | Vancomycin - pharmacology | Linezolid - pharmacology | Aged, 80 and over | Female | Urinary Tract Infections - microbiology | Ampicillin - pharmacology | Klebsiella oxytoca - drug effects | Japan | Methicillin-Resistant Staphylococcus aureus - drug effects | Ciprofloxacin - pharmacology | Pseudomonas aeruginosa - drug effects | Amikacin - pharmacology | Imipenem - pharmacology | Gram-Negative Bacteria - drug effects | Fluoroquinolones - pharmacology | Aged | Anti-Bacterial Agents - pharmacology | Population Surveillance | Proteus mirabilis - drug effects | Index Medicus
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3. Full Text Simple and Accurate Electrocardiographic Criteria to Differentiate Takotsubo Cardiomyopathy From Anterior Acute Myocardial Infarction
by Kosuge, Masami, MD and Ebina, Toshiaki, MD and Hibi, Kiyoshi, MD and Morita, Satoshi, PhD and Okuda, Jun, MD and Iwahashi, Noriaki, MD and Tsukahara, Kengo, MD and Nakachi, Tatsuya, MD and Kiyokuni, Masayoshi, MD and Ishikawa, Toshiyuki, MD and Umemura, Satoshi, MD and Kimura, Kazuo, MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2010, Volume 55, Issue 22, pp. 2514 - 2516
  The combination of the presence of ST-segment depression in lead aVR and the absence of ST-segment elevation in lead V1 identified TC with 91% sensitivity,... 
Cardiovascular | Internal Medicine | CARDIAC & CARDIOVASCULAR SYSTEMS | Severity of Illness Index | Diagnosis, Differential | Humans | Middle Aged | Male | Takotsubo Cardiomyopathy - diagnosis | Coronary Angiography | Sensitivity and Specificity | Electrocardiography | Female | Aged | Retrospective Studies | Anterior Wall Myocardial Infarction - diagnosis | Anterior Wall Myocardial Infarction - diagnostic imaging | Cohort Studies | Heart attack | Heart attacks | Medical imaging | Cardiomyopathy | Index Medicus | Abridged Index Medicus
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4. Full Text LSR antibody therapy inhibits ovarian epithelial tumor growth by inhibiting lipid uptake
by Hiramatsu, Kosuke and Serada, Satoshi and Enomoto, Takayuki and Takahashi, Yusuke and Nakagawa, Satoshi and Nojima, Satoshi and Morimoto, Akiko and Matsuzaki, Shinya and Yokoyama, Takuhei and Takahashi, Tsuyoshi and Fujimoto, Minoru and Takemori, Hiroshi and Ueda, Yutaka and Yoshino, Kiyoshi and Morii, Eiichi and Kimura, Tadashi and Naka, Tetsuji
Cancer Research, ISSN 0008-5472, 01/2018, Volume 78, Issue 2, pp. 516 - 527
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, but it still lacks effective treatment options. In this study, we utilized proteomic... 
SURVIVAL | WOMEN | POPULATION | LIPOLYSIS-STIMULATED RECEPTOR | ONCOLOGY | METASTATIC BREAST-CANCER | MONOCLONAL-ANTIBODY | HER2 | BLOCKADE | CHEMOTHERAPY | PLUS | Cell Proliferation | Prognosis | Follow-Up Studies | Receptors, Lipoprotein - immunology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Male | Neoplasms, Glandular and Epithelial - immunology | Case-Control Studies | Receptors, Lipoprotein - metabolism | Neoplasm Recurrence, Local - immunology | Neoplasm Recurrence, Local - pathology | Tissue Distribution | Biomarkers, Tumor - metabolism | Adult | Female | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Neoplasms, Glandular and Epithelial - pathology | Antibody-Dependent Cell Cytotoxicity | Neoplasm Recurrence, Local - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Neoplasm Recurrence, Local - therapy | Neoplasms, Glandular and Epithelial - therapy | Survival Rate | Xenograft Model Antitumor Assays | Animals | Lipids - pharmacokinetics | Mice, Nude | Proteomics | Carcinoma, Ovarian Epithelial | Ovarian Neoplasms - therapy | Aged | Mice | Mice, Inbred BALB C | Apoptosis | Ovarian Neoplasms - immunology | Cell proliferation | Cell culture | Therapy | Animal models | Ovarian carcinoma | Toxicity | Xenotransplantation | Cytotoxicity | Lipids | Omentum | Malignancy | Tissues | Lymph nodes | Metastases | Ovarian cancer | Immunotherapy | Xenografts | Biocompatibility | Lipid metabolism | Inhibition | Antigens | Organs | Metabolism | Lipoproteins (very low density) | Lipolysis | Survival analysis | Medical prognosis | Cell lines | Monoclonal antibodies | Tumors | Cancer | Index Medicus
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5. Full Text Association Between Gait Speed as a Measure of Frailty and Risk of Cardiovascular Events After Myocardial Infarction
by Matsuzawa, Yasushi, MD and Konishi, Masaaki, MD, PhD and Akiyama, Eiichi, MD and Suzuki, Hiroyuki, MD and Nakayama, Naoki, MD, PhD and Kiyokuni, Masayoshi, MD, PhD and Sumita, Shinichi, MD, PhD and Ebina, Toshiaki, MD, PhD and Kosuge, Masami, MD, PhD and Hibi, Kiyoshi, MD, PhD and Tsukahara, Kengo, MD, PhD and Iwahashi, Noriaki, MD, PhD and Endo, Mitsuaki, MD, PhD and Maejima, Nobuhiko, MD and Saka, Kenichiro, MD and Hashiba, Katsutaka, MD and Okada, Kozo, MD and Taguri, Masataka, PhD and Morita, Satoshi, PhD and Sugiyama, Seigo, MD, PhD and Ogawa, Hisao, MD, PhD and Sashika, Hironobu, MD, PhD and Umemura, Satoshi, MD, PhD and Kimura, Kazuo, MD, PhD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2013, Volume 61, Issue 19, pp. 1964 - 1972
Objectives This study sought to determine the additional clinical value of gait speed to Framingham risk score (FRS), cardiac function, and comorbid conditions... 
Cardiovascular | Internal Medicine | gait speed | physical function | prognosis | myocardial infarction | MORTALITY | SURVIVAL | CARDIAC & CARDIOVASCULAR SYSTEMS | FUNCTIONING OLDER-ADULTS | DEATH | RECLASSIFICATION | DISCRIMINATION | WALKING SPEED | DISEASE | CURVE | COHORT | Myocardial Infarction - surgery | Japan - epidemiology | Predictive Value of Tests | Myocardial Infarction - mortality | Prospective Studies | Gait | Comorbidity | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Male | Frail Elderly - statistics & numerical data | Aged, 80 and over | Female | Aged | Walking - statistics & numerical data | Percutaneous Coronary Intervention | Heart | Sects | Enzymes | Medical colleges | Enzyme inhibitors | Angiotensin | Heart attack | Risk factors | Natriuretic peptides | Cardiac patients | Cardiology | Cardiovascular agents | Hospitalization | Heart attacks | Older people | Mortality | Index Medicus | Abridged Index Medicus
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6. Full Text Nationwide Post Event Survey and Analysis of the 2011 Tohoku Earthquake Tsunami
by Mori, Nobuhito and Takahashi, Tomoyuki and 2011 Tohoku Earthquake Tsunami Joint Survey Group and THE 2011 TOHOKU EARTHQUAKE TSUNAMI JOINT SURVEY GROUP
Coastal Engineering Journal, ISSN 2166-4250, 03/2012, Volume 54, Issue 1, pp. 1250001-1 - 1250001-27
At 14:46 local time on March 11, 2011, a magnitude 9.0 earthquake occurred off the coast of northeast Japan. This earthquake generated a tsunami that struck... 
inundation height | Tsunami | run-up height | post event survey | ENGINEERING, CIVIL | SRI-LANKA | ENGINEERING, OCEAN | INDIAN-OCEAN TSUNAMI | Surveys | Tsunamis | Earthquakes | Japan | Databases | Earthquake engineering | Satellite navigation systems | Coastal environments | Seismic phenomena | Inundation | Global Positioning System
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7. Full Text Estimation of Driver Workload Based on a Model of Accelerator Pedal Control While Controlling Vehicle Velocity
by Hamaguchi, Takeshi, author and Inoue, Satoshi, author and Kimura, Shigeyuki, author and Endo, Terumasa, author
SAE technical paper series, Volume 2016-01-1412.
In driver-focused vehicle development, driver workload is generally evaluated subjectively, with physiological, psychological, and behavioral indexes used to... 
Biomechanics | Human factors | Reaction and response times
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8. Full Text The Efficacy of Reduced-dose Dasatinib as a Subsequent Therapy in Patients with Chronic Myeloid Leukemia in the Chronic Phase: The LD-CML Study of the Kanto CML Study Group
by Iriyama, Noriyoshi and Ohashi, Kazuteru and Hashino, Satoshi and Kimura, Shinya and Nakaseko, Chiaki and Takano, Hina and Hino, Masayuki and Uchiyama, Michihiro and Morita, Satoshi and Sakamoto, Junichi and Sakamaki, Hisashi and Inokuchi, Koiti
Internal Medicine, ISSN 0918-2918, 2018, Volume 57, Issue 1, pp. 17 - 23
Objective The aim of this study was to prospectively investigate the efficacy and safety profiles of low-dose dasatinib therapy (50 mg once daily). Methods... 
chronic myeloid leukemia | low-dose dasatinib | LD-CML study | Chronic myeloid leukemia | Low-dose dasatinib | CHRONIC MYELOGENOUS LEUKEMIA | NATURAL-KILLER | SAFETY | BCR-ABL | FOLLOW-UP | MEDICINE, GENERAL & INTERNAL | IMATINIB-RESISTANT | MATURE NK CELLS | JAPANESE PATIENTS | DEEP MOLECULAR RESPONSE | LYMPHOCYTES | Therapy | Imatinib | Effusion | Transcription | Toxicity | Myeloid leukemia | Leukemia | Pleural effusion | Cytotoxicity | Lymphocytosis | Patients | Index Medicus | Original
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9. Full Text Nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS): first analysis on survival
by Ito, Kazuto and Saito, Shiro and Yorozu, Atsunori and Kojima, Shinsuke and Kikuchi, Takashi and Higashide, Satoshi and Aoki, Manabu and Koga, Hirofumi and Satoh, Takefumi and Ohashi, Toshio and Nakamura, Katsumasa and Katayama, Norihisa and Tanaka, Nobumichi and Nakano, Masahiro and Shigematsu, Naoyuki and Dokiya, Takushi and Fukushima, Masanori and J-POPS Investigators and For the J-POPS Investigators
International Journal of Clinical Oncology, ISSN 1341-9625, 12/2018, Volume 23, Issue 6, pp. 1148 - 1159
Investigating oncological outcomes in patients registered in the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS) in... 
External beam radiation therapy | Iodine-125 | Medicine & Public Health | Oncology | Cancer Research | Brachytherapy | Surgical Oncology | Prostate cancer | ANDROGEN SUPPRESSION | DEFINITION | BIOCHEMICAL FAILURE | ANTIGEN BOUNCE | RADIATION | ONCOLOGY | PSA KINETICS | MEN | RECTAL MORBIDITY | RADIOTHERAPY | Research | Oncology, Experimental | Analysis | Patient outcomes | Cancer | Index Medicus
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10. Full Text An Early and Simple Predictor of Severe Left Main and/or Three-Vessel Disease in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome
by Kosuge, Masami, MD and Ebina, Toshiaki, MD and Hibi, Kiyoshi, MD and Morita, Satoshi, PhD and Endo, Mitsuaki, MD and Maejima, Nobuhiki, MD and Iwahashi, Noriaki, MD and Okada, Kozo, MD and Ishikawa, Toshiyuki, MD and Umemura, Satoshi, MD and Kimura, Kazuo, MD
American Journal of Cardiology, The, ISSN 0002-9149, 2011, Volume 107, Issue 4, pp. 495 - 500
Clopidogrel should be initiated as soon as possible in patients with non–ST-segment elevation acute coronary syndrome (NSTE-ACS) except those who urgently... 
Cardiovascular | DEPRESSION | DIAGNOSIS | ARTERY-BYPASS SURGERY | ELECTROCARDIOGRAM | CARDIAC & CARDIOVASCULAR SYSTEMS | CLOPIDOGREL | ADMISSION | PROGNOSTIC UTILITY | LEAD AVR | UNSTABLE ANGINA | OUTCOMES | Multivariate Analysis | Predictive Value of Tests | Prognosis | Ticlopidine - therapeutic use | Humans | Middle Aged | Acute Coronary Syndrome - physiopathology | Male | Troponin T - blood | Acute Coronary Syndrome - pathology | Sensitivity and Specificity | Coronary Artery Disease - pathology | Aged, 80 and over | Electrocardiography | Adult | Female | Retrospective Studies | Platelet Aggregation Inhibitors - therapeutic use | Severity of Illness Index | Risk Assessment | Acute Coronary Syndrome - diagnostic imaging | Treatment Outcome | Biomarkers - blood | Ticlopidine - analogs & derivatives | Coronary Angiography | Heart Conduction System - physiopathology | Acute Coronary Syndrome - diagnosis | Coronary Artery Bypass | Acute Coronary Syndrome - therapy | Aged | Early Diagnosis | Heart | Clinical medicine | Acute coronary syndromes | Cardiology | Heart surgery | Patients | Index Medicus | Abridged Index Medicus
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11. Full Text Preparation and Optical and Electrochemical Properties of Phthalocyanines with Four or Eight Diphenylphosphino, Diphenylphosphoryl, and Diphenylthiophosphinyl Groups
by Kimura, Takeshi and Muraoka, Hiroki and Nakajo, Shiduko and Ogawa, Satoshi and Yamamoto, Satoshi and Kobayashi, Nagao
European Journal of Organic Chemistry, ISSN 1434-193X, 03/2018, Volume 2018, Issue 10, pp. 1255 - 1264
Several phthalocyanines (Pcs), in which four or eight phosphines are directly linked to their periphery, have been prepared. The starting materials,... 
Electrochemistry | Spectroscopy | Phosphorus | Molecular orbitals | Phthalocyanines | Functional organic materials | SPECTROSCOPIC PROPERTIES | CRYSTAL-STRUCTURE | NUCLEOPHILIC-SUBSTITUTION | CHEMISTRY, ORGANIC | PERIPHERAL SUBSTITUENTS | PORPHYRIN DIMERS | ELEMENT-CARBON BOND | PHOSPHORUS(V) OCTAETHYLPORPHYRINS | P(O)H COMPOUNDS | AXIAL LIGANDS | METAL-FREE | Sulfur compounds | Chemical properties | Electrochemical analysis | Refluxing | Toluene | Optical properties | Absorption spectra | Sulfur | Phosphines
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12. Full Text Chamber Music (Recorder) - CAREY, J.D. / IKEGAMI, Satoshi / NAKANISHI, Satoru / SHANNON, G. (Super Recorder Quartet, Vol. 3)
by Carey, James Duncan and Kosma, Joseph and Davis, Stan and Denza, Luigi and Gruber, Franz Xaver and Ikegami, Satoshi and Kimura, Tomoyuki and Sandrin, Pierre and Coots, J. Fred and Bratton, John and Nakanishi, Satoru and Shannon, Glen
2017, Naxos Music Library
Classical Music
Streaming Audio
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13. Full Text Region-Specific Activation of CRTC1-CREB Signaling Mediates Long-Term Fear Memory
by Nonaka, Mio and Kim, Ryang and Fukushima, Hotaka and Sasaki, Kazuki and Suzuki, Kanzo and Okamura, Michiko and Ishii, Yuichiro and Kawashima, Takashi and Kamijo, Satoshi and Takemoto-Kimura, Sayaka and Okuno, Hiroyuki and Kida, Satoshi and Bito, Haruhiko
Neuron, ISSN 0896-6273, 10/2014, Volume 84, Issue 1, pp. 92 - 106
CREB is a pivotal mediator of activity-regulated gene transcription that underlies memory formation and allocation. The contribution of a key CREB cofactor,... 
CIRCADIAN CLOCK | ENERGY-BALANCE | NEURONAL SURVIVAL | KEY REGULATOR | CAMP-RESPONSIVE ELEMENT | ELEMENT-BINDING PROTEIN | CREB COACTIVATOR TORC2 | DEPENDENT GENE-TRANSCRIPTION | UP-REGULATION | EXPRESSION | NEUROSCIENCES | Animals, Newborn | Humans | Mice, Inbred C57BL | Cells, Cultured | Rats | Male | Fear - physiology | Mice, Inbred ICR | Transcription Factors - metabolism | Hippocampus - metabolism | Animals | Cyclic AMP Response Element-Binding Protein - metabolism | Signal Transduction - physiology | Mice | Neurons - metabolism | Memory - physiology | Medical colleges | Phosphatases | Genetic transcription | Proteins | Phosphorylation | Brain-derived neurotrophic factor | Cognition & reasoning | Neurons | Rodents | Memory | Colleges & universities | Science | Nervous system | Kinases | Gene expression | Index Medicus
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