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Science, ISSN 0036-8075, 10/1999, Volume 286, Issue 5441, pp. 971 - 974
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 09/2017, Volume 58, Issue 9, pp. 2127 - 2133
Improving therapy for relapsed/refractory AML remains a challenge. We performed a retrospective analysis of outcomes following decitabine treatment in 34... 
AML | relapsed AML | Decitabine | acute myeloid leukemia | refractory AML | 1ST-LINE TREATMENT | MULTICENTER | INDUCTION CHEMOTHERAPY | PHASE-II | TRIAL | THERAPY | OLDER PATIENTS | DOSE CYTARABINE | ONCOLOGY | STEM-CELL TRANSPLANTATION | HEMATOLOGY | MYELODYSPLASTIC SYNDROMES
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2518 - 2518
Abstract Introduction Improving therapy for rel/ref AML remains a challenge. Decitabine, a DNA methyl-transferase inhibitor, initially showed promise in AML as... 
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2012, Volume 14, Issue 3, pp. 318 - 328
Repair of DNA double-strand breaks is critical to genomic stability and the prevention of developmental disorders and cancer. A central pathway for this repair... 
TARGET | SPINDLE-CHECKPOINT | NUCLEAR RIBONUCLEOPROTEIN-G | REPAIR | STABILIZATION | TAO1 | DOUBLE-STRAND BREAKS | MAMMALIAN-CELLS | PROMOTES | EXPRESSION | CELL BIOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Histone Chaperones - genetics | Humans | Histone Chaperones - metabolism | Homologous Recombination | Immunoblotting | Green Fluorescent Proteins - genetics | Gene Regulatory Networks | Nuclear Pore Complex Proteins - genetics | RNA Interference | Cell Cycle Proteins - genetics | RNA Precursors - metabolism | Nuclear Proteins - genetics | Rad51 Recombinase - metabolism | Green Fluorescent Proteins - metabolism | Rad51 Recombinase - genetics | Nuclear Pore Complex Proteins - metabolism | Cell Cycle Proteins - metabolism | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Nuclear Proteins - metabolism | RNA Precursors - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Genome, Human - genetics | Heterogeneous-Nuclear Ribonucleoproteins - genetics | Transcription Factors - metabolism | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | DNA Repair | Cell Line, Tumor | Models, Genetic | DNA Damage | BRCA2 Protein - genetics | Microscopy, Fluorescence | RNA-Binding Proteins - metabolism | Proteins | Physiological aspects | Research | Binding proteins | DNA damage | Ribonucleoproteins
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7599, pp. 398 - 401
USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes(1-9). Its effects on protein turnover are... 
PROTEIN | UBP6 | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | CYCLIN B1 | DEGRADATION | MECHANISMS | PROVIDES | 26S PROTEASOME | SUFFICIENT | EXPRESSION | Protein research | Research | Cyclin B proteins | Ubiquitin-proteasome system | Proteins | Molecular biology | Enzymes
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 01/2011, Volume 6, Issue 1, pp. 47 - 60
In the 12 years since the process of RNA interference (RNAi) was first discovered, great progress has been made in understanding its mechanism and exploiting... 
siRNA or miRNA seed sequence | RISC | microRNA (miRNA) | GENOME-WIDE RNAI | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | Short interfering RNA (siRNA) | FUNCTIONAL DISSECTION | MAMMALIAN-CELLS | DEPENDENT STIMULATION | SMALL INTERFERING RNAS | MESSENGER-RNAS | RNA Interference | RNAI off-target effect | GENE-EXPRESSION | C-ELEGANS | siRNA multiplicity validation | HIV-1 REPLICATION | RNA, Small Interfering - genetics | Gene Expression | Down-Regulation | Genomics | RNA, Messenger - genetics | Untranslated Regions | Validation Studies as Topic | Transcription, Genetic | MicroRNAs - genetics | RNA, Double-Stranded - chemistry | Genetic Techniques - standards | RNA, Small Interfering - metabolism | Short interfering RNA (siRNA): An endogenous or artificial (synthetic) small double strand RNA with perfect pairing of the two strands. One strand (called the guide strand) targets RISC to perfectly complementary mRNAs, resulting in endonucleolytic cleavage of the mRNA by the RISC component Ago2 | siRNA or miRNA seed sequence: The 5′ region of the guide strand of an siRNA or miRNA sequence, extending from nucleotides 2–7 (hexamer) or 2–8 (heptamer) | or mRNA decay | siRNA multiplicity validation: Validation of a gene-phenotype association by showing that the phenotype can be produced by multiple independent siRNAs that target different regions of the same mRNA | MicroRNA (miRNA): A mature endogenous small double strand RNA, often with imperfect pairing of the two strands, originating from processing of a precursor RNA molecule by cellular RNases. miRNAs target RISC complexes to sites that have imperfect sequence complementarity, and that are typically located in the 3′ untranslated region of the mRNA | RISC: The RNA-Induced Silencing Complexes are multi-protein complexes containing an Argonaute protein, a small single strand RNA and additional regulatory proteins | RNA interference: A cellular process that downregulates gene expression at a post-transcriptional step. One strand of a small double strand RNA (siRNA or miRNA) integrates in a protein complex called RISC and targets an mRNA with sequence complementarity for cleavage, translation inhibition and | RNAi off-target effect: Any effect of an RNAi-based treatment that is a consequence of reducing the expression of an unintended target
Journal Article