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science & technology (12) 12
humans (10) 10
life sciences & biomedicine (10) 10
ubiquitin (10) 10
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ubiquitination (7) 7
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1. Full Text Ubiquitin modifications
by Kirby N Swatek David Komander
Cell research, ISSN 1001-0602, 2016, Volume 26, Issue 4, pp. 399 - 422
N-末端 | 翻译后修饰 | 细胞数量 | 赖氨酸 | 泛素化 | 磷酸化 | 蛋白质 | 真核生物 | post-translational modification | phosphorylation | proteasomal degradation | ubiquitin | Parkin | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | Signal Transduction | Humans | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Ubiquitination | Animals | Cell Cycle | Sumoylation | Lysine - metabolism | Parkinson Disease - metabolism | Acetylation | Proteasome Endopeptidase Complex - metabolism | Index Medicus | Review
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2. Full Text Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
by Wauer, Tobias and Swatek, Kirby N and Wagstaff, Jane L and Gladkova, Christina and Pruneda, Jonathan N and Michel, Martin A and Gersch, Malte and Johnson, Christopher M and Freund, Stefan MV and Komander, David
The EMBO journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 307 - 325
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Enzymes | Phosphorylation | Kinases | Crystal structure | Index Medicus
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3. Full Text OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death
by Damgaard, Rune Busk and Elliott, Paul R and Swatek, Kirby N and Maher, Eamonn R and Stepensky, Polina and Elpeleg, Orly and Komander, David and Berkun, Yackov
EMBO molecular medicine, ISSN 1757-4676, 03/2019, Volume 11, Issue 3, p. n/a
deubiquitinases | inflammatory disease | cell death | TNF signalling | ubiquitin | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Endopeptidases - metabolism | Humans | Ubiquitin - metabolism | Male | NF-kappa B - metabolism | Signal Transduction - genetics | Endopeptidases - deficiency | Mutation - genetics | Endopeptidases - chemistry | Inflammation - metabolism | Cell Death - genetics | Cell Death - physiology | Proteomics | Inflammation - genetics | Female | Signal Transduction - physiology | Protein Processing, Post-Translational | Ubiquitination - physiology | Ubiquitination - genetics | Fibroblasts - metabolism | Ubiquitin | Tumor necrosis factor | Cell death | Transplantation | Biochemistry | Skin | Hematopoietic stem cells | Phenotypes | Therapeutic applications | Pathogenesis | Methionine | Stem cell transplantation | Diarrhea | Protein biosynthesis | Inflammation | Leukocytes | Patients | Cycloheximide | Monocytes | Cell activation | Stem cells | Fibroblasts | Skin diseases | Remission | Mutation | Binding sites | Apoptosis | Index Medicus | Immunology | Genetics, Gene Therapy & Genetic Disease
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4. Full Text Insights into ubiquitin chain architecture using Ub-clipping
by Swatek, Kirby N and Usher, Joanne L and Kueck, Anja F and Gladkova, Christina and Mevissen, Tycho E. T and Pruneda, Jonathan N and Skern, Tim and Komander, David
Nature (London), ISSN 0028-0836, 08/2019, Volume 572, Issue 7770, pp. 533 - 537
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Polyubiquitin - metabolism | Protein Kinases - metabolism | Glycine - metabolism | HCT116 Cells | Humans | Ubiquitin - chemistry | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Mitophagy | Ubiquitination | Glycine - chemistry | HeLa Cells | Polyubiquitin - chemistry | Peptide Hydrolases - metabolism | Ubiquitin | Structure | Analysis | Proteomics | Residues | Enzymes | Phosphorylation | Peptides | Chain branching | Mass spectroscopy | Mapping | Substrates | Complexity | Depolarization | Proteins | Mitochondria | Post-translation | Clipping | Scientific imaging | Parkin protein | Acetylation | Polymers | Mass spectrometry | Endoplasmic reticulum | Combinatorial analysis | Index Medicus
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5. Full Text Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling
by Michel, Martin A and Swatek, Kirby N and Hospenthal, Manuela K and Komander, David
Molecular cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 233 - 246.e5
X-ray crystallography | mitophagy | HUWE1 | microscale thermophoresis | Mfn2 | Lys6-linked ubiquitin chains | affimer | Parkin | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Ubiquitin - metabolism | Substrate Specificity | Crystallography, X-Ray | Mitochondrial Proteins - genetics | GTP Phosphohydrolases - chemistry | Ubiquitination | Mitochondrial Proteins - metabolism | Cloning, Molecular | Escherichia coli - metabolism | HEK293 Cells | Carrier Proteins - chemistry | Lysine - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Gene Expression | Protein Structure, Secondary | Signal Transduction | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ubiquitin - genetics | Ubiquitin-Protein Ligases - chemistry | Amino Acid Motifs | Carrier Proteins - genetics | Molecular Probes - chemistry | Carrier Proteins - metabolism | GTP Phosphohydrolases - metabolism | Escherichia coli - genetics | GTP Phosphohydrolases - genetics | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein Processing, Post-Translational | HeLa Cells | Kinetics | Lysine - chemistry | Ubiquitin-Protein Ligases - genetics | Tumor Suppressor Proteins | Ubiquitin | Structure | Ligases | Fluorescence microscopy | Crystals | Viral antibodies | Chemical tests and reagents | Fluorescence | Antibodies | Nucleic acids | Molecular biology | Index Medicus
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6. Full Text Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin
by Michel, Martin A and Elliott, Paul R and Swatek, Kirby N and Simicek, Michal and Pruneda, Jonathan N and Wagstaff, Jane L and Freund, Stefan M.V and Komander, David
Molecular cell, ISSN 1097-2765, 04/2015, Volume 58, Issue 1, pp. 95 - 109
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Recombinant Fusion Proteins - metabolism | Endopeptidases - chemistry | Ubiquitination | Proteolysis | Escherichia coli - metabolism | HEK293 Cells | Lysine - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Endopeptidases - metabolism | Signal Transduction | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Ubiquitin - genetics | Recombinant Fusion Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | Endopeptidases - genetics | Escherichia coli - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Protein Processing, Post-Translational | Proteasome Endopeptidase Complex - metabolism | Lysine - chemistry | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Ligases | Analysis | Medical research | Crystals | Medicine, Experimental | Molecular biology | Structure | Index Medicus
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7. Full Text Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling
by Ordureau, Alban and Paulo, Joao A and Zhang, Jiuchun and An, Heeseon and Swatek, Kirby N and Cannon, Joe R and Wan, Qiaoqiao and Komander, David and Harper, J. Wade
Molecular cell, ISSN 1097-2765, 03/2020, Volume 77, Issue 5, pp. 1124 - 1142.e10
ubiquitin ligase | deubiquitylating enzyme | Ub-clipping | mitophagyĆ | USP30 | ubiquitin | quantitative proteomics | Parkin | p97 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Ubiquitin | Embryonic stem cells | Molecular biology | Ligases | Analysis | Index Medicus
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