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Methods in molecular biology (Clifton, N.J.), 2020, Volume 2055, p. 93
In immuno-oncology (IO), the baseline host factors attract significant clinical interest as promising predictive biomarker candidates primarily due to the... 
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0140478
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have... 
D-RECEPTOR POLYMORPHISMS | WOMEN | VARIANTS | DETERMINANTS | MULTIDISCIPLINARY SCIENCES | 25(OH)D | D-BINDING PROTEIN | SERUM | D PATHWAY | PLASMA 25-HYDROXYVITAMIN D | Prospective Studies | Vitamin D3 24-Hydroxylase - genetics | Hydroxycholecalciferols - metabolism | Humans | Middle Aged | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics | Receptors, Calcitriol - genetics | Case-Control Studies | Cytochrome P450 Family 2 | Sweden | Female | Oxidoreductases Acting on CH-CH Group Donors - genetics | Hydroxycholecalciferols - blood | Genetic Predisposition to Disease | Genome-Wide Association Study | Genotype | Signal Transduction - genetics | Breast Neoplasms - genetics | Vitamin D-Binding Protein - genetics | Cholestanetriol 26-Monooxygenase - genetics | Retinoid X Receptor alpha - genetics | Breast Neoplasms - blood | Aged | Polymorphism, Single Nucleotide | Cohort Studies | Complications and side effects | Usage | Care and treatment | Vitamin D | Calcifediol | Breast cancer | Genetic aspects | Single nucleotide polymorphisms | Alfacalcidol | Research | Health aspects | Haplotypes | Cytochrome | Genes | 7-Dehydrocholesterol reductase | Risk | Population studies | Genomes | Retinoid X receptor α | Single-nucleotide polymorphism | Proteins | Metabolites | Population | 25-Hydroxyvitamin D | Statistical analysis | Cytochrome P450 | Health risks | Metabolism | Medicine | Studies | Signaling | Hospitals | Womens health | Biomarkers | Breast | Vitamin D receptors | Health risk assessment | Cancer | Clinical Medicine | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cancer and Oncology | Klinisk medicin | Cell- och molekylärbiologi | Cancer och onkologi
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2016, Volume 6, Issue 1, p. 31191
While the role of genetic risk factors in the etiology of uveal melanoma (UM) has been strongly suggested, the genetic susceptibility to UM is currently vastly... 
OCA2 | IDENTIFY | HERC2 | COLOR | MULTIDISCIPLINARY SCIENCES | MUTATIONS | GENOME-WIDE ASSOCIATION | Eye | Genetic markers | Etiology | Color | Melanoma | Single-nucleotide polymorphism | Genomes | Genetic factors | Health risk assessment | Pigmentation | Risk factors
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2011, Volume 17, Issue 8, pp. 941 - 943
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2007, Volume 39, Issue 11, pp. 1338 - 1349
Many cancer-associated genes remain to be identified to clarify the underlying molecular mechanisms of cancer susceptibility and progression. Better... 
ZYG-9 FORM | COMPLEX | CAENORHABDITIS-ELEGANS | PROTEIN | AMPLIFICATION | GENETIC INSTABILITY | TAC-1 | GENETICS & HEREDITY | C-ELEGANS | BRCA1 | MUTATIONS | Oligonucleotide Array Sequence Analysis | Humans | Ubiquitin - metabolism | Gene Expression Profiling | Gene Regulatory Networks | Case-Control Studies | BRCA2 Protein - antagonists & inhibitors | BRCA1 Protein - metabolism | Hyaluronan Receptors - metabolism | Polymerase Chain Reaction | Biomarkers, Tumor - metabolism | Centrosome - physiology | Female | Extracellular Matrix Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Neural Networks (Computer) | Genetic Predisposition to Disease | Extracellular Matrix Proteins - antagonists & inhibitors | Extracellular Matrix Proteins - genetics | RNA, Small Interfering - pharmacology | Computational Biology | Protein-Serine-Threonine Kinases - genetics | Aurora Kinases | Hyaluronan Receptors - genetics | Protein Interaction Mapping | BRCA1 Protein - genetics | BRCA2 Protein - metabolism | Breast Neoplasms - genetics | BRCA1 Protein - antagonists & inhibitors | Biomarkers, Tumor - genetics | BRCA2 Protein - genetics | Complications and side effects | Gene mutations | Genes | Breast cancer | Genetic aspects | Research | Identification and classification | Risk factors | Genetic research | Models | Cellular biology | Gene expression | Genomics
Journal Article
by Antoniou, Antonis C and Wang, Xianshu and Fredericksen, Zachary S and McGuffog, Lesley and Tarrell, Robert and Sinilnikova, Olga M and Healey, Sue and Morrison, Jonathan and Kartsonaki, Christiana and Lesnick, Timothy and Ghoussaini, Maya and Barrowdale, Daniel and Peock, Susan and Cook, Margaret and Oliver, Clare and Frost, Debra and Eccles, Diana and Evans, D. Gareth and Eeles, Ros and Izatt, Louise and Chu, Carol and Douglas, Fiona and Paterson, Joan and Stoppa-Lyonnet, Dominique and Houdayer, Claude and Mazoyer, Sylvie and Giraud, Sophie and Lasset, Christine and Remenieras, Auey and Caron, Olivier and Hardouin, Agnès and Berthet, Pascaline and Hogervorst, Frans B. L and Rookus, Matti A and Jager, Agnes and van den Ouweland, Ans and Hoogerbrugge, Nicoline and van der Luijt, Rob B and Meijers-Heijboer, Hanne and Gómez García, Encarna B and Devilee, Peter and Vreeswijk, Maaike P. G and Lubinski, Jan and Jakubowska, Anna and Gronwald, Jacek and Huzarski, Tomasz and Byrski, Tomasz and Górski, Bohdan and Cybulski, Cezary and Spurdle, Amanda B and Holland, Helene and Goldgar, David E and John, Esther M and Hopper, John L and Southey, Melissa and Buys, Sauna S and Daly, Mary B and Terry, Mary-Beth and Schmutzler, Rita K and Wappenschmidt, Barbara and Engel, Christoph and Meindl, Alfons and Preisler-Adams, Sabine and Arnold, Norbert and Niederacher, Dieter and Sutter, Christian and Domchek, Susan M and Nathanson, Katherine L and Rebbeck, Timothy and Blum, Joanne L and Piedmonte, Marion and Roiguez, Gustavo C and Wakeley, Katie and Boggess, John F and Basil, Jack and Blank, Stephanie V and Friedman, Eitan and Kaufman, Bella and Laitman, Yael and Milgrom, Roni and Anulis, Irene L and Glendon, Gord and Ozcelik, Hilmi and Kirchhoff, Tomas and Vijai, Joseph and Gaudet, Mia M and Altshuler, David and Guiducci, Candace and Loman, Niklas and Harbst, Katja and Rantala, Johanna and Ehrencrona, Hans and Gerdes, Anne-Marie and Thomassen, Mads and Sunde, Lone and Peterlongo, Paolo and Manoukian, Siranoush and Bonanni, Bernardo and Viel, Alessana and Radice, Paolo and ... and KConFab and EMBRACE and GEMO Study Collaborators and GENICA and MOD SQUAD and HEBON and SWE-BRCA and kConFab and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för genetik och patologi and Uppsala universitet
Nature genetics, ISSN 1061-4036, 2010, Volume 42, Issue 10, pp. 885 - 892
Journal Article
Journal of Translational Medicine, ISSN 1479-5876, 04/2018, Volume 16, Issue 1, pp. 82 - 82
Background: Immune checkpoint inhibitors (anti-CTLA-4, anti-PD-1, or the combination) enhance anti-tumor immune responses, yielding durable clinical benefit in... 
Antibodies | Biomarker | Toxicity | Immunotherapy | Melanoma | PATHWAYS | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | COMBINED NIVOLUMAB | INDUCTION | BIOMARKERS | ANTI-CTLA-4 | CUTANEOUS MELANOMA | BLOCKADE | IPILIMUMAB | Physiological aspects | Care and treatment | Research | Patient outcomes
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182483
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10173 - 8
Multiple primary melanoma (MPM) has been associated with a higher 10-year mortality risk compared to patients with single primary melanoma (SPM). Given that... 
UNITED-STATES | SURVIVAL | POPULATION | IDENTIFIES 3 | RISK-FACTORS | DENDRITIC CELLS | GENE | MULTIDISCIPLINARY SCIENCES | CUTANEOUS MELANOMA | TRANSCRIPTION FACTOR PU.1 | GENOME-WIDE ASSOCIATION | Genetic variance | Genotyping | Immunomodulation | Melanoma | Genetic diversity | Survival | Immune system
Journal Article