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PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Immune system | Neurodegenerative diseases | Secretion | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, p. e0162717
Parkinson's disease (PD) is histologically described by the deposition of alpha-synuclein, whose accumulation in Lewy bodies causes dopaminergic neuronal... 
SIGNALING PATHWAYS | OXIDATIVE STRESS | ACTIVATES MICROGLIA | THP-1 CELLS | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TARGET | MUTATION | NORMAL MOUSE-BRAIN | FAMILIAL PARKINSONS-DISEASE | NF-KAPPA-B | NEURODEGENERATIVE DISEASES | Microglia - metabolism | Gene Expression | Parkinson Disease - pathology | Reactive Oxygen Species - metabolism | Signal Transduction | Humans | Cells, Cultured | Mutant Proteins - genetics | Mutant Proteins - metabolism | Parkinson Disease - genetics | Point Mutation | Inflammation - metabolism | Animals | Inflammation Mediators - metabolism | Inflammation - genetics | Microglia - pathology | Mice | Parkinson Disease - metabolism | alpha-Synuclein - genetics | alpha-Synuclein - metabolism | Amino Acid Substitution | Gene mutations | Genetic aspects | Cell culture | Oxidative stress | Phosphorylation | Neurosciences | Transcription factors | Parkinson's disease | Disease | Laboratories | Neurobiology | Activation | Kinases | Synuclein | Proteins | Antioxidants | Stimulators | Neurodegeneration | Cascades | Tumor necrosis factor-TNF | Physiology | Life sciences | Degeneration | Movement disorders | Communication | Dopamine receptors | NF-κB protein | Dopamine | Neurodegenerative diseases | Neurons | Inflammation | Mutants | Microglia | Lewy bodies | Signaling | Brain research | Reactivity | Mutation
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 06/2019, Volume 16, pp. 419 - 433
Interleukin-6 (IL-6)-type cytokines share the common receptor glycoprotein 130 (gp130), which activates a signaling cascade involving Janus kinases (JAKs) and... 
microRNAs | cytokine | signal transduction | inflammation | liver | STAT3 | gp130 | cancer | interleukin-6 | JAK1
Journal Article
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 11/2018, Volume 104, Issue 5, pp. 969 - 985
Interleukin‐27 (IL27) is a type‐I cytokine of the IL6/IL12 family and is predominantly secreted by activated macrophages and dendritic cells. We show that IL27... 
cytokine | OSM | interferon | IFN‐γ | IDO‐1 | IFN-γ | IDO-1 | NATURAL-KILLER-CELLS | COMPLETE REGRESSION | IL-27 | IMMUNOLOGY | CANCER | TH1 DIFFERENTIATION | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | IFN-gamma | INTERFERON-GAMMA | INTERLEUKIN-27 | REGULATORY T-CELLS | HEMATOLOGY
Journal Article
Cytokine, ISSN 1043-4666, 11/2015, Volume 76, Issue 1, p. 99
IL-6 plays important roles in regulation of liver functions and promotes hepatocarcinogenesis. As the contribution of IL-6-induced miRNAs to these effects is... 
Development and progression | Liver diseases | MicroRNA
Journal Article
Journal Article
Arthritis Research & Therapy, ISSN 1478-6354, 12/2008, Volume 10, p. R141
Interleukin-6 (IL-6) is thought to play a pathogenic role in rheumatoid arthritis and synovium is a major source of IL-6 release. We investigated the ability... 
Rheumatoid arthritis | Physiological aspects | Cytokine receptors | Development and progression | Retinoids | Research | Interleukin-6
Journal Article
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