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SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10292 - 15
We developed a novel series of antimalarial compounds based on a 4-cyano-3-methylisoquinoline. Our lead compound MB14 achieved modest inhibition of the growth... 
INVASION | TRANSPORTER | MULTIDISCIPLINARY SCIENCES | MUTATION | RESISTANCE | DEPENDENT PROTEIN-KINASE | MALARIA PARASITE | CANDIDATE | CATION ATPASE PFATP4 | IDENTIFICATION | SPIROINDOLONE KAE609 | Malaria | Sodium | Antimalarial agents | Erythrocytes | Membrane permeability | Lysis | Genomes | Parasites | Permeability
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2019, Volume 294, Issue 14, pp. 5720 - 5734
The Plasmodium falciparum ATPase PfATP4 is the target of a diverse range of antimalarial compounds, including the clinical drug candidate cipargamin. PfATP4... 
Na+ pump | SURVIVAL | INTRAERYTHROCYTIC MALARIA PARASITE | protozoan parasite | PROTEIN | ATPase | BIOCHEMISTRY & MOLECULAR BIOLOGY | cipargamin | sodium transporter | TgATP4 | malaria | SPIROINDOLONE | PFATP4 | Toxoplasma gondii | drug action | PLASMODIUM-FALCIPARUM | CATION ATPASE | membrane transport | NA+ | X-RAY-MICROANALYSIS | EXTRUSION
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 8795 - 15
Four hundred structurally diverse drug-like compounds comprising the Medicines for Malaria Venture's 'Pathogen Box' were screened for their effect on a range... 
TARGET | ACID | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | CANDIDATE | CATION ATPASE PFATP4 | EXTRUSION
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2018, Volume 293, Issue 34, pp. 13327 - 13337
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2018, Volume 62, Issue 6
For an increasing number of antimalarial agents identified in high-throughput phenotypic screens, there is evidence that they target PfATP4, a putative Na+... 
Transporters | PfATP4 | Antimalarial agents | KAE609 | TARGET | INTRAERYTHROCYTIC MALARIA PARASITE | antimalarial agents | ACID | transporters | MEMBRANE-PERMEABILITY | MICROBIOLOGY | SPIROINDOLONE ANTIMALARIALS | PLASMODIUM-FALCIPARUM | PHARMACOLOGY & PHARMACY | RED-BLOOD-CELLS | ERYTHROCYTE | CATION ATPASE PFATP4 | EXTRUSION
Journal Article
Journal Article
Journal Article
ACS Infectious Diseases, ISSN 2373-8227, 01/2017, Volume 3, Issue 1, pp. 34 - 44
Journal Article
ACS Central Science, ISSN 2374-7943, 10/2016, Volume 2, Issue 10, pp. 687 - 701
The development of new antimalarial compounds remains a pivotal part of the strategy for malaria elimination. Recent large-scale phenotypic screens have... 
MEDICINAL CHEMISTRY | OPEN INNOVATION | TARGET | SPIROINDOLONE ANTIMALARIALS | TROPICAL DISEASES | PLASMODIUM-FALCIPARUM | STARTING POINTS | CYCLOPROPYL CARBOXAMIDES | OPEN-SOURCE SOFTWARE | MALARIA PARASITE | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
by Van Voorhis, Wesley C and Adams, John H and Adelfio, Roberto and Ahyong, Vida and Akabas, Myles H and Alano, Pietro and Alday, Aintzane and Alemán Resto, Yesmalie and Alsibaee, Aishah and Alzualde, Ainhoa and Andrews, Katherine T and Avery, Simon V and Avery, Vicky M and Ayong, Lawrence and Baker, Mark and Baker, Stephen and Ben Mamoun, Choukri and Bhatia, Sangeeta and Bickle, Quentin and Bounaadja, Lotfi and Bowling, Tana and Bosch, Jürgen and Boucher, Lauren E and Boyom, Fabrice F and Brea, Jose and Brennan, Marian and Burton, Audrey and Caffrey, Conor R and Camarda, Grazia and Carrasquilla, Manuela and Carter, Dee and Belen Cassera, Maria and Chih-Chien Cheng, Ken and Chindaudomsate, Worathad and Chubb, Anthony and Colon, Beatrice L and Colón-López, Daisy D and Corbett, Yolanda and Crowther, Gregory J and Cowan, Noemi and D’Alessandro, Sarah and Le Dang, Na and Delves, Michael and DeRisi, Joseph L and Du, Alan Y and Duffy, Sandra and Abd El-Salam El-Sayed, Shimaa and Ferdig, Michael T and Fernández Robledo, José A and Fidock, David A and Florent, Isabelle and Fokou, Patrick V. T and Galstian, Ani and Gamo, Francisco Javier and Gokool, Suzanne and Gold, Ben and Golub, Todd and Goldgof, Gregory M and Guha, Rajarshi and Guiguemde, W. Armand and Gural, Nil and Guy, R. Kiplin and Hansen, Michael A. E and Hanson, Kirsten K and Hemphill, Andrew and Hooft van Huijsduijnen, Rob and Horii, Takaaki and Horrocks, Paul and Hughes, Tyler B and Huston, Christopher and Igarashi, Ikuo and Ingram-Sieber, Katrin and Itoe, Maurice A and Jadhav, Ajit and Naranuntarat Jensen, Amornrat and Jensen, Laran T and Jiang, Rays H. Y and Kaiser, Annette and Keiser, Jennifer and Ketas, Thomas and Kicka, Sebastien and Kim, Sunyoung and Kirk, Kiaran and Kumar, Vidya P and Kyle, Dennis E and Lafuente, Maria Jose and Landfear, Scott and Lee, Nathan and Lee, Sukjun and Lehane, Adele M and Li, Fengwu and Little, David and Liu, Liqiong and Llinás, Manuel and Loza, Maria I and Lubar, Aristea and Lucantoni, Leonardo and Lucet, Isabelle and Maes, Louis and Mancama, Dalu and ...
PLoS Pathogens, ISSN 1553-7366, 07/2016, Volume 12, Issue 7, pp. e1005763 - e1005763
Journal Article