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DNA repair, 12/2018, Volume 74, p. 17
DNA replication fidelity maintains low mutation rates in bacteria. The ε-subunit of a replisome generally acts as the main proofreader during replication,... 
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2014, Volume 370, Issue 11, pp. 1019 - 1028
Journal Article
DNA Repair, ISSN 1568-7864, 02/2019, Volume 74, pp. 17 - 25
DNA replication fidelity maintains low mutation rates in bacteria. The ε-subunit of a replisome generally acts as the main proofreader during replication,... 
Replication | Exonuclease | Inhibition | DNA polymerase | Mycobacterium tuberculosis | SELECTIVE-INHIBITION | DNA-POLYMERASES | FIDELITY | PATHWAY | THERMUS-THERMOPHILUS HB8 | PYROPHOSPHATE | GENETICS & HEREDITY | TOXICOLOGY | EXCISION | BINDING | SUBUNIT | REVEALS | Index Medicus
Journal Article
eLife, ISSN 2050-084X, 07/2016, Volume 5, Issue JULY
Enhanced expression of the MYC transcription factor is observed in the majority of tumors. Two seemingly conflicting models have been proposed for its... 
CHIP-SEQ | TRANSFORMATION | METABOLISM | DNA | TRANSCRIPTION | BIOLOGY | C-MYC | BINDING | EXPRESSION | NEGATIVE FEEDBACK LOOP | GENOME | Observations | Genetic regulation | Promoters (Genetics) | Proteins | Ontology | Gene regulation | Ordinary differential equations | Affinity | Mathematical models | Myc protein | Gene expression | Ribonucleic acid--RNA | Promoters | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
PLoS Biology, ISSN 1544-9173, 2014, Volume 12, Issue 9, pp. e1001954 - e1001954
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, pp. 5680 - 5680
We recently identified a high prevalence of mutations affecting the catalytic (C alpha) subunit of protein kinase A (PKA) in cortisol-secreting adrenocortical... 
CYCLASE | CYCLIC-AMP | MCCUNE-ALBRIGHT SYNDROME | HOLOENZYME | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | ADRENAL-TUMORS | PHOSPHODIESTERASE | HYPERPLASIA | SOMATIC MUTATIONS | CAMP | Adrenocortical Adenoma - enzymology | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - chemistry | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - genetics | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Cushing Syndrome - enzymology | Cushing Syndrome - pathology | Adrenocortical Adenoma - genetics | Protein Stability | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - metabolism | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - chemistry | Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Adrenal Cortex Neoplasms - enzymology | Catalytic Domain | Cushing Syndrome - genetics | Adrenal Cortex Neoplasms - pathology | Adrenocortical Adenoma - pathology | Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - genetics | Adrenal Cortex Neoplasms - genetics | Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - chemistry | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics | Cell Line, Tumor | Protein Binding | Mutation | Index Medicus
Journal Article
Structure, ISSN 0969-2126, 01/2018, Volume 26, Issue 1, pp. 137 - 144.e3
Ctf18-RFC is an alternative PCNA loader which plays important but poorly understood roles in multiple DNA replication-associated processes. To fulfill its... 
replication fork stalling | DNA replication | PCNA | architecture of the eukaryotic replisome | protein-DNA interactions | winged-helix domains | cohesion establishment | DNA polymerase epsilon | clamp loader | protein-protein interactions | SISTER-CHROMATID COHESION | CELL NUCLEAR ANTIGEN | EUKARYOTIC REPLISOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-POLYMERASE EPSILON | ESTABLISHMENT | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | SLIDING CLAMP | LOADER COMPLEX | BIOPHYSICS | REPLICATION FORK | S-PHASE | Saccharomyces cerevisiae - genetics | Protein Multimerization | Substrate Specificity | Crystallography, X-Ray | DNA Polymerase II - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Replication Protein C - chemistry | Protein Interaction Domains and Motifs | Binding Sites | DNA Polymerase II - genetics | Binding, Competitive | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Chromosomal Proteins, Non-Histone - metabolism | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | DNA Replication | Recombinant Proteins - genetics | DNA - metabolism | Replication Protein C - metabolism | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | DNA Polymerase II - chemistry | DNA-Binding Proteins - chemistry | Chromosomal Proteins, Non-Histone - genetics | DNA - genetics | DNA - chemistry | Protein Conformation, beta-Strand | Escherichia coli - genetics | Replication Protein C - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Kinetics | Chromosomal Proteins, Non-Histone - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Excavating machinery | Structure | DNA | Protein-protein interactions | Crystals | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. 8272 - 8277
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e102389 - e102389
RNA polymerase II dependent transcription and nucleotide excision repair are mediated by a multifaceted interplay of subunits within the general transcription... 
DOMAIN | SNAKE-VENOM | CRYSTAL-STRUCTURE | FACTOR IIH | MULTIDISCIPLINARY SCIENCES | GLYCOPROTEIN IB | TRANSCRIPTION FACTOR TFIIH | DNA-REPAIR | MULTIPLE SEQUENCE ALIGNMENT | P44 SUBUNIT | NUCLEOTIDE EXCISION-REPAIR | Fungal Proteins - chemistry | RNA Helicases - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Transcription Factor TFIIH - chemistry | RNA Helicases - chemistry | Protein Subunits - metabolism | Transcription Factor TFIIH - genetics | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Protein Subunits - genetics | von Willebrand Factor - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Chaetomium - chemistry | Gene Expression | Protein Structure, Secondary | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Fungal Proteins - genetics | Sequence Homology, Amino Acid | Chaetomium - metabolism | Sequence Alignment | Escherichia coli - genetics | von Willebrand Factor - chemistry | Transcription Factor TFIIH - metabolism | Protein Subunits - chemistry | Fungal Proteins - metabolism | RNA | Protein-protein interactions | Von Willebrand factor | Protein binding | Transcription factors | Molecular structure | Trichothiodystrophy | Xeroderma pigmentosum | Biology | Thermophilic fungi | Kinases | DNA repair | DNA-directed RNA polymerase | DNA helicase | Proteins | Fungi | Protein folding | XPD protein | Deoxyribonucleic acid--DNA | Nucleotide excision repair | RNA polymerase | Chromatography | Interfaces | Polymerase | Ribonucleic acids | Venom | Protein expression | Mutation | Protein interaction | RNA polymerase II | Binding sites | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article