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Cancer Cell, ISSN 1535-6108, 12/2013, Volume 24, Issue 6, pp. 691 - 693
An elegant paper by Anchoori and colleagues in this issue of describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome... 
ONCOLOGY | CANCER | CELL BIOLOGY | Animals | Membrane Glycoproteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Female | Piperidones - pharmacology | Neoplasms - drug therapy | Ubiquitin | Enzyme inhibitors | Index Medicus
Journal Article
Current Protocols in Immunology, ISSN 1934-3671, 2015, Volume 2015, pp. 9.10.1 - 9.10.9
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e56132 - e56132
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 28, pp. 24882 - 24895
BH3 mimetics are small molecules designed or discovered to mimic the binding of BH3-only proteins to the hydrophobic groove of antiapoptotic BCL2 proteins. The... 
CYTOCHROME-C | APOPTOSIS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | SENSITIVITY | BAX | BCL-2 PROTEINS | INHIBITORS | RELEASE | CELL-DEATH | Humans | Peptide Fragments - pharmacology | Endoplasmic Reticulum Stress - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | Activating Transcription Factor 3 - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - pharmacology | bcl-Associated Death Protein - genetics | Peptidomimetics - pharmacology | Endoplasmic Reticulum Stress - drug effects | Membrane Proteins - genetics | Activating Transcription Factor 4 - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Signal Transduction - genetics | Sulfonamides - pharmacology | Activating Transcription Factor 3 - metabolism | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Activating Transcription Factor 4 - metabolism | Signal Transduction - drug effects | Myeloid Cell Leukemia Sequence 1 Protein | K562 Cells | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus | BH3 Mimetics | Vinblastine | ER Stress | Leukemia | Microtubules | BCL2 | Anticancer Drug | Cell Biology | Apoptosis | MCL1
Journal Article
Cell, ISSN 0092-8674, 2003, Volume 113, Issue 3, pp. 357 - 367
Nucleotide excision repair (NER) is a major cellular defense against the carcinogenic effects of ultraviolet light from the sun. Mutational inactivation of NER... 
Journal Article
ISSN 1477-0520, 1/2012, Volume 1, Issue 1, pp. 181 - 194
Syringolins, a class of natural products, potently and selectively inhibit the proteasome and show promising antitumour activity. To gain insight in the mode... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2016, Volume 59, Issue 15, pp. 7177 - 7187
This work reports the development of highly potent and selective inhibitors of the β5c catalytic activity of human constitutive proteasomes. The work describes... 
Dose-Response Relationship, Drug | Proteasome Inhibitors - chemical synthesis | Cell Line | Proteasome Inhibitors - pharmacology | Humans | Drug Design | Models, Molecular | Proteasome Inhibitors - chemistry | Molecular Structure | Structure-Activity Relationship | Proteasome Endopeptidase Complex - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 3, pp. 1626 - 1642
Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the... 
Journal Article