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Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1027 - 1031
The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal... 
NETWORK | INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE | POLYCYSTIC KIDNEY-DISEASE | BIOLOGY | GENETICS & HEREDITY | DISORDERS | PROTEINS | FIBROBLASTS | Humans | Fluorescent Dyes - metabolism | Culture Media, Serum-Free | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Fibroblasts - ultrastructure | Obesity - genetics | Embryo, Mammalian - metabolism | Intellectual Disability - genetics | Indoles - metabolism | Tubulin - metabolism | Cell Nucleus - metabolism | Transfection | Mice, Mutant Strains | Cilia - ultrastructure | Bardet-Biedl Syndrome - genetics | Chromones - pharmacology | Microsatellite Repeats | Fibroblasts - metabolism | Genetic Linkage | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Cilia - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Fluorescent Antibody Technique, Direct | Retinal Degeneration - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Mice, Transgenic | Genetic Markers | Cilia - metabolism | Cilia - genetics | Pigment Epithelium of Eye - metabolism | Animals | Embryo, Mammalian - cytology | Signal Transduction - physiology | Fibroblasts - cytology | Mice | Polymorphism, Single Nucleotide | Mutation | Pigment Epithelium of Eye - cytology | Penis - abnormalities | Gene mutations | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Brain diseases | Proteins | Tissue | Scanning electron microscopy | Transmission electron microscopy | Cysts | Rodents | Cell division | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1032 - 1036
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2007, Volume 104, Issue 43, pp. 16834 - 16839
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 05/2005, Volume 16, Issue 5, pp. 2218 - 2233
Endosomal trafficking is regulated by the recruitment of effector proteins to phosphatidylinositol 3-phosphate [PtdIns(3)P] on early endosomes. At the plasma... 
Journal Article
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 05/2005, Volume 16, Issue 5, pp. 2218 - 2233
Endosomal trafficking is regulated by the recruitment of effector proteins to phosphatidylinositol 3-phosphate [PtdIns(3)P] on early endosomes. At the plasma... 
ACTIVATION | FUSION | 3-PHOSPHATE | CLATHRIN-COATED VESICLES | RAB5 | PLECKSTRIN-HOMOLOGY-DOMAIN | PHOSPHATIDYLINOSITOL 3-KINASE | LIPID PRODUCTS | TRANS-GOLGI NETWORK | BINDING | CELL BIOLOGY
Journal Article
Nature genetics, ISSN 1061-4036, 9/2009, Volume 41, Issue 9, pp. 1032 - 1036
Phosphotidylinositol (PtdIns) signaling is tightly regulated, both spatially and temporally, by subcellularly localized PtdIns kinases and phosphatases that... 
Journal Article
Molecular biology of the cell, ISSN 1059-1524, 05/2005, Volume 16, Issue 5, pp. 2218 - 2233
Endosomal trafficking is regulated by the recruitment of effector proteins to phosphatidylinositol 3-phosphate [PtdIns(3)P] on early endosomes. At the plasma... 
Phosphatidylinositol Phosphates - metabolism | Humans | Cercopithecus aethiops | rab GTP-Binding Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Resting Phase, Cell Cycle | Endosomes - metabolism | Phosphatidylinositol 4,5-Diphosphate - metabolism | Transfection | Mice, Mutant Strains | Cell Membrane - metabolism | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CHO Cells | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | rab GTP-Binding Proteins - metabolism | Cricetinae | Phosphoric Monoester Hydrolases - genetics | Signal Transduction | Membrane Proteins - genetics | Biological Transport, Active - drug effects | Cells, Cultured | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins c-akt | Animals | Androstadienes - pharmacology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Mice | Epidermal Growth Factor - pharmacology | Mutation | In Vitro Techniques | Phosphoric Monoester Hydrolases - metabolism | COS Cells | Phosphoric Monoester Hydrolases - chemistry | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 02/2005, Volume 16, Issue 5, pp. 2218 - 2233
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2002, Volume 277, Issue 35, p. 31857
The enzyme(s) responsible for the production of inositol hexakisphosphate (InsP 6 ) in vertebrate cells are unknown. In fungal cells, a 2-kinase designated... 
Journal Article
01/2001, ISBN 9780493454443
Phosphatidylinositols are involved in the regulation of an array of cellular processes, including cell growth, differentiation, cell motility, and apoptosis.... 
Cellular biology | Molecular biology | Biochemistry
Dissertation
Advances in Enzyme Regulation, ISSN 0065-2571, 2008, Volume 48, Issue 1, pp. 10 - 17
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2010, Volume 5, Issue 1, pp. e8909 - e8909
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2005, Volume 102, Issue 52, pp. 18854 - 18859
Numerous inositol polyphosphate 5-phosphatases catalyze the degradation of phosphatidylinositol-4,5-bisphosphate ( ) to phosphatidylinositol-4-phosphate... 
Enzymes | Inositols | Biological Sciences | Phosphatases | HEK293 cells | Epithelial cells | HeLa cells | Antibodies | Lipids | Polyphosphates | Phosphatidylinositols | Phosphatidylinositol 5-phosphate | Cell signaling | Lysosome | ACTIVATION | MYOTUBULARIN | MULTIDISCIPLINARY SCIENCES | PTEN | RECEPTOR | VIRULENCE | MAMMALIAN-CELLS | PATHWAY | 5-PHOSPHATE | cell signaling | lysosome | phosphatidylinositol 5-phosphate | PHOSPHATASES | Phosphatidylinositol Phosphates - metabolism | Humans | Inositol Polyphosphate 5-Phosphatases | Cercopithecus aethiops | Molecular Sequence Data | RNA, Messenger - metabolism | Endosomes - metabolism | Phosphatidylinositol Phosphates - chemistry | Tissue Distribution | Receptor, Epidermal Growth Factor - metabolism | Lysosomes - metabolism | Transfection | Time Factors | Cloning, Molecular | Fluorescent Dyes - pharmacology | Catalysis | Amino Acid Sequence | Cell Line | Green Fluorescent Proteins - metabolism | Signal Transduction | Phosphatidylinositols - chemistry | Epidermal Growth Factor - metabolism | Amino Acid Motifs | Hydrolysis | Sequence Homology, Amino Acid | Blotting, Northern | Animals | Burkholderia pseudomallei - metabolism | HeLa Cells | Phosphoric Monoester Hydrolases - metabolism | COS Cells | DNA, Complementary - metabolism | Microscopy, Fluorescence | Phosphoric Monoester Hydrolases - chemistry | RNA, Small Interfering - metabolism | Inositol phosphates | Lysosomes | Chemical properties | Phosphates | Signal transduction | Biochemistry | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 2011, Volume 14, Issue 4, pp. 466 - 477
Osteoporosis is a multifactorial genetic disease characterized by reduction of bone mass due to dysregulation of osteoclast differentiation or maturation.... 
DENSITY | WOMEN | RANKL | HOMEOSTASIS | ACTIVATION | LINKAGE SCAN | ENDOCRINOLOGY & METABOLISM | NFATC1 | SRC KINASE-ACTIVITY | OSTEOCLAST DIFFERENTIATION | EXPRESSION | CELL BIOLOGY | Phosphoric Monoes