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Angewandte Chemie International Edition, ISSN 1433-7851, 08/2016, Volume 55, Issue 36, pp. 10612 - 10615
The design of inhibitors of intracellular protein–protein interactions (PPIs) remains a challenge in chemical biology and drug discovery. We propose a cyclized... 
protein–protein interactions | helix-loop-helix peptides | inhibitors | cell-penetrating peptides | epitope grafting | P53-MDM2 INTERACTION | DOMAIN | LIBRARY | CHEMISTRY, MULTIDISCIPLINARY | CANCER-THERAPY | protein-protein interactions | P53 | IN-VIVO ACTIVATION | MDM2 | ANTAGONISTS | SELECTION | TUMOR-SUPPRESSOR PATHWAY | Amino Acid Sequence | Protein Conformation, alpha-Helical | Tumor Suppressor Protein p53 - antagonists & inhibitors | Protein Interaction Maps - drug effects | Humans | Tumor Suppressor Protein p53 - metabolism | Peptides, Cyclic - pharmacology | Proto-Oncogene Proteins c-mdm2 - chemistry | Arginine - analogs & derivatives | Peptides, Cyclic - chemistry | Protein Interaction Mapping | Arginine - pharmacology | Drug Design | Cell Line, Tumor | Molecular Docking Simulation | Tumor Suppressor Protein p53 - chemistry | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Peptides | Arginine | Drug discovery | Permeability | Tumor proteins | Protein-protein interactions | Antigenic determinants | Proteins | Binding | Residues | p53 Protein | Confocal microscopy | Biology | Confocal | Design analysis | Grafting | Design | Penetration | Inhibitors | Microscopy | Computer applications | Helix-loop-helix proteins | Inhibition | Intracellular | Position (location) | Localization | Protein interaction | Cancer
Journal Article
Journal Article
Internal Medicine (Tokyo, 1992), ISSN 0918-2918, 01/2012, Volume 51, Issue 17, pp. 2443 - 2447
Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis or transverse myelitis with anti-aquaporin 4 (AQP4) antibodies (1). We herein... 
Journal Article
Rinsho shinkeigaku = Clinical neurology, ISSN 0009-918X, 09/2011, Volume 51, Issue 9, p. 683
We report two patients with encephalitis associated with antibodies against NR1-NR2 heteromers of the NMDA receptor that showed dramatic improvement after... 
Immunoglobulins, Intravenous - therapeutic use | Immunomodulation | Humans | Adult | Female | Male | Aged | Anti-N-Methyl-D-Aspartate Receptor Encephalitis - therapy | Methylprednisolone - administration & dosage
Journal Article
07/2018
A touch input device that includes an operation input unit, a control unit, a memory unit and a display unit. The operation input unit includes a pressing... 
COMPUTING | COUNTING | PHYSICS | ELECTRIC DIGITAL DATA PROCESSING | CALCULATING
Patent
07/2019
A display device includes a housing, an operation surface, a position sensor, a press sensor, and a display unit. The position sensor detects a touched... 
COMPUTING | COUNTING | PHYSICS | ELECTRIC DIGITAL DATA PROCESSING | CALCULATING
Patent
02/2016
A touch input device that includes an operation input unit, a control unit, a memory unit and a display unit. The operation input unit includes a pressing... 
COMPUTING | COUNTING | PHYSICS | ELECTRIC DIGITAL DATA PROCESSING | CALCULATING
Patent
01/2016
A touch-input device (1) is provided with: an operation input unit (10); a control unit (20); a storage unit (21); and a display unit (30). The operation input... 
COMPUTING | COUNTING | PHYSICS | ELECTRIC DIGITAL DATA PROCESSING | CALCULATING
Patent
02/2019
Provided is a pressure sensor with which it is possible, without forming a physical switch, to detect a pressing operation received at a location other than... 
SEMICONDUCTOR DEVICES | BASIC ELECTRIC ELEMENTS | ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR | COMPUTING | COUNTING | PHYSICS | ELECTRIC DIGITAL DATA PROCESSING | CALCULATING | ELECTRICITY
Patent
Journal Article
12/2018
A touch input device includes a sensor for detecting a plurality of touch positions at which a touch operation has been performed on an operation surface, a... 
ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICESUSING STATIC MEANS TO PRESENT VARIABLE INFORMATION | DISPLAY | ADVERTISING | SEALS | COMPUTING | COUNTING | PHYSICS | ELECTRIC DIGITAL DATA PROCESSING | EDUCATION | CALCULATING | CRYPTOGRAPHY
Patent
11/2018
An electronic device that provides a number of function modes and operates by selecting one of the function modes. The device includes an audio output unit and... 
ELECTRIC COMMUNICATION TECHNIQUE | COMPUTING | COUNTING | PHYSICS | ELECTRIC DIGITAL DATA PROCESSING | TELEPHONIC COMMUNICATION | CALCULATING | ELECTRICITY
Patent
11/2018
When determining that a level of a deformation detection signal is greater than a threshold, a controller assumes that a touch operation is performed at an... 
COMPUTING | COUNTING | PHYSICS | ELECTRIC DIGITAL DATA PROCESSING | CALCULATING
Patent
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