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Current Cancer Drug Targets, ISSN 1568-0096, 02/2016, Volume 16, Issue 2, pp. 119 - 129
The ubiquitin system controls protein stability and function. F-box proteins form SCF (SKP1-Cullin1-F-box protein)-type ubiquitin (E3) ligases to selectively... 
Ubiquitin | Human cancer | E3 ligase | FBXW7 | F-box protein | SCF complex | SKP2 | β-TrCP | Proteasome | proteasome | PROTEASOMAL DEGRADATION | KAPPA-B-ALPHA | beta-TrCP | MESENCHYMAL TRANSITION | ubiquitin | BREAST-CANCER | ONCOLOGY | human cancer | PHOSPHORYLATION-DEPENDENT UBIQUITINATION | MYELOGENOUS LEUKEMIA | TUMOR-SUPPRESSOR | CYCLIN D1 DEGRADATION | TRANSCRIPTIONAL TARGET
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 02/2016, Volume 16, Issue 2, pp. 100 - 100
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 12/2013, Volume 70, Issue 24, pp. 4785 - 4794
Journal Article
Cancer Science, ISSN 1347-9032, 08/2009, Volume 100, Issue 8, pp. 1374 - 1381
Cellular levels of products from both oncogenes and tumor suppressor genes in normal cells need to be critically regulated to avoid malignant transformation.... 
E3 LIGASE | ONCOLOGY | PHOSPHORYLATION-DEPENDENT UBIQUITINATION | DNA-DAMAGE | C-MYC | DOWN-REGULATION | S-PHASE | HIGH EXPRESSION | CELL-CYCLE CONTROL | LIGASE COMPLEX | F-BOX PROTEIN | Genes, Tumor Suppressor | Humans | Tumor Suppressor Proteins - genetics | Oncogenes | Ubiquitin - metabolism | Ubiquitin | Genetic aspects | Tumor proteins | Ligases | Tumors | Index Medicus
Journal Article
Current Drug Targets, ISSN 1389-4501, 2012, Volume 13, Issue 13, pp. 1616 - 1621
The possible physiological significance of long non-coding RNAs (lncRNAs) has only recently been recognized. Technical innovations such as the super... 
ANRIL | HOTAIR | Kcnq1ot1 | INK4 locus | Human cancers | LncRNA | Polycomb | Xist | lncRNA | COLORECTAL CANCERS | DOSAGE COMPENSATION | TUMOR-SUPPRESSOR GENE | EARLY MOUSE EMBRYOS | BECKWITH-WIEDEMANN-SYNDROME | POOR-PROGNOSIS | polycomb | XIST RNA | BINDING PROTEINS | human cancers | PHARMACOLOGY & PHARMACY | X-CHROMOSOME INACTIVATION | ANRIL LOCUS
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 02/2016, Volume 16, Issue 2, pp. 157 - 174
In the ubiquitylation system, E3 ubiquitin ligases play a key role in determining substrate specificity and catalyzing the transfer of ubiquitin from E2... 
Ubiquitin | RBR | RING | Cancer | HECT | SELF-UBIQUITINATION | NEDD4 FAMILY | LINEAR UBIQUITINATION | DNA-DAMAGE | DOWN-REGULATION | P53 PATHWAY | TRIM FAMILY PROTEINS | ubiquitin | INTERACTING PROTEIN-1 NDFIP1 | TUMOR-SUPPRESSOR FUNCTION | ONCOLOGY | DEPENDENT DEGRADATION
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 02/2016, Volume 16, Issue 2, pp. 130 - 135
The ubiquitin-proteasome pathway is involved in various biological processes. Several oncogenic E3 ligases target tumor suppressor proteins for... 
WWP | E3 ligase | Oral cancer | P27 | Ubiquitin proteasome system | Smurf1 | Skp2 | Chemical inhibitor | p27(Kip1) | P27 DEGRADATION | ubiquitin proteasome system | MEDIATED DEGRADATION | SKP2 PROMOTER | CDK INHIBITOR | HIGH EXPRESSION | KAPPA-B | DEPENDENT KINASE INHIBITOR | G1 PHASE | ONCOLOGY | POOR-PROGNOSIS | SQUAMOUS-CELL CARCINOMA | oral cancer
Journal Article
Cancer Science, ISSN 1347-9032, 11/2017, Volume 108, Issue 11, pp. 2122 - 2129
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy known, with an extremely poor prognosis due to the lack of an efficient diagnostic scheme... 
Cathepsin B | pancreatic cancer | CD4+ T cell | cystatin A | peripheral blood | CD4 | T cell | DIAGNOSIS | PROGNOSIS | BLOOD MONONUCLEAR-CELLS | HEPATOCELLULAR-CARCINOMA | SERUM CATHEPSIN-B | ONCOLOGY | COLORECTAL-CANCER | INHIBITORS | CD4(+) T cell | CYSTEINE PROTEASES | EPIDEMIOLOGY | PROGRESSION | Cystatin A - genetics | Inflammation - pathology | Adenocarcinoma - pathology | Prognosis | Cathepsin B - genetics | Humans | Middle Aged | RNA, Messenger - genetics | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation, Neoplastic | Male | CD4-Positive T-Lymphocytes - pathology | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - genetics | Lymphocytes, Tumor-Infiltrating - pathology | Inflammation - genetics | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Adenocarcinoma - genetics | Aged | Biomarkers, Tumor - genetics | Adenocarcinoma | Immunohistochemistry | Care and treatment | Cysteine | Protease inhibitors | RNA | Pancreatic cancer | Cathepsins | T cells | Gene expression | Cystine | Cystatin | Cysteine proteinase | Lymphocytes T | Malignancy | Metastasis | Blood | Lymphocytes | Surgery | Peripheral blood | Hemoglobin | Pancreas | Age | Antigens | Blood cells | Neutrophils | Proteinase inhibitors | Patients | Investigations | Esophagus | CD4 antigen | Beta cells | Medical prognosis | Biomarkers | Cancer | Original
Journal Article
Journal Article
Current Drug Targets, ISSN 1389-4501, 2012, Volume 13, Issue 13, pp. 1587 - 1587
Journal Article
Current Drug Targets, ISSN 1389-4501, 12/2012, Volume 13, Issue 13, pp. 1588 - 1592
In eukaryotic cells, DNA replication is tightly regulated to occur only once per cell cycle. DNA licensing is a mechanism to guarantee this aim; that is,... 
DNA biosynthesis | Replication origins | Cell cycle | Replication initiation | Replication | G1 phase
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 02/2006, Volume 54, Issue 2, pp. 242 - 244
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, p. 10574
Recent evidence has revealed that senescence induction requires fine-tuned activation of p53, however, mechanisms underlying the regulation of p53 activity... 
CELLS | SECRETORY PHENOTYPE | ACETYLATION | LYSINE METHYLATION | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | IN-VIVO | CELLULAR SENESCENCE | ACTIVATES P53 | FEEDBACK LOOP | Ubiquitin | Degradation | Senescence | Phenotypes | Lysine | p53 Protein | Mice | Catalysis | Ubiquitin-protein ligase
Journal Article