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Nature Reviews Endocrinology, ISSN 1759-5029, 10/2013, Volume 9, Issue 10, p. 615
Over the past two decades, insulin resistance has been considered essential to the aetiology of type 2 diabetes mellitus (T2DM). However, insulin resistance... 
Type 2 diabetes | Physiological aspects | Pancreatic beta cells | Genetic aspects | Research | Risk factors
Journal Article
Journal of the Japan Diabetes Society, ISSN 0021-437X, 2018, Volume 61, Issue 2, pp. 36 - 38
Journal Article
Journal of the Japan Diabetes Society, ISSN 0021-437X, 2016, Volume 59, Issue 5, pp. 336 - 339
Journal Article
Journal Article
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 03/2015, Volume 73, Issue 3, p. 509
Among islet cell types, much less attention has been paid to α cells than to β cells, but glucagon, the product of α cells, has been shown to play a major role... 
Diabetes Mellitus, Type 2 - physiopathology | Humans | Glucagon - physiology | Glucagon - secretion | Diabetes Mellitus, Type 2 - drug therapy | Glucagon - antagonists & inhibitors
Journal Article
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 03/2015, Volume 73, Issue 3, pp. 509 - 516
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 08/2019, Volume 20, Issue 15, p. 3699
To date, type 2 diabetes is considered to be a bi-hormonal disorder rather than an insulin-centric disorder, suggesting that glucagon is as important as... 
pancreatic alpha cells | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CELLS | MOUSE | GLUCOSE-TRANSPORT | CHEMISTRY, MULTIDISCIPLINARY | DELTA-CELLS | DEPENDENT REGULATION | AMINO-ACIDS | SOMATOSTATIN | glucagon | GLUCAGON RECEPTOR ANTAGONIST | SECRETION | insulin resistance | pancreatic α cells
Journal Article
Nature Genetics, ISSN 1061-4036, 04/2012, Volume 44, Issue 4, pp. 406 - 412
Restoration of regulated insulin secretion is the ultimate goal of therapy for type 1 diabetes. Here, we show that, unexpectedly, somatic ablation of Foxo1 in... 
TRANSCRIPTION FACTORS | INTESTINAL EPITHELIUM | GLUCAGON-LIKE PEPTIDE-1 | EMBRYONIC STEM-CELLS | BETA-CELLS | GROWTH | GENETICS & HEREDITY | PANCREAS | DIFFERENTIATION | EXPRESSION | ENDOCRINE-CELLS | Forkhead Transcription Factors - physiology | Stem Cells - cytology | Enteroendocrine Cells - cytology | Insulin - biosynthesis | C-Peptide - biosynthesis | Insulin-Secreting Cells - metabolism | Sulfonylurea Compounds - pharmacology | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Nerve Tissue Proteins - biosynthesis | Neuroendocrine Cells - metabolism | Cell Differentiation | Insulin-Secreting Cells - cytology | Enteroendocrine Cells - metabolism | Diabetes Mellitus, Experimental - metabolism | Insulin - genetics | C-Peptide - metabolism | Insulin Secretion | Forkhead Transcription Factors - deficiency | Wnt Signaling Pathway | Insulin-Secreting Cells - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Mice, Transgenic | Glucose - pharmacology | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Streptozocin - pharmacology | Gastrointestinal Tract - metabolism | Insulin - metabolism | Animals | Forkhead Box Protein O1 | Gastrointestinal Tract - cytology | Mice | Hyperglycemia - therapy | Physiological aspects | Research | Microbiota (Symbiotic organisms) | Drug therapy | Type 1 diabetes | Insulin | Proteins | Studies | Biomedical research | Rodents | Pancreas | Experiments | Manuscripts
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 2184
Journal Article
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 2013, Volume 71, Issue 2, pp. 217 - 223
Journal Article
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 02/2013, Volume 71, Issue 2, p. 217
Energy homeostasis is maintained by the balance between energy intake (food intake) and energy expenditure, when the former exceeds the latter, one becomes... 
Sirtuin 1 - metabolism | Hypothalamus - metabolism | Forkhead Transcription Factors - metabolism | Humans | Signal Transduction - physiology | Forkhead Box Protein O1 | Energy Metabolism - physiology | Obesity - metabolism
Journal Article