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Immunity, ISSN 1074-7613, 06/2009, Volume 30, Issue 6, pp. 860 - 874
Missense mutations of the gene encoding NLRP3 are associated with autoinflammatory disorders characterized with excessive production of interleukin-1β (IL-1β).... 
MOLIMMUNO | CELLIMMUNO | RHEUMATOID-ARTHRITIS | T(H)17 CELLS | TGF-BETA | IL-17-PRODUCING T-CELLS | INTERLEUKIN-1-BETA SECRETION | CASPASE-1 INFLAMMASOME | CYTOKINE MILIEU | IMMUNOLOGY | CIAS1 MUTATIONS | NEUTROPHIL RECRUITMENT | NALP3 INFLAMMASOME | Interleukin-18 - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Skin - metabolism | Mutation - immunology | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - immunology | Adenosine Triphosphate - metabolism | Receptors, Antigen, T-Cell - immunology | Interleukin-1beta - biosynthesis | Carrier Proteins - immunology | Macrophages - immunology | Skin - pathology | Cytokines - immunology | Skin - immunology | Antigen-Presenting Cells - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Interleukin-1beta - immunology | Adenosine Triphosphate - immunology | Inflammation - immunology | Mutation - genetics | Antigen-Presenting Cells - immunology | Carrier Proteins - genetics | Cell Differentiation - immunology | Interleukin-18 - biosynthesis | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammation - genetics | Mice | Analysis | Genetic aspects | Immune response | Studies | Bone marrow | Mutation | Gene expression | Immune system
Journal Article
Journal Article
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 11/2018, Volume 9, p. 2566
It is logical to assume that a major pro-inflammatory mechanism, i.e., the NLRP3 inflammasome would play a prominent role in the pathogenesis of the... 
NLRP3 | Inflammasome | IL-18 | Interleukin-1β | IBD-inflammatory bowel diseases | inflammasome | interleukin-1β
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2006, Volume 12, Issue 1, pp. 99 - 106
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2001, Volume 194, Issue 5, pp. 629 - 644
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 2, pp. 834 - 842
Journal Article
Immunity, ISSN 1074-7613, 2006, Volume 25, Issue 3, pp. 473 - 485
In this study, we determined conditions leading to the development of colitis in mice with nucleotide binding oligomerization domain 2 (NOD2) deficiency, a... 
MOLIMMUNO | HUMDISEASE | SIGNALING | LEISHMANIA-MAJOR | INFLAMMATORY-BOWEL-DISEASE | MEDIATED-IMMUNITY | CROHNS-DISEASE | ESCHERICHIA-COLI | MICE | KAPPA-B | NOD2 | IMMUNOLOGY | INTESTINAL EPITHELIAL-CELLS | T-CELLS | Toll-Like Receptor 2 - genetics | Colitis - genetics | Humans | Inflammatory Bowel Diseases - immunology | Antigens, Bacterial - immunology | Male | Inflammatory Bowel Diseases - metabolism | Epitopes - immunology | Intracellular Signaling Peptides and Proteins - deficiency | Toll-Like Receptor 2 - deficiency | Intestinal Mucosa - immunology | Inflammatory Bowel Diseases - genetics | Colitis - immunology | Intracellular Signaling Peptides and Proteins - genetics | Antigen-Presenting Cells - metabolism | Cells, Cultured | Mice, Transgenic | Nod2 Signaling Adaptor Protein | Protein Structure, Tertiary - genetics | Signal Transduction - genetics | Intestinal Mucosa - microbiology | Antigen-Presenting Cells - immunology | Mice, Knockout | Animals | Toll-Like Receptor 2 - physiology | Colitis - metabolism | Mice | Intracellular Signaling Peptides and Proteins - physiology | Antigens | Medical colleges | Peptides | Albumin | Crohn's disease | Biological response modifiers | T cells | Diseases | Oligomers | Crohn's disease in children | Children | Colitis | Interferon gamma | Inflammatory bowel disease | Proteins | Studies | Statistical analysis | Lymphocytes | Rodents | Ligands | Kinases | Experiments | Crohns disease
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2006, Volume 12, Issue 1, pp. 99 - 106
Interleukin (IL)-13 is a major inducer of fibrosis in many chronic infectious and autoimmune diseases. In studies of the mechanisms underlying such induction,... 
NK-T-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ULCERATIVE-COLITIS | TISSUE FIBROSIS | INTERLEUKIN-13 | GROWTH FACTOR-BETA-1 GENE | OXAZOLONE COLITIS | CELL BIOLOGY | IN-VIVO | MICE | PULMONARY-FIBROSIS | ALPHA-2 CHAIN
Journal Article
Journal Article