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Seikagaku, ISSN 0037-1017, 2017, Volume 89, Issue 3, pp. 325 - 332
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2012, Volume 18, Issue 10, pp. 1570 - 1574
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57479 - e57479
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, pp. e0209509 - e0209509
Modulating the complement system is a promising strategy in drug discovery for disorders with uncontrolled complement activation. Although some of these... 
SERUM HALF-LIFE | IMMUNOGENICITY | PHARMACOKINETICS | COMPLEMENT INHIBITOR ECULIZUMAB | MULTIDISCIPLINARY SCIENCES | IN-VIVO | HEMOPHILIA-A | MONOCLONAL-ANTIBODY | EMICIZUMAB PROPHYLAXIS | DEPENDENT ANTIGEN-BINDING | THERAPEUTIC ANTIBODY | Endosomes - immunology | Protein Engineering - methods | Humans | Macaca fascicularis | Antibodies, Monoclonal - therapeutic use | Drug Discovery - methods | Complement Activation - immunology | Complement C5 - isolation & purification | Recombinant Proteins - isolation & purification | Time Factors | Complement C5 - immunology | Computer Simulation | Antibodies, Monoclonal - immunology | Complement Activation - drug effects | Histocompatibility Antigens Class I - immunology | Immune System Diseases - immunology | Antibody Affinity | Immune System Diseases - drug therapy | Mice, Transgenic | Histocompatibility Antigens Class I - genetics | Antibodies, Monoclonal - genetics | Animals | Receptors, Fc - immunology | Mutagenesis | Recombinant Proteins - immunology | Receptors, Fc - genetics | Mice | Complement C5 - antagonists & inhibitors | Hydrogen-Ion Concentration | Viral antibodies | Protein engineering | Usage | Physiological aspects | Antibodies | Genetic aspects | Research | Complement (Immunology) | Neonates | Plasma | Intravenous administration | Immune clearance | Disorders | Complement | Monkeys | Dosage | pH effects | Accumulation | Engineering | Salvage | Hemophilia | Recycling | Drug dosages | Binding | Antigens | Surface charge | Immunoglobulins | Fc receptors | Complement activation | Complement component C5 | Mutation | Endosomes | Neutralization | Pharmaceuticals | Polymorphism | Index Medicus | pH
Journal Article
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 07/2018, Volume 16, Issue 7, pp. 1383 - 1390
Journal Article
by Yamagami, Keitaro and Kurogi, Ryota and Kurogi, Ai and Nishimura, Kunihiro and Onozuka, Daisuke and Ren, Nice and Kada, Akiko and Nishimura, Ataru and Arimura, Koichi and Ido, Keisuke and Mizoguchi, Masahiro and Sakamoto, Tetsuya and Kayama, Takamasa and Suzuki, Michiyasu and Arai, Hajime and Hagihara, Akihito and Iihara, Koji and Masayoshi, Takigami and Kenji, Kamiyama and Kiyohiro, Houkin and Shougo, Nishi and Tetsuyuki, Yoshimoto and Sadao, Kaneko and Koji, Oka and Hiroshi, Ooyama and Kyousuke, Kamada and Kenichi, Makino and Naoki, Tokumitsu and Kazuhiro, Sako and Susumu, Suzuki and Nozomi, Suzuki and Naoto, Izumi and Kazumi, Nitta and Masahumi, Ootaki and Masanori, Isobe and Mikio, Nishiya and Takaaki, Yamazaki and Syouji, Mabuchi and Kuniaki, Ogasawara and Naohiko, Kubo and Yukihiko, Shimizu and Keiichi, Saito and Tatumi, Yamanome and Atsuo, Yoshino and Mitsuyuki, Fujitsuka and Masaaki, Takami and Hirotoshi, Ohtaka and Teruyuki, Hirano and Yosiaki, Shiokawa and Takaharu, Okada and Ichiro, Suzuki and Michihiro, Kohno and Jou, Haraoka and Yoshinori, Arai and Noriyoshi, Kawamura and Akira, Isoshima and Masaharu, Yasue and Mitsuhiko, Hokari and Takayoshi, Kobayashi and Kensuke, Kawai and Taketoshi, Maehara and Hajime, Arai and Makoto, Noguchi and Haruhiko, Hoshino and Hirofumi, Hiyama and Kensaku, Yoshida and Osamu, Utsugi and Yasuaki, Takeda and Kouichi, Tamaki and Hirohide, Karasudani and Takao, Urabe and Shiro, Kobayashi and Michio, Nakamura and Yorio, Koguchi and Junichi, Ono and Sumio, Suda and Hiromu, Hadeishi and Toshio, Fukutake and Kenji, Wakui and Hirokazu, Tanno and Naoki, Ishige and Takashi, Ohasi and Hideki, Sakai and Yasuaki, Nishimura and Takayuki, Watanabe and Takashi, Matsumoto and Naoki, Koketsu and Yuichi, Hirose and Manabu, Doyu and Toshinori, Hasegawa and Naoto, Kuwayama and Shinichi, Terao and Nobuhiko, Mizutani and Noriyuki, Suzaki and Satoshi, Okuda and Keizo, Yasui and Yukio, Seki and Yasuhiro, Hasegawa and Akira, Ikeda and Youtarou, Takeuchi and ... and J-ASPECT Study Collaborators
World Neurosurgery, ISSN 1878-8750, 2019
Background: The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging... 
Aging | Hospital mortality | Prognosis | Traumatic brain injury | Subdural hematoma | Index Medicus
Journal Article
Journal Article
Journal Article
Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 2010, Volume 58, Issue 1, pp. 38 - 45
Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is regarded as a promising target for developing new anticoagulant drugs. In previous... 
Journal Article