Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 8, pp. 861 - 863
Clear cell sarcoma of the kidney (CCSK) is one of the major pediatric renal neoplasms, but its associated genetic abnormalities are largely unknown. We...
SUBTYPE | COMPLEX | THERAPY | GENETICS & HEREDITY | TUMOR STUDY-GROUP | WILMS-TUMOR | SOMATIC MUTATIONS | DURATION | SOCIETY | POLYCOMB GROUP | REVEALS | Immunohistochemistry | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Kidney Neoplasms - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Sequence Homology, Nucleic Acid | Blotting, Western | Sequence Homology, Amino Acid | Base Sequence | HEK293 Cells | Female | Sarcoma, Clear Cell - metabolism | Sarcoma, Clear Cell - genetics | Child | Tandem Repeat Sequences - genetics | Repressor Proteins - metabolism | Sarcoma | Kidney cancer | Development and progression | Genetic aspects | Microsatellites (Genetics) | Disease susceptibility | Identification and classification | Health aspects | Genetics | Tumorigenesis | Kidneys | Genes | Tumors
SUBTYPE | COMPLEX | THERAPY | GENETICS & HEREDITY | TUMOR STUDY-GROUP | WILMS-TUMOR | SOMATIC MUTATIONS | DURATION | SOCIETY | POLYCOMB GROUP | REVEALS | Immunohistochemistry | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Kidney Neoplasms - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Sequence Homology, Nucleic Acid | Blotting, Western | Sequence Homology, Amino Acid | Base Sequence | HEK293 Cells | Female | Sarcoma, Clear Cell - metabolism | Sarcoma, Clear Cell - genetics | Child | Tandem Repeat Sequences - genetics | Repressor Proteins - metabolism | Sarcoma | Kidney cancer | Development and progression | Genetic aspects | Microsatellites (Genetics) | Disease susceptibility | Identification and classification | Health aspects | Genetics | Tumorigenesis | Kidneys | Genes | Tumors
Journal Article
2.
Analysis of gene expression and DNA methylation patterns in childhood acute lymphoblastic leukemia
[Rinshō ketsueki] The Japanese journal of clinical hematology, ISSN 0485-1439, 04/2016, Volume 57, Issue 4, pp. 425 - 429
Journal Article
3.
Analysis of gene expression and DNA methylation patterns in childhood acute lymphoblastic leukemia
[Rinsho ketsueki] The Japanese journal of clinical hematology, ISSN 0485-1439, 04/2016, Volume 57, Issue 4, p. 425
The 5-year survival rate of patients with childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) now exceeds 90%, though there are still patients...
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | DNA Methylation | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Child
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | DNA Methylation | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Child
Journal Article
British Journal of Haematology, ISSN 0007-1048, 11/2019, Volume 187, Issue 3, pp. 372 - 376
Summary We performed a retrospective analysis of leukaemic surface antigen expression and genomic data from a total of 100 RUNX1‐RUNX1T1–positive paediatric...
acute myeloid leukaemia | RUNX1‐RUNX1T1 | CD19 | Genetic research | Pediatrics | Gene mutations | Analysis | Confidence intervals | Antigens | CD19 antigen | Leukemia | Runx1 protein | Lymphomas | Mutation | Gene expression | Multivariate analysis | Risk analysis | Lymphoma | Risk factors
acute myeloid leukaemia | RUNX1‐RUNX1T1 | CD19 | Genetic research | Pediatrics | Gene mutations | Analysis | Confidence intervals | Antigens | CD19 antigen | Leukemia | Runx1 protein | Lymphomas | Mutation | Gene expression | Multivariate analysis | Risk analysis | Lymphoma | Risk factors
Journal Article
Journal of Human Genetics, ISSN 1434-5161, 09/2016, Volume 61, Issue 9, pp. 797 - 801
The pharmacokinetics among children has been altered dynamically. The difference between children and adults is caused by immaturity in things such as...
RATES | METHYLTRANSFERASE | SUSCEPTIBILITY | GENETICS & HEREDITY | RISK | POLYMORPHISM | CANCER-STUDY-GROUP | JAPANESE CHILDREN | VARIANT | PREDNISOLONE | Pharmacogenetics | Age Factors | Genetic Association Studies | Gene Frequency | Humans | Mercaptopurine - administration & dosage | Methyltransferases - genetics | Pyrophosphatases - genetics | Child, Preschool | Genotype | Infant | Male | Antimetabolites, Antineoplastic - administration & dosage | Polymorphism, Genetic | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Alleles | Female | Child
RATES | METHYLTRANSFERASE | SUSCEPTIBILITY | GENETICS & HEREDITY | RISK | POLYMORPHISM | CANCER-STUDY-GROUP | JAPANESE CHILDREN | VARIANT | PREDNISOLONE | Pharmacogenetics | Age Factors | Genetic Association Studies | Gene Frequency | Humans | Mercaptopurine - administration & dosage | Methyltransferases - genetics | Pyrophosphatases - genetics | Child, Preschool | Genotype | Infant | Male | Antimetabolites, Antineoplastic - administration & dosage | Polymorphism, Genetic | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Alleles | Female | Child
Journal Article
International Journal of Hematology, ISSN 0925-5710, 11/2013, Volume 98, Issue 5, pp. 578 - 588
Infants (<1 year old) with acute myeloid leukemia (AML) are particularly vulnerable to intensive cytotoxic therapy. Indeed, the mortality rate was high among...
Acute respiratory distress syndrome | Medicine & Public Health | Hematology | Oncology | Early death | Infants | Acute myeloid leukemia | AML | TRIALS | CYTARABINE | HEMATOLOGY | CHILDREN | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Japan | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Child, Preschool | Induction Chemotherapy | Infant | Male | Treatment Outcome | Leukemia, Myeloid, Acute - mortality | Leukemia, Myeloid, Acute - diagnosis | Chromosome Aberrations | Leukemia, Myeloid, Acute - drug therapy | Female | Registries | Child | Infant, Newborn | Pediatrics | Reports | Research | Oncology, Experimental | Cancer
Acute respiratory distress syndrome | Medicine & Public Health | Hematology | Oncology | Early death | Infants | Acute myeloid leukemia | AML | TRIALS | CYTARABINE | HEMATOLOGY | CHILDREN | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Japan | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Child, Preschool | Induction Chemotherapy | Infant | Male | Treatment Outcome | Leukemia, Myeloid, Acute - mortality | Leukemia, Myeloid, Acute - diagnosis | Chromosome Aberrations | Leukemia, Myeloid, Acute - drug therapy | Female | Registries | Child | Infant, Newborn | Pediatrics | Reports | Research | Oncology, Experimental | Cancer
Journal Article
International Journal of Hematology, ISSN 0925-5710, 8/2017, Volume 106, Issue 2, pp. 269 - 281
ZNF384-related fusion genes are associated with a distinct subgroup of B-cell precursor acute lymphoblastic leukemias in childhood, with a frequency of...
ZNF384 | Medicine & Public Health | Hematology | Transcription | Oncology | EP300 | GATA3 | CD33 | YOUNG-ADULTS | KINASE | LINEAGE SWITCH | RISK | TRANSCRIPTION FACTOR GATA-3 | REARRANGEMENT | PHENOTYPE ACUTE-LEUKEMIA | ADOLESCENTS | CIZ/NMP4 | HEMATOLOGY | SUBGROUP | GATA3 Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Gene Fusion - physiology | Gene Expression - genetics | Humans | E1A-Associated p300 Protein - genetics | E1A-Associated p300 Protein - physiology | Gene Expression Regulation, Developmental - genetics | Up-Regulation - genetics | Trans-Activators - physiology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Gene Fusion - genetics | Leukemia, B-Cell - genetics | Trans-Activators - genetics | Cell Line, Tumor | Leukemia, B-Cell - immunology | Child | Hematopoietic Stem Cells | Medical colleges | Anopheles | DNA microarrays | Genes | Genetic research | Genetic aspects | Children | Acute lymphocytic leukemia | Genetic transcription | Health aspects | Hematopoietic stem cells | Cancer | Antigens | Acute lymphatic leukemia | Pathogenesis | Leukemia | CD13 antigen | Lymphatic leukemia | Gene expression | Kinases | Hemopoiesis | Biological effects | Lymphocytes B | Stem cells | GATA-3 protein | Aberration | Fusion protein
ZNF384 | Medicine & Public Health | Hematology | Transcription | Oncology | EP300 | GATA3 | CD33 | YOUNG-ADULTS | KINASE | LINEAGE SWITCH | RISK | TRANSCRIPTION FACTOR GATA-3 | REARRANGEMENT | PHENOTYPE ACUTE-LEUKEMIA | ADOLESCENTS | CIZ/NMP4 | HEMATOLOGY | SUBGROUP | GATA3 Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Gene Fusion - physiology | Gene Expression - genetics | Humans | E1A-Associated p300 Protein - genetics | E1A-Associated p300 Protein - physiology | Gene Expression Regulation, Developmental - genetics | Up-Regulation - genetics | Trans-Activators - physiology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Gene Fusion - genetics | Leukemia, B-Cell - genetics | Trans-Activators - genetics | Cell Line, Tumor | Leukemia, B-Cell - immunology | Child | Hematopoietic Stem Cells | Medical colleges | Anopheles | DNA microarrays | Genes | Genetic research | Genetic aspects | Children | Acute lymphocytic leukemia | Genetic transcription | Health aspects | Hematopoietic stem cells | Cancer | Antigens | Acute lymphatic leukemia | Pathogenesis | Leukemia | CD13 antigen | Lymphatic leukemia | Gene expression | Kinases | Hemopoiesis | Biological effects | Lymphocytes B | Stem cells | GATA-3 protein | Aberration | Fusion protein
Journal Article
Journal of Materials Science: Materials in Medicine, ISSN 0957-4530, 12/2017, Volume 28, Issue 12, pp. 1 - 10
We have developed a method to functionalize polystyrene (PS) cell culture plates with hydroxyapatite (HAp) via protein adsorption layers such as human serum...
Biomedical Engineering | Polymer Sciences | Materials Science | Regenerative Medicine/Tissue Engineering | Ceramics, Glass, Composites, Natural Materials | Surfaces and Interfaces, Thin Films | Biomaterials | CARBOXYL GROUP | FUNCTIONALIZATION | ALTERNATE SOAKING PROCESS | CELLS | MATERIALS SCIENCE, BIOMATERIALS | APATITE-FORMING ABILITY | ENGINEERING, BIOMEDICAL | WOLLASTONITE | POLYMER SURFACES | BIOMIMETIC PROCESS | BONE | POLYAMIDE FILMS | Child development | Adsorption | Collagen | Stem cells | Albumin | Polystyrene | Glutamate | Lysozyme | Phosphates | Glutamic acid | Cell culture | Surgical implants | Collagen (type I) | Calcium | Mesenchyme | Surface chemistry | Tissue culture | Hydroxyapatite | Proteins | Biomedical materials | Biocompatibility | Deposition | Plates | Human serum albumin | Polystyrene resins | Albumen | Incubation | Serum albumin | Protein adsorption | Calcium phosphates | Body fluids | Bone | Coating | In vitro methods and tests | Calcium ions
Biomedical Engineering | Polymer Sciences | Materials Science | Regenerative Medicine/Tissue Engineering | Ceramics, Glass, Composites, Natural Materials | Surfaces and Interfaces, Thin Films | Biomaterials | CARBOXYL GROUP | FUNCTIONALIZATION | ALTERNATE SOAKING PROCESS | CELLS | MATERIALS SCIENCE, BIOMATERIALS | APATITE-FORMING ABILITY | ENGINEERING, BIOMEDICAL | WOLLASTONITE | POLYMER SURFACES | BIOMIMETIC PROCESS | BONE | POLYAMIDE FILMS | Child development | Adsorption | Collagen | Stem cells | Albumin | Polystyrene | Glutamate | Lysozyme | Phosphates | Glutamic acid | Cell culture | Surgical implants | Collagen (type I) | Calcium | Mesenchyme | Surface chemistry | Tissue culture | Hydroxyapatite | Proteins | Biomedical materials | Biocompatibility | Deposition | Plates | Human serum albumin | Polystyrene resins | Albumen | Incubation | Serum albumin | Protein adsorption | Calcium phosphates | Body fluids | Bone | Coating | In vitro methods and tests | Calcium ions
Journal Article
International Journal of Hematology, ISSN 0925-5710, 05/2018, Volume 107, Issue 5, pp. 586 - 595
Acute myeloid leukemia harboring internal tandem duplication of FMS-like tyrosine kinase 3 (AML (FLT3-ITD)) is associated with poor prognosis. We evaluated the...
AML | Alleric ratio | FLT3-ITD | Childhood | NUP98-NSD1 | INTERNAL TANDEM DUPLICATION | FLT3 INHIBITORS | CELL TRANSPLANTATION | RELAPSE | IMPACT | POOR-PROGNOSIS | PROGNOSTIC-SIGNIFICANCE | MUTATIONS | HEMATOLOGY | EXPRESSION | NUP98/NSD1 | Research | Children | Health aspects | Oncology, Experimental | Cancer | Tyrosine | Myeloid leukemia | Leukemia | Stem cell transplantation | Transplantation | Multivariate analysis | Survival | Patients | Hematopoietic stem cells | Hemopoiesis | Medical prognosis | Remission | Flt3 protein | Mutation | Acute myeloid leukemia | Protein-tyrosine kinase
AML | Alleric ratio | FLT3-ITD | Childhood | NUP98-NSD1 | INTERNAL TANDEM DUPLICATION | FLT3 INHIBITORS | CELL TRANSPLANTATION | RELAPSE | IMPACT | POOR-PROGNOSIS | PROGNOSTIC-SIGNIFICANCE | MUTATIONS | HEMATOLOGY | EXPRESSION | NUP98/NSD1 | Research | Children | Health aspects | Oncology, Experimental | Cancer | Tyrosine | Myeloid leukemia | Leukemia | Stem cell transplantation | Transplantation | Multivariate analysis | Survival | Patients | Hematopoietic stem cells | Hemopoiesis | Medical prognosis | Remission | Flt3 protein | Mutation | Acute myeloid leukemia | Protein-tyrosine kinase
Journal Article
Pediatrics International, ISSN 1328-8067, 01/2018, Volume 60, Issue 1, pp. 47 - 51
Background Gene abnormalities, particularly chromosome rearrangements generating gene fusion, are associated with clinical characteristics and prognosis in...
diagnosis | acute myeloid leukemia | fusion gene | multiplex polymerase chain reaction | Japanese Pediatric Leukemia/Lymphoma Study Group | SURVIVAL | AML | Japanese Pediatric Leukemia | CYTOGENETICS | CANCER | CHILDREN | TRANSCRIPTS | RELAPSE | POLYMERASE-CHAIN-REACTION | Lymphoma Study Group | PEDIATRICS | ACUTE PROMYELOCYTIC LEUKEMIA | Prognosis | Humans | Child, Preschool | Infant | Male | Multiplex Polymerase Chain Reaction | Reverse Transcriptase Polymerase Chain Reaction | Genetic Testing - methods | Leukemia, Myeloid, Acute - diagnosis | Oncogene Fusion | Oncogene Proteins, Fusion - genetics | Karyotyping | Adolescent | Female | Biomarkers, Tumor - genetics | Retrospective Studies | Child | Leukemia, Myeloid, Acute - genetics | Genetic research | Pediatrics | Genetic aspects | Genes | Genetic screening | Cancer | Multiplexing | Myeloid leukemia | Leukemia | Abnormalities | Karyotypes | Fluorescence | Reverse transcription | Runx1 protein | Chromosome rearrangements | Patients | Lymphoma | Polymerase chain reaction | Promyeloid leukemia | AML1 protein | Fluorescence in situ hybridization | Fusion protein | Acute myeloid leukemia | Acute promyeloid leukemia
diagnosis | acute myeloid leukemia | fusion gene | multiplex polymerase chain reaction | Japanese Pediatric Leukemia/Lymphoma Study Group | SURVIVAL | AML | Japanese Pediatric Leukemia | CYTOGENETICS | CANCER | CHILDREN | TRANSCRIPTS | RELAPSE | POLYMERASE-CHAIN-REACTION | Lymphoma Study Group | PEDIATRICS | ACUTE PROMYELOCYTIC LEUKEMIA | Prognosis | Humans | Child, Preschool | Infant | Male | Multiplex Polymerase Chain Reaction | Reverse Transcriptase Polymerase Chain Reaction | Genetic Testing - methods | Leukemia, Myeloid, Acute - diagnosis | Oncogene Fusion | Oncogene Proteins, Fusion - genetics | Karyotyping | Adolescent | Female | Biomarkers, Tumor - genetics | Retrospective Studies | Child | Leukemia, Myeloid, Acute - genetics | Genetic research | Pediatrics | Genetic aspects | Genes | Genetic screening | Cancer | Multiplexing | Myeloid leukemia | Leukemia | Abnormalities | Karyotypes | Fluorescence | Reverse transcription | Runx1 protein | Chromosome rearrangements | Patients | Lymphoma | Polymerase chain reaction | Promyeloid leukemia | AML1 protein | Fluorescence in situ hybridization | Fusion protein | Acute myeloid leukemia | Acute promyeloid leukemia
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3928 - 3928
Abstract Background: It is well known that PAX5 related fusion proteins are mainly associated with leukemogenesis of B cell precursor acute lymphoblastic...
Journal Article
Genes, Chromosomes and Cancer, ISSN 1045-2257, 11/2019, Volume 58, Issue 11, pp. 820 - 823
Acute promyelocytic leukemia (APL) is cytogenetically characterized by the t(15;17) (q24;q21), although cases without this translocation exist. These cases are...
acute promyelocytic leukemia | cryptic insertion | children | TBL1XR1/RARA | TRANS-RETINOIC ACID | IDENTIFICATION | REARRANGEMENT | RELAPSE | ONCOLOGY | TBL1XR1 | T(15/17) | GENETICS & HEREDITY | RARA | PCR | Chemotherapy | Chromosomes | Analysis | Genomics | Cancer | Translocation | Transcription | Pathogenesis | Leukemia | Karyotypes | Insertion | Case reports | Transplantation | Genomes | Girls | Gene sequencing | Promyeloid leukemia | Cord blood | Remission | Fusion protein | Retinoic acid | Acute promyeloid leukemia
acute promyelocytic leukemia | cryptic insertion | children | TBL1XR1/RARA | TRANS-RETINOIC ACID | IDENTIFICATION | REARRANGEMENT | RELAPSE | ONCOLOGY | TBL1XR1 | T(15/17) | GENETICS & HEREDITY | RARA | PCR | Chemotherapy | Chromosomes | Analysis | Genomics | Cancer | Translocation | Transcription | Pathogenesis | Leukemia | Karyotypes | Insertion | Case reports | Transplantation | Genomes | Girls | Gene sequencing | Promyeloid leukemia | Cord blood | Remission | Fusion protein | Retinoic acid | Acute promyeloid leukemia
Journal Article
Pediatrics International, ISSN 1328-8067, 01/2018, Volume 60, Issue 1, pp. 41 - 46
Background In acute myeloid leukemia (AML), accurate detection of minimal residual disease (MRD) enables better risk‐stratified therapy. There are few studies,...
minimal residual disease | acute myeloid leukemia | fusion gene | prognosis | polymerase chain reaction | AML | PROGNOSTIC IMPACT | CONTRIBUTE | MULTIPARAMETER FLOW-CYTOMETRY | RISK | REARRANGEMENT | THERAPY | RT-PCR | PEDIATRICS | STRATIFICATION | Recurrence | Oncogene Proteins, Fusion - metabolism | Prognosis | Humans | Leukemia, Myeloid, Acute - metabolism | Child, Preschool | Infant | Male | Neoplasm, Residual | Leukemia, Myeloid, Acute - diagnosis | Adolescent | Biomarkers, Tumor - metabolism | Female | Retrospective Studies | Child | Real-Time Polymerase Chain Reaction | Pediatrics | Relapse | RNA | Analysis | Genes | Genetic research | Genetic aspects | Diseases | Cancer | Myeloid leukemia | Leukemia | Health risks | Minimal residual disease | Runx1 protein | Ribonucleic acid--RNA | Lymphoma | Survival | Patients | Polymerase chain reaction | AML1 protein | Fusion protein | Acute myeloid leukemia | Monitoring
minimal residual disease | acute myeloid leukemia | fusion gene | prognosis | polymerase chain reaction | AML | PROGNOSTIC IMPACT | CONTRIBUTE | MULTIPARAMETER FLOW-CYTOMETRY | RISK | REARRANGEMENT | THERAPY | RT-PCR | PEDIATRICS | STRATIFICATION | Recurrence | Oncogene Proteins, Fusion - metabolism | Prognosis | Humans | Leukemia, Myeloid, Acute - metabolism | Child, Preschool | Infant | Male | Neoplasm, Residual | Leukemia, Myeloid, Acute - diagnosis | Adolescent | Biomarkers, Tumor - metabolism | Female | Retrospective Studies | Child | Real-Time Polymerase Chain Reaction | Pediatrics | Relapse | RNA | Analysis | Genes | Genetic research | Genetic aspects | Diseases | Cancer | Myeloid leukemia | Leukemia | Health risks | Minimal residual disease | Runx1 protein | Ribonucleic acid--RNA | Lymphoma | Survival | Patients | Polymerase chain reaction | AML1 protein | Fusion protein | Acute myeloid leukemia | Monitoring
Journal Article
Molecular Therapy, ISSN 1525-0016, 02/2011, Volume 19, Issue 2, pp. 400 - 407
Human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the potential to differentiate into all cell lineages, including hepatocytes,...
MEDICINE, RESEARCH & EXPERIMENTAL | MOUSE | PROLIFERATION | CULTURE | HEPATOCYTE-LIKE CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ADENOVIRUS VECTOR | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | DIFFERENTIATION | LIVER DEVELOPMENT | EXPRESSION | FUNCTIONAL HEPATOCYTES | Embryonic Stem Cells - metabolism | Transcription Factors - physiology | Embryonic Stem Cells - cytology | Humans | Cytochrome P-450 Enzyme System - metabolism | Genes, Homeobox - genetics | Transcription Factors - genetics | Genetic Vectors - genetics | Homeodomain Proteins - genetics | Cell Differentiation - genetics | Hepatocytes - cytology | Adenoviridae - genetics | Cytochrome P-450 Enzyme System - genetics | Homeodomain Proteins - physiology | Induced Pluripotent Stem Cells - cytology | Cell Differentiation - physiology | Genes, Homeobox - physiology | Induced Pluripotent Stem Cells - metabolism | Original
MEDICINE, RESEARCH & EXPERIMENTAL | MOUSE | PROLIFERATION | CULTURE | HEPATOCYTE-LIKE CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ADENOVIRUS VECTOR | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | DIFFERENTIATION | LIVER DEVELOPMENT | EXPRESSION | FUNCTIONAL HEPATOCYTES | Embryonic Stem Cells - metabolism | Transcription Factors - physiology | Embryonic Stem Cells - cytology | Humans | Cytochrome P-450 Enzyme System - metabolism | Genes, Homeobox - genetics | Transcription Factors - genetics | Genetic Vectors - genetics | Homeodomain Proteins - genetics | Cell Differentiation - genetics | Hepatocytes - cytology | Adenoviridae - genetics | Cytochrome P-450 Enzyme System - genetics | Homeodomain Proteins - physiology | Induced Pluripotent Stem Cells - cytology | Cell Differentiation - physiology | Genes, Homeobox - physiology | Induced Pluripotent Stem Cells - metabolism | Original
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 05/2019, Volume 66, Issue 5, pp. e27612 - n/a
Journal Article
16.
Full Text
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
Nature Genetics, ISSN 1061-4036, 08/2017, Volume 49, Issue 8, pp. 1274 - 1281
The outcome of treatment-refractory and/or relapsed pediatric T cell acute lymphoblastic leukemia (T-ALL) is extremely poor(1), and the genetic basis for this...
ACTIVATION | INTEGRATED MOLECULAR ANALYSIS | NOTCH PATHWAY | GENETICS & HEREDITY | GENE-EXPRESSION | TUMOR-SUPPRESSOR | TRANSCRIPTION FACTOR PU.1 | NETWORKS | MUTATIONS | MLL | HEMATOPOIETIC PROGENITORS | T-Lymphocyte Subsets | Genetic Predisposition to Disease | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Humans | Child, Preschool | Gene Fusion | Infant | Male | Proto-Oncogene Proteins - genetics | Gene Expression Profiling | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Adolescent | Survival Analysis | Trans-Activators - genetics | Female | Child | Physiological aspects | Genetic aspects | Research | Acute lymphocytic leukemia | T cells | Gene fusion | Risk factors | Cell proliferation | Pediatrics | Transcription factors | Profiling | Acute lymphatic leukemia | Transcription | Risk groups | Maturation | CD8 antigen | Leukemia | Genes | Lymphocytes T | Lymphatic leukemia | Gene expression | CD4 antigen | Gene sequencing | Proteins | PU.1 protein | Cell growth | Lymphocytes | Stem cells | Cells (biology) | Mutation | Cancer
ACTIVATION | INTEGRATED MOLECULAR ANALYSIS | NOTCH PATHWAY | GENETICS & HEREDITY | GENE-EXPRESSION | TUMOR-SUPPRESSOR | TRANSCRIPTION FACTOR PU.1 | NETWORKS | MUTATIONS | MLL | HEMATOPOIETIC PROGENITORS | T-Lymphocyte Subsets | Genetic Predisposition to Disease | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Humans | Child, Preschool | Gene Fusion | Infant | Male | Proto-Oncogene Proteins - genetics | Gene Expression Profiling | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Adolescent | Survival Analysis | Trans-Activators - genetics | Female | Child | Physiological aspects | Genetic aspects | Research | Acute lymphocytic leukemia | T cells | Gene fusion | Risk factors | Cell proliferation | Pediatrics | Transcription factors | Profiling | Acute lymphatic leukemia | Transcription | Risk groups | Maturation | CD8 antigen | Leukemia | Genes | Lymphocytes T | Lymphatic leukemia | Gene expression | CD4 antigen | Gene sequencing | Proteins | PU.1 protein | Cell growth | Lymphocytes | Stem cells | Cells (biology) | Mutation | Cancer
Journal Article