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index medicus (4) 4
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1. Full Text Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species
by Kjærbølling, Inge and Vesth, Tammi C and Frisvad, Jens C and Nybo, Jane L and Theobald, Sebastian and Kuo, Alan and Bowyer, Paul and Matsuda, Yudai and Mondo, Stephen and Lyhne, Ellen K and Kogle, Martin E and Clum, Alicia and Lipzen, Anna and Salamov, Asaf and Ngan, Chew Yee and Daum, Chris and Chiniquy, Jennifer and Barry, Kerrie and LaButti, Kurt and Haridas, Sajeet and Simmons, Blake A and Magnuson, Jon K and Mortensen, Uffe H and Larsen, Thomas O and Grigoriev, Igor V and Baker, Scott E and Andersen, Mikael R and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) and Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2018, Volume 115, Issue 4, pp. E753 - E761
The fungal genus of Aspergillus is highly interesting, containing everything from industrial cell factories, model organisms, and human pathogens. In... 
Fumigatus | Comparative genomics | Aspergillus | Secondary metabolism | III POLYKETIDE SYNTHASES | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | AFLATOXIN BIOSYNTHESIS | ACID BIOSYNTHESIS | WHOLE GENOMES | comparative genomics | FAMILY | ALIGNMENT | POLYPHASIC TAXONOMY | fumigatus | secondary metabolism | CHLORFLAVONIN | Multigene Family | Secondary Metabolism - genetics | Aflatoxins - biosynthesis | Allergens - genetics | Phylogeny | Aspergillus - metabolism | Whole Genome Sequencing | Aflatoxins - genetics | DNA Methylation | Terpenes - metabolism | Genome, Fungal | Aspergillus - pathogenicity | Aspergillus - genetics | Flavonoids - biosynthesis | Indole Alkaloids - metabolism | Evolution, Molecular | Microbiological research | Metabolites | Physiological aspects | Genetic aspects | Research | Nucleotide sequencing | DNA sequencing | BASIC BIOLOGICAL SCIENCES | Biological Sciences | PNAS Plus
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2. Full Text Strategies to establish the link between biosynthetic gene clusters and secondary metabolites
by Kjærbølling, Inge and Mortensen, Uffe H and Vesth, Tammi and Andersen, Mikael R
Fungal Genetics and Biology, ISSN 1087-1845, 09/2019, Volume 130, pp. 107 - 121
Filamentous fungi produce a vast number of bioactive secondary metabolites (SMs), some of which have found applications in the pharmaceutical industry... 
Polyketide synthase | Nonribosomal peptide synthetase | Secondary metabolites | Filamentous fungi | Biosynthetic gene clusters | NATURAL-PRODUCT | ASPERGILLUS-NIDULANS | GIBBERELLA-FUJIKUROI | FUNGAL POLYKETIDE BIOSYNTHESIS | NITROGEN REGULATION | CHEMICAL DIVERSITY | GENETICS & HEREDITY | SYNTHETIC BIOLOGY | MYCOLOGY | HETEROLOGOUS EXPRESSION | RECYCLABLE MARKER | Anopheles | Genes | Genomics | BCG | BCG vaccines | Genetic research | Genetic aspects | Genetic engineering | Plant metabolites | Immunosuppressive agents
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3. Full Text Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation
by Matsuda, Yudai and Bai, Tongxuan and Phippen, Christopher B. W and Nødvig, Christina S and Kjærbølling, Inge and Vesth, Tammi C and Andersen, Mikael R and Mortensen, Uffe H and Gotfredsen, Charlotte H and Abe, Ikuro and Larsen, Thomas O
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2587 - 10
Novofumigatonin (1), isolated from the fungus Aspergillus novofumigatus, is a heavily oxygenated meroterpenoid containing a unique orthoester moiety. Despite... 
ANTIBIOTIC BIOSYNTHESIS | DISRUPTION | GENE | TRANSFORMATION SYSTEM | FERROUS IRON | TERRETONIN BIOSYNTHESIS | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | DIOXYGENASE | ASPERGILLUS-ORYZAE | FUNGAL MEROTERPENOIDS | Prostaglandin-E Synthases - metabolism | Biosynthetic Pathways | Fungal Proteins - genetics | Aspergillus - metabolism | Iron - metabolism | Terpenes - metabolism | Gene Deletion | Prostaglandin-E Synthases - genetics | CRISPR-Cas Systems | Peroxides - metabolism | Aspergillus - genetics | Catalysis | Ketoglutaric Acids - metabolism | Fungal Proteins - metabolism | Fungi | CRISPR | Enzymes | Orthoesters | Clonal deletion | Heme | Deletion | Homology | Iron | Biosynthesis | Chemical synthesis | Gene deletion
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4. Full Text Development of a Bacterial Biosensor for Rapid Screening of Yeast p‑Coumaric Acid Production
by Siedler, Solvej and Khatri, Narendar K and Zsohár, Andrea and Kjærbølling, Inge and Vogt, Michael and Hammar, Petter and Nielsen, Christian F and Marienhagen, Jan and Sommer, Morten O. A and Joensson, Haakan N
ACS Synthetic Biology, ISSN 2161-5063, 10/2017, Volume 6, Issue 10, pp. 1860 - 1869
Transcription factor-based biosensors are used to identify producer strains, a critical bottleneck in cell factory engineering. Here, we address two challenges... 
PROTEIN | EVOLUTION | ESCHERICHIA-COLI | TRANSCRIPTION | BIOCHEMICAL RESEARCH METHODS | OPTIMIZATION | MUTATIONS | SACCHAROMYCES-CEREVISIAE | STRAIN | CORYNEBACTERIUM-GLUTAMICUM | MICROFLUIDICS | Transcription Factors - metabolism | Corynebacterium glutamicum - metabolism | Propionates - metabolism | Bacterial Proteins - metabolism | Biosensing Techniques - methods | Escherichia coli - metabolism
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5. Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species
by Inge Kjærbølling and Tammi C Vesth and Jens C Frisvad and Jane L Nybo and Sebastian Theobald and Alan Kuo and Paul Bowyer and Yudai Matsuda and Stephen Mondo and Ellen K Lyhne and Martin E Kogle and Alicia Clum and Anna Lipzen and Asaf Salamov and Chew Yee Ngan and Chris Daum and Jennifer Chiniquy and Kerrie Barry and Kurt LaButti and Sajeet Haridas and Blake A Simmons and Jon K Magnuson and Uffe H Mortensen and Thomas O Larsen and Igor V Grigoriev and Scott E Baker and Mikael R Andersen
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2018, Volume 115, Issue 4, p. E753
The fungal genus of Aspergillus is highly interesting, containing everything from industrial cell factories, model organisms, and human pathogens. In... 
Allergens | Pathogens | Gene clusters | Genomics | Genes | Virulence | Genomes | Genetic diversity | Biosynthesis | Phylogeny | Gene sequencing | Fungi | Pathogenicity | Secondary metabolites | Metabolites | Phylogenetics
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6. Full Text Resistance Gene-Directed Genome Mining of 50 Aspergillus Species
by Kjærbølling, Inge and Vesth, Tammi and Andersen, Mikael R
mSystems, ISSN 2379-5077, 05/2019, Volume 4, Issue 4
Fungal secondary metabolites are a rich source of valuable natural products, and genome sequencing has revealed a proliferation of predicted biosynthetic gene... 
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7. Full Text Resistance Gene-Directed Genome Mining of 50 Aspergillus Species
by Kjaerbolling, I and Vesth, T and Andersen, MR
MSYSTEMS, ISSN 2379-5077, 07/2019, Volume 4, Issue 4
Fungal secondary metabolites are a rich source of valuable natural products, and genome sequencing has revealed a proliferation of predicted biosynthetic gene... 
fungal | genomes | PENTALENOLACTONE | MICROBIOLOGY | comparative genomics | resistance | Aspergillus | natural products | BLOCKS | secondary metabolism | BIOSYNTHESIS | SEQUENCE | bioactive compounds | NIDULANS | CLUSTER | genome mining | Drugs | Enzymes | Dehydrogenases | Gene clusters | Cyclosporins | Genes | Homology | Genomes | Investigations | Proteins | Secondary metabolites | Metabolites | Natural products | Bioactive compounds | Penicillin | Species | Cancer
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8. High throughput droplet sorting of yeast for p-Coumaric acid production detected by co-encapsulated E. coli biosensor bacteria
by Siedler, Solvej and Khatri, Narendar K and Zsohár, Andrea and Kjærbølling, Inge and Vogt, Michael and Hammar, Petter and Stahlhut, Steen G and Marienhagen, Jan and Sommer, Morten O. A and Joensson, Haakan N
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, 2016, pp. 551 - 552
High throughput screening | Synthetic biology | Biosensors | Droplet microfluidics
Conference Proceeding
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