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1. Full Text Target temperature management after out-of-hospital cardiac arrest—a randomized, parallel-group, assessor-blinded clinical trial—rationale and design
by Nielsen, Niklas, MD, PhD and Wetterslev, Jørn, MD, PhD and al-Subaie, Nawaf, MD and Andersson, Bertil, MD and Bro-Jeppesen, John, MD and Bishop, Gillian, MD and Brunetti, Iole, MD and Cranshaw, Julius, MD, PhD and Cronberg, Tobias, MD, PhD and Edqvist, Kristin, MD and Erlinge, David, MD, PhD and Gasche, Yvan, MD, PhD and Glover, Guy, MD, PhD and Hassager, Christian, MD, DMSc and Horn, Janneke, MD, PhD and Hovdenes, Jan, MD, PhD and Johnsson, Jesper, MD, PhD and Kjaergaard, Jesper, MD, DMSc and Kuiper, Michael, MD, PhD and Langørgen, Jørund, MD and Macken, Lewis, MBBS and Martinell, Louise, MD and Martner, Patrik, MD and Pellis, Thomas, MD and Pelosi, Paolo, MD and Petersen, Per, MD and Persson, Stefan, MD and Rundgren, Malin, MD, PhD and Saxena, Manoj, BSc and Svensson, Robert, MD and Stammet, Pascal, MD and Thorén, Anders, MD, PhD and Undén, Johan, MD, PhD and Walden, Andrew, MD, PhD and Wallskog, Jesper, MD and Wanscher, Michael, MD, PhD and Wise, Matthew P., MD, DPhil and Wyon, Nicholas, MD, PhD and Åneman, Anders, MD, PhD and Friberg, Hans, MD, PhD and Anestesi- och intensivvårdskliniken VIN and Sinnescentrum and Östergötlands Läns Landsting and Linköpings universitet and Hälsouniversitetet and Anestesi- och intensivvårdskliniken US
American Heart Journal, ISSN 0002-8703, 2012, Volume 163, Issue 4, pp. 541 - 548
Background Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia... 
Cardiovascular | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | QUALITY | THERAPEUTIC HYPOTHERMIA | RECOMMENDATIONS | CONSORT STATEMENT | GUIDELINES | SHORT-FORM | CARDIOPULMONARY-RESUSCITATION | CARE | Out-of-Hospital Cardiac Arrest - therapy | Multicenter Studies as Topic | Humans | Quality of Life | Treatment Outcome | Body Temperature | Research Design | Randomized Controlled Trials as Topic | Clinical trials | Cardiac arrest | Teknik och teknologier | TEKNIKVETENSKAP | Engineering and Technology | TECHNOLOGY
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2. Full Text Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest
by Nielsen, Niklas and Wetterslev, Jørn and Cronberg, Tobias and Erlinge, David and Gasche, Yvan and Hassager, Christian and Horn, Janneke and Hovdenes, Jan and Kjaergaard, Jesper and Kuiper, Michael and Pellis, Tommaso and Stammet, Pascal and Wanscher, Michael and Wise, Matt P and Åneman, Anders and Al-Subaie, Nawaf and Boesgaard, Søren and Bro-Jeppesen, John and Brunetti, Iole and Bugge, Jan Frederik and Hingston, Christopher D and Juffermans, Nicole P and Koopmans, Matty and Køber, Lars and Langørgen, Jørund and Lilja, Gisela and Møller, Jacob Eifer and Rundgren, Malin and Rylander, Christian and Smid, Ondrej and Werer, Christophe and Winkel, Per and Friberg, Hans and TTM Trial Investigators
The New England Journal of Medicine, ISSN 0028-4793, 12/2013, Volume 369, Issue 23, pp. 2197 - 2206
In this trial, 950 patients who had been resuscitated from out-of-hospital cardiac arrest were randomly assigned to targeted temperature management at either... 
Cardiopulmonary Resuscitation - methods | Follow-Up Studies | Out-of-Hospital Cardiac Arrest - complications | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Out-of-Hospital Cardiac Arrest - mortality | Models, Statistical | Body Temperature | Withholding Treatment | Out-of-Hospital Cardiac Arrest - therapy | Treatment Failure | Hypothermia, Induced | Adult | Female | Aged | Unconsciousness - etiology | Coma | Heart | Intervention | Intensive care | Mortality | Body temperature | Critical care | Rhythm | Patients | Cardiopulmonary resuscitation--CPR | Fever | Temperature effects | Anesthesia | Hypothermia
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3. Full Text Neuron-Specific Enolase as a Predictor of Death or Poor Neurological Outcome After Out-of-Hospital Cardiac Arrest and Targeted Temperature Management at 33°C and 36°C
by Stammet, Pascal, MD and Collignon, Olivier, PhD and Hassager, Christian, MD, DMSc and Wise, Matthew P., MD, DPhil and Hovdenes, Jan, MD, PhD and Åneman, Anders, MD, PhD and Horn, Janneke, MD, PhD and Devaux, Yvan, PhD and Erlinge, David, MD, PhD and Kjaergaard, Jesper, MD, DMSc and Gasche, Yvan, MD and Wanscher, Michael, MD, PhD and Cronberg, Tobias, MD, PhD and Friberg, Hans, MD, PhD and Wetterslev, Jørn, MD, PhD and Pellis, Tommaso, MD and Kuiper, Michael, MD, PhD and Gilson, Georges, PhD and Nielsen, Niklas, MD, PhD and TTM-Trial Investigators and Anestesiologi och intensivvård and Kardiologi and Lund University and Anesthesiology and Intensive Care and Neurologi, Lund and Cardiology and Lunds universitet and Neurology, Lund
Journal of the American College of Cardiology, ISSN 0735-1097, 2015, Volume 65, Issue 19, pp. 2104 - 2114
Abstract Background Neuron-specific enolase (NSE) is a widely-used biomarker for prognostication of neurological outcome after cardiac arrest, but the... 
Cardiovascular | Internal Medicine | neuroprognostication | biomarker | cerebral performance | prognosis | Brain Ischemia - epidemiology | Temperature | Prognosis | Prospective Studies | Follow-Up Studies | Out-of-Hospital Cardiac Arrest - complications | Humans | Middle Aged | Europe - epidemiology | Male | Out-of-Hospital Cardiac Arrest - mortality | Treatment Outcome | Biomarkers - blood | Brain Ischemia - etiology | Incidence | Brain Ischemia - enzymology | Phosphopyruvate Hydratase - blood | Hypothermia, Induced - methods | Female | Out-of-Hospital Cardiac Arrest - enzymology | Anesthesia | Neurons | Analysis | Cardiac arrest | Confidence intervals | Heart attacks | Statistical analysis | Laboratories | Mortality | Brain damage | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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4. Full Text Neonatal BCG vaccination has no effect on recurrent wheeze in the first year of life: A randomized clinical trial
by Thøstesen, Lisbeth Marianne, MD and Stensballe, Lone Graff, MD, PhD and Pihl, Gitte Thybo, MSc and Kjærgaard, Jesper, MD, PhD and Birk, Nina Marie, MD and Nissen, Thomas Nørrelykke, MD and Jensen, Aksel Karl Georg, PhD and Aaby, Peter, DMSc, MSc and Olesen, Annette Wind, MD, PhD and Jeppesen, Dorthe Lisbeth, MD, PhD and Benn, Christine Stabell, MD, PhD, DMSc and Kofoed, Poul-Erik, MD, DMSc
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 6, pp. 1616 - 1621.e3
Background Recurrent wheeze (RW) is frequent in childhood. Studies have suggested that BCG vaccination can have nonspecific effects, reducing general... 
Allergy and Immunology | infant | recurrent wheeze | heterologous immunity | BCG | vaccination | nonspecific effects | SURVIVAL | CALMETTE-GUERIN VACCINATION | PREVALENCE | IMMUNOLOGY | CHILDHOOD ASTHMA | CHILDREN | MULTICENTER TRIAL | ALLERGY | BIRTH | Infants (Newborn) | Clinical trials | Wheeze | Vaccination | Neonates | Multiple births | Infections | Lymphocytes T | Vaccines | Dermatitis | Gestational age | Risk factors | Atopy | Respiratory tract | Parents & parenting | Randomization | Newborn babies | Measles | Respiratory tract diseases | Children | Interviews | Age | Siblings | Food allergies | Immunization | Mortality | Accumulators | Immunodeficiency | Risk analysis | Morbidity | Asthma | Children & youth | Childbirth & labor | Tuberculosis | Birth weight
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5. Full Text Standardized EEG interpretation accurately predicts prognosis after cardiac arrest
by Westhall, Erik and Rossetti, Anea O and van Rootselaar, Anne-Fleur and Wesenberg Kjaer, Troels and Horn, Janneke and Ullén, Susann and Friberg, Hans and Nielsen, Niklas and Rosén, Ingmar and Åneman, Anders and Erlinge, David and Gasche, Yvan and Hassager, Christian and Hovdenes, Jan and Kjaergaard, Jesper and Kuiper, Michael and Pellis, Tommaso and Stammet, Pascal and Wanscher, Michael and Wetterslev, Jørn and Wise, Matt P and Cronberg, Tobias and Saxena, Manoj and Miller, Jennene and Inskip, Deborah and Macken, Lewis and Finfer, Simon and Eatough, Noel and Hammond, Naomi and Bass, Frances and Yarad, Elizabeth and O'Connor, Anne and Bird, Simon and Jewell, Timothy and Davies, Gareth and Ng, Karl and Coward, Sharon and Stewart, Antony and Micallef, Sharon and Parker, Sharyn and Cortado, Dennis and Gould, Ann and Harward, Meg and Thompson, Kelly and Glass, Parisa and Myburgh, John and Smid, Onej and Belholavek, Jan and Kreckova, Marketa and Kral, Ales and Horak, Jan and Otahal, Michal and Rulisek, Jan and Malik, Jan and Prettl, Martin and Wascher, Michael and Boesgaard, Soeren and Moller, Jacob E and Bro-Jeppesen, John and Johansen, Ane Loof and Campanile, Vincenzo and Peratoner, Alberto and Verginella, Francesca and Leone, Daniele and Pellis, Thomas and Roncarati, Anea and Franceschino, Eliana and Sanzani, Anna and Martini, Alice and Perlin, Micol and Pelosi, Paolo and Brunetti, Iole and Insorsi, Angelo and Pezzato, Stefano and de Luca, Giorgio and Gazzano, Emanuela and Ottonello, Gian Anea and Furgani, Anea and Telani, Rosanna and Maiani, Simona and Werer, Christophe and Kieffer, Jaqueline and van der Veen, Annelou L and Winters, Tineke and Juffermans, Nicole P and Egbers, Ph and Boerma, EC and Gerritsen, R. T and Buter, H and de Jager, C and de Lange, F and Loos, M and Koetsier, P. M and Kingma, W. P and Bruins, N and de Kock, L and Koopmans, M and Bosch, Frank and Raaijmakers, Monique A. M and Metz-Hermans, S. W. L and ... and TTM-trial investigators and Clinical Neurophysiology and Anestesiologi och intensivvård and Department of Clinical Sciences, Lund and Lund University and Anesthesiology and Intensive Care and Neurologi, Lund and Klinisk neurofysiologi and Institutionen för kliniska vetenskaper, Lund and Lunds universitet and Neurology, Lund
Neurology, ISSN 0028-3878, 2016, Volume 86, Issue 16, pp. 1482 - 1490
To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to... 
Severity of Illness Index | Single-Blind Method | Prognosis | Follow-Up Studies | Comorbidity | Brain - physiopathology | Humans | Anticonvulsants - therapeutic use | Male | Seizures - diagnosis | Treatment Outcome | Electroencephalography | Heart Arrest - physiopathology | Hypnotics and Sedatives - therapeutic use | Body Temperature | Seizures - therapy | Heart Arrest - diagnosis | Seizures - physiopathology | Time Factors | Sensitivity and Specificity | Hypothermia, Induced | Female | Aged | Heart Arrest - therapy | 284 | Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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6. Bacillus Calmette-Guérin vaccination at birth: Effects on early childhood infections, growth, and development
by Kjærgaard, Jesper
Danish Medical Journal, ISSN 2245-1919, 11/2016, Volume 63, Issue 11
The Bacillus Calmette-Guérin vaccine (BCG), which is used to protect against tuberculosis, has been associated with a variety of other effects since it was... 
FALSE DISCOVERY RATE | SURVIVAL | IMMUNE-RESPONSE | MEDICINE, GENERAL & INTERNAL | WEIGHT CHILDREN | PROTECTION | GUINEA-BISSAU | GUT MICROBIOME | MYCOBACTERIUM-BOVIS | NEONATAL BCG VACCINATION | BRAIN | Infection - epidemiology | Humans | Vaccination | Denmark - epidemiology | Infant | Child Development - drug effects | Psychomotor Performance - drug effects | BCG Vaccine - administration & dosage | Infant, Newborn | Randomized Controlled Trials as Topic
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7. Full Text Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest: an analysis of the TTH48 trial
by De Fazio, C and Skrifvars, MB and Soreide, E and Creteur, J and Grejs, AM and Kjaergaard, J and Laitio, T and Nee, J and Kirkegaard, H and Taccone, FS
CRITICAL CARE, ISSN 1466-609X, 02/2019, Volume 23, Issue 1, pp. 61 - 9
BackgroundThe aim of this study was to explore the performance and outcomes for intravascular (IC) versus surface cooling devices (SFC) for targeted... 
Cooling | EFFICACY | FEASIBILITY | SAFETY | Cardiac arrest | MILD THERAPEUTIC HYPOTHERMIA | DEVICE | TTM | CARDIOPULMONARY-RESUSCITATION | INTENSIVE-CARE-UNIT | Outcome | ASSOCIATION | Methods | Hypothermia | CRITICAL CARE MEDICINE | Comparative analysis | Health aspects | Mortality
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8. Full Text Detection of Pulmonary Embolism with Combined Ventilation-Perfusion SPECT and Low-Dose CT: Head-to-Head Comparison with Multidetector CT Angiography
by Gutte, Henrik and Mortensen, Jann and Jensen, Claus Verner and Johnbeck, Camilla Bardram and von der Recke, Peter and Petersen, Claus Leth and Kjaergaard, Jesper and Kristoffersen, Ulrik Sloth and Kjaer, Andreas
The Journal of Nuclear Medicine, ISSN 0161-5505, 12/2009, Volume 50, Issue 12, pp. 1987 - 1992
The diagnosis of pulmonary embolism (PE) is usually established by a combination of clinical assessment, D-dimer testing, and imaging with either pulmonary... 
DIAGNOSIS | POPULATION | MANAGEMENT | clinical cardiology | SCINTIGRAPHY | DEEP-VEIN THROMBOSIS | PLANAR | SPECT/CT | V/Q SPECT | COMPUTED-TOMOGRAPHY | SOCIETY | CT angiography | SPIRAL CT | pulmonary embolism | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Pulmonary Ventilation | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | Tomography, X-Ray Computed | Pulmonary Artery - diagnostic imaging | Radiation Dosage | Time Factors | Sensitivity and Specificity | Female | Aged | Perfusion Imaging | Pulmonary Embolism - diagnostic imaging | Pulmonary Embolism - physiopathology | Tomography | Medical imaging | Lungs | Medical diagnosis | Index Medicus
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9. Full Text Refractory out-of-hospital cardiac arrest with ongoing cardiopulmonary resuscitation at hospital arrival - Survival and neurological outcome without extracorporeal cardiopulmonary resuscitation
by Gregers, Emilie and Kjærgaard, Jesper and Lippert, Freddy and Thomsen, Jakob H and Køber, Lars and Wanscher, Michael and Hassager, Christian and Søholm, Helle
Critical Care, ISSN 1364-8535, 09/2018, Volume 22, Issue 1, pp. 242 - 11
Background: The prognosis in refractory out-of-hospital cardiac arrest (OHCA) with ongoing cardiopulmonary resuscitation (CPR) at hospital arrival is often... 
Ongoing CPR | Survival | Refractory cardiac arrest | Cardiac arrest | EMERGENCY | COUNCIL | CPR | GUIDELINES | ADULTS | AMERICAN-HEART-ASSOCIATION | CARE | COMORBIDITY | LIFE-SUPPORT | ETHICS | CRITICAL CARE MEDICINE | Complications and side effects | Care and treatment | Patient outcomes | Emergency medicine | CPR (First aid) | Methods
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10. Full Text Response by Wiberg et al to Letter Regarding Article, “Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest: A Randomized Controlled Trial”
by Wiberg, Sebastian and Hassager, Christian and Kjaergaard, Jesper
Circulation, ISSN 0009-7322, 05/2017, Volume 135, Issue 20, pp. e1044 - e1045
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11. Full Text Mechanical circulatory support for decompensated heart failure: the last remaining indication for intra-aortic balloon pump?
by Kjaergaard, Jesper and Møller, Jacob Eifer and Hassager, Christian
EuroIntervention, ISSN 1774-024X, 09/2019, Volume 15, Issue 7, pp. 571 - 573
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12. Full Text Associations between partial pressure of oxygen and neurological outcome in out-of-hospital cardiac arrest patients: An explorative analysis of a randomized trial
by Ebner, Florian and Ullén, Susann and Åneman, Anders and Cronberg, Tobias and Mattsson, Niklas and Friberg, Hans and Hassager, Christian and Kjærgaard, Jesper and Kuiper, Michael and Pelosi, Paolo and Undén, Johan and Wise, Matt P and Wetterslev, Jørn and Nielsen, Niklas
Critical Care, ISSN 1364-8535, 01/2019, Volume 23, Issue 1, pp. 30 - 11
Objective: Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation... 
Biomarker | Cerebral performance | Partial pressure of oxygen | Serum tau | Out of hospital cardiac arrest | ALPHA-STAT | CARDIOPULMONARY | HYPEROXIA | AMERICAN-HEART-ASSOCIATION | INTERNATIONAL LIAISON COMMITTEE | THERAPEUTIC HYPOTHERMIA | ARTERIAL OXYGEN | CEREBRAL-BLOOD-FLOW | CARBON-DIOXIDE | RESUSCITATION | CRITICAL CARE MEDICINE | Brain | Patient outcomes | Analysis | Cardiac patients | Injuries | Cardiac arrest
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13. Full Text BCG vaccination at birth and early childhood hospitalisation: a randomised clinical multicentre trial
by Stensballe, Lone Graff and Sørup, Signe and Aaby, Peter and Benn, Christine Stabell and Greisen, Gorm and Jeppesen, Dorthe Lisbeth and Birk, Nina Marie and Kjærgaard, Jesper and Nissen, Thomas Nørrelykke and Pihl, Gitte Thybo and Thøstesen, Lisbeth Marianne and Kofoed, Poul-Erik and Pryds, Ole and Ravn, Henrik
Archives of Disease in Childhood, ISSN 0003-9888, 03/2017, Volume 102, Issue 3, pp. 224 - 231
BackgroundThe BCG vaccine is administered to protect against tuberculosis, but studies suggest there may also be non-specific beneficial effects upon the... 
vaccine | Bacillus Calmette-Guérin (BCG | infant | non-specific effect | hospitalisation | REGISTER | CELLS | IMPACT | IMMUNE-RESPONSES | DISEASE | MEASLES | PEDIATRICS | INFECTION | CALMETTE-GUERIN VACCINATION | NONSPECIFIC PROTECTION | CHILDREN | Follow-Up Studies | Humans | Risk Factors | Child, Preschool | Hospitalization - statistics & numerical data | Perinatal Care | Infant | Male | Socioeconomic Factors | BCG Vaccine | Tuberculosis - prevention & control | Denmark | Female | Infant, Newborn | Clinical trials | BCG vaccination | Usage | Care and treatment | Tuberculosis | 1506 | Original
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