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1. Full Text Principles of Experience-Dependent Neural Plasticity: Implications for Rehabilitation After Brain Damage
by Kleim, Jeffrey A and Jones, Theresa A
Journal of Speech, Language, and Hearing Research, ISSN 1092-4388, 02/2008, Volume 51, Issue 1, pp. S225 - S239
Theresa A. Jones University of Texas at Austin Contact author: Jeffrey A. Kleim, Brain Rehabilitation Research Center (151A), Malcom Randall VA Hospital, 1610... 
Recovery | Plasticity | Rehabilitation | PRIMARY SOMATOSENSORY CORTEX | plasticity | recovery | DENDRITIC STRUCTURAL PLASTICITY | PRIMARY MOTOR CORTEX | LINGUISTICS | rehabilitation | TRANSCRANIAL MAGNETIC STIMULATION | SENSORIMOTOR CORTICAL DAMAGE | LONG-TERM POTENTIATION | INDUCED MOVEMENT THERAPY | ADULT SQUIRREL-MONKEYS | FOREBRAIN CHOLINERGIC SYSTEM | EXERCISE INDUCES ANGIOGENESIS | Neurological Impairments | Intervention | Brain | Cognitive Processes | Models | Learning Strategies | Animals | Brain Damage, Chronic - rehabilitation | Brain Injury, Chronic - physiopathology | Neuronal Plasticity | Humans | Brain Injury, Chronic - rehabilitation | Brain Damage, Chronic - physiopathology | Recovery of Function | Neuroplasticity | Brain damage | Care and treatment | Research | Human subjects | Changes | Neurosciences | Nervous system | Behavior | Neurological disorders
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2. Full Text What do motor "recovery" and "compensationg" mean in patients following stroke?
by Levin, Mindy F and Kleim, Jeffrey A and Wolf, Steven L
Neurorehabilitation and Neural Repair, ISSN 1545-9683, 05/2009, Volume 23, Issue 4, pp. 313 - 319
Hemiplegia | Stroke | Terminology | Rehabilitation | Recovery | Compensation
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3. Full Text Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord
by DeAnna L. Adkins and Jeffery Boychuk and Michael S. Remple and Jeffrey A. Kleim
Journal of Applied Physiology, ISSN 8750-7587, 12/2006, Volume 101, Issue 6, pp. 1776 - 1782
The motor cortex and spinal cord possess the remarkable ability to alter structure and function in response to differential motor training. Here we review the... 
Endurance training | Skill training | Spinal cord plasticity | Motor cortex plasticity | Strength training | strength training | MOVEMENT REPRESENTATIONS | SPORT SCIENCES | PHYSIOLOGY | endurance training | motor cortex plasticity | FUNCTIONAL REORGANIZATION | DENDRITIC STRUCTURAL PLASTICITY | PRIMATE H-REFLEX | TRANSCRANIAL MAGNETIC STIMULATION | MUSCLE STRENGTH | SENSORIMOTOR CORTEX | CENTRAL-NERVOUS-SYSTEM | spinal cord plasticity | ADULT SQUIRREL-MONKEYS | CROSS-SECTIONAL AREA | skill training | Physical Fitness - physiology | Motor Cortex - physiology | Motor Neurons - physiology | Humans | Adaptation, Physiological - physiology | Muscle, Skeletal - physiology | Action Potentials - physiology | Pyramidal Tracts - physiopathology | Animals | Movement - physiology | Neuronal Plasticity - physiology | Muscle Contraction - physiology | Spinal Cord - physiology | Exercise - physiology
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4. Regenerative Rehabilitation and Genomics: Frontiers in Clinical Practice
by Ambrosio, Fabrisia and Kleim, Jeffrey A
Physical Therapy, ISSN 0031-9023, 04/2016, Volume 96, Issue 4, pp. 430 - 430
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5. Full Text BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
by Schallert, Kellan and Cramer, Steven C and Chan, Sheila and Procaccio, Vincent and Jimenez, Richard and Kleim, Jeffrey A and Pringle, Erin
Nature Neuroscience, ISSN 1097-6256, 06/2006, Volume 9, Issue 6, pp. 735 - 737
Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography.... 
TRANSCRANIAL MAGNETIC STIMULATION | NEUROSCIENCES | MODULATION | HUMAN-MEMORY | Motor Cortex - anatomy & histology | Nerve Regeneration - genetics | Brain-Derived Neurotrophic Factor - genetics | Motor Cortex - physiology | Recovery of Function - genetics | Motor Skills - physiology | Humans | Genotype | Male | Neuropsychological Tests | Transcranial Magnetic Stimulation | Learning - physiology | Neuronal Plasticity - genetics | Movement - physiology | Evoked Potentials, Motor - genetics | Brain Mapping | Adult | Amino Acid Substitution - genetics | Female | Polymorphism, Genetic - genetics | Valine - genetics | Methionine - genetics | Neuroplasticity | Neural transmission | Regulation | Research | Motor learning | Genetic polymorphisms
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6. Full Text Regenerative Rehabilitation and Genomics: Frontiers in Clinical Practice
by Ambrosio, F and Kleim, J.A
Physical Therapy, ISSN 0031-9023, 04/2016, Volume 96, Issue 4, pp. 430 - 432
According to Khan and Scott,3 in the late 19th century, the Oxford English Dictionary defined the term mechanotherapy as "the employment of mechanical means... 
ORTHOPEDICS | REHABILITATION | Attitude of Health Personnel | Clinical Decision-Making | Genomics | Humans | Physical Therapy Specialty | Professional Role | Physical Therapists | Regenerative Medicine | Rehabilitation | Periodicals as Topic | Patient Selection | Precision Medicine | Practice | Forecasts and trends | Regenerative medicine | Physical therapists | Innovations | Tissue engineering | Curricula | Patients | Brain research | Students | Precision medicine | Stem cells | Physiology | Clinical medicine | Physical therapy
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7. Full Text Neural plasticity and neurorehabilitation: Teaching the new brain old tricks
by Kleim, Jeffrey A
Journal of Communication Disorders, ISSN 0021-9924, 2011, Volume 44, Issue 5, pp. 521 - 528
Highlights â–º Neural plasticity is the neurobiological mechanism supporting functional improvement after brain injury. â–º The brain uses different neural... 
Psychiatry | Neural plasticity, Motor cortex, Stroke, Synaptic plasticity | DENDRITIC PLASTICITY | Neural plasticity | Stroke | SQUIRREL-MONKEYS | FUNCTIONAL REORGANIZATION | PRIMARY MOTOR CORTEX | INDUCED POTENTIATION | RECOVERY | LINGUISTICS | TRANSCRANIAL MAGNETIC STIMULATION | SENSORIMOTOR CORTEX | ADULT-RAT | Motor cortex | Synaptic plasticity | REHABILITATION | FOCAL CORTICAL ISCHEMIA | Neurological Impairments | Brain | Cognitive Processes | Therapy | Head Injuries | Injuries | Diseases | Brain - physiopathology | Humans | Neuronal Plasticity - drug effects | Motor Cortex - physiopathology | Brain Injuries - physiopathology | Electric Stimulation Therapy | Recruitment, Neurophysiological - physiology | Brain - drug effects | Learning - physiology | Animals | Neuronal Plasticity - physiology | Brain Injuries - rehabilitation | Recovery of Function - physiology | Teachers | Brain injury
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8. Full Text Neural Plasticity: The Biological Substrate For Neurorehabilitation
by Warraich, Zuha, BS and Kleim, Jeffrey A., PhD
PM&R, ISSN 1934-1482, 2010, Volume 2, Issue 12, pp. S208 - S219
Abstract Decades of basic science have clearly demonstrated the capacity of the central nervous system (CNS) to structurally and functionally adapt in response... 
Physical Medicine and Rehabilitation | SPORT SCIENCES | REHABILITATION | Learning - physiology | Animals | Neuronal Plasticity - physiology | Motor Skills - physiology | Humans | Brain Injuries - rehabilitation | Recovery of Function - physiology | Brain Injuries - physiopathology | Central Nervous System Diseases - rehabilitation | Electric Stimulation Therapy | Central Nervous System - injuries | Central Nervous System Diseases - physiopathology
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9. Full Text Motor Enrichment and the Induction of Plasticity Before or After Brain Injury
by Kleim, Jeffrey A and Jones, Theresa A and Schallert, Timothy
Neurochemical Research, ISSN 0364-3190, 11/2003, Volume 28, Issue 11, pp. 1757 - 1769
Voluntary exercise, treadmill activity, skills training, and forced limb use have been utilized in animal studies to promote brain plasticity and functional... 
Biochemistry, general | Neurosciences | Parkinson's disease | BDNF | exercise | experience | stroke | degeneration | Neurology | enrichment | FGF-2 | rehabilitation | Biomedicine | GDNF | neurotrophic factors | Aging | Enrichment | Experience | Stroke | Exercise | Degeneration | Rehabilitation | Neurotrophic factors | MIDDLE CEREBRAL-ARTERY | USE-DEPENDENT EXAGGERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL ISCHEMIC-INJURY | ADULT-RATS | NEUROSCIENCES | UNILATERAL SENSORIMOTOR CORTEX | LATERAL HYPOTHALAMIC-LESIONS | CENTRAL-NERVOUS-SYSTEM | aging | LONG-TERM POTENTIATION | INDUCED MOVEMENT THERAPY | EXERCISE INDUCES ANGIOGENESIS | Exercise Therapy - methods | Motor Activity - physiology | Humans | Nerve Degeneration - physiopathology | Treatment Outcome | Brain Injuries - therapy | Brain Injuries - physiopathology | Physical Conditioning, Animal - physiology | Nerve Degeneration - pathology | Animals | Neuronal Plasticity - physiology | Cognition - physiology | Recovery of Function - physiology | Exercise - physiology | Brain Injuries - pathology | Nerve Degeneration - therapy
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10. Full Text What Do Motor "Recovery" and "Compensation" Mean in Patients Following Stroke?
by Levin, MF and Kleim, JA and Wolf, SL
NEUROREHABILITATION AND NEURAL REPAIR, ISSN 1545-9683, 05/2009, Volume 23, Issue 4, pp. 313 - 319
There is a lack of consistency among researchers and clinicians in the use of terminology that describes changes in motor ability following neurological... 
Stroke | Terminology | CORTEX ACTIVATION | RANDOMIZED CONTROLLED-TRIAL | CORTICAL REORGANIZATION | Recovery | PREMOTOR CORTEX | FUNCTIONAL MRI | CLINICAL NEUROLOGY | REACHING PERFORMANCE | UPPER EXTREMITY FUNCTION | Compensation | Hemiplegia | Rehabilitation | QUALITY-OF-LIFE | HEMIPARETIC STROKE | INDUCED MOVEMENT THERAPY | Disability Evaluation | Outcome Assessment (Health Care) - methods | Humans | Stroke - complications | Stroke Rehabilitation | Terminology as Topic | Stroke - physiopathology | Outcome Assessment (Health Care) - standards | Interdisciplinary Communication | Movement Disorders - physiopathology | Neuronal Plasticity - physiology | Movement Disorders - etiology | Recovery of Function - physiology | Hemiplegia - rehabilitation | Hemiplegia - complications | Movement Disorders - rehabilitation | Hemiplegia - physiopathology | Stroke (Disease) | Physiological aspects | Care and treatment | Stroke patients | Motor ability | Analysis
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11. Full Text Functional Reorganization of the Rat Motor Cortex Following Motor Skill Learning
by Jeffrey A. Kleim and Scott Barbay and Randolph J. Nudo
Journal of Neurophysiology, ISSN 0022-3077, 12/1998, Volume 80, Issue 6, pp. 3321 - 3325
Kleim, Jeffrey A., Scott Barbay, and Randolph J. Nudo. Functional reorganization of the rat motor cortex following motor skill learning. J. Neurophysiol. 80:... 
ORGANIZATION | MOVEMENT REPRESENTATIONS | CORTICAL ABLATIONS | PHYSIOLOGY | SENSORIMOTOR CORTEX | NEURONS | ADULT-RATS | FORELIMB CORTEX | ALTERS | NEUROSCIENCES | TACTILE EXPERIENCE | LESIONS | Microelectrodes | Motor Cortex - physiology | Electric Stimulation | Motor Skills - physiology | Forelimb - physiology | Electrophysiology | Hindlimb - physiology | Rats | Hindlimb - innervation | Male | Forelimb - innervation | Learning - physiology | Animals | Pyramidal Cells - physiology | Brain Mapping | Motor Cortex - cytology
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12. Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation
by Kleim, Jeffrey A and Kleim, Jeffrey A and Kleim, Erin D and Kleim, Erin D and Cramer, Steven C and Cramer, Steven C
Nature Protocols, ISSN 1754-2189, 06/2007, Volume 2, Issue 7, pp. 1675 - 1684
Measuring changes in the characteristics of corticospinal output has become a critical part of assessing the impact of motor experience on cortical... 
PERIPHERAL-NERVE | STROKE | MOVEMENT REPRESENTATIONS | HUMAN MOTOR CORTEX | EXCITABILITY | BIOCHEMICAL RESEARCH METHODS | DEPENDENT PLASTICITY | EXPERIENCE | MAP | MODULATION | BRAIN | Hand - innervation | Humans | Spinal Cord - physiology | Magnetic Resonance Imaging - methods | Adult | Cerebral Cortex - physiology | Reference Values | Brain Mapping - methods | Transcranial Magnetic Stimulation - methods | Brain Injuries - physiopathology | Motor Activity | Stereotaxic Techniques
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13. Full Text Translating Genomic Advances to Physical Therapist Practice: A Closer Look at the Nature and Nurture of Common Diseases
by Curtis, Catherine L and Goldberg, Allon and Kleim, Jeffrey A and Wolf, Steven L
Physical Therapy, ISSN 0031-9023, 04/2016, Volume 96, Issue 4, pp. 570 - 580
The Human Genome Project and the International HapMap Project have yielded new understanding of the influence of the human genome on health and disease,... 
FUNCTIONAL POLYMORPHISM | MEDICINE GENOMICS | PAIN SENSITIVITY | CARDIOVASCULAR-DISEASE | REHABILITATION | FAMILIAL AGGREGATION | ORTHOPEDICS | AMERICAN-HEART-ASSOCIATION | KNEE OSTEOARTHRITIS | SCIENTIFIC STATEMENT | CORONARY-ARTERY-DISEASE | GENETIC RISK SCORE | Genetic Predisposition to Disease | Genome-Wide Association Study | Pharmacogenetics | Genomics | Humans | Cardiovascular Diseases - therapy | Cardiovascular Diseases - genetics | Osteoarthritis - genetics | Osteoarthritis - therapy | Motor Activity - genetics | Physical Fitness | Physical Therapy Specialty | Polymorphism, Single Nucleotide | Precision Medicine | Evaluation | Forecasts and trends | Physical therapy | Therapeutics, Physiological | DNA methylation | Twins | Genes | Mortality | Chronic illnesses
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14. Full Text Motor skill learning induces changes in white matter microstructure and myelination
by Sampaio-Baptista, Cassandra and Khrapitchev, Alexandre A and Foxley, Sean and Schlagheck, Theresa and Scholz, Jan and Jbabdi, Saad and DeLuca, Gabriele C and Miller, Karla L and Taylor, Amy and Thomas, Nagheme and Kleim, Jeffrey and Sibson, Nicola R and Bannerman, David and Johansen-Berg, Heidi
Journal of Neuroscience, ISSN 0270-6474, 2013, Volume 33, Issue 50, pp. 19499 - 19503
Learning a novel motor skill is associated with well characterized structural and functional plasticity in the rodent motor cortex. Furthermore, neuroimaging... 
NERVOUS-SYSTEM | CORTEX | SYNAPTOGENESIS | NEUROPLASTICITY | REORGANIZATION | DIFFUSION | NEUROSCIENCES | Learning - physiology | Motor Cortex - physiology | Myelin Sheath - physiology | Animals | Neuronal Plasticity - physiology | Anisotropy | Diffusion Magnetic Resonance Imaging | Nerve Fibers, Myelinated - physiology | Rats | Male | Psychomotor Performance - physiology | Brief Communications
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15. Full Text BDNF val66met polymorphism influences motor system function in the human brain
by McHughen, Stephanie A and Rodriguez, Paul F and Kleim, Jeffrey A and Kleim, Erin D and Crespo, Laura Marchal and Procaccio, Vincent and Cramer, Steven C
Cerebral Cortex, ISSN 1047-3211, 05/2010, Volume 20, Issue 5, pp. 1254 - 1262
Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth... 
Genetics | Genotype | FMRI | Cortex | Plasticity | Brain-Derived Neurotrophic Factor - genetics | Humans | Male | Brain - physiology | Psychomotor Performance - physiology | Functional Laterality - genetics | Young Adult | Brain - blood supply | Fingers - physiology | Movement - physiology | Adult | Female | Oxygen - blood | Neuropsychological Tests | Learning - physiology | Magnetic Resonance Imaging | Analysis of Variance | Image Processing, Computer-Assisted | Adolescent | Brain Mapping | Polymorphism, Single Nucleotide - genetics | Valine - genetics | Methionine - genetics | Cohort Studies | cortex | fMRI | plasticity | genetics | genotype
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16. Full Text The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture
by Tennant, Kelly A and Adkins, Deanna L and Donlan, Nicole A and Asay, Aaron L and Thomas, Nagheme and Kleim, Jeffrey A and Jones, Theresa A
Cerebral Cortex, ISSN 1047-3211, 04/2011, Volume 21, Issue 4, pp. 865 - 876
The organization of forelimb representation areas of the monkey, cat, and rat motor cortices has been studied in depth, but its characterization in the mouse... 
motor map | intracortical microstimulation | forelimb representation | cytoarchitecture | primary motor cortex | LABORATORY MICE | MOVEMENT REPRESENTATIONS | HOUSING CONDITIONS | CORTICAL REPRESENTATION | MAP EXPANSION | FUNCTIONAL REORGANIZATION | NEUROSCIENCES | MUS-MUSCULUS | SENSORIMOTOR CORTEX | DUCHENNE MUSCULAR-DYSTROPHY | ADULT SQUIRREL-MONKEYS | Mice - anatomy & histology | Motor Cortex - anatomy & histology | Animals | Electric Stimulation | Mice, Inbred C57BL | Brain Mapping | Male | Forelimb - innervation
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