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1. Full Text Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study
by Ross, Owen A, Dr and Soto-Ortolaza, Alexandra I, BSc and Heckman, Michael G, MS and Aasly, Jan O, Prof and Abahuni, Nadine, MD and Annesi, Grazia, Prof and Bacon, Justin A, BSc and Bardien, Soraya, PhD and Bozi, Maria, MD and Brice, Alexis, Prof and Brighina, Laura, MD and Van Broeckhoven, Christine, Prof and Carr, Jonathan, Prof and Chartier-Harlin, Marie-Christine, Prof and Dardiotis, Efthimios, MD and Dickson, Dennis W, Prof and Diehl, Nancy N, BS and Elbaz, Alexis, Prof and Ferrarese, Carlo, Prof and Ferraris, Alessandro, MD and Fiske, Brian, PhD and Gibson, J Mark, Prof and Gibson, Rachel, PhD and Hadjigeorgiou, Georgios M, MD and Hattori, Nobutaka, Prof and Ioannidis, John PA, Prof and Jasinska-Myga, Barbara, MD and Jeon, Beom S, Prof and Kim, Yun Joong, Prof and Klein, Christine, Prof and Kruger, Rejko, MD and Kyratzi, Elli, MD and Lesage, Suzanne, PhD and Lin, Chin-Hsien, MD and Lynch, Timothy, Prof and Maraganore, Demetrius M, Prof and Mellick, George D, PhD and Mutez, Eugénie, MD and Nilsson, Christer, Prof and Opala, Grzegorz, Prof and Park, Sung Sup, Prof and Puschmann, Andreas, MD and Quattrone, Aldo, Prof and Sharma, Manu, PhD and Silburn, Peter A, Prof and Sohn, Young Ho, Prof and Stefanis, Leonidas, MD and Tadic, Vera, MD and Theuns, Jessie, PhD and Tomiyama, Hiroyuki, MD and Uitti, Ryan J, Prof and Valente, Enza Maria, Prof and van de Loo, Simone, PhD and Vassilatis, Demetrios K, PhD and Vilariño-Güell, Carles, PhD and White, Linda R, Prof and Wirdefeldt, Karin, MD and Wszolek, Zbigniew K, Prof and Wu, Ruey-Meei, Prof and Farrer, Matthew J, Prof and Genetic Epidemiology Parkinson's D and Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium and Sektion IV and Lund University and Psychiatry (Lund) and Klinisk neurogenetik and MultiPark: Multidisciplinary research focused on Parkinson´s disease and Psykiatri, Lund and Division IV and Clinical Neurogenetics and Lunds universitet
Lancet Neurology, The, ISSN 1474-4422, 2011, Volume 10, Issue 10, pp. 898 - 908
Summary Background Background The leucine-rich repeat kinase 2 gene ( LRRK2 ) harbours highly penetrant mutations that are linked to familial parkinsonism.... 
Neurology | POPULATION | SIFT | METAANALYSIS | RISK-FACTOR | GENE | TRAITS | PROTEIN FUNCTION | CHALLENGES | CLINICAL NEUROLOGY | GENOME-WIDE ASSOCIATION | COMPREHENSIVE ANALYSIS | Genetic Predisposition to Disease | Gene Frequency | Humans | Middle Aged | Risk Factors | Protein-Serine-Threonine Kinases - genetics | Exons - genetics | Genotype | Male | International Cooperation | Parkinson Disease - genetics | Case-Control Studies | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Young Adult | Ethnic Groups - genetics | Adolescent | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Genome-Wide Association Study - methods | Medical colleges | Medical research | Neurosciences | Parkinson's disease | Lubrication and lubricants | Medicine, Experimental | Biological apparatus and supplies | Genetics | Agriculture | Disease susceptibility | Diagnostic imaging | Biometry | Neurologi | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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2. Full Text Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial
by Nash, Peter, Prof and Kirkham, Bruce, Prof and Okada, Masato, MD and Rahman, Proton, Prof and Combe, Benard, Prof and Burmester, Gerd-Ruediger, Prof and Adams, David H, PhD and Kerr, Lisa, MSPH and Lee, Chin, MD and Shuler, Catherine L, MS and Genovese, Mark, Prof and SPIRIT-P Study Grp and SPIRIT-P2 Study Group
Lancet, The, ISSN 0140-6736, 2017, Volume 389, Issue 10086, pp. 2317 - 2327
Summary Background Patients who have had inadequate response to tumour necrosis factor inhibitors have fewer treatment options and are generally more treatment... 
Internal Medicine | INTERLEUKIN-17A | CRITERIA | CELLS | MEDICINE, GENERAL & INTERNAL | SECUKINUMAB | ADALIMUMAB | EFFICACY | SAFETY | MONOCLONAL-ANTIBODY | PROGRESSION | DISEASE-ACTIVITY | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Global Health | Arthritis, Psoriatic - drug therapy | Humans | Middle Aged | Female | Male | Treatment Outcome | Tumor Necrosis Factors - therapeutic use | Dermatologic Agents - therapeutic use | Clinical trials | Monoclonal antibodies | Care and treatment | Psoriatic arthritis | Necrosis | Interleukins | Product development | Therapy | Pathogenesis | Funding | Interleukin | Arthritis | Criteria | Immunotherapy | Tumor necrosis factor-TNF | Safety | Diagnosis | Dosing | Signs and symptoms | Biological products | Effectiveness | Psoriasis | Cytokines | Therapeutic applications | Injection | Patients | Inhibitors | Tumor necrosis factor | TNF inhibitors | Fatalities
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3. Full Text Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial
by Dimopoulos, Meletios A and Dimopoulos, Athanasios and Gay, Francesca and Schjesvold, Fredrik and Beksac, Meral and Hajek, Roman and Weisel, Katja Christina and Weisel, Katja and Goldschmidt, Hartmut and Maisnar, Vladimir and Moreau, Philippe and Min, Chang Ki and Pluta, Andrzej and Pluta, Agnieszka and Chng, Wee Joo and Chng, Wee-Joo and Kaiser, Martin and Zweegman, Sonja and Mateos, Maria-Victoria and Mateos, Maria Victoria and Spencer, Andrew and Iida, Shinsuke and Morgan, Gareth and Suryanarayan, Kaveri and Teng, Zhaoyang and Skacel, Tomas and Palumbo, Antonio and Dash, Ajeeta B and Gupta, Neeraj and Labotka, Richard and Rajkumar, S Vincent and Bar, Daniel and Basso, Alfredo and Fantl, Dorotea and He, Simon and Horvath, Neomi and Lee, Cindy and Lee, Jae Hoon and Rowlings, Phillip and Taylor, Kerry and Cochrane, Tara and Kwok, Fiona and Ramanathan, Sundreswran and Agis, Hermine and Zojer, Niklas and Kentos, Alain and Offner, Fritz and Van Droogenbroeck, Jan and Wu, Ka Lung and Maiolino, Angelo and Martinez, Gracia and Zanella, Karla and Capra, Marcelo and Araújo, Sérgio and Gregora, Evzen and Pour, Ludek and Scudla, Vlastimil and Spicka, Ivan and Abildgaard, Niels and Andersen, Niels and Jensen, Bo Amdi and Helleberg, Carsten and Plesner, Torben and Salomo, Morten and Svirskaite, Asta and Delarue, Richard and Blau, Igor and Schieferdecker, Aneta and Teleanu, Veronica and Munder, Markus and Röllig, Christoph and Salwender, Han-Juergen and Fuhrmann, Stephan and Duerig, Jan and Zeis, Matthias and Klein, Stefan and Reimer, Peter and Schmidt, Christian and Scheid, Christof and Mayer, Karin and Hoffmann, Martin and Sosada, Markus and Delimpasi, Sosana and Kyrtsonis, Mary-Christine and Anagnostopoulos, Achilleas and Nagy, Zsolt and Illés, Árpád and Egyed, Miklós and Borbényi, Zita and Mikala, Gabor and Dally, Najib and Horowitz, Netanel and Gutwein, Odit and Nemets, Anatoly and Vaxman, Iuliana and Shvetz, Olga and Trestman, Svetlana and Ruchlemer, Rosa and Nagler, Arnon and Tadmor, Tamar and ... and TOURMALINE-MM3 Study Grp and TOURMALINE-MM3 study group
The Lancet, ISSN 0140-6736, 01/2019, Volume 393, Issue 10168, pp. 253 - 264
Maintenance therapy following autologous stem cell transplantation (ASCT) can delay disease progression and prolong survival in patients with multiple myeloma.... 
DIAGNOSED MULTIPLE-MYELOMA | DEXAMETHASONE | HIGH-DOSE THERAPY | IMPROVES SURVIVAL | BORTEZOMIB | THALIDOMIDE | INDUCTION | LENALIDOMIDE MAINTENANCE | CHEMOTHERAPY | MEDICINE, GENERAL & INTERNAL | Therapy | Transplants & implants | Toxicity | Multiple myeloma | Medical services | Clinical trials | Stem cell transplantation | Transplantation | Peripheral neuropathy | Randomization | Motivation | Melphalan | Diagnosis | Safety | Drug dosages | Autografts | Cell survival | Hematology | Maintenance | Patients | Survival | Chemotherapy | Stem cells | Adults | Tourmaline | Pharmaceuticals | Index Medicus | Abridged Index Medicus
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4. Full Text Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials
by Cahn, Pedro and Madero, Juan Sierra and Arribas, José Ramón and Antinori, Andrea and Ortiz, Roberto and Clarke, Amanda E and Hung, Chien-Ching and Rockstroh, Jürgen K and Girard, Pierre-Marie and Sievers, Jörg and Man, Choy and Currie, Alexander and Underwood, Mark and Tenorio, Allan R and Pappa, Keith and Wynne, Brian and Fettiplace, Anna and Gartland, Martin and Aboud, Michael and Smith, Kimberly and Cassetti, Lidia and David, Daniel and Figueras, Laura and Losso, Marcelo and Lopardo, Gustavo and Lupo, Sergio and Porteiro, Norma and Sánchez, Marisa and Bloch, Mark and Cooper, David and Finlayson, Robert and Kelleher, Anthony and Koh, Kenneth and Lewis, David and McMahon, James and Moore, Richard and Roth, Norman and Shields, Matthew and De Wit, Stephane and Florence, Eric and Goffard, Jean-Christophe and Demeester, Remy and Lacor, Patrick and Vandercam, Bernard and Vandekerckhove, Linos and Angel, Jonathan and Baril, Jean-Guy and Conway, Brian and De Pokomandy, Alexandra and Szabo, Jason and Walmsley, Sharon and Bouchaud, Olivier and Chidiac, Christian and Delobel, Pierre and Goujard, Cecile and Katlama, Christine and Molina, Jean-Michel and Pialoux, Gilles and Philibert, Patrick and Bogner, Johannes and Esser, Stefan and Krznaric, Ivanka and Lehmann, Clara and Spinner, Christoph and Stellbrink, Hans-Jurgen and Stephan, Christoph and Stoehr, Albrecht and Barchi, Enrico and Caramello, Pietro and Castelli, Francesco and Cattelan, Anna Maria and D'Arminio Monforte, Antonella and Di Biagio, Antonio and Di Perri, Giovanni and Gori, Andrea and Maggiolo, Franco and Menzaghi, Barbara and Migliorino, Guglielmo and Mussini, Cristina and Penco, Giovanni and Puoti, Massimo and Rizzardini, Giuliano and Gulminetti, Roberto and Lazzarin, Adriano and Quirino, Tiziano and Sighinolfi, Laura and Viale, Pierluigi and Amaya Tapia, Gerardo and Andrade Villanueva, Jaime and Granados Reyes, Enrique R and Perez Rios, Alma and Santoscoy Gomez, Mario and Den Hollander, Jan and Rijnders, Bart and Hidalgo, José A and Hercilla Vasquez, Luis and Illescas, Luis and Olczak, Anita and Mansinho, Kamal and Correia Pacheco, Patricia Paula and ... and GEMINI Study Team
The Lancet, ISSN 0140-6736, 01/2019, Volume 393, Issue 10167, pp. 143 - 155
Effective two-drug regimens could decrease long-term drug exposure and toxicity with HIV-1 antiretroviral therapy (ART). We therefore aimed to evaluate the... 
ABACAVIR | MEDICINE, GENERAL & INTERNAL | THERAPY | ONCE-DAILY DOLUTEGRAVIR | SAFETY | OPEN-LABEL | INHIBITORS | TENOFOVIR/EMTRICITABINE | RITONAVIR | Anti-Retroviral Agents - therapeutic use | Emtricitabine - adverse effects | Emtricitabine - therapeutic use | Tenofovir - adverse effects | Double-Blind Method | Tenofovir - therapeutic use | Anti-HIV Agents - adverse effects | HIV Infections - virology | Humans | Middle Aged | Anti-Retroviral Agents - adverse effects | Male | RNA, Viral - blood | Lamivudine - adverse effects | HIV-1 - isolation & purification | Heterocyclic Compounds, 3-Ring - adverse effects | Heterocyclic Compounds, 3-Ring - therapeutic use | Lamivudine - therapeutic use | Adult | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | Drug Therapy, Combination | Viral Load - drug effects | Clinical trials | Antiviral agents | HIV (Viruses) | Analysis | Anti-HIV agents | Health care | Emtricitabine | Antiretroviral drugs | Therapy | Tablets | Toxicity | Lamivudine | Infections | Exposure | Ribonucleic acid--RNA | Drug resistance | Antiretroviral therapy | Tenofovir | Randomization | Motivation | Antiretroviral agents | Human immunodeficiency virus--HIV | Adults | Safety | Drug therapy
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5. Full Text Performance of the CMS muon detector and muon reconstruction with proton-proton collisions at $\sqrt{s}=$ 13 TeV
by CMS Collaboration
04/2018
JINST 13 (2018) P06015 The CMS muon detector system, muon reconstruction software, and high-level trigger underwent significant changes in 2013-2014 in... 
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6. Full Text Search for black holes and sphalerons in high-multiplicity final states in proton-proton collisions at $\sqrt{s} =$ 13 TeV
by CMS Collaboration and Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States) and Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Journal of High Energy Physics (Online), ISSN 1029-8479, 05/2018, Volume 2018, Issue 11
JHEP 11 (2018) 042 A search in energetic, high-multiplicity final states for evidence of physics beyond the standard model, such as black holes, string balls,... 
Physics - High Energy Physics - Experiment | Beyond Standard Model | Hadron-Hadron scattering (experiments) | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
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7. Dokumente zur Telemann-Rezeption 1767 bis 1907
by Klein, Christine
1998, Schriftenreihe zur mitteldeutschen Musikgeschichte. Serie II, Forschungsbeiträge, ISBN 3932090314, Volume Bd. 1, xl, 370
Telemann, Georg Philipp, 1681-1767 Appreciation | Telemann, Georg Philipp, 1681-1767 Sources
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8. Full Text Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
by Elbaz, Alexis and Ross, Owen A and Ioannidis, John P. A and Soto‐Ortolaza, Alexandra I and Moisan, Frédéric and Aasly, Jan and Annesi, Grazia and Bozi, Maria and Brighina, Laura and Chartier‐Harlin, Marie‐Christine and Destée, Alain and Ferrarese, Carlo and Ferraris, Alessandro and Gibson, J. Mark and Gispert, Suzana and Hadjigeorgiou, Georgios M and Jasinska‐Myga, Barbara and Klein, Christine and Krüger, Rejko and Lambert, Jean‐Charles and Lohmann, Katja and van de Loo, Simone and Loriot, Marie‐Anne and Lynch, Timothy and Mellick, George D and Mutez, Eugénie and Nilsson, Christer and Opala, Grzegorz and Puschmann, Andreas and Quattrone, Aldo and Sharma, Manu and Silburn, Peter A and Stefanis, Leonidas and Uitti, Ryan J and Valente, Enza Maria and Vilariño‐Güell, Carles and Wirdefeldt, Karin and Wszolek, Zbigniew K and Xiromerisiou, Georgia and Maraganore, Demetrius M and Farrer, Matthew J and Genetic Epidemiology Parkinson's and Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium and on behalf of the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium and Lund University and Psychiatry (Lund) and Neurologi, Lund and MultiPark: Multidisciplinary research focused on Parkinson´s disease and Psykiatri, Lund and Lunds universitet and Neurology, Lund
Annals of Neurology, ISSN 0364-5134, 05/2011, Volume 69, Issue 5, pp. 778 - 792
Objective: We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson... 
COMMON VARIANTS | RISK-FACTORS | METAANALYSIS | POLYMORPHISMS | TAU-GENE | SUSCEPTIBILITY | ALPHA-SYNUCLEIN | HAPLOTYPE | NEUROSCIENCES | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Humans | Middle Aged | Logistic Models | Male | Parkinson Disease - genetics | Case-Control Studies | tau Proteins - genetics | Age of Onset | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Retrospective Studies | alpha-Synuclein - genetics | Odds Ratio | Haplotypes | Genes | Parkinsons disease | Clinical Medicine | Neurologi | Neurology | Medical and Health Sciences | Medicin och hälsovetenskap | Psykiatri | Klinisk medicin | Psychiatry | Geriatrik | Geriatrics
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9. Full Text FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation
by Klein, Tobias and Abgottspon, Daniela and Wittwer, Matthias and Rabbani, Said and Herold, Janno and Jiang, Xiaohua and Kleeb, Simon and Lüthi, Christine and Scharenberg, Meike and Bezençon, Jacqueline and Gubler, Erich and Pang, Lijuan and Smiesko, Martin and Cutting, Brian and Schwardt, Oliver and Ernst, Beat
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2010, Volume 53, Issue 24, pp. 8627 - 8641
Urinary tract infection (UTI) by uropathogenic Escherichia coli (UPEC) is one of the most common infections, particularly affecting women. The interaction of... 
MEDIATED ADHESION | TYPE-1 FIMBRIAE | CHEMISTRY, MEDICINAL | INHIBITION | AFFINITY | MANNOSE | DRUGS | FIMBRIATED ESCHERICHIA-COLI | RECEPTOR | COLONIZATION | BINDING | Humans | Cell Membrane Permeability | Host-Pathogen Interactions - drug effects | Mannosides - pharmacokinetics | Colony Count, Microbial | Blood Proteins - metabolism | Intestinal Absorption | Drug Design | Female | Urinary Tract Infections - microbiology | Urinary Bladder - microbiology | Binding, Competitive | Caco-2 Cells | Escherichia coli Infections - drug therapy | Adhesins, Escherichia coli | Administration, Oral | Solubility | Escherichia coli Infections - microbiology | Benzoates - chemical synthesis | Urinary Tract Infections - drug therapy | Anti-Bacterial Agents - chemical synthesis | Fimbriae Proteins - antagonists & inhibitors | Animals | Prodrugs - pharmacokinetics | Uropathogenic Escherichia coli - drug effects | Anti-Bacterial Agents - pharmacokinetics | Mannosides - pharmacology | Benzoates - pharmacology | Prodrugs - chemical synthesis | Protein Binding | Mannosides - chemical synthesis | Urinary Bladder - drug effects | Anti-Bacterial Agents - pharmacology | Mice | Uropathogenic Escherichia coli - enzymology | Prodrugs - pharmacology | Benzoates - pharmacokinetics
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10. Literatur im Kontext
: Festschrift für Helmut Schrey zum 65. Geburtstag am 6. 1. 1985
by Schrey, Helmut and Haas, Renate and Klein-Braley, Christine
1985, 1. Aufl. --, Duisburger Studien., ISBN 9783883456126, Volume Bd. 10, viii, 459
Study and teaching | Literature | History and criticism | Schrey, Helmut | English literature
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11. Full Text Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States
by DuBose, Stephanie N., MPH and Hermann, Julia M., MS and Tamborlane, William V., MD and Beck, Roy W., MD, PhD and Dost, Axel, MD and DiMeglio, Linda A., MD, MPH and Schwab, Karl Otfried, MD and Holl, Reinhard W., MD and Hofer, Sabine E., MD and Maahs, David M., MD, PhD and Type 1 Diabet Exchange Clinic and Type 1 Diabetes Exchange Clinic Network and Diabetes Prospective Follow-up Registry
Journal of Pediatrics, The, ISSN 0022-3476, 2015, Volume 167, Issue 3, pp. 627 - 632.e4
Objective To examine the current extent of the obesity problem in 2 large pediatric clinical registries in the US and Europe and to examine the hypotheses that... 
Pediatrics | YOUNG-ADULTS | T1D EXCHANGE | QUALITY MANAGEMENT | INSULIN-RESISTANCE | ADOLESCENTS | DISEASE RISK-FACTORS | BODY-MASS INDEX | PEDIATRICS | WEIGHT-GAIN | METABOLIC-CONTROL | CHILDREN | Body Mass Index | Diabetes Mellitus, Type 1 - epidemiology | Glycated Hemoglobin A - analysis | United States - epidemiology | Hypoglycemia - epidemiology | Humans | Austria - epidemiology | Child, Preschool | Male | Germany - epidemiology | Obesity - epidemiology | Adolescent | Female | Registries | Child | Type 1 diabetes | Hemoglobin | Youth | Teenagers | Children | Health aspects | Obesity in adolescence | World health | Glycosylated hemoglobin
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