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Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P213 - P213
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 8, pp. 3858 - 3863
Neuronal cytoplasmic and intranuclear aggregates of RNA-binding protein TDP-43 are a hallmark feature of neurodegenerative diseases such as amyotrophic lateral... 
Brain | Pathology | Nervous system diseases | Spinal cord | Neurons | Transgenic animals | Antibodies | Amyotrophic lateral sclerosis | Frontotemporal lobar degeneration | Mice | Protein aggregation | Neurodegeneration | FTLD | Motor neuron disease | Dementia | motor neuron disease | PROTEIN | NUCLEIC-ACID BINDING | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | neurodegeneration | UBIQUITIN IMMUNOHISTOCHEMISTRY | AMYOTROPHIC-LATERAL-SCLEROSIS | NEURODEGENERATIVE DISEASES | DROSOPHILA | CELLULAR TOXICITY | protein aggregation | dementia | MUTATIONS | AGGREGATION | Frontotemporal Lobar Degeneration - pathology | Amyotrophic Lateral Sclerosis - genetics | Humans | Mice, Transgenic | Paralysis - genetics | Mutation, Missense | Paralysis - pathology | DNA-Binding Proteins - genetics | Muscle Spasticity - pathology | DNA-Binding Proteins - metabolism | Amyotrophic Lateral Sclerosis - pathology | Inclusion Bodies - genetics | Animals | Frontotemporal Lobar Degeneration - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Frontotemporal Lobar Degeneration - genetics | Inclusion Bodies - metabolism | Muscle Spasticity - genetics | Development and progression | Nervous system | Genetic aspects | Degeneration | Paralysis | Binding proteins | Health aspects | Proteins | Neurosciences | Rodents | Mutation | Ribonucleic acid--RNA | Index Medicus | Biological Sciences
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 3/2013, Volume 125, Issue 3, pp. 413 - 423
Genetic analysis revealed the hexanucleotide repeat expansion GGGGCC within the regulatory region of the gene C9orf72 as the most common cause of familial... 
Pathology | hnRNP A3 | Neurosciences | Medicine & Public Health | Neurodegeneration | TDP-43 | FTLD | ALS | C9orf72 | DEMENTIA | PROTEIN | EXPANSIONS | AMYOTROPHIC-LATERAL-SCLEROSIS | PATHOLOGY | FRONTOTEMPORAL LOBAR DEGENERATION | NEUROSCIENCES | MASS-SPECTROMETRY | CLINICAL NEUROLOGY | GENE | HEXANUCLEOTIDE REPEAT | Frontotemporal Lobar Degeneration - pathology | Gene Expression Regulation - genetics | Sequestosome-1 Protein | Amyotrophic Lateral Sclerosis - genetics | Humans | Repetitive Sequences, Nucleic Acid - physiology | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | Hippocampus - pathology | Chromatography, High Pressure Liquid | Mutation - genetics | DNA-Binding Proteins - metabolism | Proteins - genetics | Amyotrophic Lateral Sclerosis - pathology | Transfection | Frontotemporal Lobar Degeneration - metabolism | Mass Spectrometry | Amyotrophic Lateral Sclerosis - metabolism | HEK293 Cells | Inclusion Bodies - pathology | C9orf72 Protein | Frontotemporal Lobar Degeneration - genetics | Adaptor Proteins, Signal Transducing - metabolism | Inclusion Bodies - metabolism | RNA, Small Interfering - metabolism | Immunohistochemistry | Brain | RNA | Analysis | Physiological aspects | Amyotrophic lateral sclerosis | Genetic aspects | Binding proteins | Genetic translation | Protein binding | Index Medicus | Translation | Toxicity | Regulatory sequences | Metabolism | RNA-binding protein | Autopsy | Inclusion bodies | Genetic analysis | Mutation | Frontotemporal dementia | Hippocampus
Journal Article
EMBO reports, ISSN 1469-221X, 07/2017, Volume 18, Issue 7, pp. 1186 - 1198
Sequence variations in the triggering receptor expressed on myeloid cells 2 ( TREM 2) have been linked to an increased risk for neurodegenerative disorders... 
neurodegeneration | TREM | Alzheimer's disease | microglia | chemotaxis | TREM2 | GENE-EXPRESSION SIGNATURE | CELLS | FLUID SOLUBLE TREM2 | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRONTOTEMPORAL DEMENTIA | BONE-CYSTS | AMYOTROPHIC-LATERAL-SCLEROSIS | APOLIPOPROTEIN-E | CELL BIOLOGY | IN-VIVO | TRANSGENIC MICE | Neurons - pathology | Alzheimer Disease - physiopathology | Frontotemporal Dementia | Loss of Function Mutation | Humans | Cells, Cultured | Receptors, Immunologic - deficiency | Neurodegenerative Diseases - genetics | Gene Expression Profiling | Chemotaxis | Membrane Glycoproteins - genetics | Myeloid Cells | Microglia - physiology | Neurodegenerative Diseases - physiopathology | Alzheimer Disease - genetics | Receptors, Immunologic - genetics | Membrane Glycoproteins - deficiency | Phagocytosis | Brain | Leukocyte migration | Brain slice preparation | Central nervous system | Disorders | Stimulation | Cortex (somatosensory) | Attractants | Neurodegeneration | Clusters | Amyloid | Degeneration | Laser damage | Plaques | Injuries | Myeloid cells | Neurodegenerative diseases | Gene clusters | Shielding | Gene expression | Ablation | Microglia | Lipoproteins | Frontotemporal dementia | Alzheimers disease | Cell migration | Apoptosis | Index Medicus | Neuroscience | Immunology | Molecular Biology of Disease
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2012, Volume 11, Issue 1, pp. 54 - 65
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2017, Volume 36, Issue 13, pp. 1837 - 1853
Genetic variants in the triggering receptor expressed on myeloid cells 2 ( TREM 2) increase the risk for several neurodegenerative diseases including... 
neurodegeneration | TREM | frontotemporal dementia | regulated intramembrane proteolysis | neuroinflammation | TREM2 | NASU-HAKOLA-DISEASE | FLUID SOLUBLE TREM2 | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBROSPINAL-FLUID | APOLIPOPROTEIN-E | CELL BIOLOGY | TRANSLOCATOR PROTEIN | IN-VIVO | MYELOID CELLS-2 TREM2 | GAMMA-SECRETASE | Immunohistochemistry | Humans | Mutant Proteins - genetics | Positron-Emission Tomography | Mutation, Missense | Gene Knock-In Techniques | Membrane Glycoproteins - genetics | Magnetic Resonance Imaging | Animals | Microglia - physiology | Perfusion | Brain - pathology | Glucose - metabolism | Mice | Receptors, Immunologic - genetics | Disease Models, Animal | Frontotemporal Dementia - pathology | Neuroimaging | Brain | Editing | Risk | Stimulation | Genomes | Glucose | Macrophages | Blood | Phagocytes | Glucose metabolism | Alterations | Missense mutation | Cerebral blood flow | Rodents | Dementia disorders | Alzheimer's disease | Age | CRISPR | Myeloid cells | Medical imaging | Neurodegenerative diseases | Positron emission | Metabolism | Patients | Blood flow | Microglia | Neurological diseases | Magnetic resonance imaging | Emissions control | Resonance | Mutation | Frontotemporal dementia | Alzheimers disease | Positron emission tomography | Dementia | Index Medicus | Neuroscience | Molecular Biology of Disease
Journal Article
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 6/2014, Volume 127, Issue 6, pp. 845 - 860
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 05/2016, Volume 8, Issue 5, pp. 466 - 476
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 10/2017, Volume 9, Issue 10, pp. 1356 - 1365
Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 ( TREM 2) support an essential function of microglia... 
neurodegeneration | phagocytosis | TREM | regulated intramembrane proteolysis | Alzheimer's disease | TREM2 | MEDICINE, RESEARCH & EXPERIMENTAL | MICROGLIAL RESPONSE | FLUID SOLUBLE TREM2 | INTRAMEMBRANE PROTEOLYSIS | GOLGI-APPARATUS | AMYLOID PRECURSOR PROTEIN | APOLIPOPROTEIN-E | DISEASE | BETA-PROTEIN | MYELOID CELLS-2 TREM2 | GAMMA-SECRETASE | Amyloid Precursor Protein Secretases - genetics | Membrane Glycoproteins - metabolism | ADAM10 Protein - genetics | Humans | ADAM10 Protein - metabolism | Histidine - metabolism | Mutation, Missense | Phagocytosis - genetics | ADAM17 Protein - metabolism | Sequence Analysis, Protein | HEK293 Cells | Cell Membrane - metabolism | Membrane Proteins - metabolism | Membrane Proteins - genetics | Phagocytosis - physiology | THP-1 Cells | Immunity, Innate | Serine - metabolism | Membrane Glycoproteins - genetics | Microglia | ADAM17 Protein - genetics | Amyloid Precursor Protein Secretases - metabolism | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Histidine | Proteases | Proteolysis | Mass spectrometry | Immunoglobulins | Myeloid cells | Neurodegenerative diseases | Serine | Mass spectroscopy | Innate immunity | Cell surface | Phagocytes | Missense mutation | Coding | Mutation | Alzheimers disease | Endoplasmic reticulum | Phagocytosis | Index Medicus | Neuroscience | Immunology | Report | Reports | Genetics, Gene Therapy & Genetic Disease
Journal Article